Current situation and challenges for mental health focused on treatment and care in Japan and the Philippines - highlights of the training program by the National Center for Global Health and Medicine
AbstractBackground and purposeMental health has emerged as an important public health concern in recent years. With a high proportion of children and adolescents affected by mental disorders, it is important to ensure that they are provided with proper care and treatment. With the goal of sharing the activities and good practices on child and adolescent mental health promotion, care, and treatment in Japan and the Philippines, the National Center for Global Health and Medicine conducted a training program on the promotion of mental health focused on treatment and care in Japan and the Philippines in September and November ...
Source: BMC Proceedings - August 3, 2020 Category: Biomedical Science Source Type: research

A systems approach for optimizing implementation to impact: meeting report and proceedings of the 2019 In the Trenches: Implementation to Impact International Summit  
ConclusionsThere is increased interest globally in the benefits that can accrue from adopting a systems approach to research and innovation. Various organizations in Canada and internationally have made considerable progress onImplementation to Impact, often as a result of well-planned initiatives. The Summit highlights the value of 1) collaboration between researchers and potential users, and 2) the adoption by funders of approaches involving an increasing range of responsibilities and activities. The Summit website (https://inthetrenchessummit.com/) will be periodically updated with new resources and information about fu...
Source: BMC Proceedings - July 24, 2020 Category: Biomedical Science Source Type: research

Strengthening capacities among digital health leaders for the development and implementation of national digital health programs in Nigeria
ConclusionsThe DH capacity development workshop was a good forum to deliberate important issues regarding sustainable and cost-effective DH solutions that could be scaled to strengthen health service delivery in Nigeria. Insightful ideas for scaling DH in Nigeria and other related settings emanated from the workshop, necessitating the need for a focused government commitment and leadership in institutionalizing digital health in Nigeria. (Source: BMC Proceedings)
Source: BMC Proceedings - July 23, 2020 Category: Biomedical Science Source Type: research

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report
AbstractThe Human Papillomavirus (HPV) Prevention and Control Board is an independent multidisciplinary board of international experts that disseminates relevant information on HPV to a broad array of stakeholders and provides guidance on strategic, technical and policy issues in the implementation of HPV control programs. In response to drastic drop of vaccine coverage following the adverse event crisis in Carmen del Bolivar, Colombia, the HPV Prevention and Control Board in collaboration with the Colombian National Cancer Institute and Colombian League Against Cancer convened a meeting in Bogota, Columbia (November 2018)...
Source: BMC Proceedings - June 22, 2020 Category: Biomedical Science Source Type: research

Proceedings of the 4 th BEAT-PCD Conference and 5 th PCD Training School
AbstractPrimary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility andsitus abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. ‘Better Experimental Approaches to Treat Primary Ciliary Dyskinesia’ (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world t...
Source: BMC Proceedings - June 19, 2020 Category: Biomedical Science Source Type: research

Abstracts from the International Science Symposium on HIV and Infectious Diseases (ISSHID 2019): Proceedings
(Source: BMC Proceedings)
Source: BMC Proceedings - June 19, 2020 Category: Biomedical Science Source Type: research

Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
(Source: BMC Proceedings)
Source: BMC Proceedings - May 25, 2020 Category: Biomedical Science Source Type: research

Proceedings of the International Workshop ‘Integration of International Expertise in the Development of a Mental Health Surveillance System in Germany’
(Source: BMC Proceedings)
Source: BMC Proceedings - May 4, 2020 Category: Biomedical Science Source Type: research

Abstracts from the 9th International Conference for Healthcare and Medical Students (ICHAMS)
(Source: BMC Proceedings)
Source: BMC Proceedings - April 30, 2020 Category: Biomedical Science Source Type: research

Leveraging implementation science to reduce inequities in Children ’s mental health care: highlights from a multidisciplinary international colloquium
AbstractBackground and purposeAccess to evidence-based mental health care for children is an international priority. However, there are significant challenges to advancing this public health priority in an efficient and equitable manner. The purpose of this international colloquium was to convene a multidisciplinary group of health researchers to build an agenda for addressing disparities in mental health care access and treatment for children and families through collaboration among scholars from the United States and Europe engaged in innovative implementation science and mental health services research.Key highlightsGui...
Source: BMC Proceedings - April 6, 2020 Category: Biomedical Science Source Type: research

