Post-traumatic stress disorder and incident fractures in the Danish population
ConclusionsOur findings suggest that PTSD is associated with increased fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - October 17, 2018 Category: Orthopaedics Source Type: research

Correction to: Hip fracture trends in the United States, 2002 to 2015
The name of the first author, E.M. Lewiecki, was rendered incorrectly in the original publication. The publisher regrets any inconvenience and is pleased to correct the error here. (Source: Osteoporosis International)
Source: Osteoporosis International - October 17, 2018 Category: Orthopaedics Source Type: research

Correction to: Differences in bone quality and strength between Asian and Caucasian young men
The second name of the ninth author, X.E. Guo, was incorrectly coded as part of his surname. The publisher apologises for the inconvenience caused. (Source: Osteoporosis International)
Source: Osteoporosis International - October 17, 2018 Category: Orthopaedics Source Type: research

European guidance for the diagnosis and management of osteoporosis in postmenopausal women
ConclusionsA platform is provided on which specific guidelines can be developed for national use. (Source: Osteoporosis International)
Source: Osteoporosis International - October 15, 2018 Category: Orthopaedics Source Type: research

Patients with prostate cancer and androgen deprivation therapy have increased risk of fractures —a study from the fractures and fall injuries in the elderly cohort (FRAILCO)
ConclusionsPatients with prostate cancer and ADT is a fragile patient group with substantially increased risk of osteoporotic fractures both compared to patients without prostate cancer and compared to those with prostate cancer without ADT. We believe that this must be taken in consideration in all patients with prostate cancer already at the initiation of ADT. (Source: Osteoporosis International)
Source: Osteoporosis International - October 15, 2018 Category: Orthopaedics Source Type: research

Incidence and risk factors for hip fracture in elderly patients undergoing lumbar spine surgery: a nationwide database study with 11-year follow-up
ConclusionFall prevention for the elderly undergoing lumbar spinal surgery is necessary due to the highly increased hip fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - October 15, 2018 Category: Orthopaedics Source Type: research

Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing spondylitis
ConclusionsSerum HGF was increased in male AS patients and associated with higher mSASSS and lower BMD. In addition, serum HGF was positively associated with risk factors for osteoproliferation such as age, CRP and smoking. HGF could be a potential biomarker of importance for the bone metabolism in AS.Trial registrationNCT00858819. (Source: Osteoporosis International)
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Prediction of incident vertebral fracture using CT-based finite element analysis
ConclusionThis study shows an association between vertebral strength measures and incident vertebral fracture in men and women. Though limited by a small sample size, our findings also suggest that bone strength estimates by CT-based FEA provide equivalent or better ability to predict incident vertebral fracture compared to CT-based aBMD. Our study confirms that CT-based estimates of vertebral strength from FEA are useful for identifying patients who are at high risk for vertebral fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Osteoporosis prevention: where are the barriers to improvement in a French general population? A qualitative study
ConclusionUnderstanding people ’s representation of OP might help to provide patients with relevant information in order to optimize their preventive behavior and decrease the burden of the disease. (Source: Osteoporosis International)
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Gene-based GWAS analysis for consecutive studies of GEFOS
ConclusionsGene-based analysis as a supplementary strategy to SNP-based genome-wide association studies, when applied here, is shown that it helped identify some novel BMD-associated genes. In addition to its empirically increased statistical power, gene-based analysis also provides a higher testing stability for identification of BMD genes. (Source: Osteoporosis International)
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women
AbstractSummaryAn exploratory study in elderly women and men from the Geneva Retirees Cohort indicates that low-frequency quantitative ultrasound measurement at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk.IntroductionThe contribution of distal radius bone mineral density (BMD) and cortical microstructure to fracture risk has recently been demonstrated. In this exploratory study, we investigated whether low-frequency quantitative ultrasound measurement at the distal radius may capture the peripheral determinants of b...
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Discordant pattern of peripheral fractures in diabetes: a meta-analysis on the risk of wrist and ankle fractures
ConclusionThe risk of fractures is increased in diabetes at the ankle and decreased at the wrist. The same pattern is observed in obesity. Although bone microarchitectural features are different in obesity and diabetes, the epidemiology of peripheral fractures is similar in both diseases suggesting that microarchitecture may not be the major determinant of peripheral fractures in these populations. (Source: Osteoporosis International)
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults
AbstractSummaryBone remodeling markers (BRMs) are suppressed following the consumption of a meal. Our findings indicate that a single session of continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, performed 1 h after a meal attenuates the postprandial suppression of BRMs.IntroductionAcute exercise transiently increases BRMs including osteocalcin (tOC) and the undercarboxylated form of osteocalcin (ucOC), a hormone that is implicated in glucose regulation. The effects of acute exercise and exercise-intensity on postprandial levels of tOC and ucOC are unknown.MethodsTwenty-seven adult...
Source: Osteoporosis International - October 10, 2018 Category: Orthopaedics Source Type: research

LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients
ConclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures
ConclusionsSystemic bone loss following fracture may increase the risk of future fractures at all skeletal sites. There is a need for improved understanding of mechanisms leading to apparent accelerated bone loss following a fracture in order to reduce subsequent fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study
ConclusionsThese results suggest a role for FGF23/klotho axis on bone and vascular metabolism in dialysis populations. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

The association of cortisol and adrenal androgen with trabecular bone score in patients with adrenal incidentaloma with and without autonomous cortisol secretion
AbstractSummaryDespite ethnic differences in cortisol sensitivity, only one study in Caucasians has assessed trabecular bone score (TBS) in patients with subclinical hypercortisolism (SH). We showed that both subtle cortisol excess and reduced adrenal androgen may contribute to impaired bone quality in Asian women with SH.IntroductionOne study in Caucasians has assessed trabecular bone score (TBS), an index of bone microstructure, in adrenal incidentaloma (AI) patients with subclinical hypercortisolism (SH). There are ethnic differences in cortisol sensitivities between Caucasian and Asian populations. We investigated the ...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Effects of osteoporosis drug treatments on cortical and trabecular bone in the femur using DXA-based 3D modeling
ConclusionResults obtained in this head-to-head study are consistent with those obtained using computed tomography in the literature. DXA-based modeling techniques could complement standard DXA examination to monitor treatment effects on trabecular and cortical compartments. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Short-term association between outdoor air pollution and osteoporotic hip fracture
This study examines the association of the levels of different airborne pollutants on the incidence of osteoporotic hip fracture in a southern European region. Association was detected between SO2 and NO2 and hospital admissions due to hip fracture.IntroductionTo examine the short-term effects of outdoor air pollution on the incidence of osteoporotic hip fracture in a southern European region.MethodsThis is an ecological retrospective cohort study based on data obtained from three databases. In a time-series analysis, we examined the association between hip fracture incidence and different outdoor air pollutants (sulfur di...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Relationship of American Indian blood quantum with osteoporosis risk: a cross-sectional study of American Indian women in Oklahoma
ConclusionsIn this cohort of women who identified as AI, greater Indian BQ was associated with a decrease in the prevalence of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Genetic variation in Wnt/ β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study
AbstractSummaryThe association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/ β-catenin and ER pathways.IntroductionSome athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/ β-catenin signalling pathways with low BMD in elite and pre-eli...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

The associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults
ConclusionSubclinical cIMT is associated with an increased risk of hip fractures despite being associated with increased BMD. This finding suggests that vascular health, even in its early stages, is linked to bone health, by pathways other than BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Maximal strength training improves musculoskeletal health in amphetamine users in clinical treatment
This study investigated if MST-induced improvements in force generating capacity improved bone mineral density (BMD), trabecular bone score, and body composition in amphetamine users participating in 3-months clinical treatment.MethodsOf 40 randomized patients, 23 completed the study: 11 in the supervised training group (TG; 8 men, 3 women, 34  ± 10 years) and 12 in the control group (CG; 9 men, 3 women, 32 ± 8 years). The TG performed hack-squat MST three times a week for 12 weeks with an intensity of ~90% of one repetition maximum (1RM). Both groups attended conven...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

