Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before i...
Source: Current Oncology - June 23, 2022 Category: Cancer & Oncology Authors: Adel Shahnam Robyn Sayer Unine Herbst Raghwa Sharma Won-Hee Yoon Tim Dinihan Bo Gao Source Type: research
Well-differentiated cerebellum in an ovarian mature cystic teratoma: a case report and review of the literature
ConclusionWe report this case of well-differentiated cerebellum within ovarian teratoma to expand the pool of cases reported in literature of this extremely rare entity, as only 22 cases with such findings have been reported in literature to the best of our knowledge. This finding poses a diagnostic challenge to the pathologist due to its rarity and its similarity to immature teratoma. We thus emphasize that thorough sampling of ovarian teratoma is of paramount importance and to keep the aforementioned diagnosis in mind and not confuse it with immature elements, especially in intraoperative consultation and frozen sections...
Source: Journal of Medical Case Reports - June 1, 2022 Category: General Medicine Source Type: research
113 A dermoid cyst as a recurrence of immature teratoma, which had been treated with cystectomy, in a patient with family history of mature teratoma
Objectives: Teratomas are among the most common types of ovarian germ cell tumors, and are mature (benign) in 95% of the cases. [1,2] Immature teratomas account for less than 1% of all teratomas and their incidence is 0.12 per 100,000 woman-years. [3] This case presentation refers to a 17-year-old girl with an ovarian tumor, which was found in the follow-up of her treated immature teratoma. Study design: A 14-year-old patient, in 2016, was admitted urgently into a pediatric clinic with an intermittent lower pelvic pain, fever and vomiting. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 1, 2022 Category: OBGYN Authors: M. Diakosavvas, A. Douligeris, I. Chatzipapas, L Michala Source Type: research
PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue
AbstractNevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas and medulloblastomas. ThePTCH1 gene, responsible for NBCCS, suppresses the hedgehog signaling pathway, which is recognized as one of the important pathways in tumorigenesis and, thus, is a therapeutic target in cancer. In the present study, we generatedPTCH1−/− induced pluripotent stem cells (iPSCs) from NBCCS patient-derived iPSCs (PTCH1+/ −) by gene editing. The proliferation ofPTCH1−/− iPSCs was accelerated due to the activation of the hedgehog signaling pa...
Source: Hormones and Cancer - May 27, 2022 Category: Cancer & Oncology Source Type: research
