Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
CONCLUSION: TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α agents. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Special attention is needed for tapering and HZ.PMID:38659488 | PMC:PMC11036499 | DOI:10.3748/wjg.v30.i13.1871 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Source Type: research

Ileorectal anastomosis in ulcerative colitis: what do surgeons and patients need to know? A systematic literature review
CONCLUSIONS: For some patients, IRA can offer restorative surgery in the short or long term, with acceptable cancer risk, failure rate and postoperative complications, while avoiding the higher risks associated with IPAA.PMID:38660816 | DOI:10.1308/rcsann.2024.0012 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 25, 2024 Category: Surgery Authors: M R Orchard A Saracino J Hooper J Shabbir Source Type: research

Sensors, Vol. 24, Pages 2727: Faecal Volatile Organic Compound Analysis in De Novo Paediatric Inflammatory Bowel Disease by Gas Chromatography & ndash;Ion Mobility Spectrometry: A Case & ndash;Control Study
In conclusion, faecal VOC profiles of paediatric IBD patients differ significantly from those of CGIs. (Source: Sensors)
Source: Sensors - April 25, 2024 Category: Biotechnology Authors: Eva Vermeer Jasmijn Z. Jagt Trenton K. Stewart James A. Covington Eduard A. Struys Robert de Jonge Nanne K. H. de Boer Tim G. J. de Meij Tags: Article Source Type: research

Bowel Resection Margins in Crohn's Disease: Do They Matter?
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786376Many patients with Crohn's disease (CD) will ultimately require surgical intervention for refractory disease despite recognizing that surgery does not cure CD. The initial operation, primarily for ileocolic disease, is focused on resecting the offending pathology and ideally providing a reduced likelihood for subsequent operations and additional bowel loss through surgical techniques. The appropriate margin, macro- vs. microscopic, lays in balance to provide an adequate resection that minimizes bowel loss, compared to an extensive resection which ensures a thorough resectio...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Choi, Beatrix Cohen, David Schwartzberg, David M. Tags: Review Article Source Type: research

Preoperative Optimization of Crohn's Patients before Abdominopelvic Surgery
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786380In this article, we review and identify modifiable risk factors associated with postoperative complications of Crohn's disease. We highlight the importance of factors such as nutrition, corticosteroids, immunomodulators, abscesses, ideal timing of surgery, and biologic and small-molecule therapy on surgical outcomes. Herein, we discuss the strategies for attenuating these risk factors. Special consideration is given to venous thromboembolism prophylaxis in this patient population. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAA...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Moussally, Moustafa Paski, Shirley C. Cohen, Benjamin Holubar, Stefan D. Tags: Review Article Source Type: research

Pouchitis: pathophysiology and management
Nature Reviews Gastroenterology & Hepatology, Published online: 25 April 2024; doi:10.1038/s41575-024-00920-5Pouchitis is a common condition that can occur after intestinal surgery. In this Review, Shen discusses our current understanding of the multifactorial pathophysiology, diagnosis and management of pouchitis, primarily in patients with underlying ulcerative colitis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 25, 2024 Category: Gastroenterology Authors: Bo Shen Source Type: research

Basket, Umbrella, and Platform Trials: The Potential for Master Protocol -Based Trials in Inflammatory Bowel Disease
(Source: Gastroenterology)
Source: Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Sailish Honap, Bruce E. Sands, Vipul Jairath, Silvio Danese, Eric Vicaut, Laurent Peyrin-Biroulet Tags: Commentary Source Type: research

Insights into treatment of complex Crohn's perianal fistulas
AbstractComplex perianal fistula is a common complication of Crohn ’s disease (CD) which leads to negative impact on patient’s quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a colorectal surgeon, applying combined surgical and medical therapy. One of frequently practiced surgical p rocedures is seton placement in the fistula tract, which is used to control perianal sepsis and drain the fistula, while preventing recurrent abscess formation.Darvadstrocel, a suspension of expanded, allogeneic, adipose-derived, mesenchymal stem cells, is safe ...
Source: BMC Proceedings - April 25, 2024 Category: Biomedical Science Source Type: research

The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals
ConclusionDespite initiation of biological treatment, the risk of intestinal surgery remains high in pediatric IBD patients and often the need for surgery emerges after the transition to adult IBD clinics. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research

Updates in the Management of Crohn's Disease
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786382 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Clinics in Colon and Rectal Surgery)
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Khaitov, Sergey Tags: Preface Source Type: research

Correction: Gene expression analysis of intestinal IL-8, IL-17 A and IL-10 in patients with celiac and inflammatory bowel diseases
Mol Biol Rep. 2024 Apr 24;51(1):569. doi: 10.1007/s11033-024-09440-6.NO ABSTRACTPMID:38658466 | DOI:10.1007/s11033-024-09440-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Elham Aghamohamad Nastaran Asri Aylin Odak Mohammad Rostami-Nejad Vahid Chaleshi Yasaman Hajinabi Maryam Eslami Saeed Mohammadian Haftcheshmeh Fahimeh Sadat Gholam-Mostafaei Hamid Asadzadeh-Aghdaei Andrea Masotti Mohammad Reza Zali Source Type: research

Iron supplementation in patients with chronic inflammatory bowel disease: recommendations for a practical approach
Z Gastroenterol. 2024 Apr 24. doi: 10.1055/a-2274-1610. Online ahead of print.ABSTRACTIron deficiency is the predominant cause of anemia. Iron deficiency anemia plays a major role, especially in patients with inflammatory bowel disease (IBD), and is the most common extraintestinal manifestation and IBD-associated systemic complication. The presence of anemia leads to a reduction in quality of life in patients with IBD associated with limitations in physical, emotional, and cognitive function. In addition, it is associated with an increased hospitalization rate. For this reason, iron supplementation is of particular importa...
Source: Zeitschrift fur Gastroenterologie - April 24, 2024 Category: Gastroenterology Authors: Katharina Stratmann Viktoria Hentschel Stefan Zeuzem Irina Blumenstein Jochen Klaus Source Type: research

Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
CONCLUSIONS: The HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe.PMID:38656653 | DOI:10.1007/s40121-024-00963-w (Source: Herpes)
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Alen Marijam Nikki Vroom Amit Bhavsar Inga Posiuniene Nicolas Lecrenier Hilde Vroling Source Type: research