Adenocarcinoma arising from intracranial recurrent mature teratoma and featuring mutated KRAS and wild‐type BRAF genes
In conclusion, the intracranial mature teratomas should require long‐term follow‐up, and clinicians, radiologists and pathologists should be aware of the potential for malignant progression of recurrent intracranial mature cystic teratoma despite gross total resection and no neurologic symptoms. (Source: Neuropathology)
Source: Neuropathology - June 1, 2014 Category: Neurology Authors: Eun Soo Kim, Mi Jung Kwon, Joon Ho Song, Dong Hoon Kim, Hye‐Rim Park Tags: CASE REPORT Source Type: research
Histopathology of pineal germ cell tumors.
Abstract
Germ cell tumors (GCTs) classically occur in gonads. However, they are the most frequent neoplasms in the pineal region. The pineal location of GCTs may be caused by the neoplastic transformation of a primordial germ cell that has mismigrated. The World Health Organization (WHO) recognizes 5 histological types of intracranial GCTs: germinoma and non-germinomatous tumors including embryonal carcinoma, yolk sac tumor, choriocarcinoma and mature or immature teratoma. Germinomas and teratomas are frequently encountered as pure tumors whereas the other types are mostly part of mixed GCTs. In this situa...
Source: Neuro-Chirurgie - April 9, 2014 Category: Neurosurgery Authors: Vasiljevic A, Szathmari A, Champier J, Fèvre-Montange M, Jouvet A Tags: Neurochirurgie Source Type: research
Non‐genomic estrogen/estrogen receptor α promotes cellular malignancy of immature ovarian teratoma in vitro
In conclusion, estrogenic signals exert malignant transformation capacity of cancer cells, exclusively through non‐genomic regulation in female germ cell tumors. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - October 21, 2013 Category: Cytology Authors: Yao‐Chin Hung, Wei‐Chun Chang, Lu‐Min Chen, Ying‐Yi Chang, Ling‐Yu Wu, Wei‐Min Chung, Tze‐Yi Lin, Liang‐Chi Chen, Wen‐Lung Ma Tags: Original Research Article Source Type: research
Imaging characteristics of primary intracranial teratoma.
CONCLUSION: Primary intracranial teratomas are usually localized in the pineal and the suprasellar regions, and often present an ovoid or lobulated mass with or without multilocularity on MRI. Marked enhancement of the solid portion or the thick wall of the tumor was the key feature for distinguishing mature teratoma and malignant teratoma.
PMID: 24103916 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - October 8, 2013 Category: Radiology Authors: Liu Z, Lv X, Wang W, An J, Duan F, Feng X, Chen X, Ouyang B, Li S, Singh S, Qiu S Tags: Acta Radiol Source Type: research
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
Conclusion:
Understanding methylation patterns may identify the developmental stage at which the GCT arose and the at-risk period when environmental exposures could be most harmful. Further, identification of relevant genetic pathways could lead to the development of new targets for therapy. (Source: BMC Cancer)
Source: BMC Cancer - June 27, 2013 Category: Cancer & Oncology Authors: James AmatrudaJulie RossBrock ChristensenNicholas FustinoKenneth ChenAnthony HootenHeather NelsonJacquelyn KurigerDinesh RakhejaA FrazierJenny Poynter Source Type: research
Primary renal teratoma: a rare entity
We present a case of intrarenal immature teratoma in a six-month-old baby girl.Virtual slidesThe virtual slides for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1746249869599954. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 25, 2013 Category: Pathology Authors: Karima Idrissi-SerhrouchniHinde El-FatemiAziz El madiKhadija BenhayounLaila ChbaniTaoufik HarmouchYoussef BouabdellahAfaf Amarti Source Type: research
Immature teratoma of the nose and paranasal sinuses masquerading as bilateral nasal polyposis: A unique presentation
SK Aggarwal, A Keshri, P AgarwalJournal of Postgraduate Medicine 2013 59(2):138-141Teratomas are tumors of multipotent cells derived from all three germ cell layers and recapitulate normal organogenesis. Teratomas are hypothesized to arise by misplacement of multipotent germ cells. Teratoma is usually developmental and sometimes congenital neoplasm which displays both solid and cystic components with gross and microscopic differentiation into a wide variety of tissues representative of all three germ layers-ectoderm, mesoderm and endoderm. We are describing a case which was initially diagnosed as bilateral nasal polyposis ...
