Bone microarchitecture and bone turnover in hepatic cirrhosis
ConclusionsHepatic cirrhosis deteriorates both trabecular and cortical microarchitecture, regardless of disease severity. Areal bone mineral density is diminished at all sites as a sign of generalized affection. In patients with hepatic cirrhosis, regardless of its origin or disease severity, aBMD measurements are an appropriate tool for osteologic screening. (Source: Osteoporosis International)
Source: Osteoporosis International - February 20, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 –Posters Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - February 20, 2019 Category: Orthopaedics Source Type: research

Discovery of potential biomarkers for osteoporosis using LC-MS/MS metabolomic methods
AbstractSummaryOur study focused on the associations of metabolites with BMD and osteoporosis, finding that several metabolites are associated with BMD, and metabolites combined with bone turnover markers tend to be more sensitive in distinguishing osteoporosis in both males and postmenopausal females, which might be meaningful for the early diagnosis of osteoporosis.IntroductionOur study aimed to evaluate the association of metabolites with bone, trying to find new metabolic markers that are distinguishing for low bone mineral density (BMD).MethodsOur study recruited 320 participants, including 138 males and 182 postmenop...
Source: Osteoporosis International - February 18, 2019 Category: Orthopaedics Source Type: research

Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study
AbstractSummaryA retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporosis-related vertebral fractures was performed. Trabecular volumetric bone mineral density was the measurement that best discriminates between fracture and control groups.IntroductionThe aim of the present study was to evaluate the association of DXA-derived 3D measurements at the lumbar spine with osteoporosis-related vertebral fractures.MethodsWe retrospectively analyzed a database of 74 postmenopausal women: 37 subjects with incident vertebral fractures and 37 age-matched controls without any type of f...
Source: Osteoporosis International - February 15, 2019 Category: Orthopaedics Source Type: research

Multiple vertebral fractures as the first manifestation of systemic mastocytosis
AbstractSystemic mastocytosis is a clonal disease of the mast cell progenitors of the bone marrow. The clinical picture varies from asymptomatic (indolent) to highly aggressive (mast cell leukemia). Up to one-third of patients with SM have osteoporosis and fractures. The following is an analysis of the case of a young patient with multiple fractures as the first manifestation of SM. (Source: Osteoporosis International)
Source: Osteoporosis International - February 15, 2019 Category: Orthopaedics Source Type: research

Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients
ConclusionsThere are various protein factors, such as DDX5, PSMC2, CSNK1A1, PLIN1, ILK, and TPM4, differentially expressed in the bone marrow microenvironment of osteoporotic patients, providing new ideas for finding therapeutic targets for osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - February 9, 2019 Category: Orthopaedics Source Type: research

Correction to: Comments on Feskanich et al.: Milk and other dairy foods and risk of hip fracture in men and women
The last sentence of the published letter contains an error. The correct sentence is shown here: “Not mentioning that fermented milk has potential probiotic antioxidant and anti-inflammatory effects, effects on gut microbiota [2], and that the galactose content is 5-32% lower (depending on type and storage time) than that of milk [20, 21] results in a skewed argument. (Source: Osteoporosis International)
Source: Osteoporosis International - February 8, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Oral Communications Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - February 8, 2019 Category: Orthopaedics Source Type: research

All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture
AbstractSummaryIn the first year, after an osteoporotic fracture of a hip, forearm, upper arm, or spine, the dispensing rates of antidepressants and benzodiazepines increased significantly. After those fractures, recent and past use of antidepressants and benzodiazepines was associated with increased all-cause mortality; current use was not associated with mortality risk.IntroductionIt remains unclear to what extent use of antidepressants and benzodiazepines is associated with mortality risk after a major osteoporotic fracture (MOF). We aimed to study the cumulative use of antidepressants and benzodiazepines during the yea...
Source: Osteoporosis International - February 8, 2019 Category: Orthopaedics Source Type: research