Evidence-based policy making for health promotion to reduce the burden of non-communicable diseases in Moldova
AbstractThe Republic of Moldova faces several concurrent health challenges most notably an increase in chronic non-communicable diseases, spiralling health care costs and widening health inequalities. To accelerate progress in their resolution there is a need for new and innovative health promotion and behaviour change communication interventions. The Ministry of Health, Labour and Social Protection in collaboration with the newly created National Agency for Public Health held a conference on the occasion of theMoldovan National Day of Health Promotion on 14th March 2018 in which national and invited international experts ...
Source: BMC Proceedings - March 6, 2020 Category: Biomedical Science Source Type: research

Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia
ConclusionMost of theK. pneumoniae isolates demonstrated resistance to a wide range of antibiotics and are biofilm producers. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

The effect of 5 α-oleandrin on keloid fibroblast activities
ConclusionsThe 5 α-oleandrin has good antifibrotic effect in keloid fibroblast activities. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

A diagnostic approach for differentiating abdominal tuberculosis from ovarian malignancy: a case series and literature review
ConclusionMinimally invasive tests to establish the diagnosis of abdominal tuberculosis should be optimized to reduce the burden risk of laparotomy. Careful diagnostic steps should be followed to avoid wrong diagnosis. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Effect of gamma-mangostin on testosterone levels in Leydig cell culture of Sprague-Dawley rat induced by advanced glycation end products: a preliminary study
ConclusionThe testosterone level in Leydig cell cultures induced by AGE were lower than those not given, but similar in the AGE-only group and group given gamma-mangostin. The mean testosterone levels in all groups were in the range of expected levels (0.025 –15 ng/105 cells/24  h). Further study with larger samples is important to clarify and confirm our findings. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates of Staphylococcus epidermidis
ConclusionThe 1-monolaurin can inhibit growth and eradicate the biofilm formed by clinical isolates ofS. epidermidis, however, it has neither inhibit nor kill planktonic cells ofS. epidermidis. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Use of air stacking to improve pulmonary function in Indonesian Duchenne  muscular dystrophy patients: bridging the standard of care gap in low middle income country setting
ConclusionUse of manual exsufflation in combination with the manual ventilation bag for air stacking to improve cough performance is recommended as the first step of respiratory management in DMD patients. Provision of manual ventilation bag serve as an affordable and effective device for respiratory support in the early stage of respiratory involvement in those non-ambulatory patients with DMD. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Risk factors of preoperative Hirschsprung-associated enterocolitis
ConclusionThe incidence of preoperative HAEC in our hospital is considered relatively moderate, with the most common findings of distended abdomen and dilated loops of bowel. None of the identified risk factors have an association with the development of HAEC in our patients. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Outcome of adult congenital heart disease patients undergoing cardiac surgery: clinical experience of dr. Sardjito hospital
ConclusionSurgery in adult patients with congenital heart disease may be successfully performed with low morbidity and mortality. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Heparanase upregulation from adipocyte associates with inflammation and endothelial injury in diabetic condition
ConclusionHeparanase upregulation in fat tissue was associated with endothelial injury and inflammation in hyperglycemia conditions. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients
ConclusionThe prevalence of BRAF V600 mutation in Indonesian primary skin nodular melanoma cases is low and significantly associated with anatomic location and lymphovascular invasion. It is lower than prevalences in other Asian populations as well as in Caucasian populations and suggests that melanoma cases in Javanese people may have distinct clinicopathological characteristics from other Asian ethnicities. (Source: BMC Proceedings)
Source: BMC Proceedings - December 16, 2019 Category: Biomedical Science Source Type: research

Conference Proceedings – 4 th International Conference on Molecular Diagnostics and Biomarker Discovery: Antibody Technology
(Source: BMC Proceedings)
Source: BMC Proceedings - December 10, 2019 Category: Biomedical Science Source Type: research

