Rare retroperitoneal conditions that mimic uterine myoma.
Authors: Popovici RM, Cărăuleanu A, Costea CF, Florea ID, Scripcariu DV, Mogoş RA, Cheaito A, Tănase AE, Haba RM, Grigore M Abstract The most frequent tumoral condition of the uterus is represented by uterine myoma. The diagnosis, in most cases, is established by clinical examination and ultrasound scan. Nevertheless, there are rare cases, in which the surgical findings reveal a retroperitoneal tumor instead of a uterine myoma. These could be represented by schwannomas or Castleman disease. The schwannomas are rarely malignant and arise from the Schwann cells of nerve fibers. These tumors are frequently found a...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Microfluidic endothelium-on-a-chip development, from in vivo to in vitro experimental models.
Authors: Bulboacă AE, Boarescu PM, Melincovici CS, Mihu CM Abstract In the last years, animal testing in medical research has been a controversial topic because of various reasons, such as ethical considerations and species differences. Therefore, more attention has been given to develop new technologies that can replace animal experiments and create in vitro models. Organ-on-a-chip (OOC) technology is a new and advanced technology based on microfluidic devices that can mimic the structure and function of entire organs and tissues as in vitro models. OOC models are miniature tissues and organs that assign characte...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Genetic aspects in schizophrenia. Receptoral theories. Metabolic theories.
Authors: Trifu SC, Vlăduţi A, Trifu AI Abstract Ties between schizophrenia (SCZ) and genetics are undeniably significant issue prone to be discussed in the nowadays psychology. Recent research on this domain focuses more on specific genes and heredity (specifically monozygotic pairs of twins) for diagnosing SCZ, than on environmental influences. SCZ is considered a multifactorial disease, thought to convert from a merger of risk and biological genes and environmental factors that could alter and reshape the trajectory of brain development. On this regard, this review sums up recent and innovative methods of disti...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Host immune response in chronic hepatitis C infection: involvement of cytokines and inflammasomes.
Authors: Boldeanu MV, Siloşi I, Bărbulescu AL, Sandu RE, Geormăneanu C, Pădureanu V, Popescu-Drigă MV, Poenariu IS, Siloşi CA, Ungureanu AM, Dijmărescu AL, Boldeanu L Abstract Chronic liver disease is a major health issue worldwide and chronic hepatitis C (CHC) is associated with an increased risk of cirrhosis and hepatocellular carcinoma (HCC). There is evidence that the hepatitis C virus (HCV) infection is correlated with immune senescence by way of immune activation and chronic inflammation, which lead to increased metabolic and cardiovascular risk, as well as progressive liver damage. Both the innate and...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Abdominal wall endometriosis versus desmoid tumor - a challenging differential diagnosis.
Authors: Cărăuleanu A, Popovici RM, Costea CF, Mogoş RA, Scripcariu DV, Florea ID, Cheaito A, Tănase AE, Haba RM, Grigore M Abstract AIM: Abdominal wall endometriosis (AWE) in young women, with previous gynecological abdominal surgery, is the first condition considered by many practitioners when a tumor in the region of the scar appears. AWE seems to be caused by an iatrogenic transfer of endometrial cells at the level of the scar. The onset of the disease may be late in many cases. Despite the fact that the disease could be totally asymptomatic, there are certain risk factors that can be identified during the ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Morphopathological changes in obsessive-compulsive disorder.
Authors: Drăgoi AM, Pecie LG, Patrichi BE, Ladea M Abstract The pathophysiology of the obsessive-compulsive disorder (OCD) has been studied for many years using several structural magnetic resonance imaging, discovering that the anomalies of function and structure of the brain are widespread, they involve different areas, structures and circuits with a complex interconnectivity. More than that, these anomalies cover all the life of a patient, from early childhood, due to variations of developmental stages until adult life. The research is highly important also because OCD has a major hereditary factor, with the ph...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Mild TBI in the elderly - risk factor for rapid cognitive impairment in Alzheimer's disease.
