Ovarian hydatid cyst - systematic review of clinicopathological and immunohistochemical characteristics of an unusual entity.
In conclusion, the ovarian location of HD should be considered in any differential diagnosis of a cystic lesion, while it does not exclude synchronous ovarian tumors. These cases reinforce the necessity of better measures of prophylaxis and screening of HD in endemic areas. PMID: 31912083 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Update in pediatric primary brain tumors - from histology to genetically defined tumors.
Authors: Cojocaru E, Mihăilă D, Leon-Constantin MM, Cobzaru RG, Rîpă CV, Trandafirescu MF, Trandafir LM Abstract In childhood and in adolescence, primary tumors of the central nervous system (CNS) are the second most common malignancy after leukemia. The most common entities are gliomas, craniopharyngiomas and embryonal tumors, including primitive neuroectodermal tumors of the CNS, such as medulloblastoma. Proper management of malignancies requires a histological diagnosis, especially in childhood, since diagnostic errors have a significant negative influence on the treatment and subsequently on the patien...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The role of HPV infection in oropharyngeal cancer.
Authors: Budu VA, Decuseară T, Balica NC, Mogoantă CA, Rădulescu LM, Chirilă M, Maniu AA, Mistra DM, Muşat GC, Oprişcan IC, Georgescu MG Abstract BACKGROUND: Human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has been recognized as a distinct disease entity associated with oral HPV infection with high-risk serotypes, mainly among white man at younger age. Lifetime number of oral sex partners of HPV-positive OPSCC patients is the strongest risk factor associated. HPV type 16 is now established as oncogenic and it is the main cause (over the 80%) of this type of OPSCC, followed b...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The extremely rare concha of Zuckerkandl reviewed and reported.
CONCLUSIONS: Co-existence of two supreme conchae could either indicate their origin from different ethmoturbinals, or from the split of a commonly unique supreme one. Zuckerkandl's concha deserves therefore to be considered when anatomical descriptions, or studies, are delivered. PMID: 31912086 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Neuroinflammation in systemic lupus erythematosus - a review.
Authors: Bărbulescu AL, Sandu RE, Vreju AF, Ciurea PL, Criveanu C, Firulescu SC, Chisălău AB, Pârvănescu CD, Ciobanu DA, Radu M, Pădureanu V, Boldeanu MV, Albu VC Abstract Neuroinflammation is a complex process that contributes to the pathogenesis of both immune mediated and neurodegenerative pathologies. Systemic lupus erythematosus (SLE) is the prototype of connective tissue diseases that can present the complete spectrum of neurological and psychiatric dysfunctions. The precise etiological diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is rather difficult to be established and it i...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Toxicity and health impact of nanoparticles. Basic biology and clinical perspective.
Authors: Olaru DG, Olaru A, Kassem GH, Popescu-Drigă MV, Pinoşanu LR, Dumitraşcu DI, Popescu EL, Hermann DM, Popa-Wagner A Abstract Stroke has limited restorative treatment options. In search of new therapeutic strategies for the ischemic brain, cell-based therapies offered new hope, which has been, in the meanwhile, converted into a more realistic approach recognizing difficulties related to unfavorable environments causing low survival rates of transplanted neuronal precursors. Stem cell therapies are based on the transplantation of neuronal precursor cells (NPCs), adult stem cells propagated in cell culture o...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Heterogeneity of human fibroblasts isolated from hypertrophic scar.
In conclusion, our data could provide an explanation regarding the inconsistent efficacy of topic therapies for hypertrophic scars. PMID: 31912089 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

SMAD4 and TGF βR2 expression in pancreatic ductal carcinoma.
