Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique
Talanta. 2024 Apr 27;275:126172. doi: 10.1016/j.talanta.2024.126172. Online ahead of print.ABSTRACTNanoparticles (NPs) could be uptake orally and exposed to digestive tract through various sources such as particulate pollutant, nanomedicine and food additive. Inflammatory bowel disease (IBD), as a global disease, induced disruption of the intestinal mucosal barrier and thus altered in vivo distribution of NPs as a possible consequence. However, related information was relatively scarce. Herein, in vivo distribution of typical silica (SiO2) and titania (TiO2) NPs was investigated in healthy and IBD models at cell and animal...
Source: Talanta - May 1, 2024 Category: Chemistry Authors: Mingyue Tan Yunqing Wang Yunxia Ji Rongchao Mei Xizhen Zhao Jie Song Jinmao You Lingxin Chen Xiaoyan Wang Source Type: research

MicroRNAs in inflammatory bowel disease: What do we know and what can we expect?
World J Gastroenterol. 2024 Apr 28;30(16):2184-2190. doi: 10.3748/wjg.v30.i16.2184.ABSTRACTMicroRNAs (miRNAs), small non-coding RNAs composed of 18-24 nucleotides, are potent regulators of gene expression, contributing to the regulation of more than 30% of protein-coding genes. Considering that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells, there is an interest in exploring their importance in inflammatory bowel disease (IBD). IBD is a chronic and multifactorial disease of the gastrointestinal tract; the main forms are Crohn's disease and ulcerative colitis. Several s...
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Ellen Cristina Souza de Oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Source Type: research

Potential Efficacy of Janus Kinase Inhibitors in the Treatment of a Patient With Coexisting Peripheral and Axial Spondyloarthritis and Ulcerative Colitis
J Rheumatol. 2024 May 1:jrheum.2024-0055. doi: 10.3899/jrheum.2024-0055. Online ahead of print.ABSTRACTTumor necrosis factor inhibitors are effective and recommended in treating patients with coexisting spondyloarthritis (SpA) and ulcerative colitis (UC); however, the evidence of their superiority over other drugs is insufficient.1 Although Janus kinase inhibitors (JAKi) have shown effectiveness in treating UC and psoriatic arthritis, there are no reports of treating coexisting SpA and UC with JAKi monotherapy.PMID:38692666 | DOI:10.3899/jrheum.2024-0055 (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2024 Category: Rheumatology Authors: Sho Ishigaki Nobuhiko Kajio Noritada Yoshikawa Hiroaki Taguchi Source Type: research

Cytomegalovirus Infection in Adult Patients with Inflammatory Bowel Disease: A Literature Review
Arch Iran Med. 2024 May 1;27(5):277-286. doi: 10.34172/aim.2024.40.ABSTRACTHuman cytomegalovirus (HCMV) is classified within the Herpesvirales order and is prevalent in 50%‒80% of the general population. Most carriers experience this infection without noticeable clinical symptoms. HCMV causes a lifelong latent infection that can be reactivated due to immune disorders and inflammation. The reactivation of HCMV becomes particularly significant when it coincides with inflammatory bowel disease (IBD). While cytomegalovirus (CMV) colitis in IBD patients was identified years ago, the role of CMV in triggering flare-ups, acute ...
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Zahra Momayaz Sanat Zeinab Siami Sudabeh Alatab Homayoon Vahedi Zeinab Fanni Source Type: research

MicroRNAs in inflammatory bowel disease: What do we know and what can we expect?
World J Gastroenterol. 2024 Apr 28;30(16):2184-2190. doi: 10.3748/wjg.v30.i16.2184.ABSTRACTMicroRNAs (miRNAs), small non-coding RNAs composed of 18-24 nucleotides, are potent regulators of gene expression, contributing to the regulation of more than 30% of protein-coding genes. Considering that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells, there is an interest in exploring their importance in inflammatory bowel disease (IBD). IBD is a chronic and multifactorial disease of the gastrointestinal tract; the main forms are Crohn's disease and ulcerative colitis. Several s...
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Ellen Cristina Souza de Oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Source Type: research

