Haemorrhagic Fever With Renal Syndrome (HFRS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model
Chemosphere. 2022 Oct 19:136924. doi: 10.1016/j.chemosphere.2022.136924. Online ahead of print.ABSTRACTTetrabromobisphenol A (TBBPA) is widely used in industrial production as a halogenated flame retardant (HFR). Its substitutes and derivatives are also commonly employed as HFRs. Consequently, they can be frequently detected in environmental and human samples. The potential developmental toxicity of TBBPA and its analogs, particularly to the human liver, is still controversial or not thoroughly assessed. Therefore, in this study, we focused on the early stages of human liver development to explore the toxic effects of thos...
Source: Chemosphere - October 22, 2022 Category: Chemistry Authors: Shichang Li Renjun Yang Nuoya Yin Miaomiao Zhao Shuxian Zhang Francesco Faiola Source Type: research

The Hospital Frailty Risk Score (HFRS) applied to primary data: protocol for a systematic review
Introduction Frailty is characterised by vulnerability to adverse health outcomes and increases with age. Many frailty risk scores have been developed. One important example is the Hospital Frailty Risk Score (HFRS) which has the potential to be widely used and automatically calculated which will provide accurate assessment of frailty in a time/cost-effective manner. This systematic review, therefore, seeks to describe the HFRS use since its publication in 2018. Methods and analysis The proposed systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will include...
Source: BMJ Open - October 19, 2022 Category: General Medicine Authors: Alshibani, A., Warner, B., Owen, R. K., Mukherjee, A., Gilbert, T., Conroy, S. Tags: Open access, Geriatric medicine Source Type: research

IJERPH, Vol. 19, Pages 13433: Genetic Evolution Analysis and Host Characteristics of Hantavirus in Yunnan Province, China
In this study, a total of 488 murine-shaped animals were captured in the three regions of Mile City, Mangshi City and Lianghe County in Yunnan Province, and then the type of HV was identified by multiplex real-time RT-PCR and sequenced. The results indicate that 2.46% of the murine-shaped animal specimens were infected with HV. A new subtype of Seoul virus (SEOV) was found in the rare rat species Rattus nitidus in Lianghe County, and the two strains of this new subtype were named YNLH-K40 and YNLH-K53. Through the phylogenetic analysis of this new subtype, it is shown that this new subtype is very similar to the type S5 of...
Source: International Journal of Environmental Research and Public Health - October 18, 2022 Category: Environmental Health Authors: Na Wang Jia-Xiang Yin Yao Zhang Li Wu Wen-Hong Li Yun-Yan Luo Rui Li Zi-Wei Li Shu-Qing Liu Tags: Article Source Type: research

Anti-platelet factor 4/heparin antibodies in patients with Hantaan virus infection
CONCLUSIONS: Hantaan virus infection produces nonpathogenic antibodies against PF4/heparin; however, the generation mechanism of these antibodies requires further study.PMID:36246479 | PMC:PMC9548412 | DOI:10.1002/rth2.12813 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 17, 2022 Category: Hematology Authors: Meng Wang Chun-Mei Zhang Ying Ma Kang Tang Xi-Yue Zhang Xiao-Zhou Jia Hai-Feng Hu Ran Zhuang Bo-Quan Jin Yu-Si Zhang Yun Zhang Source Type: research

Viruses, Vol. 14, Pages 2247: Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome
In this study, KHF4 and KHF5 were compared to evaluate pathological differences in mice in vitro and in vivo. The characteristics of the two glycoproteins were not significantly different in vitro. However, the virulent KHF5 strain targeted the lungs and caused pneumonia and edema in vivo. Both strains induced high infectivity levels in the liver and caused hepatitis; however, petechial hemorrhage and glycogen storage reduction were observed in KHF5-infected mice alone. Renal hemorrhage was observed using viral antigens in the tubular region of KHF5-infected mice. In addition, an increase in white blood cell levels and neu...
Source: Viruses - October 13, 2022 Category: Virology Authors: Zhouoxing Wei Kenta Shimizu Rakiiya S. Sarii Devinda S. Muthusinghe Sithumini M. W. Lokupathirage Junko Nio-Kobayashi Kumiko Yoshimatsu Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2243: Increased CD4+CD8+ Double Positive T Cells during Hantaan Virus Infection
In conclusion, this study identified, for the first time, an accumulation of DP T cells in the peripheral blood of HFRS patients and suggested these DP T cells belonging to CD8+T cells lineage. The DP T cells shared the similar characteristics with cytotoxic T cells (CTL) and exerted an anti-viral role in HFRS. (Source: Viruses)
Source: Viruses - October 13, 2022 Category: Virology Authors: Huiyuan Zhang Yazhen Wang Ying Ma Kang Tang Chunmei Zhang Meng Wang Xiyue Zhang Manling Xue Xiaozhou Jia Haifeng Hu Na Li Ran Zhuang Boquan Jin Lihua Chen Yun Zhang Yusi Zhang Tags: Article Source Type: research

