Anti-vibriosis bioactive molecules from marine-derived variant < em > Streptomyces < /em > sp. ZZ741A

In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that the activity might come from the inhibition of Outer membrane protein U (OmpU).PMID:38486398 | DOI:10.1080/14786419.2024.2321487

Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research