Clinically Relevant Markers Aiding in Management of Benign and Immature Ovarian Teratomas
The objective of our study was to compare presenting features of mature and immature teratomas in a retrospective cohort analysis in order to identify any unique patient or tumor features that may help to anticipate risk of malignancy. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - February 19, 2016 Category: OBGYN Authors: Kristen Kelley, Celestine Shauching Tung, Haleh Sangi-Haghpeykar, Jennifer E. Dietrich Source Type: research
High Frequency of Malignant Transformation of Ovarian Mature Teratoma into Squamous Cell Carcinoma in Young Patients in Northeast Brazil
The malignant behavior of an ovarian teratoma is related to immaturity, or rarely to the malignant transformation of a somatic component in a mature teratoma (MT). The aim of this work was to review 189 consecutive ovarian teratomas diagnosed between 2006 and 2010 at a public referral center for cancer in Brazil, focusing on cases of MT with malignant transformation. MTs with transformation to squamous cell carcinoma (SCC) were further analyzed by immunohistochemistry for p16 staining. The median age of all patients was 36 yr (mean age, 39.6 yr; SD±4.9). Mature and immature teratomas represented 95.7% (181/189) and 4.2% o...
Source: International Journal of Gynecological Pathology - February 11, 2016 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
Mature Teratoma Confined to the Posterior Fossa
We describe a girl who presented with hydrocephalus caused by a posterior fossa tumor that was ultimately diagnosed as a mature teratoma following complete extirpation. Unusual imaging characteristics which produced confusion preoperatively were, however, very consistent with mature teratomas that are encountered in the gonads. Immature elements were universally absent; therefore, extirpation was curative. Hydrocephalus is unlikely to resolve after tumor removal, and cerebrospinal fluid diversion may be required.Pediatr Neurosurg (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - January 12, 2016 Category: Neurosurgery Source Type: research
Clinical management of teratoma, a rare hypothalamic-pituitary neoplasia
Abstract
Intracranial teratomas are rare and comprise about 0.5 % of all intracranial tumours. Actually, a total of 15 cases of sellar-suprasellar teratoma have been described in the last 24 years. Although rare, hypothalamic-pituitary teratomas should be taken into account in the differential diagnosis of hypothalamic-pituitary region tumours. The current review focuses on the clinical and therapeutic management of pituitary region teratomas. Teratomas occur more frequently in children and young adults than in the older population and in males as compared to females. Symptoms at diagnosis are us...
Source: Endocrine - December 23, 2015 Category: Endocrinology Source Type: research
Immunophenotypic features of immaturity of neural elements in ovarian teratoma
Abstract
Neural components in mature teratomas are common and the general assumption is that they are quite similar to those in the mature central nervous system (CNS). We investigated 44 ovarian teratomas by immunohistochemistry to determine cellular and structural immaturity of neural elements. Most teratomas contained cells differentiating into astrocytes positive for nestin, a neural stem cell marker. These nestin-positive astrocytes generally co-expressed glial fibrillary acidic protein-delta, an immature astrocyte marker. Olig2-positive cells were randomly scattered. Areas comprising cells that diff...
Source: Virchows Archiv - December 5, 2015 Category: Pathology Source Type: research
Immature Teratoma Associated With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.
Authors: Malayev Y, Alberts J, Verardi MA, Mattison AR, Imlay S
Abstract
Gynecologic teratomas commonly present with pelvic symptoms. The authors report a case of teratoma causing acute psychosis, encephalopathy, and sudden-onset seizures in a previously healthy 33-year-old woman. After common organic causes were excluded, investigation revealed an immature teratoma containing brain tissue on her left ovary. Anti-N-methyl-D-aspartate receptor encephalitis was diagnosed and, with excision and medical management, her symptoms resolved and she was discharged home in stable condition. Encephalopathy is not com...
