What recent primary studies tell us about ovarian teratomas in children: a scoping review
AbstractOur knowledge of ovarian teratomas in children is still far from complete, and much remains to be discovered. Here, we conduct a scoping review of the primary research related to ovarian teratomas in pediatric age. To our knowledge, there is no published synthesis of the literature surrounding ovarian teratomas in children using scoping review methodology. We identified 24 studies from 11 countries; 18 studies were retrospective, 3 were prospective, and 3 were experimental. There were 6 studies concerning mature teratomas, 5 concerning immature teratomas, and 13 that included both tumor types. Overall, 9 out of all...
Source: Cancer and Metastasis Reviews - January 30, 2020 Category: Cancer & Oncology Source Type: research
Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components
Modern Pathology, Published online: 07 January 2020; doi:10.1038/s41379-019-0446-yMultiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components (Source: Modern Pathology)
Source: Modern Pathology - January 6, 2020 Category: Pathology Authors: Michael B. Heskett John Z. Sanborn Christopher Boniface Benjamin Goode Jocelyn Chapman Karuna Garg Joseph T. Rabban Charles Zaloudek Stephen C. Benz Paul T. Spellman David A. Solomon Raymond J. Cho Source Type: research
Sacrococcygeal teratoma: Clinical characteristics, management, and long-term outcomes in a prospective study from a Tertiary Care Center
Conclusions: Teratomas are the most common germ cell tumors of the sacrococcygeal region. Most of the tumors are benign, and the incidence of malignancy increases with age. The evaluation of malignancy is, therefore, necessary in these children. Excellent survival of 95% was achieved in this series. Morbidity due to associated malformation, disease recurrence, and treatment may persist in these patients; hence, proper follow-up is needed. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - November 26, 2019 Category: Surgery Authors: Devendra Kumar Yadav Samir Kant Acharya Deepak Bagga Vishesh Jain Anjan Dhua Prabudh Goel Source Type: research
Anti-N-methyl-d-aspartate receptor encephalitis induced by bilateral ovarian teratomas with distinct histopathologic types: A case report and brief literature review
Rationale:
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder that is most frequently induced by ovarian teratoma in young females. The condition can be controlled and reversed via ovarian tumor resection and immunotherapy. However, anti-NMDAR encephalitis induced by bilateral ovarian teratomas with distinct histopathologic types is rarely reported in the literature.
Patient concerns:
A 23-year-old woman presented with seizures.
Diagnoses:
The diagnosis was anti-NMDAR encephalitis associated with ovarian teratomas based on positive anti-NMDAR antibody tests in both the cerebrospinal f...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Derivation of Neural stem cells from Human Teratomas
In conclusion, spheres with the characteristics of neural stem cells were obtained from the primary culture of a human infantile teratoma. These spheres are considered to have the potential to undergo a natural course of neural development in humans. (Source: Stem Cell Research)
Source: Stem Cell Research - October 19, 2019 Category: Stem Cells Source Type: research
GCT-29 - Behaviour and outcome of paediatric immature teratomas at children cancer hospital in Egypt. What did we learn over 10 years?
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 4Author(s): S. Ahmed, M. Shafiey, M. Elwakeel, M. Ahmed, L. Basiouny (Source: European Urology Supplements)
Source: European Urology Supplements - September 13, 2019 Category: Urology & Nephrology Source Type: research
GCT-27 - Pure paediatric ovarian immature teratomas: the French experience
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 4Author(s): R. Pavone, V. Ro, F. Dijoud, L. Galmiche, D. Orbach, C. Briandet, M. Pasquet, A. Bertrand, B. Fresneau, C. Faure-Conter (Source: European Urology Supplements)
Source: European Urology Supplements - September 13, 2019 Category: Urology & Nephrology Source Type: research
Cervical giant immature teratoma in a newborn: A challenge for survival
Nagarjuna Kumbha, Allu Rohita, Sarweswar Porca Reddy, Ambati Karuna SagarJournal of Indian Association of Pediatric Surgeons 2019 24(4):307-308
Teratomas are a conglomerate of heterogenous cells arising from totipotent germ cells. Cervical teratomas occur 1 per 20,000 to 40,000 live births constituting 1.6-9.3% of all paediatric teratomas . They can present antenatally with cervical mass or polyhydramnios and postnatally with respiratory distress and facial disfigurement. Complete excision of the tumour prevents malignant transformation. Timing of the surgery is based on severity of airway compromise. Surgical ...
