Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Unveiling Therapeutic Avenues for Crohn's Disease Management: Exploring Inhibitors for Adherent-Invasive Escherichia coli Propanediol Dehydratase
CONCLUSION: Ultimately, the results of this study have revealed five compounds to possess the potential to serve as inhibitors of pduC of AIEC. However, experimental studies are still needed to validate the findings of this study.PMID:38659270 | DOI:10.2174/0115734064295521240227052730 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Mohammed Bourhia Md Eram Hosen Md Omar Faruqe Faria Tasnim Mohamed Taibi Amine Elbouzidi Yousef A Bin Jardan Samir Ibenmoussa Abdeslam Asehraou Source Type: research

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research

Disease clearance in ulcerative colitis: A new therapeutic target for the future
This article summarizes the concept of DC and its current evidence.PMID:38659483 | PMC:PMC11036494 | DOI:10.3748/wjg.v30.i13.1801 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Syed Adeel Hassan Neeraj Kapur Fahad Sheikh Anam Fahad Somia Jamal Source Type: research

Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease
CONCLUSION: For the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.PMID:38659482 | PMC:PMC11036493 | DOI:10.3748/wjg.v30.i13.1899 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Source Type: research

Disease clearance in ulcerative colitis: A new therapeutic target for the future
This article summarizes the concept of DC and its current evidence.PMID:38659483 | PMC:PMC11036494 | DOI:10.3748/wjg.v30.i13.1801 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Syed Adeel Hassan Neeraj Kapur Fahad Sheikh Anam Fahad Somia Jamal Source Type: research

Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease
CONCLUSION: For the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.PMID:38659482 | PMC:PMC11036493 | DOI:10.3748/wjg.v30.i13.1899 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Source Type: research

Ileorectal anastomosis in ulcerative colitis: what do surgeons and patients need to know? A systematic literature review
CONCLUSIONS: For some patients, IRA can offer restorative surgery in the short or long term, with acceptable cancer risk, failure rate and postoperative complications, while avoiding the higher risks associated with IPAA.PMID:38660816 | DOI:10.1308/rcsann.2024.0012 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 25, 2024 Category: Surgery Authors: M R Orchard A Saracino J Hooper J Shabbir Source Type: research

Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation
In conclusion, nitazoxanide protects against DSS-induced ulcerative colitis in mice through improving intestinal barrier and inhibiting inflammation and the underlying mechanism involves AMPK activation and JAK2/STAT3 inhibition.PMID:38663798 | DOI:10.1016/j.cbi.2024.111013 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Hu-Tai-Long Zhu Jing Luo Yi Peng Xiao-Fan Cheng Shang-Ze Wu Yin-Di Zhao Le Chang Zhi-Jie Sun De-Li Dong Source Type: research

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research

Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF- κB pathways
This study highlights gut microbiota's role in IBD drug development, offering insights for BZA's future development and its clinical applications.PMID:38663540 | DOI:10.1016/j.ejphar.2024.176611 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Liumei Liang Jingdan Zhang Junxiong Chen Yu Tian Weiqian Li Mengchen Shi Sijing Cheng Yinhai Zheng Chen Wang Huanliang Liu Xiangling Yang Weibiao Ye Source Type: research

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research