Diagnosis and management of osteoporosis in chronic kidney disease stages 4 to 5D: a call for a shift from nihilism to pragmatism
Abstract The European Renal Association –European Dialysis and Transplant Association (ERA-EDTA) CKD-MBD working group, in collaboration with the Committee of Scientific Advisors of the International Osteoporosis Foundation, published a position paper for the diagnosis and management of osteoporosis in patients with CKD stages 4–5D (e GFR
Source: Osteoporosis International - November 22, 2021 Category: Orthopaedics Source Type: research

Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis
ConclusionsWe demonstrated that transcriptome fine-mapping identifies more osteoporosis-related genes and provides key insight into the development of novel targeted therapeutics for the treatment of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - November 22, 2021 Category: Orthopaedics Source Type: research

Socio-economic inequalities in fragility fracture incidence: a systematic review and meta-analysis of 61 observational studies
ConclusionOur results show that low SES, measured at the individual level, is a risk factor for fragility fracture. Low BMI and unhealthy behaviours are important mediators of the effect of SES on fracture risk. Strategies to prevent fractures and reduce unhealthy behaviours should aim to tackle structural inequalities in society thereby reducing health inequalities in fragility fracture incidence. (Source: Osteoporosis International)
Source: Osteoporosis International - November 22, 2021 Category: Orthopaedics Source Type: research

Trends and regional variation in vertebroplasty and kyphoplasty in Switzerland: a population-based small area analysis
ConclusionsVP/BKP procedure rates increased and regional variation across Switzerland declined but remained at a high level. A substantial part of the regional variation remained unexplained by potential determinants of variation. (Source: Osteoporosis International)
Source: Osteoporosis International - November 22, 2021 Category: Orthopaedics Source Type: research

Long-term risk of subsequent major osteoporotic fracture and hip fracture in men and women: a population-based observational study with a 25-year follow-up
ConclusionsThe risk of subsequent fractures following an initial fracture was increased over 25 years and the magnitude of risk was initially greater in men than in women. (Source: Osteoporosis International)
Source: Osteoporosis International - November 22, 2021 Category: Orthopaedics Source Type: research

The cumulative incidence of and risk factors for morphometric severe vertebral fractures in Japanese men and women: the ROAD study third and fourth surveys
This study aimed to estimate the incidence of morphometric vertebral fracture (VF) and severe VF (sVF) in men and women and clarify whether the presence of a mild VF (mVF) increases the risk of incident sVF.MethodsData from the population-based cohort study, entitled the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, were analyzed. In total, 1190 participants aged  ≥ 40 years (mean age, 65.0 ± 11.2) years completed whole-spine lateral radiography both at the third (2012–2013, baseline) and fourth surveys performed 3 years later (2015–2016...
Source: Osteoporosis International - November 19, 2021 Category: Orthopaedics Source Type: research

In memoriam: Bernardo Stolnicki
(Source: Osteoporosis International)
Source: Osteoporosis International - November 17, 2021 Category: Orthopaedics Source Type: research

Opportunistic Use of Lumbar Magnetic Resonance Imaging for Osteoporosis Screening
ConclusionOpportunistic use of MRI is a simple, effective tool that may help recognize patients who are at risk for complications related to bone disease. A VBQ  >  3.0 can identify patients who need additional diagnostic evaluation. (Source: Osteoporosis International)
Source: Osteoporosis International - November 13, 2021 Category: Orthopaedics Source Type: research

Single pharmacy governed denosumab home administration: optimal adherence by means of a fracture liaison service (FLS) and home care collaboration
ConclusionIt was possible to achieve 94% adherence for Dmab injections treatment just by transferring the complete supply chain to one pharmacy-initiated home care provider after treatment initiation by either a physician or FLS health care professional. (Source: Osteoporosis International)
Source: Osteoporosis International - November 13, 2021 Category: Orthopaedics Source Type: research

Radiographic indexes in AP hip radiographs prior to total hip arthroplasty reveal candidates with low BMD
Abstract   SummaryUsing anteroposterior (AP) hip radiograph, we measured several indexes to investigate the association with bone mineral density (BMD) before THA and found a highly effective index to predict femoral BMD. This technique is helpful for both patients and clinicians to identify potential candidates with low BMD to whom DXA examination is particularly recommended.IntroductionThe purpose of the study is to identify patients with low bone mineral density (BMD) prior to total hip arthroplasty with the help of AP hip radiographs.MethodsIndexes on AP hip radiographs and T-scores from DXA examination of th...
Source: Osteoporosis International - November 13, 2021 Category: Orthopaedics Source Type: research