The Forteo Patient Registry linkage to multiple state cancer registries: study design and results from the first 8  years
ConclusionsBased on the estimated 242,782 person-years of observation as of the eighth annual linkage and projecting current enrollment rate to study end in 2024, it is anticipated that the completed study will be able to detect a fourfold increase in the risk of osteosarcoma if one exists. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Do sarcopenia and/or osteoporosis increase the risk of frailty? A 4-year observation of the second and third ROAD study surveys
ConclusionsPreventing osteoporosis and coexistence of osteoporosis and sarcopenia may help reduce the risk of frailty. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Oral bisphosphonate prescription and non-adherence at 12 months in patients with hip fractures treated in an acute geriatric unit
ConclusionsAt 12  months, there was low adherence to treatment with oral bisphosphonates in our model. A lower BI prior to treatment is a predictive factor for non-adherence treatment with oral bisphosphonate. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Bone metabolism, density, and geometry in postmenopausal women with vitamin D insufficiency: a cross-sectional comparison of the effects of elevated parathyroid levels
AbstractSummaryIncreased levels of parathyroid hormone (PTH) may have adverse effects on bone health. In a cross-sectional design, we investigated this hypothesis among 102 postmenopausal vitamin D insufficient women. Elevated PTH was associated with altered bone geometry, decreased bone mineral density in the spine, and increased bone turnover.IntroductionIn vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry.MethodsUsing a cross-sectional design, we investigate...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Social inequality and fractures —secular trends in the Danish population: a case-control study
ConclusionIn conclusion, we have demonstrated important, stable associations between social inequality, assessed using income, marital status, and area of residence, and fracture at the population level. These findings can inform approaches to healthcare, and suggest that much thought should be given to novel interventions aimed especially at those living alone, and ideally societal measures to reduce social inequality. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Long-term oral bisphosphonates delay healing after tooth extraction: a single institutional prospective study
This study aimed to evaluate the clinical safety of continuing oral bisphosphonate therapy in patients undergoing tooth extraction.MethodsWe prospectively enrolled 132 patients (20 men, 112 women) who were receiving oral bisphosphonates for the prevention or treatment of osteoporosis and required tooth extraction. All patients were managed using an identical protocol, which included preoperative antibiotic prophylaxis and did not necessarily require complete wound closure. The patients were classified into groups according to the duration of bisphosphonate administration:  10 years (n = 12). The g...
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Breech presentation is associated with lower bone mass and area: findings from the Southampton Women ’s Survey
ConclusionsThese results suggest that breech presentation is associated with lower neonatal whole-body BMC and BA, which may relate to altered prenatal loading in babies occupying a breech position; these differences did not persist into later childhood. Modest differences in 4-year hip BMC and BA require further investigation. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Postural control is associated with muscle power in post-menopausal women with low bone mass
ConclusionsOur findings show that, in post-menopausal women with low bone mass, neuromuscular power is a more important determinant of postural control than muscle strength or size. Our findings provide evidence to support the integration of power or speed training into falls prevention and balance training programs in post-menopausal women with osteopenia and osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Antihistamine use and the risk of injurious falls or fracture in elderly patients: a systematic review and meta-analysis
ConclusionsFirst-generation antihistamine use is considerably associated with increased risk of injurious falls or fracture among the elderly. Clinicians need to exercise caution when prescribing first-generation antihistamines to elderly patients. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies
ConclusionsThe present meta-analysis suggests that higher SHBG levels predict an increased risk of fracture in older adults. Further studies should aim to elucidate the complex biological mechanisms by which SHBG may affect fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - October 1, 2018 Category: Orthopaedics Source Type: research

The associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults
ConclusionSubclinical cIMT is associated with an increased risk of hip fractures despite being associated with increased BMD. This finding suggests that vascular health, even in its early stages, is linked to bone health, by pathways other than BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - September 13, 2018 Category: Orthopaedics Source Type: research

The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography —The Maastricht Study
ConclusionsIn this study with predominantly well-treated T2DM participants with relatively short-term diabetes duration, inadequate blood glucose control was negatively associated with cortical bone measures of the radius. In contrast, trabecular number was increased at both sites. Studies of larger sample size are warranted for more detailed investigations of bone density and bone quality in patients with T2DM. (Source: Osteoporosis International)
Source: Osteoporosis International - September 13, 2018 Category: Orthopaedics Source Type: research

Bisphosphonate therapy in an infant with generalized arterial calcification with an ABCC6 mutation
AbstractGeneralized arterial calcification of infancy (GACI) is a rare genetic disorder with high infantile mortality, described to be due toENPP1, and less commonlyABCC6 mutations. Bisphosphonate treatment has been described to improve survival in ENPP1-positive GACI patients, but few studies have described bisphosphonate treatment in ABCC6-positive patients. Without therapy, patients will die before 6  months of age. Our patient is now 3 years old, former recipient twin of twin-to-twin transfusion syndrome (TTTS). Initial fetal echocardiogram at 19 weeks showed calcifications of the ascending aorta and pul...
Source: Osteoporosis International - September 11, 2018 Category: Orthopaedics Source Type: research

Contribution of bone turnover markers to the variation in bone mineral density: a study in Vietnamese men and women
ConclusionThe elevation in bone formation marker PINP and bone resorption marker beta-CTX in postmenopausal women was greater than in elderly men. However, only beta-CTX was modestly but significantly associated with BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - September 8, 2018 Category: Orthopaedics Source Type: research

Notch in skeletal physiology and disease
In conclusion, Notch signaling is a novel pathway that regulates skeletal homeostasis in health and disease. (Source: Osteoporosis International)
Source: Osteoporosis International - September 7, 2018 Category: Orthopaedics Source Type: research

Impact of mild and moderate/severe vertebral fractures on physical activity: a prospective study of older women in the UK
ConclusionThis is the first study of older women from the UK that explored the prospective association between vertebral fracture and physical activity duration. Moderate/severe fractures were associated with reduced walking duration. Mild fractures had no impact on future physical ability. (Source: Osteoporosis International)
Source: Osteoporosis International - September 7, 2018 Category: Orthopaedics Source Type: research

Incorporating the patient perspective in the study of rare bone disease: insights from the osteogenesis imperfecta community
ConclusionsThis work will help guide the incorporation of PROs into the next phase of the BBDC Natural History Study of OI and underscores the importance of including PROs in the study of rare diseases. (Source: Osteoporosis International)
Source: Osteoporosis International - September 6, 2018 Category: Orthopaedics Source Type: research

Impaired residual renal function predicts denosumab-induced serum calcium decrement as well as increment of bone mineral density in non-severe renal insufficiency
This study assessed the risk factors for reduced cCa concentration following denosumab administration and anal yzed factors predictive of changes in bone mineral density (BMD).MethodsSeventy-seven osteoporotic patients, not including those with CKD stages 4 –5D, were treated with 60 mg denosumab once every 6 months. Biochemical parameters and BMD were analyzed from prior to the initial dose until 1 month after the second dose.ResultsFollowing the first administration of denosumab, cCa levels decreased, reaching a minimum on day 7. Multiple linear regression analyses showed that baseline cCa, estimated ...
Source: Osteoporosis International - September 5, 2018 Category: Orthopaedics Source Type: research

Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck
ConclusionsThe REMS approach can be used for non-ionizing osteoporosis diagnosis directly on lumbar spine and femoral neck with a good level of accuracy and precision. However, a more rigorous operator training is needed to limit the erroneous acquisitions and to ensure the full clinical practicability. (Source: Osteoporosis International)
Source: Osteoporosis International - September 4, 2018 Category: Orthopaedics Source Type: research

