Fracture risk assessment in celiac disease: a registry-based cohort study
ConclusionsCeliac disease is associated with an increased risk of major osteoporotic fractures. When celiac disease is considered as a secondary osteoporosis risk factor or BMD is included in FRAX assessment, FRAX accurately predicts fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - August 3, 2020 Category: Orthopaedics Source Type: research

Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location
This study investigated whether CT-based bone density and strength measurements from the thoracic spine predict incident vertebral fracture and compared the performance of thoracic and lumbar bone measurements to predict incident vertebral fracture.MethodsThis case-control study of community-based men and women (age 74.6  ± 6.6) included 135 cases with incident vertebral fracture at any level and 266 age- and sex-matched controls. We used baseline CT scans to measure integral and trabecular volumetric bone mineral density (vBMD) and vertebral strength (via finite element analysis, FEA) at the T8 and L2...
Source: Osteoporosis International - August 3, 2020 Category: Orthopaedics Source Type: research

Dietary Inflammatory Index in relation to bone mineral density, osteoporosis risk and fracture risk: a systematic review and meta-analysis
ConclusionOur analysis indicated that diets with high pro-inflammatory components might increase the risk of osteoporosis and fractures and lower BMD of lumbar spine and total hip. More prospective studies involving populations of diverse ages and genders are expected to further verify the universality of the results. (Source: Osteoporosis International)
Source: Osteoporosis International - August 1, 2020 Category: Orthopaedics Source Type: research

Real-world effectiveness of osteoporosis treatment in the oldest old
ConclusionsOsteoporosis medication in women>  80 years in clinical practice likely works, and the magnitude of effect is similar to what was estimated in younger women. The choice between osteoporosis treatment and calcium/vitamin D after fracture in women ≥ 80 years is not random but appears associated with the patient’s health stat us and presence of vertebral fractures, rather than the known risk profile of sustaining a fracture at a high age. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Alendronate medication possession ratio and the risk of second hip fracture: an 11-year population-based cohort study in Taiwan
AbstractSummaryAlendronate is effective in preventing second hip fracture in osteoporotic patients. However, no consensus exists on the duration that is effective in preventing a second hip fracture. Our study demonstrated that risk can be reduced when the prescription is ≥ 6 months for the year following the index hip fracture.IntroductionAlendronate is effective in preventing second hip fracture in osteoporotic patients. However, no consensus exists on the accurate medication possession ratio (MPR) that is effective in preventing a second hip fracture. Our objective was to compare the risk of second hip fr...
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Having caregiving responsibilities affects management of fragility fractures and bone health
ConclusionFragility fracture is associated with, and potentially leads to an impairment of, an important social role in patients providing physical and emotional support and supervision for dependents as caregivers. Further, an important cause of fragility fracture can occur in the act of caregiving. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Secular trends in the initiation of therapy in secondary fracture prevention in Europe: a multi-national cohort study including data from Denmark, Catalonia, and the United  Kingdom
ConclusionDespite repeated calls for improved secondary fracture prevention, an unacceptably large treatment gap remains, with time trends indicating that the problem may be getting worse in recent years. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Existing severe osteoporotic vertebral fractures in elderly Chinese males were only weakly associated with higher further vertebral fracture risk at year-4 follow-up
(Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

What can we learn about corticosteroid therapy as a treatment for COVID-19?
(Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Correction to: Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women
The original version of this article, published on 14 December 2018, unfortunately contained a mistake. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Correspondence to “Denosumab-induced hypocalcemia in patients with osteoporosis: can you know who will get low?”
(Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Correction to: Abaloparatide effect on forearm bone mineral density and wrist fracture risk in postmenopausal women with osteoporosis
The original version of this article, published on 21 March 2019, unfortunately contains some typos in Figs.  2, 3, 4, and Supplemental Fig. 1. The corrected figures are given below. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Response to letter to the editor OSIN-D-20-00441 re: “Denosumab-induced hypocalcemia in patients with osteoporosis: can you know who will get low?”
(Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Risk of acute myocardial infarction among new users of bisphosphonates: a nested case –control study
ConclusionThe results do not support a cardioprotective effect of bisphosphonates regardless of the duration of treatment, age, sex or background cardiovascular risk. However, a small protective effect could have been masked if patients with osteoporosis have had a background higher risk of AMI. (Source: Osteoporosis International)
Source: Osteoporosis International - July 14, 2020 Category: Orthopaedics Source Type: research