Source: Journal of the American Osteopathic Association - November 18, 2015 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R
Abstract
Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research
Diagnostic algorithm for teratodermoidal tumors of mediastinum
Conclusion: Comprehensive assessment of clinical and instrumental data in 80% of cases allowed correct diagnosis before surgery with confirmation of malignant and benign mediastinal teratodermoid formations and provide adequate treatment policy and rational choice of surgical approach. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Pakhomov, G., Hayaliev, R., Eshonhodjaev, O., Makhmudov, A., Mustafaev, A. Tags: 8.1 Thoracic Surgery Source Type: research
Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative
CONCLUSIONSThe grade was the most important risk factor for relapse in ovarian ITs. Among grade 3 patients, the stage was significantly associated with relapse. Adjuvant chemotherapy did not decrease relapses in the pediatric cohort; its role in adults remains unresolved. Cancer 2015. © 2015 American Cancer Society. (Source: Cancer)
Source: Cancer - October 20, 2015 Category: Cancer & Oncology Authors: Farzana Pashankar, Juliet P. Hale, Ha Dang, Mark Krailo, William E. Brady, Carlos Rodriguez‐Galindo, James C. Nicholson, Matthew J. Murray, Deborah F. Bilmire, Sara Stoneham, G. Suren Arul, Thomas A. Olson, Daniel Stark, Furqan Shaikh, James F. Amatruda Tags: Original Article Source Type: research
Germ cell tumors: Treatment consensus across all age groups through MaGIC [Malignant Germ Cell International Collaborative]
This editorial discusses the treatment approach to immature teratomas across pediatric and adult age groups by the Malignant Germ Cell International Collaborative. (Source: Cancer)
Source: Cancer - October 20, 2015 Category: Cancer & Oncology Authors: Jean A. Hurteau, Terri Febbraro Tags: Editorial Source Type: research
Unusual presentation of immature teratoma of the neck: A rare case report
We present a case of 4-month-old female child at age of 4 th month with right submandibular region swelling. Computed tomography neck showed ill-defined, multiloculated cystic lesion with enhancing thick septations in the right side of the neck. Excision biopsy revealed Grade I - immature teratoma - cervical region. On 1-year of close follow-up, no evidence of local recurrence or metastasis was seen. Unlike adults, teratomas in children are often congenital and very rarely turn malignant. The treating consultant should be aware of their natural history, clinical features, pathology, and principles of management. (Source: J...
Source: Journal of Cancer Research and Therapeutics - October 9, 2015 Category: Cancer & Oncology Authors: K Jayaprakash ShettyHL Kishan PrasadSandeep RaiY Sunil KumarShubha BhatNetra SajjanChandrika Rao Source Type: research
Prepubertal Testicular Teratomas and Epidermoid Cysts: Comparison of Clinical and Sonographic Features
Conclusions—
Testicular masses in children younger than 8 months with AFP levels higher than 23 ng/mL and size larger than 2.5 cm need to be considered for orchiectomy rather than testis-sparing tumorectomy because of the increased frequency of immature teratomas versus mature teratomas or epidermoid cysts. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - September 24, 2015 Category: Radiology Authors: Chang, M.-Y., Shin, H. J., Kim, H. G., Kim, M.-J., Lee, M.-J. Tags: Original Research Source Type: research
A Young Female With Metastatic Nongestational Choriocarcinoma
Germ cell tumors of the ovary most likely to affect adolescent girls and young women are non–epithelial-based tumors and include dysgerminomas, yolk sac tumors, immature teratomas, embyronal cell tumors, and nongestational choriocarcinomas (NGCs), occurring without an antecedent pregnancy.1,2 NGC is rare3 and more often occurs in mixed form than as a pure primary ovarian choriocarcinoma. In men, NGC can occur as a testicular choriocarcinoma. (Source: Seminars in Oncology)
Source: Seminars in Oncology - September 17, 2015 Category: Cancer & Oncology Authors: Budhi Singh Yadav, Bhavana Rai, Vanita Suri, Kanchan K. Mukherjee, Amanjit Bal, Robert Morgan, Nicole A. Shonka, Shashi Lele, Gloria J. Morris Tags: Current Clinical Practice Source Type: research
Seminars in Oncology Current Clinical Practice
Germ cell tumors of the ovary most likely to affect adolescent girls and young women are non-epithelial-based tumors which include dysgerminomas, yolk sac tumors, immature teratomas, embyronal cell tumors, and nongestational choriocarcinomas, occurring without an antecedent pregnancy.1,2 Non-gestational choriocarcinoma (NGC), is rare situation 3, and more often occurs in mixed form than as a pure primary ovarian choriocarcinoma. In men NGC can occur as a testicular choriocarcinoma. (Source: Seminars in Oncology)
Source: Seminars in Oncology - September 17, 2015 Category: Cancer & Oncology Authors: Budhi Singh Yadav, Bhavana Rai, Vanita Suri, Kanchan K Mukherjee, Amanjit Bal, Robert Morgan, Nicole A Shonka, Shashi Lele, Gloria J Morris Source Type: research
Gastric teratoma in children: Our experience
Conclusion Gastric teratoma is almost always benign and has predilection for male sex. It commonly presents as a palpable abdominal mass. Complete surgical excision is curative. Close observation is recommended for Grade 2 and 3 immature teratomas. The prognosis is excellent. (Source: Formosan Journal of Surgery)
Source: Formosan Journal of Surgery - July 26, 2015 Category: Surgery Source Type: research
