Inflammatory Bowel Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Colorectal Neoplasia in the Setting of Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):673-684. doi: 10.1016/j.suc.2023.12.006. Epub 2023 Dec 26.ABSTRACTInflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (colorectal adenocarcinoma [CRC]) compared with the general population. IBD-related CRC is related to poorer outcomes than non-IBD-related CRC, and it accounts for 10% to 15% of death in patients with IBD. As such, screening guidelines have been made specific to this population recommending shorter intervals of endoscopic screening to detect dysplasia and CRC relative to the general population. Advances in endoscopic technology allow...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Maura Walsh Shahrose Rahman Rebecca Gologorsky Vassiliki Liana Tsikitis Source Type: research

Surgical Emergencies in Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):685-699. doi: 10.1016/j.suc.2023.11.012. Epub 2023 Dec 14.ABSTRACTInflammatory bowel disease (IBD) patients are at risk for undergoing emergency surgery for fulminant disease, toxic megacolon, bowel perforation, intestinal obstruction, or uncontrolled gastrointestinal hemorrhage. Unfortunately, medical advancements have failed to significantly decrease rates of emergency surgery for IBD. It is therefore important for all acute care and colorectal surgeons to understand the unique considerations owed to this often-challenging patient population.PMID:38677830 | DOI:10.1016/j.suc.2023.11.01...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: John Van Eaton Quinton M Hatch Source Type: research

Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research

Colorectal Neoplasia in the Setting of Inflammatory Bowel Disease
Surg Clin North Am. 2024 Jun;104(3):673-684. doi: 10.1016/j.suc.2023.12.006. Epub 2023 Dec 26.ABSTRACTInflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (colorectal adenocarcinoma [CRC]) compared with the general population. IBD-related CRC is related to poorer outcomes than non-IBD-related CRC, and it accounts for 10% to 15% of death in patients with IBD. As such, screening guidelines have been made specific to this population recommending shorter intervals of endoscopic screening to detect dysplasia and CRC relative to the general population. Advances in endoscopic technology allow...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Maura Walsh Shahrose Rahman Rebecca Gologorsky Vassiliki Liana Tsikitis Source Type: research

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion
Microorganisms. 2024 Mar 23;12(4):642. doi: 10.3390/microorganisms12040642.ABSTRACTCurcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin's ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatmen...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Junwen Zhu Lan He Source Type: research

Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis
Medicina (Kaunas). 2024 Mar 26;60(4):539. doi: 10.3390/medicina60040539.ABSTRACTOxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic renal disease, and inflammatory bowel disease (IBD). However, the precise mechanism involved remains to be clarified. We formerly identified a novel apoptosis-inducing humoral protein, in a hypoxia/reoxygenation-conditioned medium of cardiac myocytes, which proved to be 69th tyrosine-sulfated eukaryotic trans...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Akihito Nakajima Tomoyoshi Shibuya Takako Yao Tsutomu Fujimura Kimie Murayama Ko Okumura Akihito Nagahara Yoshinori Seko Source Type: research

Bear Bile Powder Improves Ulcerative Colitis by Protecting the Intestinal Mechanical Barrier and Regulating Intestinal Flora
CONCLUSION: Oral administration of a certain dose of BBP can significantly improve the symptoms of ulcerative colitis in mice. Part of the reason may be that it increases the expression of tight junction proteins, regulates specific flora in the intestine of mice, and maintains intestinal barrier homeostasis. In the future, the clinical application value of BBP will be explored, and BBP will be developed as a drug with the potential to treat UC and alleviate the pain of UC patients.PMID:38676524 | DOI:10.2174/0113816128294893240403074953 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Zi-Bo Liu Xun Ye Chun-Jie Wu Da-Neng Wei Source Type: research

Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know
Surg Clin North Am. 2024 Jun;104(3):647-656. doi: 10.1016/j.suc.2023.12.004. Epub 2023 Dec 28.ABSTRACTThe gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in the development of varying diseases. The purpose of this review is to highlight what is known about the microbiome and its impact on colorectal cancer, inflammatory bowel disease, constipation, Clostridioides difficile infectio...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Shahrose Rahman Ethan Lu Ranish K Patel Vassiliki Liana Tsikitis Robert G Martindale Source Type: research

Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
This study found that while both exogenous β-hydroxybutyrate and BD-AcAc 2 produced the same levels of plasma β-hydroxybutyrate, BD-AcAc 2 demonstrated superior effectiveness in mitigating dextran sodium sulfate-induced UC in rats. The mechanism of action involves modulating the NF-κB signaling, inhibiting the NLRP3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. Certainly, BD-AcAc 2's anti-inflammatory effects require more than just increasing plasma β-hydroxybutyrate levels and other factors contribute to its efficacy. L...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Osama A Mohammed Sameh Saber Mustafa Ahmed Abdel-Reheim Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Ali M S Eleragi Hanan B Eltahir Mohamed Osama Abdalla Emad Bahashwan Elwathiq Khalid Ibrahim Assad Ali Rezigalla Sameh Source Type: research

Medical Management of Inflammatory Bowel Disease
This article highlights several key trials and discusses modern treatment paradigms for both UC and CD based on disease severity.PMID:38677828 | DOI:10.1016/j.suc.2023.12.005 (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ranish K Patel Elisa Boden Vassiliki Liana Tsikitis Source Type: research

Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know
Surg Clin North Am. 2024 Jun;104(3):647-656. doi: 10.1016/j.suc.2023.12.004. Epub 2023 Dec 28.ABSTRACTThe gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in the development of varying diseases. The purpose of this review is to highlight what is known about the microbiome and its impact on colorectal cancer, inflammatory bowel disease, constipation, Clostridioides difficile infectio...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ethan Lu Ranish K Patel Vassiliki Liana Tsikitis Robert G Martindale Source Type: research