Authors: Stovicek PO, Friedmann C, Marinescu D, Văduva IA, Bondari S, Trifu SC, Marinescu I Abstract In recent decades, traumatic brain injury (TBI) has become one of the most important health problems worldwide and is a major cause of morbidity, mortality and economic losses. Mild traumatic brain injury (mTBI) is less considered, with clinical underestimation leading to an epidemiological underevaluation of its incidence. Many of the signs and symptoms induced by mTBI are difficult to highlight clinically, especially those related to cognitive, behavioral, or emotional impairment. The complexity of the biological...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

MR spectroscopy of the liver - a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease.
Authors: Lăpădat AM, Florescu LM, Manea NC, Gheonea DI, Pirici D, Tudoraşcu DR, Ene R, Gheonea IA Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common conditions worldwide that targets the liver parenchyma. NAFLD represents an intrahepatic triglyceride accumulation in the absence of excessive alcohol consumption and other diseases that affect the liver parenchyma. The current "gold standard" for evaluating the amount of intrahepatic fat is represented by liver biopsy, but many patients are reluctant and hardly accept undergoing this procedure due to its invasive nature. The curr...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clinical, histopathological and immunohistochemical features of brain metastases originating in colorectal cancer: a series of 27 consecutive cases.
CONCLUSIONS: BMs originating in CRC represent a rare pathology and have particular clinical and IHC features that could vary from one series to another series. In a few cases, BMs may be diagnosed in the absence of a known CRC diagnosis and in these situations, the correct diagnosis is of interest. However, a panel of antibodies can help in establishing a correct diagnosis. Our study was among the first to analyze the HER2∕neu expression pattern in BMs from CRC and we found a strong aberrant nuclear expression of this molecular marker on IHC investigation. Related to the data published so far in the literature, it is pos...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Severe traumatic brain injury (TBI) - a seven-year comparative study in a Department of Forensic Medicine.
Authors: Ţolescu RŞ, Zorilă MV, Şerbănescu MS, Kamal KC, Zorilă GL, Dumitru I, Florou C, Mogoantă L, Văduva IA, Stanca L, Zăvoi RE Abstract Deaths caused by traumatic brain injury (TBI) increase in incidence every year worldwidely, mainly in developing countries. Thus, World Health Organization (WHO) estimates that in 2020, TBI will become the third main cause of death. In our study, we evaluated the deaths caused by TBI recorded within the Institute of Forensic Medicine of Craiova, Romania, between 2011 and 2017. Therefore, according to age, the cases were divided into two groups: people aged 0-18 years o...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Congenital cataract - clinical and morphological aspects.
Authors: Tătaru CI, Tătaru CP, Costache A, Boruga O, Zemba M, Ciuluvică RC, Sima G Abstract Congenital cataract is one of the main causes of blindness in newborns and children. According to the World Health Organization (WHO), there are about 14 million children suffering from congenital cataract. Our study is based on 82 children, males - 46 (56.1%) and females - 36 (43.9%), with congenital cataract operated in the same ophthalmological centre in Bucharest, Romania. Of the 82 patients, 49 (59.76%) had bilateral cataract and 33 (40.24%) unilateral cataract. Clinically, the most frequent was the total cataract, f...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Saccular function evolution related to cochlear implantation in hearing impaired children.
This study reports the vestibular saccular functional modifications after the cochlear implantation in children. The cervical vestibular evoked myogenic potentials (cVEMPs) were performed in children before and after the cochlear implantation. Since previous studies report different vestibular impairment related to the portelectrode insertion approach, another objective of our study was to assess the saccular postoperative status depending of the insertion by cochleostomy (CO) or through the round window (RW). We performed cVEMPs for 80 patients (135 cochlear implanted ears) before and after cochlear implantation. We have ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clinical, histopathological and immunohistochemical behavior of peri-implant soft tissue.
Authors: Iacov-Crăiţoiu MM, Crăiţoiu M Abstract The presence of foreign materials in the tissues, represented in the present study by the insertion of dental implants, creates artificial structures that can sometimes cause adverse consequences, which implies the obligation to perform a complex medical assessment before inserting dental implants. This assessment appreciates the quality of the tissue, depending on which the use of a certain type of biomaterial is indicated and focuses on a certain surgical technique. We assessed the clinical, histopathological (HP) and immunohistochemical (IHC) aspects of peri-im...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma).