Effectiveness of patient education for patients with osteoporosis: a systematic review
ConclusionThere is limited evidence for the effectiveness of osteoporosis patient education. There is a need for high-quality randomized controlled trials, which should describe the characteristics of the interventions and examine the mechanisms of osteoporosis patient education.PROSPERO registration numberCRD42020211930 (Source: Osteoporosis International)
Source: Osteoporosis International - November 12, 2021 Category: Orthopaedics Source Type: research

Long-term clinical and socio-economic outcomes following wrist fracture: a systematic review and meta-analysis
ConclusionEvidence shows that a high proportion of people aged over 50  years with wrist fracture experience pain and functional limitation >  6 months after fracture. This is associated with increased healthcare costs, and reduced quality of life. Exploratory evidence was found for several candidate prognostic factors. Their predictive performance needs to be investigated further.PROSPERO:CRD42018116478 (Source: Osteoporosis International)
Source: Osteoporosis International - November 11, 2021 Category: Orthopaedics Source Type: research

A nomogram for short-term recurrent pain after percutaneous vertebroplasty for osteoporotic vertebral compression fractures
This study was designed to develop and validate a nomogram for predicting the potential risks of SRP after PVP, which may help to provide a painless postoperative experience and personalized health management for patients with OVCF.IntroductionWith the aging of China ’s population, the incidence of osteoporotic vertebral compression fractures (OVCF) has increased significantly. Percutaneous vertebroplasty (PVP) has been widely accepted due to its minimally invasive, rapid, and effective characteristics. However, it has been found that some patients have short- term recurrent pain (SRP) in the original site after surg...
Source: Osteoporosis International - November 11, 2021 Category: Orthopaedics Source Type: research

The impact of the frequency, duration and type of physiotherapy on discharge after hip fracture surgery: a secondary analysis of UK national linked audit data
AbstractSummaryAdditional physiotherapy in the first postoperative week was associated with fewer days to discharge after hip fracture surgery. A 7-day physiotherapy service in the first postoperative week should be considered as a new key performance indicator in evaluating the quality of care for patients admitted with a hip fracture.IntroductionTo examine the association between physiotherapy in the first week after hip fracture surgery and discharge from acute hospital.MethodsWe linked  data from the UK Physiotherapy Hip Fracture Sprint Audit to hospital records for 5395 patients with hip fracture in May...
Source: Osteoporosis International - November 8, 2021 Category: Orthopaedics Source Type: research

Correction to: Reference microarchitectural values measured by HR-pQCT in a Franco-Swiss cohort of young adult women
(Source: Osteoporosis International)
Source: Osteoporosis International - November 8, 2021 Category: Orthopaedics Source Type: research

Snyder-Robinson syndrome: differential diagnosis of osteogenesis imperfecta
We report a novel case of Snyder-Robinson syndrome, caused by a de novo mutation and first misdiagnosed with osteogenesis imperfecta. Clinical features, course, and genetic analysis are presented. The patient was treated with bisphosphonates for a decade, until developing an atypical femoral fracture. Teriparatide was then administered for 2  years and then changed to denosumab every 6 months, improving his bone density mass and preventing further fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - November 6, 2021 Category: Orthopaedics Source Type: research

Trends in opioid use following balloon kyphoplasty or vertebroplasty for the treatment of vertebral compression fractures
ConclusionsInterventional treatment for VCF was associated with decreased or discontinued opioid prescription fills and reduced payer costs in follow-up in a significant proportion of the study population. Reduction of opioid-based harms may represent a previously unrecognized benefit of vertebral augmentation for VCF, especially in this elderly and medically fragile population. (Source: Osteoporosis International)
Source: Osteoporosis International - November 2, 2021 Category: Orthopaedics Source Type: research

Correction to: Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using HRpQCT.
(Source: Osteoporosis International)
Source: Osteoporosis International - November 2, 2021 Category: Orthopaedics Source Type: research

