Thymolipoma - the frontier between hamartoma and neoplasia?
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):651-661. doi: 10.47162/RJME.62.3.01.ABSTRACTThymolipoma is an uncommon benign thymus lesion, with a partially deciphered etiopathogeny, being most frequently diagnosed in young patients, regardless of gender. Incidentally diagnosed in asymptomatic patients, larger thymolipomas lead to symptoms related to neighboring mediastinal structures compression, with an intensity which is correlated with the mass size. Our review presents the main epidemiological, pathogenic, clinicopathological and morphological characteristics of this rare pathology. Sometimes, thymolipomas may be associate...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Cornelia Am ălinei Adriana Grigora ş Raluca Anca Balan Laura Adriana R îşcanu Simona Eliza Giu şcă Irina Draga C ăruntu Source Type: research

Renal oncocytoma with prominent xanthomatous reaction. A rare histopathological variant of oncocytoma
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):663-670. doi: 10.47162/RJME.62.3.02.ABSTRACTRenal oncocytoma (RO) is a distinctive neoplasm with a well-recognized gross and cytoarchitectural appearance. However, on some occasions, it may show uncommon, atypical, or worrisome gross and microscopic features potentially generating diagnostic difficulties. We herein review the oncocytoma variant characterized by a significant intraneoplastic xanthomatous reaction that produces a variegated macroscopic appearance. This feature may pose a genuine diagnostic problem with conventional (clear cell) renal cell carcinoma (RCC) because this...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Jos é Fernando Val-Bernal Mar ía Francisca Garijo Jos é Javier Gómez-Román Source Type: research

Prognostic biomarkers related to tumoral microenvironment in pancreatic ductal adenocarcinoma: a systematic review
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):671-678. doi: 10.47162/RJME.62.3.03.ABSTRACTOver the past decades, pancreatic ductal adenocarcinoma (PDAC) has been coming into view due to increased mortality, the 5-year survival rate being the lowest of all cancers (around 6%). In PDAC, microenvironmental components possess prognostic relevance. The aim of this article is to perform a review of studies evaluating the composition of the tumor microenvironment to identify tumor microenvironment-related prognostic biomarkers in patients with PDAC. A literature search has been performed in three major databases PubMed®, Embase®, W...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Alina Liliana Constantin Irina Mihaela Cazacu Cezar Stroescu C ătălin Copăescu Adrian S ăftoiu Source Type: research

Morphological aspects of the vasculogenesis and angiogenesis during prenatal edification of the circle of Willis: a review
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):679-687. doi: 10.47162/RJME.62.3.04.ABSTRACTIn the literature, there are many articles reporting anatomical variations of circle of Willis (CoW), defined as those changes that lead to the inability of this anastomotic structure to maintain adequate brain flow. Because there is such a wide variation in the configuration of the CoW, its anatomical variations affect the hemodynamics of blood flow, thus contributing to the development of aneurysms or stroke. As such, we consider that a good knowledge of the embryological development of the constituent arteries of the CoW can shed some ...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Ana Maria Dumitrescu Claudia Florida Costea Cristina Furnic ă Mihaela Dana Turliuc Andrei Ionu ţ Cucu Camelia Margareta Bogd ănici Şerban Turliuc Gabriela Floren ţa Dumitrescu Anca Sava Source Type: research

Changes in skeletal dysplasia nosology
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):689-696. doi: 10.47162/RJME.62.3.05.ABSTRACTSkeletal dysplasia (SD), also called osteochondrodysplasia (OCD), is a large group of skeletal disorders (over 400 distinct entities) caused by abnormalities in bone development and growth. SDs varies according to different natural histories, prognoses, hereditary patterns to etiopathogenetic mechanisms. At birth, the incidence is low, reported at the level of each entity, but taken collectively; the incidence is estimated at 1:5000 births. Nosology is a branch of medical science. It deals with the systematic classification of diseases an...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Maria Claudia Jurc ă S ânziana Iulia Jurcă Filip Mirodot Bogdan Bercea Emilia Maria Severin Marius Bembea Alexandru Daniel Jurc ă Source Type: research

