A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice

Adult guidelines recommend BEP (bleomycin, etoposide, cisplatin) for all ovarian germ cell tumours, causing debilitating toxicities in young patients who will survive long term. Paediatricians successfully reduce toxicities by using lower bleomycin doses and substituting carboplatin for cisplatin, while testicular and paediatric immature teratomas (ITs) are safely managed with surgery alone.

Source: European Journal of Cancer - April 3, 2019 Category: Cancer & Oncology Authors: C. Newton, K. Murali, A. Ahmad, H. Hockings, R. Graham, V. Liberale, S.-J. Sarker, J. Ledermann, D.M. Berney, J. Shamash, S. Banerjee, S. Stoneham, M. Lockley Tags: Original Research Source Type: research