SMAD4 and TGFβR2 expression in pancreatic ductal carcinoma. Rom J Morphol Embryol. 2019;60(3):803-809 Authors: Văduva IA, Mărgăritescu C, Georgescu CV, Enache AO, Pădureanu R, Săftoiu A, Pirici D Abstract Pancreatic ductal carcinoma is the most common type of pancreatic cancer, and currently represents the fourth cause of death by cancer, worldwide. Among classical pancreatic markers that ascertain the histopathology, new emerging targets have been proposed for both diagnostic and prognostic purposes. In the present study, utilizing a group of 28 confirmed resected pancreatic ductal carcinoma...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clinical, imaging and histopathological correlations of gingival overgrowth: a retrospective analysis in northeastern Romanian population.
CONCLUSIONS: These findings suggest that the occurrence of gingival overgrowth can have many causes, which highlights the importance of clinical pathology in assisting practitioners with making a better diagnosis. PMID: 31912091 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Expression patterns of aquaporins 1 and 4 in stroke.
Authors: Roşu GC, Pirici I, Istrate-Ofiţeru AM, Iovan L, Tudorică V, Mogoantă L, Gîlceavă IC, Pirici D Abstract Ischemic stroke occurs through embolic or thrombotic obliteration of an artery from cerebral circulation and represents over 80% of all stroke cases. One of the fiercest complications after stroke is edema, which results from imbalanced water diffusion around the blood vessels walls. Water diffusion around blood vessel walls occurs physiologically mainly through two protein-formed pores, namely aquaporins (AQPs) 1 and 4. Here, we compare for the first time the expression patterns and colocaliza...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Pathological fractures of humerus in children. Therapeutic and pathological considerations.
CONCLUSIONS: Osteosynthesis with TEN and bone substitution is a viable option for treatment of pathological fracture of humerus, secondary to the osseous benign tumors, which required surgically treatment, despite the different HP aspects. By using a combined treatment in these cases, we eliminate the disadvantages of isolated use of the described techniques in the literature. PMID: 31912093 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Immunohistochemical evaluation of tumor budding in colorectal cancer: an important parameter with prognostic value.
Authors: Meşină C, Stoean CL, Stoean R, Săndiţă AV, Dumitrescu TV, Mogoantă SŞ, Cristian DA, Meşină-Botoran MI, Mitroi G, Gruia CL, Foarfă MC, Meşină M, Ciobanu D Abstract We analyzed 82 patients with colorectal cancer (CRC) [75 patients with mucinous adenocarcinoma (ADK) and seven patients with "signet ring cell" ADK] using multi-cytokeratin (CK) AE1∕AE3 immunohistochemical assay. In order to determine the mucinous nature of some of the lymph node metastases of the mucinous colorectal ADKs studied, Periodic Acid Schiff-Alcian Blue (PAS-AB) histochemical staining was used. The counting resul...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Comparative oncological outcomes and survival following surgery for low rectal cancer - a single center experience.
Authors: Molnar C, Nicolescu C, Grigorescu BL, Botoncea M, Butiurca VO, Petrişor MD, Gurzu S Abstract In patients with low rectal cancer, intersphincteric resection (ISR) technique is a better alternative of abdominoperineal resection (APR), but is recommended to be done in non-locally advanced stages (=T2) only. The aim of this study was to evaluate the long-term oncological outcome and survival rate in patients with early and locally advanced stages that underwent ISR, as compared to APR. In order to assess the quality of life and prognosis of patients with low rectal cancer, the 5-year follow-up was done in 72 ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Correlations between HPV, p53 and p16 in malignancies involving the retromolar trigone-oropharynx junction.
Authors: Cobzeanu BM, Popescu E, Danciu M, Paşca AS, Palade OD, Vonica SP, Rădulescu LM, Ungureanu LB, Moscalu M, Cobzeanu ML, Gheorghe Moisii L, Cobzeanu MD, Volovăţ C, Costan VV Abstract The aim of this study is to enhance knowledge regarding the behavior of human papilloma virus (HPV)-associated malignancies between two territories - maxillofacial and otorhinolaryngology. The HPV status and genotype, p16 and p53 expression were performed in 50 patients with malignancies located at the junction between the oropharynx and retromolar trigone alone or oropharynx spread to the junction. These were correlated with...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The performance of hyperadherence markers in anterior placenta praevia overlying the Caesarean scar.
