Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome
Conclusions:
Although further studies are needed, the present data supports the concept that orally administrated FSH could attenuate some of the characteristic of PCOS in the mouse model. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 6, 2015 Category: Cancer & Oncology Authors: Irene TessaroSilvia ModinaFederica FranciosiGiulia SivelliLaura TerzaghiValentina LoddeAlberto Luciano Source Type: research
Mitotically active cellular fibroma of the ovary: a case report and literature review
Conclusion:
MACF of the ovary is a newly defined category and few cases have been reported, while prognostic factors have also not yet been fully characterized. Long-term clinical follow-up is necessary. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 6, 2015 Category: Cancer & Oncology Authors: Takashi YamadaKimiaki HattoriHidetoshi SatomiYoshinobu HiroseGo NakaiAtsushi DaimonAtsushi HayashiYoshito TeraiMasahide OhmichiMasaharu Fukunaga Source Type: research
Can steroidal ovarian suppression during the luteal phase after oocyte retrieval reduce the risk of severe OHSS?
Conclusions:
Our findings indicate that steroidal ovarian suppression in luteal phase after oocyte retrieval seems to be unable to prevent severe OHSS in high-risk patients with embryo cryopreservation. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 23, 2015 Category: Cancer & Oncology Authors: Ya-Qin WangJin LuoWang-Min XuQin-Zhen XieWen-Jie YanGeng-Xiang WuJin Yang Source Type: research
Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model
Conclusions:
Poor clinical performance of novel chemotherapeutics might reflect inappropriate preclinical models. Here we present an ovarian i.p. model that recapitulates the histopathological and chemoresistant features of the clinical disease. In addition, we demonstrate that the novel cisplatin-delivery system, cisplatin@CB[7] may have utility in the treatment of drug-resistant ovarian human cancers. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 18, 2015 Category: Cancer & Oncology Authors: Natividad Gomez-RomanFiona McGregorNial WheateJane Plumb Source Type: research
MRI for discriminating metastatic ovarian tumors from primary epithelial ovarian cancers
Conclusions:
Significant differences between metastatic ovarian tumors and primary epithelial ovarian cancers were found in the median age of patients, laterality, the maximum diameter of lesions, uniformity of locules, enhancement patterns of solid portions and biomarkers. Metastatic ovarian tumors usually presented in the younger patients, smaller-sized, more bilateral lesions, more uniform of locules, more moderate enhancement of solid portions, and less elevated levels of CA125 and HE4 than those of primary epithelial ovarian cancers. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 28, 2015 Category: Cancer & Oncology Authors: Yanhong XuJia YangZaixian ZhangGuixiang Zhang Source Type: research
Lentivirus-mediated shRNA interference of clusterin blocks proliferation, motility, invasion and cell cycle in the ovarian cancer cells
Conclusions:
The expression of clusterin is significantly correlated with the biological characteristics of ovarian cancer cells, it may be a potential molecular for ovarian cancer treatment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 21, 2015 Category: Cancer & Oncology Authors: Yanxia FuYingrong LaiJunfeng LiuXingyang LiuZeshan YouGuofen Yang Source Type: research
Triggering final follicular maturation- hCG, GnRH-agonist or both, when and to whom?
Controlled ovarian hyperstimulation (COH) which combines GnRH antagonist co-treatment and GnRH-agonist (GnRHa) trigger has become a common tool aiming to eliminate severe early OHSS and to support the concept of an OHSS-free clinic. However, due to the reported significantly reduced clinical, efforts have been made to improve reproductive outcome. One of the suggested optional strategies aiming to improve outcome was the addition of low-dose (1500 IU) HCG bolus, administered, concomitant, 35 h or 5 days after the triggering bolus of GnRHa. All these regimens were demonstrated to rescue the luteal phase, resulting in imp...
Source: Journal of Ovarian Research - August 21, 2015 Category: Cancer & Oncology Authors: Raoul Orvieto Source Type: research
Intratumoral interleukin-6 predicts ascites formation in patients with epithelial ovarian cancer: A potential tool for close monitoring
Background:
The implication of IL-6 in the pathogenesis of epithelial ovarian cancer (EOC) is well documented. Accordingly, the clinicopathological significance of this cytokine in patients’ ascites fluid or serum has largely been investigated. Since the main source of IL-6 secreted into the biological fluids is the tumor tissue, this study was designed to investigate the status and possible clinical relevance of the IL-6 expression in an array of EOC tissue specimens.
Methods:
Tissue samples obtained from ninety-eight consecutive patients with EOC were studied using immunohistochemistry. Clinicopathological characterist...
