Machine Learning to Support Hemodynamic Intervention in the Neonatal Intensive Care Unit
Hemodynamic support in neonatal intensive care is directed at maintaining cardiovascular wellbeing. At present, monitoring of vital signs plays an essential role in augmenting care in a reactive manner. By applying machine learning techniques, a model can be trained to learn patterns in time series data, allowing the detection of adverse outcomes before they become clinically apparent. In this review we provide an overview of the different machine learning techniques that have been used to develop models in hemodynamic care for newborn infants. We focus on their potential benefits, research pitfalls, and challenges related...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: David Van Laere, Marisse Meeus, Charlie Beirnaert, Victor Sonck, Kris Laukens, Ludo Mahieu, Antonius Mulder Source Type: research

Cerebral Autoregulation in Sick Infants
Cerebrovascular autoregulation is the ability to maintain stable cerebral blood flow within a range of cerebral perfusion pressures. When cerebral perfusion pressure is outside the limits of effective autoregulation, the brain is subjected to hypoperfusion or hyperperfusion, which may cause vascular injury, hemorrhage, and/or hypoxic white matter injury. Infants born preterm, after fetal growth restriction, with congenital heart disease, or with hypoxic –ischemic encephalopathy are susceptible to a failure of cerebral autoregulation. Bedside assessment of cerebrovascular autoregulation would offer the opportunity to ...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Elisabeth M.W. Kooi, Anne E. Richter Source Type: research

Fluid Therapy
Many questions surround fluid bolus therapy and subsequent fluid management in neonatal critical care as they do in pediatric and adult critical care. This review explores the known key clinical aspects of fluid bolus therapy and fluid balance in the first 7  days of life and provides suggestions for further work in this area. It draws on the pediatric and adult critical care literature to provide thought-provoking data around the potential harms of excessive intravenous fluids, which may prove relevant to neonatology. Current data suggest that fluid b olus therapy and early-life positive fluid balance in neonates may...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Erin Grace, Amy K. Keir Source Type: research

Updates on Management for Acute and Chronic Phenotypes of Neonatal Pulmonary Hypertension
This article summarizes the causes, risk factors, hemodynamic assessment, and management of neonatal pulmonary hypertension. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Jessica Lauren Ruoss, Danielle R. Rios, Philip T. Levy Source Type: research

Neonatal Blood Pressure Standards
Blood pressure (BP) is routinely measured in newborn infants. Published BP nomograms demonstrate a rise in BP following delivery in healthy infants at all gestational ages (GA) and evidence that BP values are higher with increasing birth weight and GA. However, the complex physiology that occurs in newborn infants and range of BP values observed at all GA make it difficult to identify “normal” BP for a specific infant at a specific time under specific conditions. As such, complete hemodynamic assessment should include the physical examination, perinatal history, other vital signs, and laboratory values in addit...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Beau Batton Source Type: research

Simulation in Neonatal Echocardiography
We describe the currently available 2 echocardiography simulators designed for neonatology. Both systems are based on real 3-dimensional echocardiographic data and use an electromagnetic tracking system. Although limited data exist proving their effectiveness, deduction from other disciplines support this assumption. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Michael Weidenbach, Christian Paech Source Type: research

What Inotrope and Why?
Primary function of cardiovascular system is to meet body ’s metabolic demands. The aim of inotrope therapy is to minimise adverse impact of cardiovascular compromise. Current use of inotropes is primarily guided by the pathophysiology of cardiovascular compromise and anticipated actions of inotropes. Lack of significant reduction in morbidity and mortal ity associated with cardiovascular compromise despite inotrope use, highlights major gaps in our understanding of circulatory targets, thresholds and choices of inotrope therapy. Thus far, prevention of cardiovascular compromise remains the most effective strategy to...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Nilkant Phad, Koert de Waal Source Type: research