CONCLUSIONS: Our study suggests that the antenatal US is a useful tool in predicting PA in high-risk patients. Special attention should be given to the presence of intraplacental lacunae and abnormal myometrial vessels in cases where the placental insertion overlaps a uterine scar for best identification of PA high-risk cases. PMID: 31912097 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The morphofunctional impact of topical Lidocaine formulation in inflammatory pain - experimental study.
CONCLUSIONS: The tested substance proved analgesic properties longer and higher than EMLA but did not influenced the inflammatory reaction. PMID: 31912098 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A microscopic insight of the morphological changes induced by dental zirconia prosthetic structures.
Authors: Manolea HO, Matei IM, Nistor CML, Lazăr AC, Sălan AI, Gîngu O, Cioateră N, Iacov-Crăiţoiu MM, Gălbinaşu BM Abstract As zirconia is today probably the dental material with the largest increase in the frequency of use in dental prosthetics, the reason for this study was based on a series of clinical observations made following its use in clinical prosthetics. Thus, we were interested in two aspects: the histological evaluation of the response of the oral soft tissues to the presence of the prosthetic structures in zirconia, and the microscopic evaluation of the abrasion lesions that appeared in ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Clinico-imaging and morphological aspects of the benign serous ovarian epithelial tumors in children and adolescents.
In this study, we analyzed 24 tumors diagnosed and surgically operated in children and adolescents, in relation to clinical, histological and immunohistochemical parameters, which can provide information on the potential for growth of lesions. The average age of diagnosis was 13.2 years, the majority of tumors being present in patients over 10 years (75%), with accompanying symptoms (83.3%), unilateral (91.7%) and dimensions of maximum 10 cm (66.7%). The histopathological aspect indicated a cystic growth pattern, sometimes papillary, and in three cases, the presence of atypical focal areas of the tumor epithelium. The Ki67...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Histological and immunohistochemical aspects of the atrophic dental pulp modifications of abutment teeth.
CONCLUSIONS: Certain irreversible atrophic changes can be observed in abutment teeth's pulps, a fact that justifies the need of performing pre-prosthetic endodontic treatment. PMID: 31912101 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Differential expression pattern of annexin A2 during nephrogenesis and kidney carcinoma.
Authors: Sadashiv R, Bannur BM, Shetty P, Dinesh US, Rani H, Vishwanatha J, Deshpande SK, Bargale A, Sarathkumar, Ruikar K Abstract The creation of a cancer cell could be due to reactivation of repressed gene in the process of normal embryonic development. The differences in embryonic origins and functions of various components of nephron may contribute to the diversity of morphological patterns, molecular and immunohistochemical phenotypes of common renal neoplasms. Renal cell carcinomas (RCCs) are the most common amongst the genitourinary cancers. Annexin A2 (AnxA2) is a multifunctional calcium-regulated phosphol...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Histopathological and perioperative factors influencing the length of hospital stay and patients' outcome after radical cystectomy for urothelial carcinoma.
CONCLUSIONS: Advanced age, the complexity of urinary diversion and lymph node involvement were found as associated factors for prolonged LOS in RC patients. The impact of LOS on survival is uncertain, requiring larger, in-depth studies. PMID: 31912103 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Ovarian metastases reported after adjuvant laparoscopic oophorectomies in breast cancer.
CONCLUSIONS: The differential diagnosis between OM and primary ovarian cancer can be challenging for the pathologist as well and immunostaining is of help. GCFDP15 is the most specific for breast carcinoma. In contrast with the recent papers published in the literature, we detected TTF-1 cytoplasmic expression in invasive breast carcinoma by SPT24 clone. PMID: 31912104 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Red grape juice protects the rat thyroid gland against hypercholesterolemic changes. Ultrastructural and biochemical evidences.