Authors: Nistor-Ciurba CC, Şomcutian O, Lisencu IC, Ignat FL, Lazăr GL, Eniu DT Abstract Phyllodes tumors of the breast are biphasic tumors consisting from an epithelial component and a mesenchymal component. Usually, the mesenchymal component of the tumor is the one who dictates the malignancy of the biphasic proliferation. Presence of the malignancy of the both, epithelial [under the form of invasive carcinoma or ductal carcinoma in situ (DCIS)] and mesenchymal components is very rare. Most of the data available from the literature refers to single case presentations. This paper presents the experience of Prof....
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy.
Conclusions: Cardiac axis has a higher value for the detection of congenital cardiac abnormalities with respect to the nuchal translucency, tricuspid regurgitation and inverted A wave at the level of the venous duct. PMID: 32747904 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The sphenoethmoidal sinus and the modified anatomy of the related structures.
Authors: Rusu MC, Hostiuc S, Motoc AGM, Mogoantă CA, Sava JC, Săndulescu M Abstract The anterior extent of the sphenoidal sinus in the posterior ethmoid was less investigated. Our purpose was to study whether, or not, the occurrence of a sphenoethmoidal sinus (SES) relates to a sagitally-shortened ethmoid. A retrospective cone-beam computed tomography (CBCT) was performed on 36 patient files. In six patients were found SES extended anteriorly above the posterior third of the middle turbinate (MT). Two of these patients had bilateral SES with ethmoidal chambers included in the lateral and superior nasal walls and ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Automated Gleason grading of prostate cancer using transfer learning from general-purpose deep-learning networks.
Authors: Şerbănescu MS, Manea NC, Streba L, Belciug S, Pleşea IE, Pirici I, Bungărdean RM, Pleşea RM Abstract Two deep-learning algorithms designed to classify images according to the Gleason grading system that used transfer learning from two well-known general-purpose image classification networks (AlexNet and GoogleNet) were trained on Hematoxylin-Eosin histopathology stained microscopy images with prostate cancer. The dataset consisted of 439 images asymmetrically distributed in four Gleason grading groups. Mean and standard deviation accuracy for AlexNet derivate network was of 61.17±7 and for Goog...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Is there a relationship in-between ovarian endometriosis and ovarian cancer? Immunohistochemical profile of four cases with coexisting ovarian endometriosis and cancer.
Authors: Penciu RC, Postolache I, Steriu L, Izvoranu S, Tica AA, Mocanu ID, Sârbu V, Deacu M, Tica I, Bălţătescu GI, Tica OS, Tica VI Abstract Endometriosis (EMs) is a benign disease characterized by the presence of endometrial tissue outside the uterine cavity. EMs associated with ovarian cancer (OC) has a relative low incidence (5% to 10%), sometimes with evidence of a transition stage through atypical EMs (1.6% cases). We have assessed 135 consecutive patients with either EMs or OC and, out of them, our study reports on four cases of ovarian EMs and OC: two cases with endometrioid OC and two cases with ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Pointing on the early stages of maxillary bone and tooth development - histological findings.
Authors: Brăescu R, Săvinescu SD, Tatarciuc MS, Zetu IN, Giuşcă SE, Căruntu ID Abstract Although the morphological stages of tooth development, in parallel with maxillary bone construction, are known for decades, the intimate mechanisms of early development of the oral cavity structures and tooth's proper and associated tissues are still incompletely elucidated. Nowadays, the research in embryology was shifted from the morphological to the molecular and genetic approach. This new approach is accomplished by using in vivo and in vitro experimental studies performed on animal models and cell lines. The interest ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Immunophenotypical alterations with impact on the epithelial-mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas.