The ASA score predicts infections, cardiovascular complications, and hospital readmissions after hip fracture - A nationwide cohort study
ConclusionASA scores are routinely assessed in clinical practice and predict a wide range of postoperative complications among hip fracture patients. Since many complications may be preventable through adequate drug treatment, rehabilitation, and risk awareness, future studies should examine the mechanisms linking ASA scores to complication risk in order to improve preventive strategies. Particularly, the high risk of cardiovascular complications among patients with high ASA scores deserves clinical and scientific attention. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Predictive ability of novel volumetric and geometric indices derived from dual-energy X-ray absorptiometric images of the proximal femur for hip fracture compared with conventional areal bone mineral density: the Japanese Population-based Osteoporosis (JPOS) Cohort Study
ConclusionsvBMD obtained from 3D modeling using routinely obtained hip DXA images significantly improved hip fracture risk prediction over conventional FN-aBMD, but not TH-aBMD.Trial registrationThe Japanese Population-Based Osteoporosis (JPOS) Cohort Study was retrospectively registered as UMIN000032869 in the UMIN Clinical Trials Registry on July 1, 2018. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Bone biomechanical properties and tissue-scale bone quality in a genetic mouse model of familial dysautonomia
ConclusionThe deletion ofElp1 in neurons is sufficient to generate a mouse line which demonstrates loss of whole-bone toughness, consistent with the poor bone quality suspected in the clinical setting. The Elp1 CKO model, as with human FD, impacts the nervous system, gut, kidney function, mobility, gait, and posture. The bone quality phenotype of Elp1 CKO mice, which includes altered microarchitecture and tissue-scale material properties, is complex and likely influenced by these multisystemic changes. This mouse model may provide a useful platform to not only investigate the mechanisms responsible for bone fragility in FD...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

A randomized, controlled trial of once-weekly teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05
ConclusionOnce-weekly subcutaneous injection of teriparatide significantly reduced the incidence of morphometric vertebral fractures compared with alendronate in women with primary osteoporosis who were at high risk of fracture.Trial registrationjRCTs031180235 and UMIN000015573, March 12, 2019 (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels
ConclusionThe absorption and disposition kinetics of risedronate were successfully characterized. Simulations revealed the high discrepancy in the concentration levels observed after different dosage regimens, implying the safety profile of risedronate. In virtual patients with renal impairment, the blood levels of risedronate are increased, but not in an extent requiring dose adaptation. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Long-term effects of lifestyle and metformin interventions in DPP on bone density
ConclusionIn a cohort at high risk of diabetes, lifestyle intervention or metformin did not appear to have long-term negative effects on BMD. Potential positive effects of metformin on bone warrant further research. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Influence of denosumab on bone mineral density in a severe case of pregnancy-associated osteoporosis
AbstractPregnancy and lactation-associated osteoporosis (PLO) with predominantly subsequent vertebral fracture is a rare but severe disease with an estimated incidence of 0.4 in 100,000. In the past, patients with PLO have been predominantly treated with oral and i.v. bisphosphonates to reduce subsequent fracture risk. Hereby, the use of bisphosphonates in premenopausal women is controversial, as bisphosphonates know to persist in bone for many years and can be exposed and circulate in maternal serum and subsequently pass the placenta barrier and may have a detrimental effect on fetal bone health. Here we report the effect...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Effect of testosterone treatment on the trabecular bone score in older men with low serum testosterone
ConclusionsTBS is not clinically useful in monitoring the 1-year effect of testosterone treatment on bone structure in older hypogonadal men. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Orthogeriatric co-management reduces incidence of delirium in hip fracture patients
ConclusionOrthogeriatric co-management as an integrated care model reduced the incidence of SSD/delirium in hip fracture patients. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

A 1:1 matched case-control study on dietary protein intakes and hip fracture risk in Chinese elderly men and women
AbstractSummaryThe role of protein intake in bone has been controversial. Our case-control study among Chinese elderly concluded that a higher consumption of protein, even substituted for fat, is associated with lowered hip fracture risk. Differences in protein sources, amino acids composition, gender, and calcium sufficiency may explain the inconsistency.PurposeThe aim of the study was to investigate the association of dietary protein intakes with hip fracture risk among Chinese elderly.MethodsThis was a 1:1 age and sex matched cross-sectional study of case-control design among 1070 pairs of elderly Chinese people aged 55...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

One-year outcomes of an osteoporosis liaison services program initiated within a healthcare system
This study aimed to evaluate 1-year outcomes of an osteoporosis liaison service (OLS) program that includes two independent components: medication management services (MMS) to improve medication adherence and fracture liaison services (FLS) for secondary prevention.MethodsPatients with new hip fracture or untreated vertebral fractures enrolled in the FLS program (n = 600), and those with osteoporosis medication management issues but not necessarily fragility fractures enrolled in the MMS program (n = 499) were included. To evaluate outcomes, care coordinators assessed baseline items adapted from the 13 Best Practices Frame...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