This study aimed to assess the impact of high cholesterol diet (HCD)-induced hypercholesterolemia on the rat thyroid gland and investigate the role of grape juice (GJ) in reducing such impact through biochemical and histopathological methods. MATERIALS AND METHODS: Thirty male Wistar rats sorted into three groups (the control, HCD-fed group, and the HCD+GJ fed group for 13 weeks) were used in this study. Lipid profile, blood glucose and insulin, thyroid hormones, some oxidants/antioxidants parameters were assessed. After the end of the experiment, thyroid glands were dissected out and processed for histopathological as...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Designing an on-line database for morphological studies of three-dimensional liver tumors.
CONCLUSION: This is the first attempt to implement a full-scale on-line solution for 3D tumor representation and manipulation, corroborated with clinical and laboratory data. This technology may bring important additional information for pre-operatory evaluation, treatment planning or medical training. PMID: 31912106 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Study of antimicrobial effects of functionalized silver nanoparticles.
Authors: Popescu EL, Bălăşoiu M, Cristea OM, Stoica AE, Oprea OC, Vasile BŞ, Grumezescu AM, Băncescu G, Busuioc CJ, Mogoşanu GD, Streba CT, Mogoantă L Abstract In recent decades, the study of nanoparticles (NPs) has gained a great scientific interest, due to a wide range of potential applications, in different fields: electronic, optical and biomedical. Some of the most studied effects of NPs are antibacterial ones, because the large, sometimes unjustified and uncontrolled administration of antibiotics has led to the emergence of multidrug-resistant (MDR) bacterial strains. In our study, starting from silver...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Unilateral supplemental maxillary lateral incisor: report of three rare cases and literature review.
This article highlights that even if, in younger patients, the majority of these teeth is extracted because later in life they can cause difficulties in orthodontic and prosthetic treatment, there are still rare cases which do not necessitate treatment, because they are asymptomatic, rather well aligned and go unnoticed. Also, the article includes a detailed literature review of reported cases of supplemental maxillary lateral incisor. PMID: 31912108 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Beh çet's disease with rapidly progressive bilateral optic neuropathy and avascular femoral neck necrosis. Literature review and management update.
We present the case of a 36-year-old patient, who was admitted in the Clinic of Rheumatology for recurrent-neglected oral aphthosis, recurrent erythema nodosum, left hip pain, reduction of visual acuity of the right eye, weight loss, profuse sweating, marked fatigability. From the personal history was retained avascular necrosis of right femoral head, with arthroplasty at this level, human leukocyte antigen-B51 (HLA-B51) positive. Ophthalmological evaluation reveals severe bilateral optic neuropathy, with confirmation of neuro-Behçet's disease (NBD) diagnosis, in a Neuro-Ophthalmological Center, based on cerebral nu...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A rare case of a double high-risk gastrointestinal stromal tumor of jejunum with KIT-negative ∕PDGFRA-positive immunophenotype.
A rare case of a double high-risk gastrointestinal stromal tumor of jejunum with KIT-negative∕PDGFRA-positive immunophenotype. Rom J Morphol Embryol. 2019;60(3):963-970 Authors: Boşoteanu M, Bălţătescu GI, Deacu M, Aşchie M, Boşoteanu CA Abstract Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that represent the second most common type in the gastrointestinal system, but clinical outcomes vary due to complex molecular changes. The aim of our study is to highlight a unique case of a 5th decade male, presenting a double primary GIST of the jejunum, associated with a rare immunophen...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Replaced right hepatic artery arising from inferior pancreaticoduodenal artery, in association with left multiple renal arteries: a case report using MDCT angiography.
Authors: Costea AN, Iacob N, Pusztai AM, Pleş H, Matusz P Abstract The authors illustrate a case of a 61-year-old male who presented an extremely rare association of anatomical variations highlighted by multi-detector computed tomography (MDCT) angiography, with a replaced right hepatic artery (RRHA) arising from inferior pancreaticoduodenal artery (IPDA), in association with left multiple renal arteries (RAs). The celiac trunk (CT) arises from the abdominal aorta (AA), at the level of middle 1∕3 of L1 vertebral body. The superior mesenteric artery (SMA) origin was located at the anterior aspect of AA, at 2.5 mm...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A malignant phyllodes tumor with liposarcomatous differentiation case with 3-year follow-up.
