Adult sacrococcygeal teratoma with coccygectomy: A case report with a review of the literature.
Conclusions: Mature SCTs in adults are rare malignant lesions. In this case, the patient was cured following primary surgical excision requiring en-bloc coccygectomy.
PMID: 29184711 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - December 2, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations: a case report
Rationale:
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could reveal potential lymph node involvement and assisted locating sample sites for pathological examinations.
Patient concerns:
Help choose the right treatment strategies for patients. To better stage immature ovarian teratomas with 18F-FDG PET/CT when lymphatic metastasis is suspected while lymph node biopsy results are negative.
Diagnoses:
The ultimate pathological diagnosis was left ovarian cancer, an immature teratoma (IMT) Grade 1.
Interventions:
Surgery was the initial treatment option. Chemotherap...
Source: Medicine - December 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Mature and immature pediatric head and neck teratomas: A 15-year review at a large tertiary center
Pediatric head and neck teratomas account for less than 4% of congenital teratomas. The distinct presentations and outcomes of mature and immature head and neck teratomas have not been well established. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - December 1, 2017 Category: ENT & OMF Authors: Harish Dharmarajan, No émie Rouillard-Bazinet, Binoy M. Chandy Source Type: research
Vascular Smooth Muscle Cell Maturation Stage and Ki-67 Index are Diagnostic Biomarkers for Pathologic Grade of Ovarian Teratoma
Although immature teratoma of the ovary is a rare disease, its pathologic grading, especially between low-grade (grade 1) and high-grade (grade 2 or 3) immature teratomas, is important for optimal therapy and prognosis. This grading, however, is currently solely dependent on quantitation of neuroepithelial components as judged by subjective assessments. As we have recently successfully studied the maturation of vascular smooth muscle cells (SMCs) in other organs using an h-caldesmon to α-smooth muscle actin (α-SMA) ratio, we decided to use this ratio to investigate a potential link between teratoma grade and SMC maturati...
Source: International Journal of Gynecological Pathology - October 11, 2017 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
Immature Ovarian Teratoma: When to Give Adjuvant Therapy?
The question of giving or not adjuvant chemotherapy in pure ovarian immature teratomas (ITs) remains unsolved to date and illustrates differences in management between pediatric and adults oncologists. Because of the rarity of these tumors, this question has never been addressed through randomized trials. Standard of care for adult women with ovarian ITs is postoperative platinum based chemotherapy for all patients except FIGO stage IA, grade 1 tumors, whereas pediatric series concluded that surgery alone is curative for completely resected ovarian ITs, regardless of grade. Moreover the role of chemotherapy in incompletely...
Source: Journal of Pediatric Hematology Oncology - September 23, 2017 Category: Hematology Tags: Invited Review Source Type: research
Sacrococcygeal teratoma: late recurrence warrants long-term surveillance
ConclusionSCT can recur many years after the initial resection. Our findings suggest that all patients with SCT should be closely followed into adulthood. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - September 11, 2017 Category: Surgery Source Type: research
Split liver transplantation for retroperitoneal immature teratoma masquerading as hepatoblastoma
This study reports an infant aged 3 months with retroperitoneal immature teratoma involving the hepatic hilum, refractory to chemotherapy and treated with LT. The patient was referred to our hospital for management of a growing abdominal mass. Histopathology of a fine needle biopsy of the lesion suggested the possibility of a hepatoblastoma with teratoid features. Cisplatin‐based chemotherapy was initiated, but rapid growth of the tumor encasing the hepatic artery proper was detected, even after two cycles of chemotherapy. A split LT was carried out, and pathological examination of the explanted liver revealed the invol...