The skeletal consequences of epidural steroid injections: a literature review
ConclusionsWhile evidence is limited, studies suggest that ESIs may cause bone loss, particularly those investigating volumetric BMD. Larger doses appear to confer greater risk. Further prospective studies are needed to investigate the relationship between ESI and fracture risk. Better understanding of the skeletal consequences of ESIs will help foster strategies to prevent bone loss in the growing population of patients receiving this treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Analysis of the effects of a delay of surgery in patients with hip fractures: outcome and causes
This study analyzed characteristics of hip fracture patients who did not undergo surgery within 24 hours after hospitalization, as recommended by the Belgian quality standards. Reasons for delay were analyzed. Delay in surgery for hip fracture was related to the medical condition of the patients.IntroductionTo compare patients with optimal timing to patients with a delay in hip surgery, with respect to outcome (complications (postoperative) and mortality) and reasons for delay.MethodsA retrospective analysis of medical records compared patients operated on within 24h (Group A) to patients operated on more than 24h after ad...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

The role of diet quality and dietary patterns in predicting muscle mass and function in men over a 15-year period
ConclusionA Traditional dietary pattern higher in vegetables, wholegrain cereals, and animal protein was associated with greater skeletal muscle mass, and an anti-inflammatory diet, also rich in vegetables, fruit, and wholegrain cereals, was associated with greater skeletal muscle mass and better  muscle function over 15 years. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study
ConclusionsThese findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Subclinical hyperthyroidism is associated with increased risk of vertebral fractures in older men
AbstractSummaryIn elderly men included in MrOS-Sweden, subclinical hyperthyroidism (SHyper) was markedly associated with increased risk of vertebral fractures.IntroductionOvert hyperthyroidism is associated with increased risk of fractures. However, only a few studies have investigated whether SHyper is associated with fracture risk in elderly men. We therefore investigated if SHyper was a risk factor for fractures in Swedish men.MethodsWe followed (median 9.8 years) elderly men (n = 1856; mean age 75, range 69 –81 years) participating in the Gothenburg and Malmö subcohorts of the prospective, population-based M...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Denosumab for the treatment of primary pediatric osteoporosis
In conclusion, denosumab was highly effective in this case of primary pediatric osteoporosis, with remarkable clinical and radiological response. Transient hypercalcemia was probably due to amplification of the effect of growth spurt and puberty on bone remodeling by the transient, short-term discontinuation of the drug. Furthermore, our data suggest that mobilization of calcium from treatment-induced sclerotic transverse lines in bone metaphyses may contribute to the development of h ypercalcemia. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Internal medicine inpatients ’ prevalence of misdiagnosed severe osteoporosis
AbstractSummaryVertebral fractures (VF) related to osteoporosis (i.e., severe OP) increase the risk of disability and mortality, but they are often neglected. We observed a severe OP misdiagnosis in 28.9% of inpatients with previous spinal imaging positive for VFs. Diagnosing severe OP is crucial to reduce the health care costs of inpatients.IntroductionVertebral fractures (VFs) related to osteoporosis (OP) increase the risk of additional fractures and death. In inpatients, VFs are often neglected with consequent delay in OP treatments, prolongation of hospitalization, and reduction of life expectancy. The aim of this stud...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

The ASA score predicts infections, cardiovascular complications, and hospital readmissions after hip fracture - A nationwide cohort study
ConclusionASA scores are routinely assessed in clinical practice and predict a wide range of postoperative complications among hip fracture patients. Since many complications may be preventable through adequate drug treatment, rehabilitation, and risk awareness, future studies should examine the mechanisms linking ASA scores to complication risk in order to improve preventive strategies. Particularly, the high risk of cardiovascular complications among patients with high ASA scores deserves clinical and scientific attention. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Predictive ability of novel volumetric and geometric indices derived from dual-energy X-ray absorptiometric images of the proximal femur for hip fracture compared with conventional areal bone mineral density: the Japanese Population-based Osteoporosis (JPOS) Cohort Study
ConclusionsvBMD obtained from 3D modeling using routinely obtained hip DXA images significantly improved hip fracture risk prediction over conventional FN-aBMD, but not TH-aBMD.Trial registrationThe Japanese Population-Based Osteoporosis (JPOS) Cohort Study was retrospectively registered as UMIN000032869 in the UMIN Clinical Trials Registry on July 1, 2018. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Bone biomechanical properties and tissue-scale bone quality in a genetic mouse model of familial dysautonomia
ConclusionThe deletion ofElp1 in neurons is sufficient to generate a mouse line which demonstrates loss of whole-bone toughness, consistent with the poor bone quality suspected in the clinical setting. The Elp1 CKO model, as with human FD, impacts the nervous system, gut, kidney function, mobility, gait, and posture. The bone quality phenotype of Elp1 CKO mice, which includes altered microarchitecture and tissue-scale material properties, is complex and likely influenced by these multisystemic changes. This mouse model may provide a useful platform to not only investigate the mechanisms responsible for bone fragility in FD...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