This article presents a case of a 48-year-old woman with a breast malignant PT with liposarcomatous differentiation, diagnosed by guided core biopsy, treated by excision and subsequent simple mastectomy followed by radiotherapy, with a 3-year follow-up. PMID: 31912112 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A rare tumor in a rare location: giant cell tumor of the sacrum and ilium - case report and current perspectives.
Authors: Poll A, Nimigean VR, Vîrlan MJR, Sîrbu VD, Costache M, Ivaşcu RV, Cordun M, Nimigean V Abstract Giant cell tumor (GCT) is considered a locally aggressive, intermediate grade benign bone neoplasm. In rare cases, GCT undergoes malignant degeneration or may cause distant metastasis, mainly in the pulmonary area. Most bone GCTs are situated in the epiphysis or metaphysis of long bones, while GCTs of the pelvis are quite rare. There is no standard treatment protocol for the GCT of pelvic bones. This paper presents the therapeutic management of a rare case of a stage III GCT, situated on the iliac t...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Synchronous Warthin tumor and papillary oncocytic cystadenoma in the ipsilateral parotid gland: an unreported association.
In this report, we present the case of a 52-year-old male, established smoker, who showed simultaneously two different benign tumors in the right parotid gland. The patient complained of swelling below the angle of the mandible. Ultrasonography and computed tomography imaging revealed one mass of about 2.8 cm in the right gland. Besides, one small nodule in the left parotid gland was observed. The cytological diagnosis of the right gland was benign tumor, type IVa of the Milan system, consistent with Warthin tumor (WT). The clinical diagnosis was bilateral parotid WT. The histopathological (HP) study of the surgical specim...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Unusual occurrence of avascular necrosis with bilateral involvement and ankylosing spondylitis, meningioma and Hodgkin lymphoma.
We report the case of a 47-year-old patient, diagnosed with Hodgkin lymphoma at the age of 14. Two decades later, she was diagnosed with frontal chordoid meningioma, which was surgically removed, without radiotherapy. She was re-operated 10 years later for recurrence of meningioma. At the age of 39, she was diagnosed with bilateral avascular necrosis of the humeral head, femoral head and scaphoid bones. In the same year, she was also diagnosed with ankylosing spondylitis. We considered that the occurrence of rare chordoid meningioma, avascular necrosis with multiple locations and bilateral involvement in a patient with a m...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Unilateral left four renal arteries: case report using MDCT angiography.
We report a very rare case of a 57-year-old male who presented four left renal arteries (RAs) [one main RA and three additional renal arteries (AdRAs)] highlighted incidentally on multidetector computed tomography (MDCT) angiography, which was used to investigate the vascular system of the lower limbs. The distance between the extreme points of RAs origin (upper and lower points of origin) from abdominal aorta (AA) was in the left part of 9.83 cm. The distance between the extreme points of penetration (upper and lower points of penetration) into the left renal parenchyma was 5.23 cm. At the level of origin, the main left R...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Rare variant of renal vascularization with bilateral multiple pedicles and incomplete rotation - case report.
Authors: Zăhoi DE, Sztika D, Stoican L, Dăescu E Abstract Renal blood vessels present great morphological variability. The routine dissection of a 68-year-old male cadaver revealed multiple bilateral vascular variations associated with the incomplete rotation of both kidneys. The left kidney was supplied by three renal arteries: one superior artery and one middle artery with hilum penetration, and one inferior artery with inferior polar penetration. All three arteries arose from the aorta: two from the anterior side at levels L1 and L3, and one - the inferior artery - from the posterior side of the aorta, as a co...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A recurrent solitary glomus tumor of the forearm.