Source: Journal of Postgraduate Medicine - June 21, 2013 Category: Internal Medicine Authors: SK AggarwalA KeshriP Agarwal Source Type: research
Familial Rhabdoid Tumour "Avant La Lettre" ‐ from pathology review to exome sequencing and back again
This report raises the question as to whether molecular genetic analysis should be included in tumour classification, alongside more traditional microscopy‐based methods. The use of new sequencing technologies, particularly when applied to archived samples, will lead to many more “molecular re‐diagnoses”. This is the earliest known case of rhabdoid tumour predisposition syndrome type 2 and the only described case with an autosomal dominant pattern of inheritance, only discovered through an exome sequencing project. (Source: The Journal of Pathology)
Source: The Journal of Pathology - June 14, 2013 Category: Pathology Authors: Leora Witkowski, Emilie Lalonde, Jian Zhang, Steffen Albrecht, Nancy Hamel, Luca Cavallone, Sandra Thompson May, James C. Nicholson, Nicholas Coleman, Matthew J. Murray, Peter F. Tauber, David G. Huntsman, Stefan Schönberger, David Yandell, Martin Hassel Tags: Original Article Source Type: research
Value of dynamic contrast-enhanced MRI for tissue characterization of ovarian teratomas: Correlation with histopathology
Conclusion: TIC types are related to the specific content of the solid tissue of ovarian teratomas but cannot be used to differentiate benign and malignant ovarian teratomas. (Source: Clinical Radiology)
Source: Clinical Radiology - May 31, 2013 Category: Radiology Authors: E. Poncelet, C. Delpierre, O. Kerdraon, J.-P. Lucot, P. Collinet, M. Bazot Tags: Original Papers Source Type: research
High Resolution Genomic Profiling of Metastatic Testicular Teratomas
Testicular germ cell tumors (TGCT) are the most common malignancy in young males between the ages of 15 and 44, with increasing incidence in western industrial countries. Interestingly, the overall incidence has more than doubled over the past 50 years. Teratomas represent a subgroup of TGCTs with immense histologic diversity, consisting of well differentiated, mature tissues only or also including immature, fetal-like tissues. The pathogenic mechanism of this type of tumor remains elusive. To evaluate the genomic profile of this cohort of TGCTs, we performed high resolution SNP array analysis on ten adult metastatic testi...
Source: Cancer Genetics and Cytogenetics - May 1, 2013 Category: Genetics & Stem Cells Authors: Karen J. Ouyang, Holli Drendel, Jadwiga Szymanska, Oscar Cummings, Lawrence Einhorn, Gail H. Vance Tags: CCMC Abstracts Source Type: research
Immature ovarian teratoma with unusual gliomatosis
This study aimed to investigate an unusual case of immature ovarian teratoma with onset of mature glial cells implanted on the contralateral ovary, a challenge in the diagnosis of the second ovarian tumor. We report the case of a 31- yr-old woman, who developed at the age of 16 an immature teratoma in the right ovary that was surgically removed. Six years later mature glial implants were present on the left ovary and six months later at the level of peritoneum that relapsed after other six months. The patient suffered three surgical resections after the initial one. Paraffin sections and immunohistochemical examinations us...
Source: Journal of Ovarian Research - April 16, 2013 Category: Cancer & Oncology Authors: Ancuta Gheorghisan-GalateanuDana TerzeaMara CarsoteCatalina Poiana Source Type: research
Sacrococcygeal yolk sac tumor developing after teratoma: A clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors
Conclusions: The characteristics of SGCT in Japanese children were similar with those reported in Europe or the United States. YST developed after SCT resection not only in patients with previously reported risk factors. We recommend that patients undergo serum AFP monitoring every 3months for≥3years after SCT resection. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - April 1, 2013 Category: Surgery Authors: Mariko Yoshida, Kentaro Matsuoka, Atsuko Nakazawa, Makiko Yoshida, Takeshi Inoue, Hiroshi Kishimoto, Masahiro Nakayama, Emi Takaba, Minoru Hamazaki, Shigeaki Yokoyama, Hiroshi Horie, Mio Tanaka, Kiyoshi Gomi, Youkatsu Ohama, Hisato Kigasawa, Yoshihiro Kit Tags: Original Articles Source Type: research
[Comment] The importance of early and sustained treatment of a common autoimmune encephalitis
Josep Dalmau and colleagues' discovery that an IgG antibody targets the GluN1 subunit of the NMDA receptor (NMDAR) in a subset of patients with inflammatory encephalitis broke new ground in clinical neurology, and helped improve understanding of the pathogenesis of CNS autoimmunity. Ovarian teratoma (mature in 70% and immature in 30%) is detected in 50–60% of patients, and resection of these teratomas can lead to neurological recovery. In many patients without a detected neoplasm, unambiguous neurological improvements occur with immunotherapy (steroids, intravenous immuneglobulins, plasma exchange, or immunosuppressants)...
Source: Lancet Neurology - January 17, 2013 Category: Neurology Authors: Andrew McKeon Tags: Comment Source Type: research