Risk of osteoporosis and fracture in victims with burn injury
ConclusionPatients who have a burn injury deserve prevention intervention to reduce the risk of osteoporosis and fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - February 8, 2019 Category: Orthopaedics Source Type: research

The efficacy and safety of menatetrenone in the management of osteoporosis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsMenatetrenone significantly decreases ucOC and might improve lumbar BMD in osteoporotic patients. However, its benefit in fracture risk control is uncertain. (Source: Osteoporosis International)
Source: Osteoporosis International - February 7, 2019 Category: Orthopaedics Source Type: research

The muscle-bone unit in adolescent swimmers
ConclusionsThe contradictory results regarding BMC in swimmers found in previous studies could partly be explained with the findings of the present study that reinforce the idea that swimming is not an effective sport to practice regarding bone mass and that the muscle-bone unit is different in swimmers than in controls. (Source: Osteoporosis International)
Source: Osteoporosis International - February 7, 2019 Category: Orthopaedics Source Type: research

Association of use of Chinese herbal medicines and the risk of fracture in patients with osteoporosis: a population-based cohort study
ConclusionsThe use of CHMs was associated with lower risk of osteoporotic fracture for OS patients, suggesting that it could be integrated into conventional therapy to prevent subsequent bone fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - February 5, 2019 Category: Orthopaedics Source Type: research

The effects of cortisol and adrenal androgen on bone mass in Asians with and without subclinical hypercortisolism
ConclusionSubtle cortisol excess in premenopausal women and reduced DHEA-S in postmenopausal women and men may contribute to BMD reduction in Asians with SH. (Source: Osteoporosis International)
Source: Osteoporosis International - February 4, 2019 Category: Orthopaedics Source Type: research

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture
ConclusionsThese findings provide clinical evidence that n-3 FA is a potential inhibitor of osteoclastogenesis that favors human bone health. (Source: Osteoporosis International)
Source: Osteoporosis International - February 4, 2019 Category: Orthopaedics Source Type: research

The orthogeriatric comanagement improves clinical outcomes of hip fracture in older adults
ConclusionsOlder adults with hip fracture taken in care by the OGC showed better clinical indicators, including time to surgery, length of stay and mortality, than those managed by geriatric consultant service or usual orthopedic care. (Source: Osteoporosis International)
Source: Osteoporosis International - February 4, 2019 Category: Orthopaedics Source Type: research

Effect of benign prostatic hyperplasia on the development of spine, hip, and wrist fractures
ConclusionsPatients with benign prostatic hyperplasia exhibited an increased risk of developing vertebral compression fractures in both the thoracic and lumbar spine and also hip fractures, but did not increase the risk of wrist fracture. However, more research is needed to confirm this trend in the clinical setting. (Source: Osteoporosis International)
Source: Osteoporosis International - January 31, 2019 Category: Orthopaedics Source Type: research

Comparison of hyperparathyroidism types and utility of dual radiopharmaceutical acquisition with Tc99m sestamibi and 123 I for localization of rapid washout parathyroid adenomas
ConclusionPre-operative PTH levels and size of the gland were major determinants of Tc99m-sestamibi positivity on early-phase Tc99m-sestamibi scans, whereas size is an independent predictor of late-phase Tc99m-sestamibi positivity. Subtraction scintigraphy might be a useful tool in suspected cases of rapid washout adenomas/hyperplasia. (Source: Osteoporosis International)
Source: Osteoporosis International - January 31, 2019 Category: Orthopaedics Source Type: research

Cost-effectiveness of gastro-resistant risedronate tablets for the treatment of postmenopausal women with osteoporosis in France
ConclusionThis study provides the first economic results about GR risedronate, suggesting that it represents a cost-effective strategy compared with weekly alendronate and generic risedronate for the treatment of postmenopausal women with osteoporosis in France. (Source: Osteoporosis International)
Source: Osteoporosis International - January 30, 2019 Category: Orthopaedics Source Type: research