Correction to: Community participation and private sector engagement are fundamental to achieving universal health coverage and health security in Africa: reflections from the second Africa health forum
Following publication of the original article [1], the authors reported the following author name error is the article: (Source: BMC Proceedings)
Source: BMC Proceedings - December 2, 2019 Category: Biomedical Science Source Type: research

Abstracts from the 4 th Asian Conference in Pharmaceutical Sciences (Asia Pharm IV)
(Source: BMC Proceedings)
Source: BMC Proceedings - November 26, 2019 Category: Biomedical Science Source Type: research

Ageing, frailty and resilience in Botswana: rapid ageing, rapid change. Findings from a national working group meeting and literature review
ConclusionsFuture policy in Botswana must focus on the challenges that an ageing population brings, and development of health and care system resilience for the demographic change could be a model for healthcare policy across Southern Africa. (Source: BMC Proceedings)
Source: BMC Proceedings - November 19, 2019 Category: Biomedical Science Source Type: research

Community participation and private sector engagement are fundamental to achieving universal health coverage and health security in Africa: reflections from the second Africa health forum
ConclusionsThe Forum participants agreed that the role of community engagement and participation in the attainment of Universal Health Coverage, health security and ultimately the Sustainable Development Goals cannot be overemphasized. The public sector of Africa alone cannot achieve these three interrelated goals; other partners, such as the private sector, must be engaged. Technological innovations will be a key driver of the attainment of these goals; hence, there is need to harness the comparative advantages that they offer. Attainment of the three goals is also intertwined – achieving one paves the way for achie...
Source: BMC Proceedings - November 12, 2019 Category: Biomedical Science Source Type: research

Abstracts from the 8th International Conference for Healthcare and Medical Students (ICHAMS)
(Source: BMC Proceedings)
Source: BMC Proceedings - August 13, 2019 Category: Biomedical Science Source Type: research

CISBETI 2019 - International Congress of Health, Well-Being, Technology and Innovation
(Source: BMC Proceedings)
Source: BMC Proceedings - July 24, 2019 Category: Biomedical Science Source Type: research

Abstract Book - 4 th B Chromosome Conference
(Source: BMC Proceedings)
Source: BMC Proceedings - June 17, 2019 Category: Biomedical Science Source Type: research

Proceedings of the 2017 Advancing the Science of Community Engaged Research (CEnR) Conference
ConclusionsCommunity and stakeholder engagement can directly impact research by enhancing clinical trial design, increasing relevance, and increasing recruitment, accrual and retention (Staley K.: Exploring Impact: Public 53 Involvement in NHS, Public Health and Social Care Research – INVOLVE.; 2009, Johnson et al Clin Transl Sci 8:388-54 390, 2015, Joosten et al Acad Med 90:1646-1650, 2015). The 2017 Advancing the Science of Community Engaged Research meeting,Innovative and Effective Methods of Stakeholder Engagement in Translational Research facilitated meaningful engagement of diverse stakeholder groups including ...
Source: BMC Proceedings - April 19, 2019 Category: Biomedical Science Source Type: research

Proceedings of Advancing the Science of Community Engaged Research (CEnR): Innovative and Effective Methods of Stakeholder Engagement in Translational Research: abstracts
(Source: BMC Proceedings)
Source: BMC Proceedings - April 19, 2019 Category: Biomedical Science Source Type: research

People and research: improved health systems for West Africans, by West Africans - report on special supplement
(Source: BMC Proceedings)
Source: BMC Proceedings - February 5, 2019 Category: Biomedical Science Source Type: research

Addressing challenges in children ’s mental health in disaster-affected areas in Japan and the Philippines – highlights of the training program by the National Center for Global Health and Medicine
AbstractBackground and purposeNatural disasters such as earthquakes, typhoons, floods, and volcanic eruptions frequently occur in Republic of Philippines and mental health care for children affected by these natural disasters is a major public health concern. Aiming to train health professionals on children ’s mental health, to conduct a situational analysis to identify the local needs and resources for children’s mental health, and to propose a mental health program for children that can be transferred from Japan to the Philippines, the National Center for Global Health and Medicine (NCGM) conduct ed a trainin...
Source: BMC Proceedings - December 19, 2018 Category: Biomedical Science Source Type: research