Prediction models and questionnaires developed to predict vitamin D status in adults: a systematic review
The objective is to identify and compare existing screening tools, developed to identify vitamin D deficiency or insufficiency in adults. A systematic search of literature was conducted using MEDLINE, Scopus, Web of Science and CINAHL databases. Risk of bias and applicability concerns were assessed by quality assessment of diagnostic accuracy studies (QUADAS-2). Data were extracted on socio-demographic, anthropometric, risk factors, serum 25 hydroxyvitamin D [25(OH)D] levels, statistical methods and predictive ability. A total of 12 studies were considered for inclusion for this systematic review after screening of 4851 ab...
Source: Osteoporosis International - July 13, 2020 Category: Orthopaedics Source Type: research

Cost-effectiveness of balloon kyphoplasty and vertebroplasty versus conservative medical management in the USA
ConclusionWhile VP and BKP are more expensive treatment options than CMM in the short term, model results suggest interventional treatment is cost-effective, among patients eligible for surgery, at a US WTP threshold. This conclusion supports those from economic analyses conducted in EU-member countries. (Source: Osteoporosis International)
Source: Osteoporosis International - July 12, 2020 Category: Orthopaedics Source Type: research

Factors associated with fracture after stroke and TIA: a long-term follow-up
ConclusionStroke was positively associated with fracture in patients
Source: Osteoporosis International - July 10, 2020 Category: Orthopaedics Source Type: research

A comparison of floor surfaces for injury prevention in care settings: impact forces and horizontal pulling force required to move wheeled equipment
ConclusionsThese results can inform the development of flooring and the establishment of standards needed to underpin practice, research, and development in this field. (Source: Osteoporosis International)
Source: Osteoporosis International - July 9, 2020 Category: Orthopaedics Source Type: research

An analysis of osteoporosis in patients with hereditary multiple exostoses
AbstractSummaryWe analyzed osteoporosis in 20 HME patients. According to the T-score of BMD, 30% and 67.5% of the patients fell in the range of osteopenia in the lumbar spine and femoral neck. Our results indicate HME patients have low bone mass. They do not have abnormal bone metabolism.IntroductionThere are few reports of osteoporosis in hereditary multiple exostoses (HME) patients. Therefore, the purpose of this study was to analyze osteoporosis in HME patients.MethodsThis retrospective cohort study included 20 patients diagnosed with HME. Patients underwent bone mineral density (BMD) measurement of the lumbar spine (n&...
Source: Osteoporosis International - July 8, 2020 Category: Orthopaedics Source Type: research

Risk factors and renal outcomes of low bone mineral density in patients with non-dialysis chronic kidney disease
AbstractSummaryBone disorder is a common complication of chronic kidney disease (CKD). The clinical usefulness of bone mineral density (BMD) in CKD is not well known. Our study shows that low BMD is associated with physical activity and dietary Na/K intake ratio and can predict poor renal outcome in non-dialysis CKD.PurposeDespite evidence of a link between bone mineral disorders and chronic kidney disease (CKD), the clinical implications of bone mineral density (BMD) in CKD are not well established. We investigated risk factors and renal outcomes of low BMD in CKD.MethodsWe analyzed data from the KNOW-CKD. BMD measured by...
Source: Osteoporosis International - July 8, 2020 Category: Orthopaedics Source Type: research

Protein intake and osteosarcopenic adiposity in Korean adults aged 50  years and older
ConclusionIn conclusion, a protein intake of RNI or more is associated with a lower risk of OSA in Korean elderly men. (Source: Osteoporosis International)
Source: Osteoporosis International - July 8, 2020 Category: Orthopaedics Source Type: research

Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?
We present a narrative review of the benefits versus risks of using MHT in the management of postmenopausal osteoporosis. Current literature suggests robust anti-fracture efficacy of MHT in patients unselected for low BMD, regardless of concomitant use with progestogens, but with limited evidence of persisting skeletal benefits following cessation of therapy. Side effects include cardiovascular events, thromboembolic disease, stroke and breast cancer, but the benefit-risk profile differs according to the use of opposed versus unopposed oestrogens, type of oestrogen/progestogen, dose and route of delivery and, for cardiovas...
Source: Osteoporosis International - July 8, 2020 Category: Orthopaedics Source Type: research

Blindness increases the risk for hip fracture and vertebral fracture but not the risk for distal radius fracture: a longitudinal follow-up study using a national sample cohort
AbstractSummaryThe risks for hip fracture and vertebral fracture, but not the risk for distal radius fracture, were significantly higher in the blindness group than in the control group with a maximum 12-year follow-up.PurposeTo evaluate the influence of visual impairment on the risk for osteoporotic fractures at common sites: hip, thoracic/lumbar vertebra, and distal radius.MethodsThis longitudinal follow-up study used a database of a national sample cohort from 2002 to 2013 provided by the Korean National Health Insurance Service. Of a total of 1,125,691 subjects, 3918 patients with visual impairment and age ≥ 50 year...
Source: Osteoporosis International - July 6, 2020 Category: Orthopaedics Source Type: research

