Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Alleviative effects of sulfated polysaccharide from Ishige Okamurae against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota
Int J Biol Macromol. 2024 Apr 26:131915. doi: 10.1016/j.ijbiomac.2024.131915. Online ahead of print.ABSTRACTA water-soluble polysaccharide from the brown alga Ishige Okamurae, designated IOP-0, was obtained by preparative anion-exchange and size-exclusion chromatography. Chemical and spectroscopic investigations revealed that IOP-0 was a sulfated fucoidan with a backbone primarily composed of 3-linked and 4-linked-L-fucose with sulfate groups at C-2/C-4 of the 3-linked-L-fucose. The protective effect of IOP-0 on ulcerative colitis was evaluated in this work. The results showed that IOP-0 could significantly alleviate the s...
Source: International Journal of Biological Macromolecules - April 28, 2024 Category: Biochemistry Authors: Ling Qin Hui Xu Junhan Cao Kai Wang Liping Zhang Mengke Yao Huan Lin Changfeng Qu Jinlai Miao Source Type: research

DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/ β-catenin and focal adhesion pathways
CONCLUSION: DIREN exerts a protective effect against DSS-induced UC by ameliorating colonic fibrosis via regulation of focal adhesion and the WNT/β-catenin signaling pathway, thereby inhibiting fibroblast migration and reducing collagen secretion.PMID:38678963 | DOI:10.1016/j.biopha.2024.116671 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Weizhi Lai Yingying Wang Chen Huang Hao Xu Xunjie Zheng Ke Li Jue Wang Zhaohuan Lou Source Type: research

Clostridiodes difficile infection in inflammatory bowel disease: a clinical review
Expert Rev Anti Infect Ther. 2024 Apr 27. doi: 10.1080/14787210.2024.2347955. Online ahead of print.ABSTRACTINTRODUCTION: Strong clinical data demonstrate that inflammatory bowel disease (IBD) is an independent risk factor for Clostridiodes difficile infection (CDI) and suggest a globally increased prevalence and severity of C. difficile coinfection in IBD patients (CDI-IBD). In addition to elderly individuals, children are also at higher risk of CDI-IBD. Rapid diagnosis is essential since the clinical manifestations of active IBD and CDI-IBD are indistinguishable. Antibiotics have been well established in the treatment of...
Source: Expert Review of Anti-Infective Therapy - April 27, 2024 Category: Infectious Diseases Authors: Mengjun Tang Chunhua Wang Ying Xia Jian Tang Jiao Wang Liang Shen Source Type: research

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion
Microorganisms. 2024 Mar 23;12(4):642. doi: 10.3390/microorganisms12040642.ABSTRACTCurcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin's ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatmen...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Junwen Zhu Lan He Source Type: research

Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis
Medicina (Kaunas). 2024 Mar 26;60(4):539. doi: 10.3390/medicina60040539.ABSTRACTOxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic renal disease, and inflammatory bowel disease (IBD). However, the precise mechanism involved remains to be clarified. We formerly identified a novel apoptosis-inducing humoral protein, in a hypoxia/reoxygenation-conditioned medium of cardiac myocytes, which proved to be 69th tyrosine-sulfated eukaryotic trans...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Akihito Nakajima Tomoyoshi Shibuya Takako Yao Tsutomu Fujimura Kimie Murayama Ko Okumura Akihito Nagahara Yoshinori Seko Source Type: research

Bear Bile Powder Improves Ulcerative Colitis by Protecting the Intestinal Mechanical Barrier and Regulating Intestinal Flora
CONCLUSION: Oral administration of a certain dose of BBP can significantly improve the symptoms of ulcerative colitis in mice. Part of the reason may be that it increases the expression of tight junction proteins, regulates specific flora in the intestine of mice, and maintains intestinal barrier homeostasis. In the future, the clinical application value of BBP will be explored, and BBP will be developed as a drug with the potential to treat UC and alleviate the pain of UC patients.PMID:38676524 | DOI:10.2174/0113816128294893240403074953 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Zi-Bo Liu Xun Ye Chun-Jie Wu Da-Neng Wei Source Type: research

