Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diagnosis of Pediatric Appendicovesical Fistula by Contrast-enhanced Ultrasound: A Case Report
We reported a pediatric case of appendicovesical fistula that remained undiagnosed by non-contrast CT, fluoroscopic voiding cystourethrography (VCUG). Although the bladder orifice was identified during cystoscopy, its connection to the fistula site could not be determined. However, the trans-vesical contrast-enhanced ultrasound clearly demonstrated the presence of fistula. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Yang Xiuzhen, Xu Zheming, Yan Xiang, Ye Jingjing, Fu Junfen Source Type: research

Analysis and prediction of nutritional outcome of patients with pediatric inflammatory bowel disease from Bahrain
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease that causes anorexia, malabsorption, and increased energy requirements. Childhood IBD can significantly impact nutritional status and futu... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 24, 2024 Category: Pediatrics Authors: Hasan M. Isa, Masooma Mohamed, Ahmed Alsaei, Zahra Isa, Enjy Khedr, Afaf Mohamed and Haitham Jahrami Tags: Research Source Type: research

Molecules, Vol. 29, Pages 1940: Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
n Kangwan An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pre...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Natticha Sumneang Komsak Pintha Sarawut Kongkarnka Maitree Suttajit Napapan Kangwan Tags: Article Source Type: research

Imaging and clinical predictors of surgery in stricturing ileal Crohn ’s disease: a retrospective study from a large pediatric hospital
ConclusionSurgery remains common in stricturing pediatric CD, with increasing stricture ratio and sMaRIA score associated with need for surgical management.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 24, 2024 Category: Radiology Source Type: research

Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research

Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
CONCLUSIONS: In summary, our data suggest that Sarm1 controls the MYD88-mediated inflammatory responses in IBD via its regulation of TRAF3 recruitment.PMID:38651786 | DOI:10.1080/08820139.2024.2343889 (Source: Immunological Investigations)
Source: Immunological Investigations - April 23, 2024 Category: Allergy & Immunology Authors: Huijuan Fan Chun Song Jingyu Zhang Source Type: research

Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | PMC:PMC11045344 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research

Potential mitigating impact of a dipeptidyl peptidase-IV inhibitor, vildagliptin, on oxazolone-induced ulcerative colitis: Targeting the role of PI3K/AKT/mTOR and AMPK/Nrf2 signaling pathways
Int Immunopharmacol. 2024 Apr 22;133:112110. doi: 10.1016/j.intimp.2024.112110. Online ahead of print.ABSTRACTGrowing evidence suggests that phosphoinositide 3-kinase (PI3K) and adenosine monophosphate-activated protein kinase (AMPK) signaling cascades are critical in ulcerative colitis (UC) pathophysiology by influencing gut mucosal inflammation. Recently, the coloprotective properties of dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged. Thus, this study assessed for the first time the potential mitigating impact of a DPP-IV inhibitor, vildagliptin (Vilda), on oxazolone (OXZ)-induced colitis in rats, targeting the...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Marwa Mahmoud Awad Rehab M El-Gohary Sarah Ibrahim Muhammad Tarek Abdel Ghafar Eman E Farghal Alshimaa Aboalsoud Rehab Ahmed Ahmed El-Shaer Source Type: research

Reply to comments on: "Efficacy of cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn's disease-A prospective nationwide multicenter cohort study"
Wien Klin Wochenschr. 2024 Apr 23. doi: 10.1007/s00508-024-02363-z. Online ahead of print.NO ABSTRACTPMID:38652312 | DOI:10.1007/s00508-024-02363-z (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 23, 2024 Category: General Medicine Authors: Stefan Riss Christopher Dawoud Source Type: research

Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research

Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research