Intervention and Outcome for Neonatal Hypotension
Many observational studies have shown that infants with blood pressures (BPs) that are in the lower range for their gestational age tend to have increased complications such as an increased rate of significant intraventricular hemorrhage and adverse long-term outcome. This relationship does not prove causation nor should it create an indication for treatment. However, many continue to intervene with medication for low BP on the assumption that an increase in BP will result in improved outcome. Only adequately powered prospective randomized controlled trials can answer the question of whether individual treatments of low BP...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Keith Barrington, Afif El-Khuffash, Eugene Dempsey Source Type: research

Hypothermia and Cardiovascular Instability
Severely asphyxiated neonates have acute heart failure as part of their multiorgan dysfunction syndrome during the first days of life. Supporting the cardiovascular system during this phase is part of contemporary treatment and regarded as vital for limiting the neurodevelopmental injury. The decision to treat cardiovascular instability should be based on evaluation of end-organ function. Neonatologist-performed echocardiography in combination with other diagnostic modalities enables comprehensive real-time assessment. This review discusses associations between hemodynamics and adverse outcome, modalities for evaluating th...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Eirik Nestaas, Brian H. Walsh Source Type: research

Clinical Trials in Hemodynamic Support
This article reviews the current literature on this topic in the preterm population and outlines the challenges that have been encountered in performing such trials. Alternative studies are proposed, based on the lessons learned over the past number of years. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Eugene Dempsey, Afif EL-Khuffash Source Type: research

Hemodynamic Complications in Pregnancy
This article discusses placental development and how abnormalities in the process of vascular remodeling contribute to the multisystem maternal and fetal disease that is preeclampsia and fetal growth restriction. We review some of the consequences of this condition on the mother and fetus, aspects of the clinical management of preeclampsia and how it can influence both mother and infant in the postnatal period and beyond. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Anne Doherty, Kelsey McLaughlin, John C. Kingdom Source Type: research

Corticosteroids for Neonatal Hypotension
This article focuses on the role of adrenal insufficiency in causing refractory hypotension in preterm and term infants, the different options of corticosteroids available, and their risk/benefit profiles. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Neha Kumbhat, Shahab Noori Source Type: research

Extracorproeal Membrane Oxygenation for Hemodynamic Support
Extracorporeal membrane oxygenation was first successfully achieved in 1975 in a neonate with meconium aspiration. Neonatal extracorporeal membrane oxygenation has expanded to include hemodynamic support in cardiovascular collapse before and after cardiac surgery, medical heart disease, and rescue therapy for cardiac arrest. Advances in pump technology, circuit biocompatibility, and oxygenators efficiency have allowed extracorporeal membrane oxygenation to support neonates with increasingly complex pathophysiology. Contraindications include extreme prematurity, extremely low birth weight, lethal chromosomal abnormalities, ...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Tobias Straube, Ira M. Cheifetz, Kimberly W. Jackson Source Type: research

Advances in Cardiovascular Care in Neonates: Challenging Current Concepts
The management of the hemodynamic status of critically unwell neonates has gained considerable interest over the last 5 to 10 years. Despite this, we appear to have made little progress in improving our clinical management of hemodynamic compromise in this vulnerable population. Our overreliance on blood pressure measurements and regimented treatment protocols is partly responsible for the lack of progress in this field. The increasing realization of the underlying complexity underpinning adequate cellular metabolism has been a catalyst for further research into a variety of different tools aimed at improved diagnosis, mon...
Source: Clinics in Perinatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Afif EL-Khuffash, Eugene Dempsey Tags: Preface Source Type: research

Advanced Hemodynamic Monitoring in the Neonatal Intensive Care Unit
Clinical assessment of cardiac output by interpretation of indirect parameters has proven to be inaccurate, irrespective of the level of experience of the clinician. Objective cardiac output monitoring is feasible in newborn infants in intensive care. The most promising methods include transthoracic echocardiography, transcutaneous Doppler, electrical biosensing technologies, transpulmonary ultrasound dilution, and arterial pulse contour analysis. Simultaneous assessment of blood pressure and cardiac output enables the identification of the earliest stage of shock. Comprehensive hemodynamic monitoring is pivotal for an ind...
Source: Clinics in Perinatology - June 26, 2020 Category: Perinatology & Neonatology Authors: Willem-Pieter de Boode Source Type: research