Authors: Belulescu IC, Mărgăritescu C, Dumitrescu CI, Munteanu MC, Mărgăritescu OC Abstract Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary glands neoplasms with an indolent clinical course, slow-growing but locally aggressive and quite often with delayed recurrence and distant metastasis. In order to elucidate this tumoral behavior, we conducted an immunohistochemical study investigating the alterations of epithelial phenotype with anti-cytokeratin (CK) AE1∕AE3 and anti-E-cadherin antibodies, and the acquisition of mesenchymal phenotype with vimentin, fibronectin, N-cadherin and P...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Injectable platelet-rich fibrin influences the behavior of gingival mesenchymal stem cells.
In conclusion, 5% iPRF stimulated gMSC proliferation, and an excessively high concentration of iPRF can impair osteogenic induction. PMID: 32747910 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Influences of treadmill speed and incline angle on the kinematics of the normal, osteoarthritic and prosthetic human knee.
The objective of this paper is to measure and to study the influence of the treadmill speed and incline angle on the kinematics of flexion-extension angles of the human knee joints during 23 tests of walking overground and on plane and inclined treadmill performed by a sample of 14 healthy subjects and during of seven tests performed by a sample of five patients suffering of knee osteoarthritis (KOA), before and three months after the total knee replacement (TKR) surgery. The medium cycles computed and plotted for all experimental tests performed by the healthy subjects' sample and for the osteoarthritic (OA) patients' sam...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection.
Authors: Cîrstea AE, Buzulică RL, Pirici D, Ceauşu MC, Iman RV, Gheorghe OM, Neamţu SD, Stanca L, Ene R, Kumar-Singh S, Mogoantă L Abstract We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinţi County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcr...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clear cell change in follicular adenoma of the thyroid. A diagnostic challenge.
We report herein a new case in the right thyroid lobe of a 45-year-old man. The clinicopathological data of the 21 cases including our paper have revealed that the ages of the patients ranged from 22-70 years, with a mean of 41.6 years. There was a clear predominance in women (M:F, 1:6). The most frequent location was in either of both lobes (81.8%), rarely affecting the isthmus. One case was observed in an ectopic thyroid in the submandibular region. The size ranged from 0.7-5.5 cm (mean 2.9 cm). The type of surgical intervention where this data was reported it was lobectomy for 10 (55.5%) cases, thyroidectomy for six (33...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Leiomyosarcoma of the inferior vena cava. Our experience and a review of the literature.
We present the case of a patient with inferior vena cava leiomyosarcoma (IVCL), for whom the pathological diagnosis was different from the initially expected one, the tumor appearance on pre-operative imaging mimicking renal cell carcinoma. The intraoperative difficulty of approaching renal hilum and IVC was a factor suggesting the vascular origin of the tumor, which was confirmed at pathological analysis. The extensive defect in the IVC after tumor excision led to the decision of complete transverse suturing of IVC, as significant collateral venous circulation was already present. Because IVCL is a rare disease, there is ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Squamous metaplasia within a sigmoid adenoma. A rare feature.
We present a case of a large tubulovillous adenoma located in the sigmoid, with low-grade dysplasia and multiple foci of p16-positive immunoexpression squamous metaplasia in a 54-year-old Caucasian male, presenting with rectal bleeding. PMID: 32747915 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Male breast involvement in chronic lymphocytic leukemia. A case report and review of the literature.
Authors: Anagnostopoulou V, Mantha N, Sapalidis K, Tolparidou E, Georgiou E, Koletsa T Abstract Male breast lymphoma is a rare extranodal lymphoma occupying the mammary gland, and it could be either primary or secondary. A 78-year-old man presented an enlargement of the right breast. He had no medical history of interest. On physical examination, a unilateral, painless breast lump was found, with no skin changes or nipple discharge. There was no palpable lymphadenopathy. Routine laboratory tests revealed leukocytosis and lymphocytosis. Excisional biopsy of the breast lesion revealed mammary tissue infiltration by c...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Large giant cell tumor of the posterior iliac bone - an atypical location. A case report and literature review.