Source: Pediatric Transplantation - July 16, 2017 Category: Transplant Surgery Authors: Dongkyu Oh, Nam ‐Joon Yi, Sanghee Song, Ok Kyung Kim, Suk Kyun Hong, Kyung Chul Yoon, Sung Woo Ahn, Hyo‐Sin Kim, Hyeyoung Kim, Hyun‐Young Kim, Hyoung Jin Kang, Myungsu Lee, Kyoung Bun Lee, Kwang‐Woong Lee, Kyung Suk Suh Tags: CASE REPORT Source Type: research
Epithelial –mesenchymal transition markers in malignant ovarian germ cell tumors
In conclusion, based on this limited series, EMT‐associated markers are not associated with clinical parameters in MOGCT, in contrast to ovarian carcinoma. EMT‐related proteins are differentially expressed among various MOGCT subtypes, suggesting differences in biological characteristics associated with invasion and metastasis. (Source: APMIS)
Source: APMIS - June 6, 2017 Category: Research Authors: Olesya Solheim, Mette F ørsund, Claes G. Tropé, Sigrid Marie Kraggerud, Jahn M. Nesland, Ben Davidson Tags: Original Article Source Type: research
FDG-PET-CT in Growing Teratoma Syndrome with Non-Seminomatous Testicular Mixed Germ Cell Tumor
1070Non-seminomatous mixed (NSM) germ cell tumors (GCT) have varying percentages of malignant tumor (embryonal carcinoma, yolk sac tumor, choriocarcinoma) and teratoma (hair, teeth, bone; brain, thyroid, liver, lung tissue).1 Radical orchiectomy is initial treatment and provides histologic characterization, treatment individualized by histology and if tumor markers [alpha fetoprotein (AFP), beta subunit of human chorionic gonadotropin (beta-hCG), and lactate dehydrogenase (LDH)] normalize after orchiectomy. Initial staging is computed tomography (CT) for retroperitoneal lymphadenopathy or distant lung metastasis. 2-deoxy-2...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Williams, H., Pucar, D., McDonough, C. Tags: Prostate Posters Source Type: research
Mature and Immature Solid Teratomas Involving Uterine Corpus, Cervix, and Ovary
We report here the case of a 46-year-old patient who presented with simultaneous immature teratoma in the endometrium and mature teratomas in the ovary in association with gliomatosis peritonei but with no evidence of gestational origin; she subsequently developed multiple solid mature teratomas in the cervix and parauterine tissue. No other similar cases have been previously reported to our knowledge. There are many similarities between the patient’s pattern of recurrence and “growing teratoma syndrome (GTS)”. Although the patient was not treated with chemotherapy after her first presentation and this case does not ...
Source: International Journal of Gynecological Pathology - April 11, 2017 Category: Pathology Tags: Pathology of the Corpus: Case Report Source Type: research
Use of Molecular Genetics for Treatment of Growing Teratoma Syndrome: A Case Report
Immature ovarian teratoma is a malignant germ cell tumor treated with surgical staging and debulking with the addition of chemotherapy for cases of relapse. Growing teratoma syndrome (GTS) is the phenomenon of growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. As mature teratomas are typically unresponsive to chemotherapy, current treatment of GTS involves surgical resection to prevent compression of abdominal organs and malignant degeneration. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2017 Category: OBGYN Authors: Aaron Varghese, Rebecca M. Rentea, Atif Ahmed, Alexander Kats, Michelle Manalang, Tazim Dowlut-McElroy, Richard J. Hendrickson Source Type: research
Clinical, morphological and immunohistochemical evidence that small ‐cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ‐cell neoplasm
ConclusionsOur findings provide additional evidence to that proposed by others that SCCOHT is a primitive germ‐cell neoplasm arising from a teratoma. (Source: Histopathology)
Source: Histopathology - March 19, 2017 Category: Pathology Authors: W Glenn McCluggage, Leora Witkowski, Blaise A Clarke, William D Foulkes Tags: Original Article Source Type: research
Intracranial immature teratoma with a primitive neuroectodermal malignant transformation - case report and review of the literature.
CONCLUSIONS: The present case highlights the value of the Norris grading system (mostly used in grading ovarian immature teratomas) in a very rare case of intracerebral immature teratoma with rapid subarachnoid extension caused by an unexpected secondary "malignant transformation".
PMID: 28174809 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - February 9, 2017 Category: Journals (General) Tags: Rom J Morphol Embryol Source Type: research
Clinical, morphological and immunohistochemical evidence that small cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ cell neoplasm
ConclusionsOur findings provide additional evidence to that proposed by others that SCCOHT is a primitive germ cell neoplasm arising from a teratoma.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - January 28, 2017 Category: Pathology Authors: W Glenn McCluggage, Leora Witkowski, Blaise A Clarke, William D Foulkes Tags: Original Article Source Type: research