Lung cancer mimickers - a case series of seven patients and review of the literature
CONCLUSIONS: These are some of the main mimickers of primary or secondary lung cancers and one must be aware of these similitudes to avoid higher cost procedures, psychological stress for the patient and higher mortality.PMID:35263397 | PMC:PMC9019611 | DOI:10.47162/RJME.62.3.06 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Florina Neac şu Angela Ştefania Vârban George Simion Raluca Şurghie Oana Maria P ătraşcu Maria Sajin Mihai Dumitru Daniela Vr înceanu Source Type: research

E-cadherin, fibronectin and Slug immunoexpression in non-melanoma skin cancers
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):705-712. doi: 10.47162/RJME.62.3.07.ABSTRACTEpithelial-mesenchymal transition (EMT) is an essential biological process involved in the initiation and progression of cancer by which epithelial tumor cells lose their differentiated characteristics, such as cell-cell adhesion and apical-basal polarity and acquire a more invasive and∕or metastatic mesenchymal phenotype. The present study investigated the expression of immunomarkers with a role in EMT of non-melanoma skin cancers (NMSCs), such as E-cadherin, fibronectin and Slug, for a number of 50 NMSCs, represented by 30 cases of ba...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Alexandra Roxana Ciuciulete Alex Emilian Stepan Anne Marie Badiu Bianca C ătălina Andreiana Mirela Marinela Florescu Cristiana Eugenia Simionescu Alina Maria V îlcea Source Type: research

Hypertension induces compensatory left ventricular hypertrophy by a mechanism involving gap junction lateralization and overexpression of CD36, PKC and MMP-2
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):713-721. doi: 10.47162/RJME.62.3.08.ABSTRACTHypertension-induced left ventricular hypertrophy evolves initially as an adaptive response meant to minimize ventricular wall stress. The mechanisms involved in the preservation of the cardiac function during the "compensatory" phase of the left ventricular hypertrophy are still unclear. Therefore, we aimed at uncovering fine changes that aid the heart to cope with the increased stress in hypertension. Male golden Syrian hamsters were given NG-nitro-L-arginine methyl ester (L-NAME) for 16 weeks, and they became hypertensive (HT), develop...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: M ădălina Dumitrescu Alina Constantin Andreea Miruna Nemecz Emanuel Dr ăgan Lucia Doina Popov Gabriela Tanko Source Type: research

A morphological and immunohistochemical study of the endoscopic ultrasound-fine-needle biopsy samples from solid pancreatic masses: a single center study
CONCLUSIONS: EUS-FNB has opened up a new path for pancreatic tumor diagnosis providing enough tissue for HP examination and IHC. A panel of several immunomarkers might aid in providing new therapies for PAC patients.PMID:35263400 | PMC:PMC9019676 | DOI:10.47162/RJME.62.3.09 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Alexandru Constantinescu Cristina M ădălina Ilie-Stan Vasile Şandru Bogdan Silviu Ungureanu Dan Ionu ţ Gheonea Tudorel Ciurea Oana Mihaela Plotogea Christopher Pavel Valentin Enache Mihai Alexandru Munteanu Gabriel Constantinescu Source Type: research

Clinical and pathological features of upper limb nerve tumors - four years retrospective study
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):733-742. doi: 10.47162/RJME.62.3.10.ABSTRACTBenign peripheral nerve tumors and malignant peripheral nerve tumors are rarely found in patients with upper limb tumors. A four-year retrospective study was conducted on patients with tumors in the upper limb area admitted to the Emergency Clinical Hospital, Bucharest, Romania. Seventeen patients were admitted within this time range, 15 of which were benign and two malignant. All patients required surgical intervention after thorough clinical and imaging evaluation. Benign masses were removed, follow-up examination revealing no local rec...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Andreea Grosu-Bularda R ăzvan Nicolae Teodoreanu Flavia Francesca Li ţă Florin Vlad Hodea Andra Luana L ăzărescu Valentin Enache Andreea Maria Vr âncianu Ioan Lasc ăr Source Type: research