Sex differences in osteoporosis self-efficacy among community-residing older adults presenting for DXA
ConclusionThe OSE can be used to measure calcium and exercise self-efficacy in all older adults. However, gender differences in clinical predictors of self-efficacy and the lack of an association of prior DXA with self-efficacy imply that interventions to improve self-efficacy may be insufficient to drive significant improvement in rates of osteoporosis evaluation and treatment.Trial registrationPatient Activation after DXA Result Notification (PAADRN), NCT01507662,https://clinicaltrials.gov/ct2/show/NCT01507662 (Source: Osteoporosis International)
Source: Osteoporosis International - January 30, 2019 Category: Orthopaedics Source Type: research

Inflammatory cytokines IL-6 and TNF- α in patients with hip fracture
ConclusionWe demonstrated an association between IL-6 levels and hip fracture in our study group following the surgery. We also suggest that TNF- α and IL-6 levels are not related to the occurrence of death and walking capability after the surgery. However, these findings need further functional and clinical confirmation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 30, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Committee of National Societies (CNS) Roundtable Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 30, 2019 Category: Orthopaedics Source Type: research

Chronic kidney disease is associated with low BMD at the hip but not at the spine
ConclusionOur results highlighted that low BMD in patients with CKD is associated with age and hyperparathyroidism, and affects predominantly the hip. (Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Plenary Lecture Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Meet-the-Expert Sessions Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia – 2018 – IOF-OA-ANZBMS Joint Session Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Sponsored Symposia Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – Opening ceremony Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 28, 2019 Category: Orthopaedics Source Type: research

Risk of imminent fracture following a previous fracture in a Swedish database study
This study examined the imminent risk of a future fracture within 1 and 2  years following a first fracture in women aged 50 years and older and assessed independent factors associated with risk of subsequent fractures. The study highlights the need to intervene rapidly after a fracture to prevent further fractures.IntroductionThis study aims to determine the imminent risk of subsequent fractures within 1 and 2  years following a first fracture and to assess independent factors associated with subsequent fractures.MethodsRetrospective, observational cohort study of women aged ≥ 50 years with a...
Source: Osteoporosis International - January 24, 2019 Category: Orthopaedics Source Type: research

Intervals between bone mineral density testing with dual-energy X-ray absorptiometry scans in clinical practice
AbstractSummaryIntervals between dual-energy X-ray absorptiometry (DXA) scans were evaluated in a large cohort of typical clinical practice. Intensive DXA scanning (intervals
Source: Osteoporosis International - January 24, 2019 Category: Orthopaedics Source Type: research

Bone turnover markers are differentially affected by pre-analytical handling
ConclusionsFor the bone turnover markers P1NP and BAP, the use of both plasma and serum is recommended. Samples for CTX analysis should be taken as EDTA plasma. Samples for osteocalcin analysis can be taken in either type of plasma or serum, but should be analyzed within 3  h or preserved at − 18 °C. (Source: Osteoporosis International)
Source: Osteoporosis International - January 24, 2019 Category: Orthopaedics Source Type: research

Bisphosphonate-induced orbital inflammation: more common than once thought?
AbstractTo report two cases of bisphosphonate-induced orbital inflammation, discuss the clinic-radiological features and management options, and highlight the increasing frequency of an association previously considered extremely rare. A retrospective review of two cases presenting to our department, and review of the literature reporting this association. Two new cases of bisphosphonate-induced orbital inflammation were added to the literature. The first occurred in the context of a risedronate re-challenge, and the second with zoledronic acid. Both cases were managed successfully with topical steroids. Clinicians prescri...
Source: Osteoporosis International - January 23, 2019 Category: Orthopaedics Source Type: research