Authors: Faur CI, Pop DL, Motoc AGM, Folescu R, Grigoraş ML, Gurguş D, Zamfir CL, Iacob M, Vermeşan D, Deleanu BN, Hărăguş HG, Maliţa DC, Abu-Awwad A, Ghiga IL, Tudoran M Abstract Giant cell tumor (GCT) is a locally aggressive tumor but with benignity features, representing approximately 18% of non-malignant bone tumors in European countries, with slight female predominance. Malignancy in GCT is rare, about
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Spontaneous rupture of immature gastric teratoma with hemoperitoneum in a newborn with 3-year follow-up.
In conclusion, physicians should be aware of the existence of gastric teratoma as the differential diagnosis of a huge abdominal mass in infants, especially neonates. Complete surgical removal of the tumor and long-term follow-up has been adopted as the standard management for immature gastric teratoma, although there has been controversy with adjuvant chemotherapy. PMID: 32747918 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Fenestration of the cervical internal carotid artery misdiagnosed as dissection.
We present the case of a patient harboring a right ICA fenestration in the cervical segment, misdiagnosed as a dissection on computed tomography angiography, admitted in the Department of Neurology and treated accordingly. The possible pathological and embryological origins of arterial fenestrations are discussed, and a brief review of the literature related to ICA fenestrations is presented. PMID: 32747919 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The morphological characteristics of the physically abused child. Report of a case and literature review.
Authors: Motorca MA, Buhaş CL, Bungău SG, Judea-Pusta CT, Nicula CA, Rus M, Stănescu AMA, Venter AC, Diaconu CC, Marian P Abstract Child abuse remains a current problem, despite progress in the field of prevention and social assistance. The injuries produced by physical abuse have to be evaluated using scientific methods, in order to be considered as evidences later in Court, but also to ensure the physical and social security of the child. Among the morphological characteristics of the child (on which depends how the lesions are formed, differently in children from adults), there is the strong adherence of the ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Primary thyroid angiosarcoma in a non-endemic region - a rare case.
Authors: Tulin AD, Avino A, Răducu L, Tulin FR, Ştiru O, Balcangiu-Stroescu AE, Timofte D, Tănăsescu MD, Bălan DG, Jecan CR, Ionescu D Abstract Thyroid angiosarcoma (AS) is a specific type of vascular tumor that arises from the endothelial cells, being highly aggressive, with increased recurrence rates and metastasis. It is characterized by positive endothelial markers and co-positive markers for cytokeratins and epithelial membrane antigen. We are describing the case of a 76-year-old patient who presented to the hospital for dyspnea and asthenia. The clinical and paraclinical investigations confirmed the pres...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Ectopic lamellar Pacinian corpuscle within the thymus. Atypical or abnormal location?
Authors: Varga I, Nosál M, Babál P Abstract Lamellar (Pacinian) corpuscle is a cutaneous encapsulated sensory corpuscle, mainly functioning as a rapidly adapting low-threshold mechanoreceptor with characteristic "onion skin"-like appearance. Even though the Pacinian corpuscle is typically located in the skin, histomorphologically and confirmed by using immunohistochemical methods, we have identified it within the interstitium of the thymus of a newborn with congenital heart defect. To the best of our knowledge, this is the first such account ever to be published. The structure of the thymic ...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Ethical review of patient safety and public health in EU clinical trials legislation: impact of COVID-19 pandemic.
CONCLUSIONS: The CTR stimulates the EU clinical research and enables an independent control with regard to the respect of the interests of the CT subject. PMID: 32747923 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A research on abortion: ethics, legislation and socio-medical outcomes. Case study: Romania.
This article presents a research study on abortion from a theoretical and empirical point of view. The theoretical part is based on the method of social documents analysis, and presents a complex perspective on abortion, highlighting items of medical, ethical, moral, religious, social, economic and legal elements. The empirical part presents the results of a sociological survey, based on the opinion survey method through the application of the enquiry technique, conducted in Romania, on a sample of 1260 women. The purpose of the survey is to identify Romanians perception on the decision to voluntary interrupt pregnancy, an...