Immunoexpression of Ki67, p53 and cyclin D1 in osteosarcomas
In this study, we analyzed the immunoexpression of Ki67, p53 and cyclin D1 for 18 primitive osteosarcomas in relation to the clinicopathological prognosis parameters of the lesions. The results indicated the predominance of lesions in male young patients, with femoral location, most tumors being represented by the osteoblastic type, with high grade, size <8 cm and in advanced stages. Reactions were present in all cases, the high immunoexpression being associated with osteoblastic∕epithelioid types (Ki67, cyclin D1, p53), high grade (Ki67, cyclin D1) and advanced stage (Ki67, cyclin D1). The study revealed a positive l...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Ştefan Adrian Niculescu Dan Cristian Grecu Cristiana Eugenia Simionescu Elena Carmen Niculescu Mioara Desdemona Stepan Alex Emilian Stepan Source Type: research

Alimentary tract duplications in children - a 15 years' experience
This study reflects a 15-year single surgical team experience. We reviewed medical records of 35 consecutive patients presenting alimentary tract duplications, evaluated and managed between 2004 and 2019. The anatomical distribution included: oral structures (two cases), esophageal (three cases), gastric (three patients), jejunoileal (seven cases), ileocecal (12 cases), colonic (six cases), anorectal (one case), and one case of complex tubular duplication of the terminal ileum and entire colon with two anal openings at the perineum. Four patients had antenatal diagnosis, initially asymptomatic, were followed, after birth, ...
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Radu Iulian Sp ătaru Mircea Ovidiu Denis Lupu şoru Drago ş Şerban Monica Ivanov Dan Alexandru Iozsa Source Type: research

CK 8 ∕18: the key to differentiating intracutaneous lesions with pagetoid features
CONCLUSIONS: CK 8∕18 is an IHC marker that can help establish the diagnosis of MPD and EMPD and differentiate them from other pagetoid neoplasms, ensuring the proper diagnosis and prognosis are provided.PMID:35263404 | PMC:PMC9019624 | DOI:10.47162/RJME.62.3.13 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Andreea C ătălina Tinca Iuliu Gabriel Cocuz Mihaela Cornelia Şincu Raluca Niculescu Adrian Hora ţiu Sabău Diana Maria Chiorean Silviu Horia Morariu Sabin Gligore Turdean Ovidiu Simion Cotoi Source Type: research

Diagnostic and prognostic significance of hepatic steatosis in patients with chronic hepatitis C
In conclusion, HS is a common finding (42.42%) in patients with CHC, particularly genotypes 1 and 2. Early detection of HS by invasive or non-invasive methods is an important objective of monitoring patients with CHC, because HS is correlated with a high degree of fibrosis. Therefore, early correction of metabolic factors and early introduction of antiviral therapy are important targets for treating of patients with CHC.PMID:35263405 | PMC:PMC9019612 | DOI:10.47162/RJME.62.3.14 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Ionelia Sorina Stan Viorel Biciu şcă Patricia Durand Ana Maria Petrescu Drago ş Mihai Oancea Alexandra Roxana Ciuciulete Mihai Petrescu Ion Udri ştoiu Georgiana Cristiana Camen Mara Amalia B ălteanu Cristina Maria M ărginean Suzana D ănoiu Source Type: research

Clinical and morphological outcomes after percutaneous needle fasciotomy in Dupuytren's disease according to the contracture severity
CONCLUSIONS: The study shows that PNF has great short-term results and it is suitable for patients who prefer minimally invasive care.PMID:35263406 | PMC:PMC9019619 | DOI:10.47162/RJME.62.3.15 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 9, 2022 Category: General Medicine Authors: Cristian Tr âmbiţaş Alina Dia Tr âmbiţaş-Miron Andrei Marian Feier Octav Marius Russu Dorin Constantin Doroban ţu Klara Br înzaniuc Source Type: research