A randomized, controlled trial of once-weekly teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05
ConclusionOnce-weekly subcutaneous injection of teriparatide significantly reduced the incidence of morphometric vertebral fractures compared with alendronate in women with primary osteoporosis who were at high risk of fracture.Trial registrationjRCTs031180235 and UMIN000015573, March 12, 2019 (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels
ConclusionThe absorption and disposition kinetics of risedronate were successfully characterized. Simulations revealed the high discrepancy in the concentration levels observed after different dosage regimens, implying the safety profile of risedronate. In virtual patients with renal impairment, the blood levels of risedronate are increased, but not in an extent requiring dose adaptation. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Influence of denosumab on bone mineral density in a severe case of pregnancy-associated osteoporosis
AbstractPregnancy and lactation-associated osteoporosis (PLO) with predominantly subsequent vertebral fracture is a rare but severe disease with an estimated incidence of 0.4 in 100,000. In the past, patients with PLO have been predominantly treated with oral and i.v. bisphosphonates to reduce subsequent fracture risk. Hereby, the use of bisphosphonates in premenopausal women is controversial, as bisphosphonates know to persist in bone for many years and can be exposed and circulate in maternal serum and subsequently pass the placenta barrier and may have a detrimental effect on fetal bone health. Here we report the effect...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

A 1:1 matched case-control study on dietary protein intakes and hip fracture risk in Chinese elderly men and women
AbstractSummaryThe role of protein intake in bone has been controversial. Our case-control study among Chinese elderly concluded that a higher consumption of protein, even substituted for fat, is associated with lowered hip fracture risk. Differences in protein sources, amino acids composition, gender, and calcium sufficiency may explain the inconsistency.PurposeThe aim of the study was to investigate the association of dietary protein intakes with hip fracture risk among Chinese elderly.MethodsThis was a 1:1 age and sex matched cross-sectional study of case-control design among 1070 pairs of elderly Chinese people aged 55...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

The role of diet quality and dietary patterns in predicting muscle mass and function in men over a 15-year period
ConclusionA Traditional dietary pattern higher in vegetables, wholegrain cereals, and animal protein was associated with greater skeletal muscle mass, and an anti-inflammatory diet, also rich in vegetables, fruit, and wholegrain cereals, was associated with greater skeletal muscle mass and better  muscle function over 15 years. (Source: Osteoporosis International)
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Subclinical hyperthyroidism is associated with increased risk of vertebral fractures in older men
AbstractSummaryIn elderly men included in MrOS-Sweden, subclinical hyperthyroidism (SHyper) was markedly associated with increased risk of vertebral fractures.IntroductionOvert hyperthyroidism is associated with increased risk of fractures. However, only a few studies have investigated whether SHyper is associated with fracture risk in elderly men. We therefore investigated if SHyper was a risk factor for fractures in Swedish men.MethodsWe followed (median 9.8 years) elderly men (n = 1856; mean age 75, range 69 –81 years) participating in the Gothenburg and Malmö subcohorts of the prospective, population-based M...
Source: Osteoporosis International - November 1, 2021 Category: Orthopaedics Source Type: research

Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair
ConclusionThere is a specific pharmacologic window following polytrauma that bisphosphonates can prevent the consequences of dysregulated biomineralization, yet not impair musculoskeletal regeneration. (Source: Osteoporosis International)
Source: Osteoporosis International - October 31, 2021 Category: Orthopaedics Source Type: research

Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies
AbstractSummaryThe meta-analysis of osteoprotegerin (OPG) (TNFRSF11B) polymorphisms from genetic association  studies and genome-wide association studies was performed in order to test the hypothesis of association between OPG polymorphisms and fracture. The findings showed a significant 13% to 37% protective effect ofOPG on  fractures in postmenopausal women (PSM) (rs2073618), overall, ≥ 60y and Western subjects (rs3134069 and rs3134070).PurposeFractures in older people usually result from compromised bone integrity. The multifactorial aetiology of fractures includes both genetic and environmental f...
Source: Osteoporosis International - October 30, 2021 Category: Orthopaedics Source Type: research

Outcomes post fragility fracture among members of an integrated healthcare organization
This study highlights an unmet need in osteoporosis management, suggesting that beyond bone mineral density and fracture history, gender, fracture type, and age should be considered for fracture risk assessment. Following fragility fracture, men, patients with a spine or hip fracture, and those aged  ≥ 65 have a higher disease burden.IntroductionThe objective of this study was to characterize osteoporosis-related fracture incidence and identify predictors of subsequent fractures and mortality.MethodsThis retrospective cohort study, conducted within Kaiser Permanente Southern California, included patients a...
Source: Osteoporosis International - October 23, 2021 Category: Orthopaedics Source Type: research