Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation
This study might enhance our comprehension on the pathogenic mechanism and diagnosis of UC and offer a treatment option for UC. (Source: Inflammation)
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research

Analysis and prediction of nutritional outcome of patients with pediatric inflammatory bowel disease from Bahrain
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease that causes anorexia, malabsorption, and increased energy requirements. Childhood IBD can significantly impact nutritional status and futu... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 24, 2024 Category: Pediatrics Authors: Hasan M. Isa, Masooma Mohamed, Ahmed Alsaei, Zahra Isa, Enjy Khedr, Afaf Mohamed and Haitham Jahrami Tags: Research Source Type: research

Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research

Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
AbstractPurpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In this scoping review, we summarize recent evidence detailing the effects of synthetic environmental chemicals on autoimmune diseases and highlight current research gaps and recommendations for future studies.Recent FindingsWe identified 68 recent publications related to environmental chemical exposures and autoimmune diseases. Most studies evaluated exposure to persistent environmental chemicals and autoimmune conditions including rheumatoid arthritis (RA), systemic lu...
Source: Current Environmental Health Reports - April 24, 2024 Category: Environmental Health Source Type: research

Imaging and clinical predictors of surgery in stricturing ileal Crohn ’s disease: a retrospective study from a large pediatric hospital
ConclusionSurgery remains common in stricturing pediatric CD, with increasing stricture ratio and sMaRIA score associated with need for surgical management.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 24, 2024 Category: Radiology Source Type: research

Diagnosis of Pediatric Appendicovesical Fistula by Contrast-enhanced Ultrasound: A Case Report
We reported a pediatric case of appendicovesical fistula that remained undiagnosed by non-contrast CT, fluoroscopic voiding cystourethrography (VCUG). Although the bladder orifice was identified during cystoscopy, its connection to the fistula site could not be determined. However, the trans-vesical contrast-enhanced ultrasound clearly demonstrated the presence of fistula. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Yang Xiuzhen, Xu Zheming, Yan Xiang, Ye Jingjing, Fu Junfen Source Type: research

Molecules, Vol. 29, Pages 1940: Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
n Kangwan An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pre...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Natticha Sumneang Komsak Pintha Sarawut Kongkarnka Maitree Suttajit Napapan Kangwan Tags: Article Source Type: research

Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research

Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research

Genomic Testing Identifies Monogenic Causes in Patients with Very Early-Onset Inflammatory Bowel Disease: A Multi-center Survey in an Iranian Cohort
Clin Exp Immunol. 2024 Apr 23:uxae037. doi: 10.1093/cei/uxae037. Online ahead of print.ABSTRACTPatients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a me...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Golnaz Eslamian Mahnaz Jamee Tooba Momen Pejman Rohani Sarehossadat Ebrahimi Mehrnaz Mesdaghi Soodeh Ghadimi Mahboubeh Mansouri Seyed Alireza Mahdaviani Mahnaz Sadeghi-Shabestari Morteza Fallahpour Bibi Shahin Shamsian Narges Eslami Samin Sharafian Naghi Source Type: research

Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
CONCLUSIONS: In summary, our data suggest that Sarm1 controls the MYD88-mediated inflammatory responses in IBD via its regulation of TRAF3 recruitment.PMID:38651786 | DOI:10.1080/08820139.2024.2343889 (Source: Immunological Investigations)
Source: Immunological Investigations - April 23, 2024 Category: Allergy & Immunology Authors: Huijuan Fan Chun Song Jingyu Zhang Source Type: research

The histamine H < sub > 4 < /sub > receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice
Int Immunopharmacol. 2024 Apr 22;133:112128. doi: 10.1016/j.intimp.2024.112128. Online ahead of print.ABSTRACTUlcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as H4R antagonist (pKi 6.2) and therefore the effects and pharmacological efficacy on a DSS-induced mice model of UC were assessed in this work. Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test compound LINS01007 was administer...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Beatriz K Lippi Gustavo A B Fernandes Gabriela A Azevedo Nathani G S Negreiros Antonio W Soares Maristella A Landgraf Jo ão Paulo S Fernandes Richardt G Landgraf Source Type: research