First report of an imported case of haemorrhagic fever with renal syndrome in South Africa
S Afr Med J. 2022 Aug 2;112(8):519-525. doi: 10.7196/SAMJ.2022.v112i8.16540.ABSTRACTHaemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus infection. Hantaviruses are not endemic to South Africa, and we report the first detection of an imported case of HFRS in the country. The case involved a traveller from Croatia who presented to a Johannesburg hospital with an acute febrile illness with renal dysfunction. The patient reported visiting rurally located horse stables in Croatia before falling ill, and that a worker in the stables with similar illness was diagnosed with HFRS. Given the exposure history and cl...
Source: South African Medical Journal - October 10, 2022 Category: African Health Authors: N Moolla D Adler L Blumberg A Glass A Grobbelaar C Le Roux J Paweska J Weyer Source Type: research

Frailty, length of stay and cost in hip fracture patients
ConclusionFrailty is associated with a marked increase in total costs in hip fracture patients. HFRS proved useful in estimating LOS and outcomes for older patients with hip fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - October 5, 2022 Category: Orthopaedics Source Type: research

Response: HFRS in Patients undergoing ACDF for CSM
We greatly appreciate the Letter by Rangel et al. in regard to our published work “Leveraging HFRS to Assess How Frailty Affects Healthcare Resource Utilization after Elective ACDF for CSM”.1 We concur with the authors that there are significant limitations to analyzing an administrative billing national dataset, such as the Nationwide Inpatient Sample (NIS). Additionally, th at while HFRS was validated in older patients in an acute care setting, there may still be potential use of HFRS as risk-assessment tool to identify frailty in adults with CSM. (Source: The Spine Journal)
Source: The Spine Journal - September 30, 2022 Category: Orthopaedics Authors: Aladine A. Elsamadicy, Andrew Koo, Daniel M. Sciubba Tags: Letters to the Editor Source Type: research

Reply to the letter to the editor regarding “HFRS in patients undergoing ACDF for CSM”
We greatly appreciate the Letter by Rangel et al. in regard to our published work “Leveraging HFRS to Assess How Frailty Affects Healthcare Resource Utilization after Elective ACDF for CSM” [1]. We concur with the authors that there are significant limitations to analyzing an administrative billing national dataset, such as the Nationwide Inpatient Sample (NIS). Additionally, that while HFRS was validated in older patients in an acute care setting, there may still be potential use of HFRS as risk-assessment tool to identify frailty in adults with CSM. (Source: The Spine Journal)
Source: The Spine Journal - September 30, 2022 Category: Orthopaedics Authors: Aladine A. Elsamadicy, Andrew B. Koo, Daniel M. Sciubba Tags: Reply to Letter to the Editor Source Type: research

Benefits of heart failure-specific pharmacotherapy in frail hospitalised patients: a cross-sectional study
Conclusion This study found an association between the use of HF-specific pharmacotherapy and improved clinical outcomes in frail HF hospitalised patients when compared to those who were not on treatment. Trial registration number ANZCTRN383195. (Source: BMJ Open)
Source: BMJ Open - September 19, 2022 Category: General Medicine Authors: Sharma, Y., Horwood, C., Hakendorf, P., Thompson, C. Tags: Open access, Cardiovascular medicine Source Type: research

Transplacental transfer of plasticizers and flame retardants in fin whales (Balaenoptera physalus) from the North Atlantic Ocean
In this study we analysed samples of fin whale (Balaenoptera physalus) females and their foetuses collected in the western Iceland summer feeding grounds in 2018. Three different families of organic pollutants: organophosphate esters (OPEs); halogenated flame retardants (HFRs); and short chain chlorinated paraffins (SCCPs), were analysed and their placental transfer investigated. HFRs were detected in 87.5% of females and 100% of foetus samples with concentrations that ranged between nd-15.4 and 6.37-101 ng/g lipid weight (lw), respectively. OPEs were detected in all samples, both from females (85.8-567 ng/g lw) and foetus...
Source: Environmental Pollution - September 17, 2022 Category: Environmental Health Authors: Berta Sala Odei Garcia-Garin Asunci ón Borrell Alex Aguilar G ísli A Víkingsson Ethel Eljarrat Source Type: research

Biotransformation of Dec-604 and potential effect on thyroid deiodinase activity in highly flame retardant-exposed gulls
The objective of this study was to investigate the effect of Dec-604 on type 1 deiodinase (DIO1) in the presence of thyroxine (T4) in an in vitro DIO1 assay using liver microsomes of ring-billed gulls that are highly exposed to HFRs in the Montreal area, and to determine whether DIO1 is involved in the in vitro debromination of Dec-604. We tested the in vitro activity of DIO1 in gull liver microsomes in the presence of five concentrations of Dec-604 ranging from 0.86 to 86.21 nM. HFR concentrations (Σ40HFR) were also determined in liver samples of gulls. Results showed that total DIO1 activity in gull liver microsomes was...
Source: Environmental Research - September 8, 2022 Category: Environmental Health Authors: Madeleine L épine Jonathan Verreault Source Type: research

Adenosine Deaminase is a Potential Molecular Marker for Diagnosis and Prognosis of Haemorrhagic Fever with Renal Syndrome
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 5, 2022 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research