Mycophenolate-induced colitis in a patient with lupus nephritis: a case report and review of the literature
ConclusionThe purpose of this paper is to report a case of early-onset MMF-induced colitis in a patient with lupus nephritis who had started MMF as induction therapy. A review of the available literature on this uncommon immunosuppressive effect is also presented. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 1, 2024 Category: General Medicine Source Type: research

Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease
J Cell Mol Med. 2024 May;28(9):e18344. doi: 10.1111/jcmm.18344.ABSTRACTSingle cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages were assigned within 14,539 sequenced cells from patient-matched SCD and non-stricturing (NSCD) preparations. SCD and NSCD contained identical cell types. Amongst immune cells, B cells and plasma cells were selectively increased in SCD samples. B cell subsets suggested formation of tertiary lymphoid tissue in SCD and compared with NS...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: David T Humphreys Amy Lewis Belen Pan-Castillo Giulio Berti Charles Mein Eva Wozniak Hannah Gordon Radha Gadhok Annamaria Minicozzi Joanna ChinAleong Roger Feakins Eleni Giannoulatou Louisa K James Andrew J Stagg James Oliver Lindsay Andrew Silver Source Type: research

T3-T4 index as a prognostic marker of response to biological treatments in elderly patients with inflammatory bowel disease
Rev Esp Enferm Dig. 2024 Apr 30. doi: 10.17235/reed.2024.10445/2024. Online ahead of print.ABSTRACTFollowing the growing trend of trying to individualise treatment in inflammatory bowel disease and in view of the challenge posed by elderly patients requiring biologic treatments, we have conducted a study in our centre to assess the T3/T4 index as a predictor of response to biologic treatments in elderly patients.PMID:38685905 | DOI:10.17235/reed.2024.10445/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - April 30, 2024 Category: Gastroenterology Authors: Mar ía Martínez Burgos Ra úl Vicente Olmedo Martín V íctor Amo Trillo Patricia Romero Cara Jos é Mostazo Torres Miguel Jim énez Pérez Source Type: research

Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research

Protein-losing enteropathy: is it Crohn's disease?
Rev Esp Enferm Dig. 2024 Apr 30. doi: 10.17235/reed.2024.10461/2024. Online ahead of print.ABSTRACTCase of a 24-year-old woman presenting due to edema in lower extremities. The patient had had infectious mononucleosis three weeks prior and had medical history of suspicion of Crohn's disease (CD) (due to a non-specific ileocolitis in a colonoscopy/EnteroRM). No ongoing medication. Laboratory evaluation unveiled hypoproteinemia with severe hypoalbuminemia, no renal abnormalities. A PLE was assumed, with post-infectious or CD being the most likely culprits. Alternative causes were extensively excluded. A videocapsule revealed...
Source: Revista Espanola de Enfermedades Digestivas - April 30, 2024 Category: Gastroenterology Authors: Maria Jos é Temido Sandra Lopes Pedro Figueiredo Francisco Portela Source Type: research

Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research

Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease
J Cell Mol Med. 2024 May;28(9):e18344. doi: 10.1111/jcmm.18344.ABSTRACTSingle cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages were assigned within 14,539 sequenced cells from patient-matched SCD and non-stricturing (NSCD) preparations. SCD and NSCD contained identical cell types. Amongst immune cells, B cells and plasma cells were selectively increased in SCD samples. B cell subsets suggested formation of tertiary lymphoid tissue in SCD and compared with NS...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: David T Humphreys Amy Lewis Belen Pan-Castillo Giulio Berti Charles Mein Eva Wozniak Hannah Gordon Radha Gadhok Annamaria Minicozzi Joanna ChinAleong Roger Feakins Eleni Giannoulatou Louisa K James Andrew J Stagg James Oliver Lindsay Andrew Silver Source Type: research

Sacroiliitis in inflammatory bowel disease on abdominal computed tomography: prevalence, misses, and associated factors
CONCLUSION: Physicians should carefully evaluate SI joints on abdominal CT in patients with IBD to enable early detection of sacroiliitis, potentially leading to an early diagnosis of axSpA. In addition, if patients with IBD present with back pain, the possibility of sacroiliitis should be considered.PMID:38686835 | DOI:10.1080/03009742.2024.2337453 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - April 30, 2024 Category: Rheumatology Authors: D K Kim K-C Lee J K Kim Source Type: research