Source: Journal of Indian Association of Pediatric Surgeons - August 28, 2019 Category: Surgery Authors: Nagarjuna Kumbha Allu Rohita Sarweswar Porca Reddy Ambati Karuna Sagar Source Type: research
Differentiating presacral masses in anorectal malformations and isolated sacrococcygeal teratomas
ConclusionsCompared to patients with isolated SCT, patients with presacral mass and ARM had lower grade tumors. In addition, they had a higher proportion of sacral defects and other congenital defects, as well as worse bowel function outcomes. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - June 28, 2019 Category: Surgery Source Type: research
Fascin as a Useful Marker for Identifying Neural Components in Immature Teratomas of Human Ovary and Those Derived From Murine Embryonic Stem Cells
Immature teratoma of the human ovary is a rare disease, and its diagnosis and grading are currently based on histologic evaluation of the presence and amount of immature neural components in the tumor. Despite the importance of tumor grading, immature neural components especially without rosette formation are difficult to identify, partly because useful biomarkers for them are not yet available. Toward this goal, we investigated 16 immature teratomas from human ovaries as well as 10 of those derived from murine embryonic stem cells transplanted into immunodeficient mice. Immunohistochemistry was performed for cytokeratin, ...
Source: International Journal of Gynecological Pathology - June 12, 2019 Category: Pathology Tags: PATHOLOGY OF THE UPPER GENITAL TRACT: ORIGINAL ARTICLES Source Type: research
Recurrent ovarian immature teratoma in a 12-year-old girl: Implications for management.
Abstract
Immature teratomas (IT) are rare and recurrences uncommon. A 12-year-old female with grade 3 (high-grade) ovarian IT underwent surgical resection but experienced early recurrences; the first was treated with surgery but the second was metastatic and managed with chemotherapy, resulting in growing-teratoma-syndrome and need for further surgery. She now remains well in uneventful clinical follow-up. We believe chemotherapy could be reserved for very carefully selected recurrent IT cases, which may alter the natural history of disease.
PMID: 31176555 [PubMed - as supplied by publisher] (Sourc...
Source: Gynecologic Oncology - June 4, 2019 Category: Cancer & Oncology Authors: Frazer JL, Hook CE, Addley HC, Jackson CR, Latimer JA, Nicholson JC, Murray MJ Tags: Gynecol Oncol Source Type: research
Pediatric ovarian immature teratoma: Histological grading and clinical characteristics
Ovarian immature teratomas (ITs) are relatively rare among all pediatric ovarian tumors. The histological grading for ovarian ITs, which ranges from 1 to 3, is based on the proportion of immature neuroepithelial component. Higher-grade ITs in adults are treated as malignant neoplasms and require adjuvant chemotherapy. However, there is no consensus on the therapeutic management of pediatric ovarian ITs. The aim of our study was to analyze the histological grades and clinical characteristics of ovarian ITs in pediatric patients. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - May 22, 2019 Category: Surgery Authors: Toko Shinkai, Kouji Masumoto, Fumiko Chiba, Kazuki Shirane, Yasunari Tanaka, Tsubasa Aiyoshi, Takato Sasaki, Kentaro Ono, Chikashi Gotoh, Yasuhisa Urita, Hajime Takayasu, Ryoko Suzuki, Shingo Sakashita Source Type: research
Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives
Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research
Immunogenicity of Tumor Initiating Stem Cells: Potential Applications in Novel Anticancer Therapy
Conclusion
Several TISC-based immunotherapeutic approaches are under development in various stages of preclinical studies. As outlined in this review article, a careful and more exhaustive genetic and metabolic understanding of TISC-associated phenotypes is critical to develop novel TISC based immunotherapies. Various components within the tumor microenvironment such as tumor cells, infiltrating immune cells, and supporting stromal cells impact the TISC metabolism. This unique metabolic profile leads to upregulation of certain enzymes and proteins such as ALDH1, CEP55, IDO COA1 etc., which can be utilized for development ...
Source: Frontiers in Oncology - April 24, 2019 Category: Cancer & Oncology Source Type: research
A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice
Adult guidelines recommend BEP (bleomycin, etoposide, cisplatin) for all ovarian germ cell tumours, causing debilitating toxicities in young patients who will survive long term. Paediatricians successfully reduce toxicities by using lower bleomycin doses and substituting carboplatin for cisplatin, while testicular and paediatric immature teratomas (ITs) are safely managed with surgery alone. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 3, 2019 Category: Cancer & Oncology Authors: C. Newton, K. Murali, A. Ahmad, H. Hockings, R. Graham, V. Liberale, S.-J. Sarker, J. Ledermann, D.M. Berney, J. Shamash, S. Banerjee, S. Stoneham, M. Lockley Tags: Original Research Source Type: research