The Future of Cardiac Ultrasound in the Neonatal Intensive Care Unit
This article focuses on likely future progress in training, accreditation, digital connectivity, miniaturization, and modality development. Many documents have been published internationally to guide cardiac ultrasound training, accreditation, and implementation in the NICU, but challenges remain in providing assessments of hemodynamic status without risking missed structural diagnoses. Advances in simulation training and digital connectivity provide an opportunity to standardize approaches across institutions and continents. Development of machine learning and ultrasound modalities in turn provide huge scope for improving...
Source: Clinics in Perinatology - June 24, 2020 Category: Perinatology & Neonatology Authors: Alan Groves Source Type: research

Patent Ductus Arteriosus —Time for a Definitive Trial
More than 70 randomized controlled trials have been conducted on the management of patent ductus arteriosus (PDA) in preterm infants. Yet, clinicians are unsure if treating a PDA improves clinically important outcomes. Earlier clinical trials have primarily explored which pharmacotherapeutic agent effectively closes the PDA. Because many of these trials included older infants, had widely varying PDA definitions, and provided open-label treatment, it is difficult to draw inferences on clinical outcomes based on the results of these trials. These flaws in trial design might have contributed to the growing notion that “...
Source: Clinics in Perinatology - June 24, 2020 Category: Perinatology & Neonatology Authors: Souvik Mitra, Patrick J. McNamara Source Type: research

The Newborn Heart and Circulation
In a 1959 article exploring the physiology of newborn transition, Dr G.S. Dawes1 pointed to striking differences between the newborn and adult cardiac responses to challenges and made a fervent appeal that the cardiovascular function of the newborn should not be taken for granted just because it appears to be more resilient. “The task with which the cardiovascular system of a newborn creature is faced is not the same, quantitatively, as that in an adult. Distinct differences include the ability to survive in the total absence of oxygen….in the presence of anoxia from which any adult would rapidly succumb.&rdqu...
Source: Clinics in Perinatology - June 19, 2020 Category: Perinatology & Neonatology Authors: Lucky Jain Tags: Foreword Source Type: research

Neonatal Gastroenterology: Challenges, Controversies, and Recent Advances
CLINICS IN PERINATOLOGY (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 21, 2020 Category: Perinatology & Neonatology Authors: Sudarshan R. Jadcherla Source Type: research

Forthcoming Issues
Advances in Cardiovascular Issues (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 21, 2020 Category: Perinatology & Neonatology Source Type: research

Why Our Gastrointestinal Tract Is So Important
It is hard to overstate the importance of our gut and the multiple physiologic functions it manages, particularly in the neonatal period. In fact, long-term outcomes are directly connected to optimal nutrition and gut function in the first few years after birth.1 In a Foreword written several years ago, I had quoted Anthelme Brillat-Savarin ’s words of wisdom from nearly 300 years ago, “Tell me what you eat and I will tell you what you are.”2 Science continues to validate the truth and science behind this statement with an open challenge to us all: “If we are what we eat, then our babies are what we...
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Authors: Lucky Jain Tags: Foreword Source Type: research

Neonatalgastroenterology: Challenges, Controversies, and Recent Advances
CLINICS IN PERINATOLOGY (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Authors: Sudarshan R. Jadcherla Source Type: research

Copyright
ELSEVIER (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Source Type: research

Contributors
LUCKY JAIN, MD, MBA (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Source Type: research

Contents
Lucky Jain (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Source Type: research

Clinics In Perinatology
Advances in Cardiovascular Issues (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 19, 2020 Category: Perinatology & Neonatology Source Type: research

