Haemorrhagic Fever With Renal Syndrome (HFRS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Implications of frailty in acute ischemic stroke receiving endovascular treatment: systematic review and meta-analysis
CONCLUSION: Pre-stroke frailty is an important predictor of poor prognosis assessed by EVT and can be added to the classical predictors of stroke outcome. Routine assessment of pre-stroke frailty can help patients to make decisions about the efficacy of their choice of EVT.PMID:36964867 | DOI:10.1007/s40520-023-02383-1 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 25, 2023 Category: Geriatrics Authors: QiangJi Bao XiaoDong Huang XinTing Wu ShuJun Chen JinCai Yang JingNi Zhang Jing Li MingFei Yang Source Type: research

Risk of lymphoid malignancies increased after Puumala virus infection in Finland, 2009-2019: a retrospective register-based cohort study
CONCLUSIONS: PUUV infection is associated with lymphoid malignancies in the Finnish population, supporting the earlier studies. Further research is required to understand the pathophysiological mechanisms behind this association.PMID:36948450 | DOI:10.1016/j.ijid.2023.03.026 (Source: Cancer Control)
Source: Cancer Control - March 22, 2023 Category: Cancer & Oncology Authors: Sohvi K ääriäinen Jukka Ollgren Timothee Dub Outi Laine Marjatta Sinisalo Jussi Hepojoki Tomas Strandin Eliisa Kek äläinen Jussi Sane Outi Lyytik äinen Source Type: research

Viruses, Vol. 15, Pages 805: Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome
i Jukka Mustonen The clinical outcome of Puumala hantavirus (PUUV) infection shows extensive variation, ranging from inapparent subclinical infection (70&ndash;80%) to severe hemorrhagic fever with renal syndrome (HFRS), with about 0.1% of cases being fatal. Most hospitalized patients experience acute kidney injury (AKI), histologically known as acute hemorrhagic tubulointerstitial nephritis. Why this variation? There is no evidence that there would be more virulent and less virulent variants infecting humans, although this has not been extensively studied. Individuals with the human leukocyte antigen (HLA) a...
Source: Viruses - March 22, 2023 Category: Virology Authors: Antti Vaheri Teemu Smura Hanna Vauhkonen Jussi Hepojoki Tarja Sironen Tomas Strandin Johanna Tiet äväinen Tuula Outinen Satu M äkelä Ilkka P örsti Jukka Mustonen Tags: Opinion Source Type: research

Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden
Conclusions and implicationsThe overall health progression of re-hospitalized geriatric Covid-19 survivors did not differ dramatically from other re-hospitalized geriatric patients with similar age, sex and health at baseline. Our results emphasize that Covid-19 was especially detrimental for geriatric patients in the acute-phase, but not in the later phase. Further studies including post-vaccination samples are needed. (Source: PLoS One)
Source: PLoS One - March 22, 2023 Category: Biomedical Science Authors: Laura Kananen Source Type: research

Association of frailty with healthcare resource utilization after open thoracic/thoracolumbar posterior spinal fusion for adult spinal deformity
ConclusionOur study identified HFRS to be significantly associated with prolonged hospitalizations and non-routine discharge. Other factors that were found to be associated with increased healthcare resource utilization include age, Hispanic race, West hospital region, large hospital size, and increasing number of AEs. (Source: European Spine Journal)
Source: European Spine Journal - March 22, 2023 Category: Orthopaedics Source Type: research

Hearing Impairment and Incident Frailty in Later Life: The Health in Men Study (HIMS)
ConclusionsHearing loss is not associated with incident frailty in men aged 70 years or older when frailty was measured by HFRS. However, this statistically non-significant result could be due to the low sensitivity of study measures. Also, we found a trend that men with hearing loss were more likely to develop frailty compared with their normal-hearing peers, suggesting a potential association between hearing loss and frailty. (Source: The Journal of Nutrition, Health and Aging)
Source: The Journal of Nutrition, Health and Aging - March 20, 2023 Category: Nutrition Source Type: research

Risk of lymphoid malignancies increased after Puumala virus infection in Finland, 2009-2019: a retrospective register-based cohort study
Puumala virus (PUUV) is a hantavirus causing haemorrhagic fever with renal syndrome. Studies showing an increased risk of lymphoid malignancies following hantavirus infection, together with the observation that PUUV infects B cells motivated us to study the risk of lymphoid malignancies following PUUV infection. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 20, 2023 Category: Infectious Diseases Authors: Sohvi K ääriäinen, Jukka Ollgren, Timothee Dub, Outi Laine, Marjatta Sinisalo, Jussi Hepojoki, Tomas Strandin, Eliisa Kekäläinen, Jussi Sane, Outi Lyytikäinen Source Type: research

Pseudotyped Viruses for Orthohantavirus
Adv Exp Med Biol. 2023;1407:229-252. doi: 10.1007/978-981-99-0113-5_12.ABSTRACTOrthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathogens carried by small mammals including rodents, moles, shrews, and bats and are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) among humans. With the characteristics of low biological risk but strong operability, a variety of pseudotyped viruses have been constructed as ...
Source: Advances in Experimental Medicine and Biology - March 15, 2023 Category: Research Authors: Tingting Ning Weijin Huang Li Min Yi Yang Si Liu Junxuan Xu Nan Zhang Si-An Xie Shengtao Zhu Youchun Wang Source Type: research

Development and validation of a combined hypoxia and ferroptosis prognostic signature for breast cancer
ConclusionWe developed a novel prognostic model with hypoxia and ferroptosis-related genes to predict OS, and characterize the immune microenvironment of BC patients, which might provide new cures for clinical decision-making and individual treatment of BC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 14, 2023 Category: Cancer & Oncology Source Type: research

Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis
In this study, when Arabidopsis was exposed to four HFRs (TBBPA, TCBPA, TBBPS-MDHP, TBBPS), the stress of these compounds had different inhibitory effects on seed germination and plant growth. Transcriptome and metabolome analysis showed that all four HFRs could influence the expression of transmembrane transporters to affect ion transport, Phenylpropanoid biosynthesis, Plant-pathogen interaction, MAPK signalling pathway and other pathways. In addition, the effects of different kinds of HFR on plants also have variant characteristics. It is very fascinating that Arabidopsis shows the response of biotic stress after exposur...
Source: Ecotoxicology and Environmental Safety - March 11, 2023 Category: Environmental Health Authors: Lufang Su Dandan Guo Heping Wan Ping Wang Lan Cao Yanmin Long Chaohui Chen Yangyang Song Yonghong Zhang Changli Zeng Rui Guo Xiaoyun Liu Source Type: research

Frailty Is Associated with Increased Complications, Readmissions, and Hospitalization Costs Following Primary Total Knee Arthroplasty
This study investigated the association of the Hospital Frailty Risk Score (HFRS) with postoperative events and hospitalization costs after primary TKA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - February 27, 2023 Category: Orthopaedics Authors: Akshay Lakra, Michael K. Tram, Thomas Bernasek, Steven T. Lyons, Casey M. O ’Connor Tags: 2022 AAHKS Proceedings Source Type: research