Clostridioides difficile infection in inflammatory bowel disease: a clinical review
Expert Rev Anti Infect Ther. 2024 May 2:1-10. doi: 10.1080/14787210.2024.2347955. Online ahead of print.ABSTRACTINTRODUCTION: Strong clinical data demonstrate that inflammatory bowel disease (IBD) is an independent risk factor for Clostridiodes difficile infection (CDI) and suggest a globally increased prevalence and severity of C. difficile coinfection in IBD patients (CDI-IBD). In addition to elderly individuals, children are also at higher risk of CDI-IBD. Rapid diagnosis is essential since the clinical manifestations of active IBD and CDI-IBD are indistinguishable. Antibiotics have been well established in the treatmen...
Source: Expert Review of Anti-Infective Therapy - April 27, 2024 Category: Infectious Diseases Authors: Mengjun Tang Chunhua Wang Ying Xia Jian Tang Jiao Wang Liang Shen Source Type: research

Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know
Surg Clin North Am. 2024 Jun;104(3):647-656. doi: 10.1016/j.suc.2023.12.004. Epub 2023 Dec 28.ABSTRACTThe gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in the development of varying diseases. The purpose of this review is to highlight what is known about the microbiome and its impact on colorectal cancer, inflammatory bowel disease, constipation, Clostridioides difficile infectio...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ethan Lu Ranish K Patel Vassiliki Liana Tsikitis Robert G Martindale Source Type: research

Colorectal Neoplasia in the Setting of Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):673-684. doi: 10.1016/j.suc.2023.12.006. Epub 2023 Dec 26.ABSTRACTInflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (colorectal adenocarcinoma [CRC]) compared with the general population. IBD-related CRC is related to poorer outcomes than non-IBD-related CRC, and it accounts for 10% to 15% of death in patients with IBD. As such, screening guidelines have been made specific to this population recommending shorter intervals of endoscopic screening to detect dysplasia and CRC relative to the general population. Advances in endoscopic technology allow...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Maura Walsh Shahrose Rahman Rebecca Gologorsky Vassiliki Liana Tsikitis Source Type: research

Surgical Emergencies in Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):685-699. doi: 10.1016/j.suc.2023.11.012. Epub 2023 Dec 14.ABSTRACTInflammatory bowel disease (IBD) patients are at risk for undergoing emergency surgery for fulminant disease, toxic megacolon, bowel perforation, intestinal obstruction, or uncontrolled gastrointestinal hemorrhage. Unfortunately, medical advancements have failed to significantly decrease rates of emergency surgery for IBD. It is therefore important for all acute care and colorectal surgeons to understand the unique considerations owed to this often-challenging patient population.PMID:38677830 | DOI:10.1016/j.suc.2023.11.01...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: John Van Eaton Quinton M Hatch Source Type: research

Medical Management of Inflammatory Bowel Disease
This article highlights several key trials and discusses modern treatment paradigms for both UC and CD based on disease severity.PMID:38677828 | DOI:10.1016/j.suc.2023.12.005 (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ranish K Patel Elisa Boden Vassiliki Liana Tsikitis Source Type: research

Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know
Surg Clin North Am. 2024 Jun;104(3):647-656. doi: 10.1016/j.suc.2023.12.004. Epub 2023 Dec 28.ABSTRACTThe gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in the development of varying diseases. The purpose of this review is to highlight what is known about the microbiome and its impact on colorectal cancer, inflammatory bowel disease, constipation, Clostridioides difficile infectio...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Shahrose Rahman Ethan Lu Ranish K Patel Vassiliki Liana Tsikitis Robert G Martindale Source Type: research

Colorectal Neoplasia in the Setting of Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):673-684. doi: 10.1016/j.suc.2023.12.006. Epub 2023 Dec 26.ABSTRACTInflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (colorectal adenocarcinoma [CRC]) compared with the general population. IBD-related CRC is related to poorer outcomes than non-IBD-related CRC, and it accounts for 10% to 15% of death in patients with IBD. As such, screening guidelines have been made specific to this population recommending shorter intervals of endoscopic screening to detect dysplasia and CRC relative to the general population. Advances in endoscopic technology allow...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Maura Walsh Shahrose Rahman Rebecca Gologorsky Vassiliki Liana Tsikitis Source Type: research