We present the case of a 63-year-old patient with a fixed tumor located in the lower third of the right forearm with a long-axis diameter of 4 cm, with irregular borders and tenderness to palpation. The tumor had been surgically removed 15 years ago, but it redeveloped two months after surgery, and grew in size until the fourth month after the surgery when it stopped growing. The preoperative ultrasound showed an expansive mass suggestive of swelling/inflammation in the adjacent soft tissue and having a mass effect on the deep muscle structures. Intraoperatively, a 3/4/3 cm (antero-posterior∕transversal∕cranio-caudal) ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Cutaneous melanoma arising on pre-existing nevi - case reports.
Authors: Dogaru IM, Dumitrescu N, Oproiu AM, Jecan CR, Costache M, Pătraşcu OM, Florescu IP Abstract Skin cancer is a common healthcare issue that affects millions of people worldwide. Only a small part of that population is suffering from melanoma and an even smaller proportion has melanoma developed on a pre-existing nevus. This paper illustrates five such cases, diagnosed over an 18-month period, with their histological particular aspects. Among the total number of patients diagnosed and treated in the Department of Plastic and Reconstructive Surgery, University Emergency Hospital, Bucharest, Romania, over app...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Difficulties in histopathology diagnosis and treatment of depressive disorder of breast cancer in male - clinical case presentation.
We present the case of a 63-year-old patient that was diagnosed in another Clinic with squamous skin carcinoma, but, after complete resection in our Hospital, it was proven to be breast cancer. At diagnosis, computed tomography (CT) scan showed local disease. Adjuvant treatment, consisting in chemotherapy and radiotherapy, was administered. At the beginning of hormonal therapy, the patient had a new CT scan that showed liver and bone metastases. The patient started palliative hormonal treatment with bisphosphonates. The aim of the study was to highlight both the importance of early diagnosis and treatment and the aggressiv...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Spermatic vein aneurysm: a report of a unique case and review of the literature.
We present a case of a 22-year-old man who came to our Surgical Department with a painful, palpable mass in the right inguinal area. A spermatic vein aneurysm was diagnosed with the use of ultrasonography and it was surgically excised. The findings were confirmed by pathological examination. The patient is well, four months after surgery. A spermatic vessel aneurysm, though rare, should always be included in the differential diagnosis of a scrotal or inguinal mass. The lesion can be cured by surgical resection. PMID: 31912121 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Bridging neighboring civilizations at academic grounds: a story of Zygmunt Albert - Rector illustrissimus ac magnificus Academiae Medicae Wratislaviensis - a pathologist who visualized gamma-glutamyl transpeptidase.
Authors: Wincewicz A, Woltanowski P, Jeleń M Abstract The life stories can constitute more than simple biographies to remain great lessons of honesty, grit and steadfastness in keeping standards of medical science within a strong moral fiber and flexible wiseness in hard terms like in case of Zygmunt Albert (1908-2001). This eminent pathologist histochemically visualized tissue distribution of gamma-glutamyl transpeptidase in liver and other organs under various conditions. He was also deeply involved in experimental pathology of liver, particularly in his comprehensive studies on chrysoidin-induced hepatoma that ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Career management and personal integration in organizational culture in medical education - case study University of Medicine and Pharmacy of Craiova, Romania.
This article presents the results of a study conducted at the University of Medicine and Pharmacy of Craiova, Romania, on professors and auxiliary teaching staff of the Faculties of Medicine and General Medical Assistance, in order to identify how it relates to organizational culture, its own career and how satisfied with the choices they have made. PMID: 31912123 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Trait anxiety and coping in first year medical students.
Authors: Nechita D, Nechita F, Strunoiu LM, Albulescu DM, Vasile DL Abstract In the present study, we highlight the types of anxiety and the coping strategies employed by the students at the Medicine, Pharmacy and Nursing Faculties, at the same time comparing them with the general population. This research involved 333 first year students, 18-20 years of age. We used the Endler Multidimensional Anxiety Scales-Trait (EMAS-T) and Social Anxiety Scale-Trait (SAS-T) and two coping measuring instruments, Cognitive Emotion Regulation Questionnaire (CERQ) and Strategic Approach to Coping Scale (SACS). We obtained an overv...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Letter to the Editor: Prolonged in vitro expansion alter the biological and morphological properties of adipose stem cells.