Bone management in hematologic stem cell transplant recipients
AbstractAutologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient population suffering from the late effects of HSCT, of which, bone loss and its consequent fragility fractures lead to substantial morbidity. Altered bone health, with consequent fragility fractures, and chronic graft-versus-host disease (GVHD) are factors affecting long-...
Source: Osteoporosis International - September 3, 2018 Category: Orthopaedics Source Type: research

Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands
ConclusionThis study provides evidence that antidepressants should be used with caution following a major osteoporotic fracture. It provides needed insights that can be used to inform clinicians when assessing subsequent fracture risk in patients. (Source: Osteoporosis International)
Source: Osteoporosis International - August 15, 2018 Category: Orthopaedics Source Type: research

The effects of teriparatide on acceleration of bone healing following atypical femoral fracture: comparison between daily and weekly administration
AbstractSummaryWe compared the effectiveness of promoting bone healing between two teriparatide preparations for atypical femoral fracture (AFF). A total of 45 AFFs were included in this study, and we compared the duration of bone union. Teriparatide administered by daily injection enhanced bone union more than weekly administration in complete AFFs.IntroductionThe efficacy of teriparatide for atypical femoral fracture (AFF) has been recently reported. Although two different teriparatide preparations can be used to treat osteoporosis in Japan, daily or weekly injection, all previous reports on the effectiveness of teripara...
Source: Osteoporosis International - August 13, 2018 Category: Orthopaedics Source Type: research

Osteoporosis and osteopenia in the distal forearm predict all-cause mortality independent of grip strength: 22-year follow-up in the population-based Troms ø Study
ConclusionMen and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. (Source: Osteoporosis International)
Source: Osteoporosis International - August 9, 2018 Category: Orthopaedics Source Type: research

Short-term association between outdoor air pollution and osteoporotic hip fracture
This study examines the association of the levels of different airborne pollutants on the incidence of osteoporotic hip fracture in a southern European region. Association was detected between SO2 and NO2 and hospital admissions due to hip fracture.IntroductionTo examine the short-term effects of outdoor air pollution on the incidence of osteoporotic hip fracture in a southern European region.MethodsThis is an ecological retrospective cohort study based on data obtained from three databases. In a time-series analysis, we examined the association between hip fracture incidence and different outdoor air pollutants (sulfur di...
Source: Osteoporosis International - August 9, 2018 Category: Orthopaedics Source Type: research

Decreasing trend of bone mineral density in US multiethnic population: analysis of continuous NHANES 2005 –2014
ConclusionsAge-adjusted mean BMD decreased in 2013 –2014 in both men and women, and this significant decrease was also observed in sensitivity and subgroup analyses. The decreased BMD in 2013–2014 still remained significant even after being adjusted for multiple potentially confounding effects. (Source: Osteoporosis International)
Source: Osteoporosis International - August 8, 2018 Category: Orthopaedics Source Type: research

Build better bones with exercise (B3E pilot trial): results of a feasibility study of a multicenter randomized controlled trial of 12  months of home exercise in older women with vertebral fracture
ConclusionAn RCT of home exercise in women with vertebral fractures is feasible but  recruitment was a challenge. Suggestions are made for the conduct of future trials. (Source: Osteoporosis International)
Source: Osteoporosis International - August 8, 2018 Category: Orthopaedics Source Type: research

Glucagon-like peptide-1 receptor agonists and fracture risk: a network meta-analysis of randomized clinical trials
ConclusionThe Bayesian network meta-analysis suggests that GLP-1 RAs were associated with a decreased bone fracture risk compared to users of placebo or other anti-hyperglycemic drugs in type 2 diabetes mellitus patients, and exenatide is the best option agent with regard to the risk of fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - August 6, 2018 Category: Orthopaedics Source Type: research