Pregnancy-associated osteoporosis: a UK case series and literature review
AbstractMini Abstract: Pregnancy-associated osteoporosis (PAO) is a rare syndrome affecting women during late pregnancy and the early postpartum period. We set out to review the clinical features of ten cases of PAO from a single UK centre. Patients had attended the Royal National Hospital for Rheumatic Diseases, Bath (RNHRD) between January 2000 and June 2016. The principal criterion for inclusion was the occurrence of low trauma fractures either during pregnancy or the immediate post-partum period. Data were obtained from retrospective review of medical notes. Bone mineral density (BMD) was measured using dual-energy X-r...
Source: Osteoporosis International - January 23, 2019 Category: Orthopaedics Source Type: research

Hip fractures in Singapore: ethnic differences and temporal trends in the new millennium
ConclusionAlthough the absolute number of fractures increased, steep drops in elderly Chinese women drove a reduction in overall age-adjusted hip fracture rates. Increases in the older population will lead to a rise in total number of hip fractures, requiring budgetary planning and new preventive strategies. (Source: Osteoporosis International)
Source: Osteoporosis International - January 23, 2019 Category: Orthopaedics Source Type: research

Osteoporotic vertebral deformity with endplate/cortex fracture is associated with higher further vertebral fracture risk: the Ms. OS (Hong Kong) study results
ConclusionVertebrae with grade-1/2 VDs had a higher risk of developing ECF. Subjects with pre-existing ECFs had a higher risk of worsening or new vertebral deformities. (Source: Osteoporosis International)
Source: Osteoporosis International - January 22, 2019 Category: Orthopaedics Source Type: research

Gut microbiota composition and bone mineral loss —epidemiologic evidence from individuals in Wuhan, China
AbstractSummaryWe explored the association between gut microbiota composition and bone mineral loss in Chinese elderly people by high-throughput 16S ribosomal RNA (rRNA) gene sequencing. Compared with controls, a smaller number of operational taxonomic units (OTUs), several taxa with altered abundance, and specific functional pathways were found in individuals with low-bone mineral density (BMD).IntroductionGut microbiota plays important roles in human health and associates with a number of diseases. However, few studies explored its association with bone mineral loss in human.MethodsWe collected 102 fecal samples from eac...
Source: Osteoporosis International - January 21, 2019 Category: Orthopaedics Source Type: research

IOF Regional 7th Asia-Pacific Osteoporosis Conference Sydney, Australia 2018 – IOF-APOA Joint Session Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - January 21, 2019 Category: Orthopaedics Source Type: research

Correction to: Long-term safety and clinical performance of kyphoplasty and SpineJack ® procedures in the treatment of osteoporotic vertebral compression fractures: a pilot, monocentric, investigator-initiated study
The author list was incomplete. The complete list of authors is the following: D. Noriega, F. Rodr ίguez-Monsalve, R. Ramajo, I.Sánchez-Lite, B. Toribio, F. Ardura. The corresponding author regrets sincerely this error. The original article got update. (Source: Osteoporosis International)
Source: Osteoporosis International - January 18, 2019 Category: Orthopaedics Source Type: research

Treatment with zoledronic acid subsequent to odanacatib prevents bone loss in postmenopausal women with osteoporosis
AbstractSummaryTreatment with zoledronic acid 5  mg maintained bone turnover markers in the premenopausal range, increased lumbar spine bone mineral density, and maintained hip bone mineral density in women previously treated with odanacatib 50 mg weekly.IntroductionThe development of odanacatib (ODN), a cathepsin K inhibitor, for treatment of osteoporosis was discontinued due to an increased risk of cardiovascular events. As the treatment is considered reversible, participants from the LOFT trial in Aarhus, Denmark, were offered treatment with zoledronic acid (ZOL).MethodsSixty-seven postmenopausal women were tr...
Source: Osteoporosis International - January 17, 2019 Category: Orthopaedics Source Type: research

Dairy- and supplement-based calcium intake in adulthood and vertebral dimensions in midlife —the Northern Finland Birth Cohort 1966 Study
AbstractSummaryAmong a representative sample of 1064 Northern Finns, we studied the association of dairy- and supplement-based calcium intake in adulthood with vertebral size in midlife. Inadequate calcium intake (
Source: Osteoporosis International - January 17, 2019 Category: Orthopaedics Source Type: research