Source: Journal of Ovarian Research - August 19, 2015 Category: Cancer & Oncology Authors: Samar Masoumi-MoghaddamAfshin AminiAi-Qun WeiGregory RobertsonDavid Morris Source Type: research
MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer
Conclusions:
These data suggested that miR-200c and miR-31 may play roles in the SEOC metastasis biology and could be considered as promising targets for therapeutic purposes. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 12, 2015 Category: Cancer & Oncology Authors: Fateen IbrahimRahman JamalSaiful SyafruddinNurul Ab MutalibSazuita SaidinReena MdZinMohammad Hossain MollahNorfilza Mokhtar Source Type: research
Perspective in infertility: the ovarian stem cells
Infertility is a medical and social condition that affects millions of women worldwide and is today considered so far as a new disease. A considerable progress has been recently pursued in the field of the reproductive medicine and the infertility treatment may account for novel and modern procedures such as in vitro oocyte fertilization, egg donation, pregnancy surrogacy and preimplantation diagnosis. However, great interest has lately been reserved to the ovarian stem cells (OSCs) whose existence in woman ovaries has been proven. OSCs are thus suitable for developmental studies in infertility and in other clinical applic...
Source: Journal of Ovarian Research - August 7, 2015 Category: Cancer & Oncology Authors: Erica SilvestrisStella D¿OronzoPaola CafforioGiuseppe D¿AmatoGiuseppe Loverro Source Type: research
The prognostic significance of anti-angiogenesis therapy in ovarian cancer: a meta-analysis
In this study, we assessed the effects of anti-angiogenesis therapy on the progression free survival (PFS) and overall survival (OS) of ovarian cancer patients.Materials and methodsPubMed was searched to identify relevant studies that evaluated the therapeutic value of anti-angiogenic agents in ovarian cancer (the final search was current to Dec. 13th 2014). Reviews of each study were conducted, and the data were extracted. The primary outcomes that were analysed were progression free survival (PFS) and overall survival (OS). The pooled hazard ratio (HR) and 95 % confidence intervals (CIs) were calculated using the random...
Source: Journal of Ovarian Research - August 6, 2015 Category: Cancer & Oncology Authors: Jun LiShufen LiRuifang ChenHailin YuXin Lu Source Type: research
Leptin, its receptor and aromatase expression in deep infiltrating endometriosis
In this study, the leptin levels in the serum and peritoneal fluid (PF) were evaluated by ELISA. The protein expression of leptin and its receptors (ObR) and aromatase enzyme were evaluated by Western blot analysis of the intestine, uterosacral ligament and vaginal septum in the ectopic implants. The t-test and one-way ANOVA with Holm-Sìdak post-test were used, and p (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 5, 2015 Category: Cancer & Oncology Authors: Helder GonçalvesCarolina ZendronFernanda CavalcanteVerônica AicelesMarco OliveiraJorge ManaiaMárcio BabinskiCristiane Ramos Source Type: research
Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro
Conclusions:
Taken together, these data demonstrate that despite its sustained expression, Beclin-1 is dispensable for autophagy induction in ovarian tumor cells in vitro, yet may be retained to promote cell viability by a mechanism independent of autophagy or apoptosis regulation. Overall, this work makes novel observations about tumor expression of Beclin-1 and challenges the accepted understanding of its role in regulating autophagy in ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 4, 2015 Category: Cancer & Oncology Authors: Rohann CorreaYudith ValdesTrevor ShepherdGabriel DiMattia Source Type: research
MicroRNAs in ovarian function and disorders
MicroRNAs (miRNAs) are endogenous, small, noncoding single-stranded RNA molecules approximately 22 nucleotides in length. miRNAs are involved in the post-transcriptional regulation of various important cellular physiological and pathological processes, including cell proliferation, differentiation, apoptosis, and hormone biosynthesis and secretion. Ovarian follicles are the key functional units of female reproduction, and the development of these follicles is a complex and precise process accompanied by oocyte maturation as well as surrounding granulosa cell proliferation and differentiation. Numerous miRNAs expressed in t...
Source: Journal of Ovarian Research - August 1, 2015 Category: Cancer & Oncology Authors: Ying LiYing FangYing LiuXiaokui Yang Source Type: research
Retinoic acid has the potential to suppress endometriosis development
Conclusions:
Retinoic acid has the potential to suppress endometriosis development. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 31, 2015 Category: Cancer & Oncology Authors: Yoshiaki YamagataEiichi TakakiMasahiro ShinagawaMaki OkadaKosuke JozakiLifa LeeShun SatoRyo MaekawaToshiaki TaketaniHiromi AsadaHiroshi TamuraAkira NakaiNorihiro Sugino Source Type: research
