Subtyping of intraductal papillary mucinous neoplasms – pitfalls of MUC1 immunohistochemistry
Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN ‐lesions in the literature. Current recommendations are based on studies where antibodies against the core MUC1 protein o...
Source: APMIS - November 22, 2018 Category: Research Authors: Pia Klausen, Bojan Kovacevic, Anders Toxv ærd, Evangelos Kalaitzakis, John Gásdal Karstensen, Charlotte Vestrup Rift, Carsten Palnæs Hansen, Jan Storkholm, Peter Vilmann, Jane Preuss Hasselby Tags: Letter to the Editor Source Type: research

Issue Information
APMIS, Volume 126, Issue 12, Page 883-884, December 2018. (Source: APMIS)
Source: APMIS - November 19, 2018 Category: Research Tags: Issue Information Source Type: research

Autotaxin and vascular endothelial growth factor receptor ‐2 and ‐3 are related to vascular development during the progression of chronic viral hepatitis C
This study examines whether these two angiogenic factors cooperate in the mechanism that regulates vascular development during the progression of chronic viral hepatitis C (CVH ‐C) (Inuyama classification, F1–F4). First, surgical wedge biopsy specimens and needle biopsy specimens were obtained. Immunohistochemical staining for ATX and vascular endothelial growth factor receptor was assessed in serial sections. Immunoelectron microscopy was conducted with a perfusion‐ fixation method. In normal control liver tissue specimens, ATX was expressed at low levels within the branches of the hepatic artery and hepatic sinusoi...
Source: APMIS - November 19, 2018 Category: Research Authors: Hiroaki Yokomori, Wataru Ando, Fumihiko Kaneko, Hidekazu Suzuki, Koji Igarashi, Masaya Oda Tags: Original Article Source Type: research

The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis
Mycobacterium abscessus complex can cause severe lung infections and has proven to be a serious threat to patients with cystic fibrosis and a challenge for clinicians due to difficulties in timely diagnosis and complex multidrug treatment regimes. Mycobacterial culture is the gold standard for diagnosis, but in most cystic fibrosis centers it is performed less frequently than culture for other pathogens. Consensus today recommends just one annual mycobacterial culture for asymptomatic patients with cystic fibrosis, a strategy likely to lead to diagnostic delays. Postponement of diagnosis might be the deciding factor in whe...
Source: APMIS - November 19, 2018 Category: Research Authors: Cecilie Ravnholt, Mette Kolpen, Marianne Skov, Claus Moser, Terese L. Katzenstein, Tania Pressler, Niels H øiby, Tavs Qvist Tags: Opinion Paper Source Type: research

WHO laboratory validation of Xpert ® CT/NG and Xpert® TV on the GeneXpert system verifies high performances
In conclusion, the analytical sensitivity and specificity of the user‐friendly Xpert® CT/NG and Xpert® TV tests on the GeneXpert system were high. The results support the use of specimens from also extra ‐genital sites, for example, pharynx and rectum. However, appropriate clinical validations are additionally required. (Source: APMIS)
Source: APMIS - November 19, 2018 Category: Research Authors: Susanne Jacobsson, Iryna Boiko, Daniel Golparian, Karel Blondeel, James Kiarie, Igor Toskin, Rosanna W. Peeling, Magnus Unemo Tags: Original Article Source Type: research

Early depletion of contact system in patients with sepsis: a prospective matched control observational study
APMIS, EarlyView. (Source: APMIS)
Source: APMIS - November 6, 2018 Category: Research Authors: Ingrid Berkestedt, Pia Andersson, Heiko Herwald, John Karlsson Valik, Ola S örensen, Mikael Bodelsson Source Type: research

Maternal and congenital cytomegalovirus infections in a population ‐based pregnancy cohort study
APMIS, EarlyView. (Source: APMIS)
Source: APMIS - October 31, 2018 Category: Research Authors: Regine Barlinn, Susanne G. Dudman, Lill Trogstad, Moustafa Gibory, Fredrik Muller, Per Magnus, Halvor Rollag Source Type: research

A fatal case of enterovirus infection with secondary hemophagocytosis —case report with review of literature
APMIS,Volume 126, Issue 11, Page 877-882, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: Manoj Gopal Madakshira, Sunny Bhardwaj, Kirti Gupta, Yogesh Chander, Ashish Bhalla Source Type: research

Bartonella quintana, past, present, and future of the scourge of World War I
APMIS,Volume 126, Issue 11, Page 831-837, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: Joaquim Ruiz Source Type: research

Issue Information
APMIS,Volume 126, Issue 11, Page 829-830, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Source Type: research

Toll ‐like receptors 2, 4 and 9 and hypoxia markers HIF‐1alpha and CAIX in pancreatic intraepithelial neoplasia
APMIS,Volume 126, Issue 11, Page 852-863, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: Joni Lepp änen, Olli Helminen, Heikki Huhta, Joonas H. Kauppila, Joel Isohookana, Kirsi‐Maria Haapasaari, Peeter Karihtala, Seppo Parkkila, Juha Saarnio, Petri P. Lehenkari, Tuomo J. Karttunen Source Type: research

Prevalence of CYP2D6*4 1934G/A polymorphism in Western Indian HIV patients
APMIS,Volume 126, Issue 11, Page 842-851, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: HariOm Singh, Sonam Lata, Raman R. Gangakhedkar Source Type: research

Rapid antimicrobial susceptibility testing of positive blood cultures by direct inoculation and reading of disc diffusion tests after 3 –4 hours
APMIS,Volume 126, Issue 11, Page 870-876, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: Einar Tollaksen Weme Source Type: research

Replicon typing of plasmids in environmental Achromobacter sp. producing quinolone ‐resistant determinants
APMIS,Volume 126, Issue 11, Page 864-869, November 2018. (Source: APMIS)
Source: APMIS - October 25, 2018 Category: Research Authors: Jo ão Pedro Rueda Furlan, Danilo Garcia Sanchez, Inara Fernanda Lage Gallo, Eliana Guedes Stehling Source Type: research

Clinicopathological features of hydrophilic polymer emboli in Japanese autopsy cases
APMIS, EarlyView. (Source: APMIS)
Source: APMIS - October 16, 2018 Category: Research Authors: Masashi Miyaoka, Kazuhito Hatanaka, Toshimasa Uekusa, Naoya Nakamura Source Type: research