The cognitive effects of endocrine therapy in survivors of breast cancer: A prospective longitudinal study up to 6 years after treatment
ConclusionsIn the current observational cohort study, no detrimental effect of ET on cognitive function was identified in survivors of early ‐stage breast cancer receiving treatment with ET compared with those who were not. (Source: Cancer)
Source: Cancer - November 28, 2018 Category: Cancer & Oncology Authors: Kathleen Van Dyk, Catherine M. Crespi, Julienne E. Bower, Steven A. Castellon, Laura Petersen, Patricia A. Ganz Tags: Original Article Source Type: research

Prevalence of nonfounder BRCA1/2 mutations in Ashkenazi Jewish patients presenting for genetic testing at a hereditary breast and ovarian cancer center
ConclusionsAmong AJ patients found to have a pathogenic mutation on genetic assessment, approximately 22.8% had a mutation that would be missed with BRCA1/2 AJ founder mutation testing. Comprehensive multigene panel sequencing can provide clinically relevant genetic information for AJ patients and should be considered for genetic assessment in this population. (Source: Cancer)
Source: Cancer - November 27, 2018 Category: Cancer & Oncology Authors: Melissa K. Frey, Rohini V. Kopparam, Zhen Ni Zhou, Jessica C. Fields, Ama Buskwofie, Ann D. Carlson, Thomas Caputo, Kevin Holcomb, Eloise Chapman ‐Davis Tags: Original Article Source Type: research

Trends in liver cancer mortality in the United States: Dual burden among foreign ‐ and US‐born persons
ConclusionsEfforts that address the major risk factors for liver cancer are needed to help to alleviate the health disparities observed among foreign ‐born individuals and reverse the increasing trend observed in the US‐born population. (Source: Cancer)
Source: Cancer - November 27, 2018 Category: Cancer & Oncology Authors: Meheret Endeshaw, Benjamin D. Hallowell, Hilda Razzaghi, Virginia Senkomago, Matthew T. McKenna, Mona Saraiya Tags: Original Article Source Type: research

Safety and survival outcomes for bloodless transplantation in patients with myeloma
High ‐dose therapy (HDT) and autologous stem cell transplantation (ASCT) are established components in the treatment of multiple myeloma; however, undergoing transplantation usually requires hematopoietic support, which poses a challenge among patients who are unwilling to receive blood products. Most transplant centers decline HDT/ASCT to these patients because of safety concerns. Here, the authors’ institutional data on safety, engraftment parameters, and survival outcomes after bloodless ASCT (BL‐ASCT) are examined among patients with myeloma. This retrospective case‐control study includ ed patients who underwen...
Source: Cancer - November 27, 2018 Category: Cancer & Oncology Authors: Nisha S. Joseph, Jonathan L. Kaufman, Lawrence H. Boise, Kelly Valla, Dhwani K. Almaula, Chikaodili O. Obidike, Amelia A. Langston, Edmund K. Waller, Hanna J. Khoury, Christopher R. Flowers, Michael Graiser, Leonard T. Heffner, Sagar Lonial, Tags: Review Article Source Type: research

Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
ConclusionsThese findings indicate that aneuploidy ‐related and leukemia‐specific alterations cooperate to tolerate an abnormal chromosome number in AML, and they point to the mitotic and protein degradation machineries as potential therapeutic targets. (Source: Cancer)
Source: Cancer - November 27, 2018 Category: Cancer & Oncology Authors: Giorgia Simonetti, Antonella Padella, Italo Far ìa do Valle, Maria Chiara Fontana, Eugenio Fonzi, Samantha Bruno, Carmen Baldazzi, Viviana Guadagnuolo, Marco Manfrini, Anna Ferrari, Stefania Paolini, Cristina Papayannidis, Giovanni Marconi, Tags: Original Article Source Type: research

Issue Information
Cancer, Volume 124, Issue 21, Page 4107-4114, November 1, 2018. (Source: Cancer)
Source: Cancer - November 26, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

First Person: Hyman Muss, MD
Cancer, Volume 124, Issue 21, Page 4115-4116, November 1, 2018. (Source: Cancer)
Source: Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research

Cancer centers issue call to action regarding the human papillomavirus vaccine
Cancer, Volume 124, Issue 21, Page 4117-4117, November 1, 2018. (Source: Cancer)
Source: Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research

STAR act expected to improve care for pediatric patients with cancer
Cancer, Volume 124, Issue 21, Page 4116-4117, November 1, 2018. (Source: Cancer)
Source: Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research

Cognitive performance in survivors of breast cancer and markers of biological aging
ConclusionsThe results of the current study suggest a significant association between measures of biological aging and objective measures of cognitive performance in survivors of breast cancer. Future prospective studies are needed to confirm a causal role of biological aging as a driver of declines in cognitive function after cancer treatment. (Source: Cancer)
Source: Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Judith E. Carroll, Kathleen Van Dyk, Julienne E. Bower, Zorica Scuric, Laura Petersen, Robert Schiestl, Michael R. Irwin, Patricia A. Ganz Tags: Original Article Source Type: research

Role of adjuvant therapy in resected stage IA subcentimeter (T1a/T1b) pancreatic cancer
ConclusionsThe current study is the first to demonstrate no survival benefit for adjuvant therapy in patients with resected subcentimeter PDAC. (Source: Cancer)
Source: Cancer - November 20, 2018 Category: Cancer & Oncology Authors: Walid L. Shaib, Amit Surya Narayan, Jeffrey M. Switchenko, Sujata R. Kane, Christina Wu, Mehmet Akce, Olatunji B. Alese, Pretesh R. Patel, Shishir K Maithel, Juan M. Sarmiento, David A. Kooby, Bassel F. El ‐Rayes Tags: Original Article Source Type: research

Outcomes of secondary solid tumor malignancies among patients with myeloma: A population ‐based study
ConclusionsThe results of the current study support curative treatment approaches to secondary cancers among patients with myeloma while highlighting the need for ongoing active myeloma management. (Source: Cancer)
Source: Cancer - November 19, 2018 Category: Cancer & Oncology Authors: Peter Barth, Jorge J. Castillo, Adam J. Olszewski Tags: Original Article Source Type: research

Differential use of medical versus surgical androgen deprivation therapy for patients with metastatic prostate cancer
CONCLUSIONSRace/ethnicity, neighborhood SES, and insurance status appear to be significantly associated with receipt of surgical ADT. Future research will need to characterize other differences in initial treatments among men with advanced prostate cancer based on race/ethnicity and aim to better understand what factors drive the association between surgical ADT among men of Hispanic origin or those from areas with low neighborhood SES. (Source: Cancer)
Source: Cancer - November 16, 2018 Category: Cancer & Oncology Authors: Hala T. Borno, Daphne Y. Lichtensztajn, Scarlett L. Gomez, Nynikka R. Palmer, Charles J. Ryan Tags: Original Article Source Type: research

Prevalence of comorbidities and effect on survival in survivors of human papillomavirus –related and human papillomavirus–unrelated head and neck cancer in the United States
ConclusionsThere is a large burden of comorbidities in both patients with HPV ‐related and HPV‐unrelated HNC, both of which are associated with decreased survival. Oncologic surveillance should not be limited to the evaluation of disease status, but also should include screening for the highly prevalent conditions associated with the risk of death. (Source: Cancer)
Source: Cancer - November 16, 2018 Category: Cancer & Oncology Authors: Danielle F. Eytan, Amanda L. Blackford, David W. Eisele, Carole Fakhry Tags: Original Article Source Type: research