Oncological and Reproductive Outcomes of Cystectomy Compared with Unilateral Salpingo-Oophorectomy as Fertility-Sparing Surgery in Patients with Apparent Early Stage Pure Immature Ovarian Teratomas
CONCLUSIONS: A USO is the standard treatment for women with early stage pure IMTs who want to preserve fertility. However, a cystectomy with adjuvant chemotherapy may be a suitable fertility-sparing therapy when a cystectomy is the only surgical option.PMID:33772392 | DOI:10.1245/s10434-021-09719-z (Source: Ann Oncol)
Source: Ann Oncol - March 27, 2021 Category: Cancer & Oncology Authors: Dan Wang Shan Zhu Congwei Jia Dongyan Cao Jiaxin Yang Yang Xiang Source Type: research
ASO Author Reflections: Ovarian Cystectomy for Apparent Early-Stage Pure Immature Ovarian Teratomas
Ann Surg Oncol. 2021 Mar 18. doi: 10.1245/s10434-021-09767-5. Online ahead of print.NO ABSTRACTPMID:33738719 | DOI:10.1245/s10434-021-09767-5 (Source: Ann Oncol)
Source: Ann Oncol - March 19, 2021 Category: Cancer & Oncology Authors: Dan Wang Yang Xiang Source Type: research
ASO Author Reflections: Ovarian Cystectomy for Apparent Early-Stage Pure Immature Ovarian Teratomas
Ann Surg Oncol. 2021 Mar 18. doi: 10.1245/s10434-021-09767-5. Online ahead of print.NO ABSTRACTPMID:33738719 | DOI:10.1245/s10434-021-09767-5 (Source: Ann Oncol)
Source: Ann Oncol - March 19, 2021 Category: Cancer & Oncology Authors: Dan Wang Yang Xiang Source Type: research
Neonatal Malignant Disorders
Germ cell tumors (GCTs) comprise a wide spectrum of benign and malignant tumors. Neonatal GCTs are predominantly teratomas (mature or immature), which are typically cured with surgery alone. Relapses are infrequent even in the setting of microscopic residual disease; therefore, negative surgical margins at the cost of significant morbidity are not recommended. In neonates with metastatic malignant disease or malignant disease for which upfront surgical resection is not feasible without significant morbidity, an initial biopsy followed by neoadjuvant chemotherapy and delayed surgical resection is recommended. Carboplatin-ba...
Source: Clinics in Perinatology - February 12, 2021 Category: Perinatology & Neonatology Authors: Rachana Shah, Brent R. Weil, Christopher B. Weldon, James F. Amatruda, A. Lindsay Frazier Source Type: research
Ovarian teratomas: clinical features, imaging findings and management
Abstract
Ovarian teratomas are the most common type of germ cell tumors. There are three major subtypes of ovarian teratomas including mature, immature, and monodermal teratomas. Ultrasound, computed tomography and magnetic resonance imaging can demonstrate specific imaging findings for mature teratoma. Imaging features of immature and monodermal teratomas are less specific, but a combination of clinical features and imaging findings can help in the diagnosis. Imaging is also very helpful in guiding management. In this article, we review the epidemiology, histopathology, clinical presentation, imaging features and manag...
Source: Abdominal Imaging - January 4, 2021 Category: Radiology Source Type: research
Differential Activation of Immune Effector Processes in Mature Compared to Immature Sacrococcygeal Teratomas.
Conclusion: The broad repertoire of histological elements in SCTs reflects differences in transcriptional regulation rather than differences in gene copy numbers. A paucity of immune response in immature SCTs may be a factor contributing to their uninhibited growth.
PMID: 33063585 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 20, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Spontaneous rupture of immature gastric teratoma with hemoperitoneum in a newborn with 3-year follow-up.
In conclusion, physicians should be aware of the existence of gastric teratoma as the differential diagnosis of a huge abdominal mass in infants, especially neonates. Complete surgical removal of the tumor and long-term follow-up has been adopted as the standard management for immature gastric teratoma, although there has been controversy with adjuvant chemotherapy.