Proceedings of the 3rd BEAT-PCD Conference and 4th PCD Training School
In this report, we summarize the meeting, highlighting developments made during the meeting. (Source: BMC Proceedings)
Source: BMC Proceedings - December 18, 2018 Category: Biomedical Science Source Type: research

Abstracts from the 3rd BEAT-PCD Conference and 4th PCD Training School
(Source: BMC Proceedings)
Source: BMC Proceedings - December 18, 2018 Category: Biomedical Science Source Type: research

Cholera prevention and control in Asian countries
AbstractCholera remains a major public health problem in many countries. Poor sanitation and inappropriate clean water supply, insufficient health literacy and community mobilization, absence of national plans and cross-border collaborations are major factors impeding optimal control of cholera in endemic countries.In March 2017, a group of experts from 10 Asian cholera-prone countries that belong to the Initiative against Diarrheal and Enteric Diseases in Africa and Asia (IDEA), together with representatives from the World Health Organization, the US National Institutes of Health, International Vaccine Institute, Agence d...
Source: BMC Proceedings - December 7, 2018 Category: Biomedical Science Source Type: research

Abstracts from the 7th International Conference for Healthcare and Medical Students (ICHAMS)
(Source: BMC Proceedings)
Source: BMC Proceedings - October 29, 2018 Category: Biomedical Science Source Type: research

Methods for detecting methylation by SNP interaction in GAW20 simulation
AbstractTo examine whether single-nucleotide polymorphism (SNP) by methylation interactions can be detected, we analyzed GAW20 simulated triglycerides at visits 3 and 4 against baseline (visits 1 and 2) under 4 general linear models and 2 tree-based models in 200 replications of a sample of 680 individuals. Effects for SNPs, methylation cytosine-phosphate-guanine (CpG) effects, and interactions for SNP/CpG pairs were included. Causative SNPs/CpG pairs distributed on autosomal chromosomes 1 to 20 were tested to examine sensitivity. We also tested noncausative SNP/CpG pairs on chromosomes 21 and 22 to estimate the empirical ...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Using penalized regression to predict phenotype from SNP data
ConclusionsLASSO regression results in a heavy shrinkage of the regression coefficients, and also requires large sample sizes (several thousand individuals) to achieve good prediction. (Source: BMC Proceedings)
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations
In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine. (Source: BMC Proceedings)
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Heritability and genetic associations of triglyceride and HDL-C levels using pedigree-based and empirical kinships
This study compares the use of pedigree and empirical kinships in the GAW20 data set. Two phenotypes were assessed: triglyceride levels and high-density lipoprotein cholesterol (HDL-C) levels pre- and postintervention with the cholesterol-reducing drug fenofibrate. Using SOLAR (Sequential Oligogenic Linkage Analysis Routines), pedigree-based kinships and empirically calculated kinships (using IBDLD and LDAK) were used to calculate phenotype heritability. In addition, a genome-wide association study was conducted using each kinship model for each phenotype to identify genetic variants significantly associated with phenotypi...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Evaluation of a phenotype imputation approach using GAW20 simulated data
AbstractStatistical power, which is the probability of correctly rejecting a false null hypothesis, is a limitation of genome-wide association studies (GWAS). Sample size is a major component of statistical power that can be easily affected by missingness in phenotypic data and restrain the ability to detect associated single-nucleotide polymorphisms (SNPs) with small effect sizes. Although some phenotypes are hard to collect because of cost and loss to follow-up, correlated phenotypes that are easily collected can be leveraged for association analysis. In this paper, we evaluate a phenotype imputation method that incorpor...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Family-based genome-wide association of inflammation biomarkers and fenofibrate treatment response in the GOLDN study
AbstractIn this paper we analyzed whole-genome genetic information provided by GAW20 from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study for family data. Lipid levels such as triglycerides (TGs) and high-density lipoprotein (HDL) are measured at different time points before and after administration of an anti-inflammatory drug fenofibrate. Apart from that, the data contain some covariates and whole-genome genotype information. We propose 2 novel approaches based on Henderson ’s iterative mixed model to identify associated loci corresponding to (a) inflammatory biomarkers like TGs and HDLs togethe...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