Source: Romanian Journal of Morphology and Embryology - August 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Matrix metalloproteinases expression in lentigo maligna ∕lentigo maligna melanoma - a review of the literature and personal experience.
Matrix metalloproteinases expression in lentigo maligna∕lentigo maligna melanoma - a review of the literature and personal experience. Rom J Morphol Embryol. 2019;60(4):1091-1095 Authors: Brînzea A, Nedelcu RI, Ion DA, Turcu G, Antohe M, Hodorogea A, Călinescu A, Pirici D, Popescu R, Popescu CM, Popp CG, Nichita L, Cioplea MD, Cordun M, Zurac SA Abstract Cutaneous melanoma is the most aggressive type of skin cancer, with high invasive potential. Lentigo maligna melanoma (LMM) is a relatively rare type, accounting for about 10% of all melanomas, while the most common subtype of melanoma on the ...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Constant features of the adult maxillary bone in the site of the premaxillary suture: the sutura notha, Macalister's foramina, Parinaud's canal, and the second angle of the canalis sinuosus of Wood Jones.
Authors: Rusu MC, Iacov-Crăiţoiu MM, Săndulescu M, Cârstocea L, Stana DM Abstract Developmental theories regarding the premaxillary (incisive) suture commonly overlook it separates the premaxillary and maxillary parts of the frontal process of maxilla. Thus, one would expect that neurovascular structures within this transitory mesenchymal zone to appear embedded within the adult frontal process of maxilla. The sutura notha (false suture, Weber's sutura longitudinalis imperfecta) is a poorly described, although constantly present, shallow groove in front of the anterior lacrimal crest, being perforated by a...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Cardiovascular anomalies and evolutionary risk factors in schizophrenia - multifactorial approach.
Conclusions: An interdisciplinary approach is required between neurosciences and cardiology not only at the research level, but also in the clinical practice. Cardiac co-morbidity in subjects with schizophrenia may critically affect the survival rates of these patients. Moreover, the nature of the cardiac co-morbidity may guide the clinician in better understanding and differentiating functional psychoses from organic ones. The multifactorial approach can identify cardiovascular risk factors based on clinical, biological and neuroimaging markers. PMID: 32239085 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

New insights in the molecular pathways linking obesity, type 2 diabetes and cancer.
Authors: Popa A, Georgescu M, Popa SG, Nica AE, Georgescu EF Abstract Steadily, cancer is becoming the first cause of mortality, with over 9 million deaths estimated in 2018. Increasing evidence supports a direct association between obesity, type 2 diabetes mellitus (T2DM) and cancer, with a higher risk of cancer mortality especially for some of the most common malignancies, such as breast, colon, and rectal cancers. So far, several mechanisms underlying the cancer-diabetes relationship have been investigated revealing dysregulations of the insulin-insulin-like growth factor (IGF) system as the most important parad...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Bone turnover markers in postmenopausal osteoporosis and their correlation with bone mineral density and menopause duration.
CONCLUSIONS: Our study showed that BTMs correlated negatively with lumbar BMD and positively with each other. Resorption markers levels increase with duration of estradiol deprivation period. PMID: 32239087 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Evaluation of iNOS -2087A > G polymorphism in recurrent pregnancy loss.
CONCLUSIONS: The iNOS -2087A>G (rs2297518) gene polymorphism does not influence RPL in the study area of Dolj County, Romania. PMID: 32239088 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Correlations between histological subtypes and neurocognitive assessment of language area tumors. Our 43 case series and review of the literature.
CONCLUSIONS: A neurocognitive assessment of brain tumor patients is important for preoperative and postoperative evaluation and secondary adjustment of the surgical resection in order to improve or, at list, meantime the initial status. The role and the link between the histological type and tests alteration were observed. The results can be used for a better understanding and management of language area tumors. PMID: 32239089 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Lung injury patterns in newborns, infants and young children - morphological and immunohistochemical approaches.