Authors: Danisovic L, Bohac M, Kuniakova M, Culenova M, Varga I PMID: 31912125 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Letter to the Editor: POLG1 variants may secondarily affect mtDNA load and structure.
Authors: Finsterer J PMID: 31912126 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Letter to the Editor: Carbon monoxide (CO) poisoning, a silent epidemic.
Authors: Ferrés-Padró V, Solà Muñoz S, Jacob Rodríguez J, Membrado-Ibáñez S, Amigó Tadín M, Nogué Xarau S PMID: 31912127 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Do we know enough about the genetic involvement in laryngeal cancer susceptibility and prognostic outcome?
CONCLUSIONS: Laryngeal cancer evolution is linked to inherited risk factors found within the genetic code. Most studied were the genes belonging to NER pathways, DNA repair and xenobiotic metabolism, which all favored mutant homozygote and heterozygote variants, as high risk factors. Only five articles focused on overall survival rates with insufficient results to undisputedly predict the risk variants. The consumption of external toxins has a positive effect on the overall cancer risk in consumers. Most articles affirmed further evaluation or replication was needed in a larger scale population to conclusively validate the...
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Protean cytological, histological and immunohistochemical appearances of medullary thyroid carcinoma: current updates.
Authors: Buzdugă CM, Costea CF, Cărăuleanu A, Lozneanu L, Turliuc MD, Cucu AI, Ciocoiu M, Floria M, Tănase DM, Dragomir RA, Haba RM, Dumitrescu AM, Bogdănici CM, Ciobanu Apostol DG Abstract Medullary thyroid carcinoma (MTC) accounts for only 0.5-3% of all malignant diseases, but is responsible for more deaths every year than all the other endocrine malignancies taken together. Approximately 75-80% of MTCs occur sporadically, while the inherited forms of MTC are responsible for the rest of the cases. The heritable MTC results from a germline mutation in the rearranged during transfection (RET) proto-oncogene an...
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Antiplatelet therapy in secondary ischemic stroke prevention - a short review.
In conclusion, we can say that current recommendations focused primarily on the therapy with aspirin for the secondary prevention of stroke in patients that presented vascular events, such as ischemic stroke of non-cardioembolic cause or transient ischemic attack and, as appropriate, aspirin plus dipyridamol or clopidogrel. The new therapy with ticagrelor in secondary stroke prevention seems to be promising, but more randomized clinical trials are needed to accurately assess the safety and efficacy of this new antiplatelet drug. PMID: 31658310 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models.
Authors: Bondoc EN, Marinescu D, Marinescu I, Mălin RD, Stanca L, Zăvoi RE Abstract Epidemiological data confirm the rising incidence of depression associated with suicidal ideation and cardiovascular comorbidities of coronary type. In contradiction with the large number of antidepressant drugs, the therapeutic results are not satisfactory, with numerous existing incomplete remissions characterized by maintained cellular dysfunctionalities that amplify the cognitive deterioration and the risk of several somatic comorbidities. The surprising fact is the relatively high number of deaths in this type of patients due...
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

State of the art regarding anticoagulant and thrombolytic therapy in dental procedures.
Authors: Lazăr AC, Ilea A, Moldovan B, Ionel A, Pop AS, Păcurar M, Câmpian RS Abstract Patients with anticoagulant therapy have a high thromboembolic risk. Due to the rich oro-maxillofacial vasculature and the fact that some dental procedures may cause a bleeding, the physician should be able to correlate this risk with the hemorrhagic risk. Dental procedures are a trigger for psychic stress. One of the most important changes in acute stress is in cardiovascular system. In healthy patients, these changes are reversible and have no significant consequences, but in patients with cardiovascular diseases, the r...
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research