Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Iron supplementation in patients with chronic inflammatory bowel disease: recommendations for a practical approach
Z Gastroenterol. 2024 Apr 24. doi: 10.1055/a-2274-1610. Online ahead of print.ABSTRACTIron deficiency is the predominant cause of anemia. Iron deficiency anemia plays a major role, especially in patients with inflammatory bowel disease (IBD), and is the most common extraintestinal manifestation and IBD-associated systemic complication. The presence of anemia leads to a reduction in quality of life in patients with IBD associated with limitations in physical, emotional, and cognitive function. In addition, it is associated with an increased hospitalization rate. For this reason, iron supplementation is of particular importa...
Source: Zeitschrift fur Gastroenterologie - April 24, 2024 Category: Gastroenterology Authors: Katharina Stratmann Viktoria Hentschel Stefan Zeuzem Irina Blumenstein Jochen Klaus Source Type: research

Long-term real-world data of ustekinumab in Crohn's disease: the Stockholm ustekinumab study
CONCLUSION: Among difficult-to-treat patients with CD, ustekinumab was effective in the majority, with high drug persistence at 12 and 24 months in combination with a favourable safety profile.PMID:38655034 | PMC:PMC11036920 | DOI:10.1177/17562848241242700 (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Francesca Bello Samer Muhsen Haider Sabhan Alexandra Borin Fredrik Johansson Charlotte H öög Ole Forsberg Christina Wennerstr öm Charlotte S öderman Mikael L ördal Sven Almer Source Type: research

Stratified Patient Profiling for Vedolizumab Effectiveness in Crohn's Disease: Identifying Optimal Subgroups for Enhanced Treatment Response in the EVOLVE Study
CONCLUSIONS: Subpopulations of biologic-naive patients with CD in whom vedolizumab appeared to have a larger effect relative to anti-TNFα agents for the outcome of clinical remission were identified. Validation of the identified subpopulations and simplified rules are warranted to confirm these findings.GOV IDENTIFIER: NCT03710486. Graphical Abstract available for this article.PMID:38658485 | DOI:10.1007/s12325-024-02825-w (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Andres Yarur Gerassimos J Mantzaris Song Wang Shashi Adsul Pravin Kamble Erin Cook Gautam Sajeev Annie Guerin Brian Bressler Source Type: research

Correction: Gene expression analysis of intestinal IL-8, IL-17 A and IL-10 in patients with celiac and inflammatory bowel diseases
Mol Biol Rep. 2024 Apr 24;51(1):569. doi: 10.1007/s11033-024-09440-6.NO ABSTRACTPMID:38658466 | DOI:10.1007/s11033-024-09440-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Elham Aghamohamad Nastaran Asri Aylin Odak Mohammad Rostami-Nejad Vahid Chaleshi Yasaman Hajinabi Maryam Eslami Saeed Mohammadian Haftcheshmeh Fahimeh Sadat Gholam-Mostafaei Hamid Asadzadeh-Aghdaei Andrea Masotti Mohammad Reza Zali Source Type: research

GSE264530 Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans. [scRNAseq_MouseLPL]
Contributors : Yingcong Li ; Ciro Ram írez-Suástegui ; Richard Harris ; Francisco E Castañeda-Castro ; Daniel A Giles ; Jiani Chai ; Gregory Seumois ; Tilman Sanchez-Elsner ; Fraser Cummings ; Mitchell Kronenberg ; Pandurangan VijayanandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE235663 Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [scRNAseq_Human]
Contributors : Yingcong Li ; Ciro Ram írez-Suástegui ; Richard Harris ; Francisco E Castañeda-Castro ; Daniel A Giles ; Jiani Chai ; Gregory Seumois ; Tilman Sanchez-Elsner ; Fraser Cummings ; Mitchell Kronenberg ; Pandurangan VijayanandSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ 32 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE264463 Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [bulkRNAseq_MouseLPL]
Contributors : Yingcong Li ; Ciro Ram írez-Suástegui ; Richard Harris ; Francisco E Castañeda-Castro ; Daniel A Giles ; Jiani Chai ; Gregory Seumois ; Tilman Sanchez-Elsner ; Fraser Cummings ; Mitchell Kronenberg ; Pandurangan VijayanandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE235664 Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [scRNAseq_Mouse]
Contributors : Yingcong Li ; Ciro Ram írez-Suástegui ; Richard Harris ; Francisco E Castañeda-Castro ; Daniel A Giles ; Jiani Chai ; Gregory Seumois ; Tilman Sanchez-Elsner ; Fraser Cummings ; Mitchell Kronenberg ; Pandurangan VijayanandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ 32 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE235665 Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research

GSE247433 MiR-146a alleviates inflammatory bowel disease in mice through systematical regulation of multiple genetic networks
Contributors : Fengting Zhu ; Taotan Yang ; Changgeng PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory bowel disease (IBD) is a multiple-genes-involved chronic disease and current available targeted drugs for IBD only deliver moderate efficacy. Whether there is a single gene that systematically regulates IBD is not yet known. Here we showed that the expression of miR-146a in colon was elevated in Dextran Sulfate Sodium Salt (DSS)-induced IBD mice and patients with IBD. DSS induced dramatic body weight loss and much more rectal bleeding, shorter colon length and coli...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Stratified Patient Profiling for Vedolizumab Effectiveness in Crohn ’s Disease: Identifying Optimal Subgroups for Enhanced Treatment Response in the EVOLVE Study
ConclusionsSubpopulations of biologic-naive patients with CD in whom vedolizumab appeared to have a larger effect relative to anti-TNF α agents for the outcome of clinical remission were identified. Validation of the identified subpopulations and simplified rules are warranted to confirm these findings.ClinicalTrials.gov IdentifierNCT03710486.Graphical Abstract available for this article.Graphical Abstract (Source: Advances in Therapy)
Source: Advances in Therapy - April 24, 2024 Category: Drugs & Pharmacology Source Type: research

Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research