A lupeol derivative and other isolates with antiplasmodial activity from the stem root of < em > Rauvolfia mannii < /em > Stapf. (Apocynaceae)

Nat Prod Res. 2024 Mar 18:1-5. doi: 10.1080/14786419.2024.2327623. Online ahead of print.ABSTRACTRauvolfia mannii is a plant from western and eastern areas of African continent and is widely used in folk medicine for the treatment of various diseases including malaria. Herein, one previously undescribed acylated triterpene (1), together with five already published natural products (2-6) were removed from its roots. The chemical structures of these compounds were determined by spectroscopic and spectrometric means (NMR, HRESIMS, IR and UV). In addition to the isolated triterpenoids, components 5 and 6 are also newly reported from the genus Rauvolfia. Moreover, some constituents were further tested against the chloroquine-sensitive strain of P. falciparum (3D7). It has been found that 3 and 4 showed a moderate antiplasmodial activity with IC50 values of 46.25 and 39.79 µM respectively.PMID:38497278 | DOI:10.1080/14786419.2024.2327623
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research