CpG-set association assessment of lipid concentration changes and DNA methylation
This study ’s goals were to investigate region-based associations between DNA methylation sites and lipid-level changes in response to the treatment with fenofibrate in the GAW20 data and to investigate whether improvements in power could be obtained by taking into account correlations between DNA methylatio n at neighboring cytosine-phosphate-guanine (CpG) sites. To this end, we applied both a recently developed block-based data-dimension-reduction approach and a region-based variance-component (VC) linear mixed model to GAW20 data. We compared analyses of unrelated individuals with familial data. The region-based V...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

A deep neural network based regression model for triglyceride concentrations prediction using epigenome-wide DNA methylation profiles
ConclusionsWe demonstrated the superiority of our proposed DNN models over the SVM model for predicting triglyceride concentrations. This study also suggests that the DNN approach has advantages over other traditional machine-learning methods to model high-dimensional epigenome-wide DNAm data and other genomic data. (Source: BMC Proceedings)
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Homozygosity disequilibrium associated with treatment response and its methylation regulation
AbstractHomozygosity disequilibrium (HD), indicating a nonrandom pattern of sizable runs of homozygosity that deviates from a random allocation of homozygous and heterozygous genotypes in the genome, is an important phenomenon in population genomics and medical genomics. We performed the first genome-wide study investigating the roles of HD in pharmacogenomics and pharmacoepigenomics by analyzing GAW20 data. We inferred whole-genome profiles of homozygosity intensities and performed genome-wide homozygosity association analyses to identify regions of HD associated with triglyceride (TG) response to fenofibrate by using LOH...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Logistic Bayesian LASSO for detecting association combining family and case-control data
AbstractBecause of the limited information from the GAW20 samples when only case-control or trio data are considered, we propose eLBL, an extension of the Logistic Bayesian LASSO (least absolute shrinkage and selection operator) methodology so that both types of data can be analyzed jointly in the hope of obtaining an increased statistical power, especially for detecting association between rare haplotypes and complex diseases. The methodology is further extended to account for familial correlation among the case-control individuals and the trios. A 2-step analysis strategy was taken to first perform a genome-wise single s...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Data for GAW20: genome-wide DNA sequence variation and epigenome-wide DNA methylation before and after fenofibrate treatment in a family study of metabolic phenotypes
AbstractGAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (clinicaltrials.gov identifier NCT00083369), which included CD4+ T-cell DNA methylation at 463,995 cytosine-phosphate-guanine (CpG) sites measured before and after a 3-week treatment with fenofibrate, single-nucleotide variation at 906,600 loci, metabolic syndrome components ascertained before and af...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Gene-methylation epistatic analyses via the W-test identifies enriched signals of neuronal genes in patients undergoing lipid-control treatment
In this study, we applied the data set adaptive W-test to measure gene–methylation interactions. Performance was evaluated by the ability to detect a given set of causal markers in the data set obtained from the GAW20. Results from simulati on data analyses showed that the W-test was able to detect most markers. The method was also applied to chromosome 11 of the experimental data set and identified clusters of genes with neuronal and retinal functions, includingMPPED2I, GUCY2E,NAV2, andZBTB16. Genes from theTRIM family were also identified; these genes are potentially related to the regulation of triglyceride levels...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Genome-wide analysis in multiple-case families: assessing the relationship between triglyceride and methylation
AbstractThe main goal of this paper is to estimate the effect of triglyceride levels on methylation of cytosine-phosphate-guanine (CpG) sites in multiple-case families. These families are selected because they have 2 or more cases of metabolic syndrome (primary phenotype). The methylations at the CpG sites are the secondary phenotypes. Ascertainment corrections are needed when there is an association between the primary and secondary phenotype. We will apply the newly developed secondary phenotype analysis for multiple-case family studies to identify CpG sites where methylations are influenced by triglyceride levels. Our s...
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research