Authors: Cotoi CT, Turdean SG, Turcu ML, Pop OL, Baba DF, Mărginean CO, Buicu CF, Muntean DL Abstract Lower respiratory infections are an important cause of morbidity and mortality in children, especially in newborns, infants and young children. We conducted a retrospective study and we analyzed the causes of death in newborns, infants and young children, in the necropsy protocols from two Departments of Pathology (Mureş County Hospital and Emergency County Hospital of Târgu Mureş, Romania), between 2016-2018. We performed descriptive statistics: number of necropsies per year, distribution by gender (male...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Serological and immunohistochemical biomarkers for discrimination between benign and malignant ovarian tumors.
CONCLUSIONS: The serum levels of CA125 and HE4, ROMA index and IHC markers for surgical tissue fragments play a very important role in discriminating and reporting borderline ovarian tumors, as well as benign or malignant ovarian forms. Due to the superior sensitivity and specificity of CA125 and HE4, we can consider these markers as an alternative or additional diagnostic criterion to the ROMA index. PMID: 32239091 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Pelvic exenteration, a surgical treatment option for locally advanced, primary and recurrent neoplasia.
Authors: Muşină AM, Huţanu I, Grigore M, Scripcariu IS, Filip B, Aniţei MG, Scripcariu DV, Gavrilescu MM, Radu I, Ioanid N, Pantazescu AN, Hogea M, Panuţa A, Buna-Arvinte M, Moraru GV, Scripcariu V Abstract Pelvic exenteration (PE) is an extensive surgical procedure for locally advanced primary neoplasia (LAPN) or recurrent neoplasia (RN) that consists in the en bloc removal of the pelvic organs (rectum, internal genital organs and bladder) associated with pelvic lymph nodes. PE is classified into anterior, posterior and total, supra or infralevatorian approaches. Our aim was to evaluate the surgical procedure...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Histopathological predictive factors for the overall survival rate in patients with urothelial carcinoma of the bladder treated by radical cystectomy: a Romanian cohort study.
CONCLUSIONS: Age, tumor stage and lymph node involvement, as well as positive surgical margins represent prognostic factors in RC patients. UC variants were more likely to be associated to metastases and positive surgical margins but had no influence on OS. PMID: 32239093 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clinical, statistical, histological and immunohistochemical aspects of periodontal changes in patients with diabetes mellitus.
CONCLUSIONS: DM contributes unfavorably to the evolution of periodontal disease. The poor glycemic control and the improper oral hygiene have a negative impact on the health of the periodontium, highlighted by increased scores on PI, CI and GI scales. PMID: 32239094 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Head and neck metachronous tumors - clinical, histopathological and immunohistochemical study.
Authors: Moţ IC, Poenaru M, Mogoantă CA, Istrate-Ofiţeru AM, Oprişcan IC, Sarău CA, Mănescu MD, Enăchescu V, Dogaru CA, Popescu C, Morar R, Balica NC, Horhat ID Abstract Multiple primary tumors (MPT) represent an important factor affecting the survival of some patients. They present an incidence of about 0.7-11% of all carcinomas developing in any region of the human body, being either synchronous or metachronous. These tumors raise problems of differential diagnosis, with tumoral relapses and distance metastases; also, they involve problems related to chemotherapy, radiotherapy and surgical treatment. In th...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Malignant melanoma - the most severe skin cancer and neurological pathology.
CONCLUSIONS: Neurological involvement in MM encompasses a myriad of variants and while the clinical setting varies from one patient to another, an underlining neoplasia should be evaluated in suspected patients. PMID: 32239096 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Immunoexpression of E-, P- and N-cadherins in ovarian serous malignant tumors.
Authors: Dochiţ CM, Stepan AE, Mărgăritescu C, Florescu MM, Simionescu CE Abstract Alteration of cadherin immunophenotype is associated with the epithelial-mesenchymal transition, a complex biomolecular mechanism involved in carcinomas progression. The study investigated the immunoexpression of E-, P- and N-cadherins in 50 serous malignant tumors of ovary related to the histopathological prognostic parameters of the lesions, using a quantification based on scores that took into account the number of marked cells and the intensity of the reactions. The E-cadherin and P-cadherin immunostainings were significantly ...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research