Comparison of multiple single-nucleotide variant association tests in a meta-analysis of Genetic Analysis Workshop 19 family and unrelated data
ConclusionWe compared two meta-analysis approaches to jointly analyze multiple variants: SKAT and haplotype tests. The difference in observed results may be because the haplotype method considered all observed haplotypes, whereas SKAT weighted variants inversely to their minor allele frequency, masking the effects of common variants. The two approaches identified different top genes, and appear to be complementary. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19
AbstractBackgroundThe Genetic Analysis Workshops (GAW) are a forum for development, testing, and comparison of statistical genetic methods and software. Each contribution to the workshop includes an application to a specified data set. Here we describe the data distributed for GAW19, which focused on analysis of human genomic and transcriptomic data.MethodsGAW19 data were donated by the T2D-GENES Consortium and the San Antonio Family Heart Study and included whole genome and exome sequences for odd-numbered autosomes, measures of gene expression, systolic and diastolic blood pressures, and related covariates in two Mexican...
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Identifying rare and common variants with Bayesian variable selection
ConclusionsThe application shows that my method is powerful in identifying disease-associated variants even with the extreme rarity. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
A clustering approach to identify rare variants associated with hypertension
AbstractWith the development of the next-generation sequencing technology, the influence of rare variants on complex disease has gathered increasing attention. In this paper, we propose a clustering-based approach, the clustering sum test, to test the effects of rare variants association by using the simulated data provided by the Genetic Analysis Workshop 19 with an unbalanced case-control ratio. The control individuals are (a) clustered into several subgroups, (b) statistics of the separate subcontrol groups as compared to the case group are calculated, and (c) a combined statistic value is obtained based on a distance s...
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Constrained multivariate association with longitudinal phenotypes
ConclusionWe determined that this constrained multivariate approach improves genetic signal over the bivariate method. However, this method is still only effective in those variants that explain a moderate to large proportion of the phenotypic variance but is not as effective for gene-centric tests. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals
ConclusionsBased on the simulated data from GAW19, MONSTER and FBAT-LC were the most powerful of the methods assessed. However, there are limitations to each of these methods that should be carefully considered when conducting an analysis of rare variants in related individuals. This emphasizes the need for methods that can incorporate the advantages of each of these methods into 1 family-based association test for rare variants. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Comparing performance of non –tree-based and tree-based association mapping methods
This study presents a comparison of the 2 types of association mapping methods when they are applied to simulated data. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Integrating multiple genomic data: sparse representation based biomarker selection for blood pressure
ConclusionsOur results support the feasibility of the SRVS algorithm in integrating multiple data sets of different structure for comprehensive analysis. (Source: BMC Proceedings)
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures
AbstractCurrent rare-variant, gene-based tests of association often suffer from a lack of statistical power to detect genotype –phenotype associations as a result of a lack of prior knowledge of genetic disease models combined with limited observations of extremely rare causal variants in population-based samples. The use of pedigree data, in which rare variants are often more highly concentrated than in population-based data, has been proposed as 1 possible method for enhancing power. Methods for combining multiple gene-based tests of association into a single summaryp value are a robust approach to different genetic ar...
Source: BMC Proceedings - September 30, 2016 Category: Biomedical Science Source Type: research
Transforming Health Care in Remote Communities: report on an international conference
AbstractAn international conference titled “Transforming Health Care in Remote Communities” was held at the Chateau Lacombe Hotel in Edmonton, Canada, April 28–30, 2016. The event was organized by the University of Alberta’s School of Public Health, in partnership with the Institute for Circumpolar Health Research in Yellowknife, Nor thwest Territories, and the Qaujigiartiit Health Research Centre in Iqaluit, Nunavut.There were 150 registrants from 7 countries: Canada (7 provinces and 3 territories), United States, Denmark, Iceland, Norway, Sweden, and Australia. They included representatives of academic institutio...
Source: BMC Proceedings - August 9, 2016 Category: Biomedical Science Source Type: research
Proceedings of the International Workshop ‘From Global Burden of Disease Studies to National Burden of Disease Surveillance'
Conclusions of the workshop < /p > < p class= " a-plus-plus " > Christa Scheidt-Nave, Thomas Ziese, Judith Fuchs, Dietrich Plass < /p > (Source: BMC Proceedings)
Source: BMC Proceedings - July 24, 2016 Category: Biomedical Science Source Type: research
Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS)
Table of contents
O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes
Yvonne Sweeney, Hugh O’Neill, Garry Duffy
O2: Role of KCNQ1 in epithelial barrier repair
Daniel Creegan, Viviana Bustos, Brian J. Harvey
O3: The suitability of non-small cell lung cancer cytology preparations for the analysis of anaplastic lymphoma kinase gene rearrangements
Alexander Dalphy, Anthony O’Grady, Elaine Kay
O4: Penetrating keratoplasty and de...
Source: BMC Proceedings - July 4, 2016 Category: Biomedical Science Source Type: research
Meeting report of the 2nd German dialectical behavior therapy for adolescents network meeting
Abstract
Over the past 30 years, dialectical behavior therapy has been shown to be an effective treatment for adult borderline personality disorder. The adaptation of DBT for adolescents (DBT-A) in different patient groups has also led to some promising improvements of the respective psychopathology. During the second German DBT-A network meeting in 2015 in Mainz, Germany, a need for further research and innovative approaches in treatment of adolescents became apparent and resulted in controversial discussions. Main issues were enlarging evidence of effectiveness of DBT-A strategies with regard to fami...
Source: BMC Proceedings - July 3, 2016 Category: Biomedical Science Source Type: research
Proceedings of the 9th Annual Dubai Medical Education Symposium 2015
Table of content
I1 The 9th Annual Dubai Medical Education Symposium 2015 addresses the recent strides in medical education and clinical practice
Fouzia Shersad, Hajer Sheikh
S1 Acute lower limb ischaemia — Snow White and the Seven "Ps"
Munther I. Aldoori
S2 Learning styles in medical education
Mohammed Galal El Din Ahmed
S3 Reflection and feedback in teaching in clinical settings
Joseph Michael Muscat-Baron
S4 Medical Education in th...
Source: BMC Proceedings - May 10, 2016 Category: Biomedical Science Source Type: research
Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015
Table of contents
A1 Hope and despair in the current treatment of nasopharyngeal cancer
IB Tan
I1 NPC international incidence and risk factors
Ellen T Chang
I2 Familial nasopharyngeal carcinoma and the use of biomarkers
Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien
I3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findings
Allan Hildesheim
I5 Genetic and environmental risk factors for nasopharyngeal cancer in Southeast Asi...
Source: BMC Proceedings - April 12, 2016 Category: Biomedical Science Source Type: research