CME Accreditation Page
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - April 25, 2020 Category: Perinatology & Neonatology Source Type: research

Physiological Basis of Neonatal Aerodigestive Difficulties in Chronic Lung Disease
In the United States, preterm birth rates have steadily increased since 2014. Despite the recent advances in neonatal-perinatal care, more than 40% of very low-birth-weight infants develop chronic lung disease (CLD) and almost 25% have feeding difficulties resulting in delayed achievement of full oral feeds and longer hospital stay. Establishment of full oral feeds, a major challenge for preterm infants, becomes magnified among those on respiratory support and/or with CLD. The strategies to minimize aerodigestive disorders include supporting nonnutritive sucking, developing infant-directed feeding protocols, sensory oromot...
Source: Clinics in Perinatology - April 24, 2020 Category: Perinatology & Neonatology Authors: Shabih U. Hasan, Abhay K. Lodha, Kamran Yusuf, Stacey Dalgleish Source Type: research

Neonatal Gastroenterology: Challenges, Controversies, and Recent Advances
Neonatal research has clearly shown that diagnostic precision and rational management of neonatal feeding and gastroenterologic issues improve long-term growth and development of neonatal intensive care unit (NICU) survivors. The application of technological advances has and will continue to improve survival rates among neonates, albeit with the consequences of prolonged hospitalization, chronic morbidities, parental stress, and increased health care burden. A major determinant of long-term morbidity and function in infants is their aerodigestive quality of life, which defines the overall quality of life not only in these ...
Source: Clinics in Perinatology - April 24, 2020 Category: Perinatology & Neonatology Authors: Sudarshan R. Jadcherla Tags: Preface Source Type: research

Cholestasis in the Premature Infant
This articles discusses how prematurity affects the liver, how it responds to secondary insults, and approaches to evaluation. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - April 16, 2020 Category: Perinatology & Neonatology Authors: Carol Jean Potter Source Type: research

Gut Injury and the Microbiome in Neonates
The causes of neonatal gut injury are multifactorial and include ischemia, tissue hypoxia due to anemia, excessive inflammation, deficiency of growth factors, and food protein sensitivity. The developing intestinal microbiome plays a role in some of these forms of intestinal injury but knowledge of its relative role in each remains poorly understood. Commensal bacteria are required for normal immune development and immune tolerance. Dysbiosis in the neonatal gut that alters the patterns of commensal and pathogenic bacteria may accentuate gut injury. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - April 11, 2020 Category: Perinatology & Neonatology Authors: Mohan Pammi, Emily Hollister, Josef Neu Source Type: research

Gastrointestinal Endoscopy in the Neonate
Gastrointestinal endoscopy permits direct observation of the alimentary tract, acquisition of mucosal tissue for histopathologic examination, and other diagnostic and therapeutic maneuvers. Endoscopes of appropriate size for many neonates and an expanding array of compatible tools and accessories have broadened what is possible, although few neonatal data exist to guide use. Evaluation and treatment of gastrointestinal bleeding, evaluation and dilation of fibromuscular congenital esophageal stenosis, and the bedside placement of gastrostomy tube have been described. Careful consideration of risks, benefits, and discussions...
Source: Clinics in Perinatology - April 11, 2020 Category: Perinatology & Neonatology Authors: Ethan A. Mezoff, Kent C. Williams, Steven H. Erdman Source Type: research

Recent Advances in Necrotizing Enterocolitis Research
This article reviews the latest research strategies that are currently ongoing for early diagnosis and monitoring and prevention of the disease. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - April 9, 2020 Category: Perinatology & Neonatology Authors: Mohan Pammi, Isabelle G. De Plaen, Akhil Maheshwari Source Type: research