Changes in middle ear transmission characteristics secondary to altered bone remodelling
ConclusionsThere is a detrimental impact of reduction in bone mineral density on middle ear transmission characteristics which may go unnoticed initially. Treatment of osteoporosis may potentially mitigate hearing loss from middle ear fractures due to reduced bone mineral density. Absence of significant air-bone gap with the presence of reduced middle ear resonance frequency may be early signs of reduced BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

25(OH) vitamin D and functional outcomes in older adults admitted to rehabilitation units: the safari study
AbstractSummaryVitamin D (25(OH)D) deficiency is associated with poor physical performance; little is known about its impact on geriatric rehabilitation. We found a positive non-linear relationship between 25(OH)D and functional gain, stronger in levels
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

Estimates of hip fracture incidence in Japan using the National Health Insurance Claim Database in 2012 –2015
ConclusionsThe age-standardized hip fracture incidence rates indicated no significant change in females and significant increase in males in Japan from 2012 to 2015. (Source: Osteoporosis International)
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

Pre-discharge prognostic factors of physical function among older adults with hip fracture surgery: a systematic review
ConclusionsOur findings highlight potentially modifiable prognostic factors that could be targeted and non-modifiable prognostic factors that could be used to identify patients who may benefit from more intensive intervention or to advise patients on their expectations on recovery. Examining the efficacies of existing interventions targeting these prognostic factors would inform future studies and whether any of such interventions could be incorporated into clinical practice. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2019 Category: Orthopaedics Source Type: research

Which is the best treatment of osteoporotic vertebral compression fractures: balloon kyphoplasty, percutaneous vertebroplasty, or non-surgical treatment? A Bayesian network meta-analysis
ConclusionPVP was the most effective method for improving pain, functional status, and quality of life (based on EQ-5D). BK emerged as the best intervention for decreasing the risk of subsequent vertebral fractures and re-fractures at the treated level. NST could be ranked first in reducing adjacent vertebral fractures. The future directions of OVCFs treatment will depend on the outcomes of additional and larger randomized trials in comparing BK with PVP. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2019 Category: Orthopaedics Source Type: research

Chronic hyponatremia and association with osteoporosis among a large racially/ethnically diverse population
AbstractSummaryChronic hyponatremia may contribute to decreased bone density. We studied 341,003 men and women who underwent DXA testing and observed that individuals with chronic hyponatremia (sodium
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Bone turnover markers to explain changes in lumbar spine BMD with abaloparatide and teriparatide: results from ACTIVE
AbstractSummaryEarly PINP changes correlate with 18-month lumbar spine BMD changes and the correlation was greater with abaloparatide versus teriparatide. The uncoupling index was similar between the two agents.IntroductionWe evaluated the relationship between early PINP changes and subsequent changes in spine BMD following abaloparatide and teriparatide treatments. We also explored the use of an “uncoupling index” (UI), the balance between bone formation and bone resorption, which we hypothesised would be similar in response to these treatment groups.MethodsBlood samples were taken for measurement of bone turn...
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Primary lactase deficiency and bone mineral density in postmenopausal women
(Source: Osteoporosis International)
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Epidemiology of osteonecrosis among older adults in Sweden
ConclusionsOsteonecrosis was approximately 10 times more common than a small number of previous population-based studies have suggested. The strongest risk factors for osteonecrosis were dialysis, hip fracture, osteomyelitis, and solid organ transplantation, but only hip fractures could have contributed substantially to the disease burden. (Source: Osteoporosis International)
Source: Osteoporosis International - January 9, 2019 Category: Orthopaedics Source Type: research

A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk
ConclusionsBisphosphonate discontinuation may be considered for women who do not have low hip BMD after 3 to 5  years of initial treatment, while women who have low hip BMD may benefit from treatment continuation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 8, 2019 Category: Orthopaedics Source Type: research