Using opportunistic screening with abdominal CT to identify osteoporosis and osteopenia in patients with diabetes
AbstractSummaryOpportunistic osteoporosis screening involves measuring the attenuation of L1 vertebrae on abdominal computed tomography (CT), which correlates with DXA T-score. We found that this approach is useful for detecting low bone mass in patients with diabetes and propose L1 attenuation ≤ 135 Hounsfield units (HU) as a threshold for which DXA should be strongly considered.IntroductionAttenuation of the L1 vertebrae on computer tomography (CT) images done for other reasons ( “Opportunistic Osteoporosis Screening”) has been found to correlate well with DXA-derived T-score. However, the method an...
Source: Osteoporosis International - July 5, 2020 Category: Orthopaedics Source Type: research

Bone microstructure of adult patients with non-surgical hypoparathyroidism assessed by high-resolution peripheral quantitative computed tomography
AbstractSummaryThere is limited evidence regarding changes in bone microstructure in patients with hypoparathyroidism. In the current study, we used a non-invasive technique to assess bone structure in hypoparathyroidism patients and discovered site-specific changes which were mainly influenced by age and menstrual status. Such changes were more prominent in the trabeculae as well as in non-surgical as opposed to post-surgical patients.IntroductionHypoparathyroidism (hypoPT) is a rare disease characterized by the lack of parathyroid hormone. There is limited evidence regarding changes in bone microstructure in patients wit...
Source: Osteoporosis International - July 4, 2020 Category: Orthopaedics Source Type: research

A single dose of zoledronate preserves bone mineral density for up to 2  years after a second course of romosozumab
ConclusionA zoledronate follow-on regimen can maintain robust BMD gains achieved with romosozumab treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - July 4, 2020 Category: Orthopaedics Source Type: research

Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: new insights into its long-term management
AbstractSummaryOsteoporosis and atherosclerosis frequently coexist in patients with pheochromocytoma. The presence of osteoporosis may predict that of atherosclerosis and vice versa in patients with PHEO. These findings have implications for the long-term management of the pheochromocytoma and its potential chronic complications.IntroductionPheochromocytoma (PHEO), a catecholamine-producing tumor, is often found incidentally, and it may be present for years before it is diagnosed. However, long-term exposure to catecholamines excess may induce chronic complications, such as osteoporosis and atherosclerosis. We aimed to eva...
Source: Osteoporosis International - July 2, 2020 Category: Orthopaedics Source Type: research

Persistence and adherence to parenteral osteoporosis therapies: a systematic review
AbstractOsteoporosis is a chronic disease of low bone mass and fragility. Treatment is frequently compromised by suboptimal medication compliance causing increased morbidity. This review investigates adherence and persistence to parenteral osteoporosis therapies. Findings reveal parenteral medications requiring reduced dosing frequency have higher compliance than oral therapies. This systematic review examines real-world adherence to parenteral osteoporosis therapies. We searched PubMed, Medline, and EMBASE databases for English language observational studies that examined patient adherence and/or persistence to parenteral...
Source: Osteoporosis International - July 1, 2020 Category: Orthopaedics Source Type: research

Risk of fragility fractures in obesity and diabetes: a retrospective analysis on a nation-wide cohort
This study aims to investigate the role of obesity and diabetes on bone health in a nation-wide cohort of women with high risk of fracture.IntroductionThe role of obesity and diabetes on fracture risk is yet poorly understood. Body mass index (BMI) and bone mineral density (BMD) are strongly correlated; however, patients with elevated BMI are not protected against fractures, configuring the obesity paradox. A similar controversial association has been also found in diabetic patients. Herein, we present a retrospective analysis on 59,950 women.MethodsUsing a new web-based fracture risk-assessment tool, we have collected dem...
Source: Osteoporosis International - July 1, 2020 Category: Orthopaedics Source Type: research

Osteoporosis in the age of COVID-19
This article offers a few practical solutions. (Source: Osteoporosis International)
Source: Osteoporosis International - June 8, 2020 Category: Orthopaedics Source Type: research