Congenital Diarrheal Diseases
Early diagnosis of diarrhea is critical to prevent disease progression. Diarrhea in newborns can be congenital or acquired; acquired diarrheas are the major cause in infants. Congenital diarrheal diseases are rare and include defects in digestion, absorption, and transport of nutrients, and electrolytes; disorders of enterocyte differentiation and polarization; defects of enteroendocrine cell differentiation; dysregulation of the intestinal immune response; and dysfunction of the immune system. This review discusses the clinical approach that may help in early identification and management of different congenital diarrheal...
Source: Clinics in Perinatology - April 8, 2020 Category: Perinatology & Neonatology Authors: Mira Younis, Radhika Rastogi, Ankur Chugh, Shantanu Rastogi, Hany Aly Source Type: research

Intestinal Failure
Pediatric intestinal failure occurs when gut function is insufficient to meet the nutrient and hydration needs of the growing child. The commonest cause is short bowel syndrome with maldigestion and malabsorption following massive bowel loss. The remnant bowel adapts during the process of intestinal rehabilitation. Management promotes the achievement of enteral autonomy while mitigating the risk of comorbid disease. The future of care is likely to see expansion of pharmacologic methods for augmenting bowel adaptation, tissue engineering techniques enabling immune suppression –free autologous bowel transplant, and the...
Source: Clinics in Perinatology - April 8, 2020 Category: Perinatology & Neonatology Authors: Ethan A. Mezoff, Peter C. Minneci, Molly C. Dienhart Source Type: research

Human Milk Supplements
Human milk is the most optimal source of nutrition for preterm and term infants. However, in most preterm infants, breast milk fails to meet the energy needs of the newborn infant. Overwhelming evidence supports the fortification of breast milk in preterm infants to facilitate better short-term outcomes. Several single-nutrient and multinutrient breast milk supplements and fortifiers are used to improve the macronutrient and micronutrient content of breast milk. An individualized fortification strategy has the potential to offer better results compared with standard fortification strategies. Human milk –derived forti...
Source: Clinics in Perinatology - March 30, 2020 Category: Perinatology & Neonatology Authors: Muralidhar H. Premkumar, Leonor Adriana Massieu, Diane M. Anderson, Ganga Gokulakrishnan Source Type: research

Transfusion-related Gut Injury and Necrotizing Enterocolitis
This article summarizes recent data on NEC following red blood cell (RBC) transfusion, with a focus on the most recent literature and ongoing trials. It highlights potential mechanisms from preclinical and human physiologic studies. It also discusses the role of feeding during RBC transfusion and the risk of NEC. Ongoing randomized trials will provide important data on how liberal or conservative approaches to RBC transfusion influence the risk of NEC. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 30, 2020 Category: Perinatology & Neonatology Authors: Allison Thomas Rose, Vivek Saroha, Ravi Mangal Patel Source Type: research

Gastroesophageal Reflux Disease in the Neonatal Intensive Care Unit Neonate
Gastroesophageal reflux (GER) is considered physiologic and is a normal process; whereas, when aerodigestive consequences are associated, it is often interpreted as GER disease (GERD). However, the distinction between them remains a challenge in infants in the NICU. Reflux-type of symptoms are heterogeneous, and often managed with changes in diet, feeding methods, and acid-suppressive therapy; all these empiric therapies lack objectivity; hence, practice variation is universal. We clarify the current controversies, explain the potential role of GERD in causing symptoms and complications, and highlight current advances. The...
Source: Clinics in Perinatology - March 28, 2020 Category: Perinatology & Neonatology Authors: Kathryn A. Hasenstab, Sudarshan R. Jadcherla Source Type: research

Feeding and Swallowing Difficulties in Neonates
Development of enteral and oral feeding milestones in infants is intricately linked to physiologic maturation of the gastrointestinal tract and its complex interplay with cardiorespiratory and central nervous system control and coordination. Assessment of an infant ’s developmental skills and maturation can guide us with targeted management approaches and prediction of feeding outcomes. In this article, we review and summarize the developmental aspects of oral feeding and swallowing physiology, and current understanding of the pathophysiological changes asso ciated with feeding difficulties in infants. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 28, 2020 Category: Perinatology & Neonatology Authors: Sreekanth Viswanathan, Sudarshan Jadcherla Source Type: research