PMID: 32747918 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Can we replace adjuvant chemotherapy with surveillance for stage IA-C immature ovarian teratomas of any grade? an international multicenter analysis
The role of surveillance after surgery for stage IA-C grade 2 (G2) or grade 3 (G3) immature teratomas (ITs) is controversial with many guidelines advocating adjuvant chemotherapy. Here, we investigate the safety of surveillance in stage IA-C G1-3 ITs. (Source: European Journal of Cancer)
Source: European Journal of Cancer - August 3, 2020 Category: Cancer & Oncology Authors: Alice Bergamini, Naveed Sarwar, Gabriella Ferrandina, Giovanna Scarfone, Dee Short, Xianne Aguiar, Cristina Camnasio, Baljeet Kaur, Philip M. Savage, Gennaro Cormio, Adrian Lim, Sandro Pignata, Giorgia Mangili, Michael J. Seckl Tags: Original Research Source Type: research
Tunical Gliomatosis: An Uncommon Histological Entity.
Conclusion: Tunica vaginalis gliomatosis can occur in the setting of a retroperitoneal extragonadal congenital immature teratoma.
PMID: 32720553 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 29, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Need for risk-adapted therapy for malignant ovarian germ cell tumors: A large multicenter analysis of germ cell tumors' patients from French TMRG network.
CONCLUSION: Adjuvant chemotherapy does not seem to improve survival in stage I patients. Active surveillance can be proposed for selected patients with a complete surgical staging.
PMID: 32624235 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 1, 2020 Category: Cancer & Oncology Authors: Derquin F, Floquet A, Hardy-Bessard AC, Edeline J, Lotz JP, Alexandre J, Pautier P, Angeles MA, Delanoy N, Lefeuvre-Plesse C, Cancel M, Treilleux I, Augereau P, Lavoue V, Kalbacher E, Berton Rigaud D, Selle F, Nadeau C, Gantzer J, Joly F, Guillemet C, Pom Tags: Gynecol Oncol Source Type: research
Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations —is the term “thyroblastoma” more appropriate?
We describe three highly aggressive sporadic malignant teratoid thyroid tumors in 2 females (17 and 45 years) and one male (17 years). Histology showed triphasic neoplasms composed of solid nests of small primitive monomorphic cells embedded in a cellular stroma with primitive immature rhabdomyosarcoma-like (2) or pleomorphic sarcoma-like (1) phenotype. The third component was represented by TTF1+ /PAX8+ primitive teratoid epithelial tubules reminiscent of primitive thyroid follicles and/or Wilms tumor, admixed with scattered respiratory- or enteric-type tubules, neuroepithelial rosettes, and fetal-type squamoid nests. ...
Source: Virchows Archiv - June 6, 2020 Category: Pathology Source Type: research
Contemporary management of ovarian germ cell tumors and remaining controversies.
Abstract
Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved understanding of ovarian GCT, many questions remain. Areas of continued controversy include which stage I ovarian GCTs and immature teratomas can be observed without adjuvant therapy, appropriate risk classification for ovarian GCT, surveillance strategies, and optimal therapy for rec...
Source: Gynecologic Oncology - June 3, 2020 Category: Cancer & Oncology Authors: Veneris JT, Mahajan P, Frazier AL Tags: Gynecol Oncol Source Type: research
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification
In this study, we performed next-generation sequencing on 8 thyroid gland teratomas, including 4 malignant, 3 benign, and 1 immature. We identified DICER1 hotspot mutations in all 4 malignant cases (100%) but not in any benign/immature cases (0%). No clinically significant mutations in other genes were found in either group. We also performed immunohistochemistry to characterize the primitive components of malignant teratomas. Not only did all cases consistently contain immature neural elements (synaptophysin and INSM1 positive), but also spindled cells with rhabdomyoblastic differentiation (desmin and myogenin positive) a...
Source: The American Journal of Surgical Pathology - May 13, 2020 Category: Pathology Tags: Original Articles Source Type: research
Intramedullary cervical spinal cord teratoma
Conclusion:
ICTs are extremely rare entities that are mainly located in the center or dorsal part of the spinal cord which mainly manifest as quadriplegia and neck pain. MRI is a useful modality that provides diagnostic clues. Surgery from a posterior approach is the primary treatment, and the effect of adjuvant therapy remains uncertain. The prognosis is mainly related to the pathological nature of the tumor and not the method of resection. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Outcomes and prognostic factors of patients with recurrent and persistent malignant ovarian germ cell tumors
ConclusionsThe prognosis of recurrent and persistent MOGCTs was good after salvage therapy. The optimal salvage surgery and adjuvant standardized chemotherapy significantly impact patient prognosis. For young nulliparous patients, secondary fertility-sparing salvage therapy can be considered. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - March 19, 2020 Category: OBGYN Source Type: research