Few fragility fracture patients perceive that their bone health is affected by their comorbidities and medications
ConclusionAll patients reported a chronic health condition and/or were taking at least one medication that potentially compromised their bone health. Patient awareness of the association between bone health and other health conditions and prescribed medications was low. Health care providers should increase patients ’ awareness of the bone health significance of their chronic conditions and medications in order to minimize the risk of future fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - June 5, 2020 Category: Orthopaedics Source Type: research

Quality and effectiveness of osteoporosis treatment decision aids: a systematic review and environmental scan
AbstractDecision aids (DAs) are evidence-based tools that support shared decision-making (SDM) implementation in practice; this study aimed to identify existing osteoporosis DAs and assess their quality and efficacy; and to gain feedback from a patient advisory group on findings and implications for further research. We searched multiple bibliographic databases to identify research studies from 2000 to 2019 and undertook an environmental scan (search conducted February 2019, repeated in March 2020). A pair of reviewers, working independently selected studies for inclusion, extracted data, evaluated each trial ’s risk...
Source: Osteoporosis International - June 5, 2020 Category: Orthopaedics Source Type: research

Persistent hyperparathyroidism due to mediastinal parathyroid adenoma treated with selective arterial embolization with embosphere: first case in the literature
AbstractPrimary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the clinical setting and affects 0.3% of the population. Parathyroidectomy is the only definitive cure. Unfortunately, even in the most experienced hands, persistent primary hyperparathyroidism (P-PHPT) occurs in 4.7% of the patients. Ectopic adenomas are difficult to localize before and during operation and usually end up with P-PHPT. Herein, we presented a case with P-PHPT due to mediastinal parathyroid adenoma that was successfully ablated with selective arterial embolization. A 57-year-old female patient was admitted to our endocrin...
Source: Osteoporosis International - June 5, 2020 Category: Orthopaedics Source Type: research

Changes in spinal bone density, back muscle size, and visceral adipose tissue and their interaction following a multi-component exercise program in older men: secondary analysis of an 18-month randomized controlled trial
This study aimed to investigate the following: (1) the effect of the exercise program on paraspinal and psoas (back) muscle CSA and VAT, and 2) if any exercise-related changes in muscle CSA and/or VAT were associated with changes in spinal BMD.MethodsMen (n = 180) aged 50 –79 years were randomized to an exercise or no-exercise group. Exercise involved high-intensity progressive resistance training (60–85% max) with weight-bearing impact exercise (3 days/week) for 18 months. Quantitative computed tomography was used to assess L1–L3 Tb.vBMD, paraspinal, and psoas muscle CSA and VAT.ResultsExercise resulted ...
Source: Osteoporosis International - June 4, 2020 Category: Orthopaedics Source Type: research

Where have all the hip fractures gone?
(Source: Osteoporosis International)
Source: Osteoporosis International - June 3, 2020 Category: Orthopaedics Source Type: research

Describing the resource utilisation and costs associated withvertebral fractures: the Build Better Bones with Exercise (B3E) Pilot Trial
ConclusionsWomen with osteoporosis with a previous fracture experience a number of resources and associated costs that impact their care and quality of life. Caregiver time, medications and AEs are the biggest cost drivers for this population. The next steps would be to expand this feasibility study with more participants, longer-term follow-up and more regional variability. (Source: Osteoporosis International)
Source: Osteoporosis International - May 19, 2020 Category: Orthopaedics Source Type: research

Biomechanical Computed Tomography analysis  (BCT) for clinical assessment of osteoporosis
AbstractThe surgeon general of the USA defines osteoporosis as “a skeletal disorder characterized by compromised bone strength, predisposing to an increased risk of fracture.” Measuring bone strength,Biomechanical Computed Tomography analysis  (BCT), namely, finite element analysis of a patient’s clinical-resolution computed tomography (CT) scan, is now available in the USA as a Medicare screening benefit for osteoporosis diagnostic testing. Helping to address under-diagnosis of osteoporosis, BCT can be applied “opportunistically” to most existing CT scans that include the spine or hip re...
Source: Osteoporosis International - May 19, 2020 Category: Orthopaedics Source Type: research

Screening for high fracture risk
(Source: Osteoporosis International)
Source: Osteoporosis International - May 19, 2020 Category: Orthopaedics Source Type: research

Reply to “Screening for high fracture risk”
(Source: Osteoporosis International)
Source: Osteoporosis International - May 19, 2020 Category: Orthopaedics Source Type: research

Correction to: Effects of a resistance and balance exercise programme on physical fitness, health-related quality of life and fear of falling in older women with osteoporosis and vertebral fracture: a randomized controlled trial
The original version of this article, published on 10 January 2020, contained a mistake. An author ’s name was misspelled. (Source: Osteoporosis International)
Source: Osteoporosis International - May 19, 2020 Category: Orthopaedics Source Type: research