Approach to Feeding Difficulties in Neonates and Infants
This article clarifies current controversies, explains the potential role of safe feeding and physiologic and pathophysiologic perspectives, and highlights current advances in the field. Evidence basis for diagnostic strategies is discussed, and involves evaluation for structure and function tests, and nutrition and feeding assessment. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 28, 2020 Category: Perinatology & Neonatology Authors: Ish K. Gulati, Zakia Sultana, Sudarshan R. Jadcherla Source Type: research

Neonatal Aerodigestive Disorders
Aerodigestive disorders, those affecting the upper and lower airway or upper gastrointestinal tract, are interrelated anatomically during fetal development and functionally after birth. Successful respiration and feeding requires careful coordination to promote effective swallowing and prevent aspiration. I describe the epidemiology, including the prevalence of the most common aerodigestive disorders. The ability of an infant to feed by mouth at discharge, without a surgically placed feeding tube, is an important neurodevelopmental marker. Therefore, aerodigestive disorders have a high potential for lifelong morbidities an...
Source: Clinics in Perinatology - March 27, 2020 Category: Perinatology & Neonatology Authors: Jonathan L. Slaughter Source Type: research

Erratum
An error was made in the December 2019 issue (Volume 46, Issue 4, December 2019, Pages 709-30) Clinics in Perinatology issue. In the article “Nonpharmacological Management of Pain During Common Needle Puncture Procedures in Infants: Current Research Evidence and Practical Considerations: An Update,” the author listing Marsha Campbell Yeo RN, PhD, NNP-BC should be listed as Marsha Campbell-Yeo RN, PhD, NNP-BC. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Source Type: research

Finding a Needle in a Haystack Can be Challenging
The idiom “looking for a needle in a haystack” is often used to denote something exceptionally challenging to find. It is based on the idea that a sewing needle in a pile of dry grass would be hard to find. Indeed, such is the case with many rare diseases which display considerable phenotypic and geograph ical heterogeneity even when traced back to their genetic origin. Collectively, diseases affecting fewer than 1 in 2000 individuals are referred to as rare diseases. It is estimated that up to 300 million people worldwide are afflicted with a rare disease and 80% of these have a genetic origin. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Authors: Lucky Jain Tags: Foreword Source Type: research

Undiagnosed and Rare Diseases
CLINICS IN PERINATOLOGY (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Authors: Brett J. Bordini, Robert M. Kliegman Source Type: research

Copyright
ELSEVIER (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Source Type: research

Contributors
LUCKY JAIN, MD, MBA (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Source Type: research

Contents
Erratumxv (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Source Type: research

Forthcoming Issues
Neonatal Gastroenterology: Challenges, Controversies, and Recent Advances (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - January 28, 2020 Category: Perinatology & Neonatology Source Type: research

Undiagnosed and Rare Diseases in Perinatal Medicine: Uncommon Manifestations or Mimics of Neonatal Disorders
The first two decades of the twenty-first century have witnessed remarkable advances in perinatal outcomes, with increasingly sophisticated diagnostic modalities allowing for improved detection of congenital disorders, and breakthroughs in medical and surgical therapies allowing for impressive reductions in mortality and morbidity for both congenital and acquired conditions.1 Despite these advances, congenital disorders continue to be the leading cause of infant mortality in the United States, and diagnosis remains challenging: the spectrum of congenital disorders is broader in perinatal medicine, and yet, phenotypic varia...
Source: Clinics in Perinatology - January 5, 2020 Category: Perinatology & Neonatology Authors: Brett J. Bordini, Robert M. Kliegman Tags: Preface Source Type: research

CME Accreditation Page
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - December 26, 2019 Category: Perinatology & Neonatology Source Type: research