Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diagnosis of Pediatric Appendicovesical Fistula by Contrast-enhanced Ultrasound: A Case Report
We reported a pediatric case of appendicovesical fistula that remained undiagnosed by non-contrast CT, fluoroscopic voiding cystourethrography (VCUG). Although the bladder orifice was identified during cystoscopy, its connection to the fistula site could not be determined. However, the trans-vesical contrast-enhanced ultrasound clearly demonstrated the presence of fistula. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Yang Xiuzhen, Xu Zheming, Yan Xiang, Ye Jingjing, Fu Junfen Source Type: research

Molecules, Vol. 29, Pages 1940: Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
n Kangwan An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pre...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Natticha Sumneang Komsak Pintha Sarawut Kongkarnka Maitree Suttajit Napapan Kangwan Tags: Article Source Type: research

Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation
This study might enhance our comprehension on the pathogenic mechanism and diagnosis of UC and offer a treatment option for UC. (Source: Inflammation)
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research

Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research

Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
CONCLUSIONS: In summary, our data suggest that Sarm1 controls the MYD88-mediated inflammatory responses in IBD via its regulation of TRAF3 recruitment.PMID:38651786 | DOI:10.1080/08820139.2024.2343889 (Source: Immunological Investigations)
Source: Immunological Investigations - April 23, 2024 Category: Allergy & Immunology Authors: Huijuan Fan Chun Song Jingyu Zhang Source Type: research

Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research

Genomic Testing Identifies Monogenic Causes in Patients with Very Early-Onset Inflammatory Bowel Disease: A Multi-center Survey in an Iranian Cohort
Clin Exp Immunol. 2024 Apr 23:uxae037. doi: 10.1093/cei/uxae037. Online ahead of print.ABSTRACTPatients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a me...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Golnaz Eslamian Mahnaz Jamee Tooba Momen Pejman Rohani Sarehossadat Ebrahimi Mehrnaz Mesdaghi Soodeh Ghadimi Mahboubeh Mansouri Seyed Alireza Mahdaviani Mahnaz Sadeghi-Shabestari Morteza Fallahpour Bibi Shahin Shamsian Narges Eslami Samin Sharafian Naghi Source Type: research

Reply to comments on: "Efficacy of cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn's disease-A prospective nationwide multicenter cohort study"
Wien Klin Wochenschr. 2024 Apr 23. doi: 10.1007/s00508-024-02363-z. Online ahead of print.NO ABSTRACTPMID:38652312 | DOI:10.1007/s00508-024-02363-z (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 23, 2024 Category: General Medicine Authors: Stefan Riss Christopher Dawoud Source Type: research

Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research

GSE237845 The TNFSF12/TWEAK modulates colonic inflammatory fibroblast differentiation and promotes fibroblast-monocyte interactions
Contributors : Carlos Matellan ; Ciar án Kennedy ; Mario C ManresaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibroblasts acquire a pro-inflammatory phenotype in inflammatory bowel disease (IBD), but the factors driving this process and how fibroblasts contribute to the immune response is incompletely understood. The TNF superfamily factor 12 (TWEAK) has gained interest as a mediator of chronic inflammation. Here, we explore its role as a driver of inflammatory responses in fibroblasts and its contribution to fibroblast-monocyte interaction using human primary colonic fibroblas...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE237994 Dynamic Changes in Extracellular Vesicle-Associated miRNAs Elicited by Abdominal Ultrasound in Peripheral Blood of Inflammatory Bowel Disease Patients
Contributors : Neha Mishra ; Nathan Baran ; Florian Tran ; Philip RosenstielSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBlood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect the cellular and functional state of their site of site of origin. As ultrasound waves may lead to an increased release of EVs, we hypothesized that application of ultrasound waves on inflamed intestinal tissue in IBD...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

Tofacitinib and peficitinib inhibitors of Janus kinase for autoimmune disease treatment: a quantum biochemistry approach
Phys. Chem. Chem. Phys., 2024, Advance Article DOI: 10.1039/D3CP06332A, PaperJackson L. Amaral, Naiara C. Lucredi, Victor L. B. Fran ça, Samuel J. M. Santos, Francisco F. Maia, Pablo A. Morais, Pedro F. N. Souza, Jurandir F. Comar, Valder N. Freire Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Sour...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 22, 2024 Category: Chemistry Authors: Jackson L. Amaral Source Type: research

Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease
CONCLUSIONS: The fecal microbiota in IBD patients with EIMs is distinct from that in IBD patients without EIM and could be important for EIM pathogenesis.PMID:38648495 | DOI:10.1080/07853890.2024.2338244 (Source: Annals of Medicine)
Source: Annals of Medicine - April 22, 2024 Category: Internal Medicine Authors: Sandra Hertz Jacqueline Moltzau Anderson Hans Linde Nielsen Claire Schachtschneider Kathryn E McCauley Mustafa Özçam Lone Larsen Susan V Lynch Henrik Nielsen Source Type: research

Abdominal aortic mural thrombus in association with active ulcerative colitis
We describe a case of subacute lower limb ischemia due to AMT associated with active ulcerative colitis (UC). A 46-year-old man with active UC was referred to our hospital for the evaluation and treatment of left leg pain. Ultrasound and contrast computed tomography showed occlusion of the left popliteal artery, and an AMT in the abdominal aorta between the inferior mesenteric artery and the aortic bifurcation. We started anticoagulant therapy, intravenous infliximab, and cytapheresis. Four weeks after initiating anticoagulation therapy, we were able to successfully treat the AMT with anticoagulation therapy without surgic...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Yushi Oyama Satoshi Koiwa Takuya Maruyama Ayako Kozuka Seiichi Hiramori Takahiro Kobayashi Kumiko Yahikozawa Takuya Miyagi Takahiro Sakai Kyuhachi Otagiri Hiroshi Kitabayashi Source Type: research

Advances in molecular mechanisms of inflammatory bowel disease ‑associated colorectal cancer (Review)
Oncol Lett. 2024 Apr 9;27(6):257. doi: 10.3892/ol.2024.14390. eCollection 2024 Jun.ABSTRACTThe link between inflammation and cancer is well documented and colonic inflammation caused by inflammatory bowel disease (IBD) is thought to be a high-risk factor for the development of colorectal cancer (CRC). The complex crosstalk between epithelial and inflammatory cells is thought to underlie the progression from inflammation to cancer. The present review collates and summarises recent advances in the understanding of the pathogenesis of IBD-associated CRC (IBD-CRC), including the oncogenic mechanisms of the main inflammatory si...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhi Wang Yu Chang Haibo Sun Yuqin Li Tongyu Tang Source Type: research