Advanced 2D image processing technique to predict hip fracture risk in an older population based on single DXA scans
Conclusion2D SSAM can dramatically improve hip fracture prediction at high specificity levels and estimate the year of the impending fracture using standard clinical images. This has the potential to be implemented in clinical practice to estimate hip fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - May 15, 2020 Category: Orthopaedics Source Type: research

Characterization of fracture liaison service non-responders after invitation by home visits and questionnaires
ConclusionFLS non-responders consider fracture risk as low. Note, 50 patients (about 25%) consented with a home visit after one telephone call, mainly older women with a major fracture. This non-responder subgroup with high subsequent fracture risk is therefore approachable for secondary fracture prevention. (Source: Osteoporosis International)
Source: Osteoporosis International - May 13, 2020 Category: Orthopaedics Source Type: research

Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters
AbstractThis systematic review and meta-analysis set out to determine the effect of dynamic resistance exercise (DRT) on areal bone mineral density (aBMD) in postmenopausal women and derive evidence-based recommendations for optimized training protocols. A systematic review of the literature according to the PRISMA statement included (a) controlled trials, (b) of isolated DRT with at least one exercise and one control group, (c) with intervention durations ≥ 6 months, (d) aBMD assessments at lumbar spine or proximal femur, (e) in cohorts of postmenopausal women. We searched eight electronic databases up to M...
Source: Osteoporosis International - May 12, 2020 Category: Orthopaedics Source Type: research

Vertebral fracture is associated with myocardial infarction in incident hemodialysis patients: a Korean nationwide population-based study
ConclusionIn HD patients, fracture was significantly associated with MI, especially for vertebral fractures patients. (Source: Osteoporosis International)
Source: Osteoporosis International - May 11, 2020 Category: Orthopaedics Source Type: research

Physical activity, sedentary time, and longitudinal bone strength in adolescent girls
ConclusionThe effects of physical activity on bone may be dependent on maturity. Therefore, physical activity interventions, with attention to maturity status, may be required to optimize bone strength in girls. (Source: Osteoporosis International)
Source: Osteoporosis International - May 9, 2020 Category: Orthopaedics Source Type: research

HbA1c variability, in addition to mean HbA1c, predicts incident hip fractures in Chinese people with type 2 diabetes
AbstractSummaryType 2 diabetes is associated with an increased risk of hip fractures. We hypothesize that long-term glycemic variability predicts incident hip fractures. We demonstrated that HbA1c variability predicted incident hip fractures independent of mean HbA1c, suggesting the potential benefits of minimizing glycemic variability in addition to optimizing mean glycemia for bone health.IntroductionType 2 diabetes is associated with an increased risk of hip fractures, and a linear relationship between HbA1c levels and hip fracture incidence has been observed. We hypothesize that HbA1c variability also predicts incident...
Source: Osteoporosis International - May 8, 2020 Category: Orthopaedics Source Type: research

Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence
ConclusionsThe cumulative evidence from prospective cohort studies reassuringly suggests that the risk of hip fracture may not be elevated among people who consume milk, yogurt, and cheese, and that a greater consumption of milk or yogurt may even be associated with a lower risk of hip fracture depending on the factors that may differ across the population of interest. (Source: Osteoporosis International)
Source: Osteoporosis International - May 7, 2020 Category: Orthopaedics Source Type: research

Correction to: Bone health in estrogen-free contraception
The article [Bone health in estrogen-free contraception], written by [P. Hadji, E. Colli, P.-A. Regidor], was originally published. (Source: Osteoporosis International)
Source: Osteoporosis International - May 7, 2020 Category: Orthopaedics Source Type: research

Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats
This study evaluated the peri-implant bone repair in orchiectomized rats receiving intermittently PTH 1-34. The treatment returned the bone quality and quantity of the animals to normal in the computerized microtomography, laser confocal microscopy, and histological analysis. The PTH 1-34 promoted marked bone formation with increased volume, improved quality, and greater bone turnover.IntroductionOsteoporosis can be a problem in implant osseointegration. So this study aimed to evaluate the quantity and quality of peri-implant bone repair in orchiectomized Wistar rats receiving intermittently administered PTH 1-34.MethodsAn...
Source: Osteoporosis International - May 7, 2020 Category: Orthopaedics Source Type: research

Bone densitometry worldwide: a global survey by the ISCD and IOF
AbstractSummaryIn a global survey of fracture liaison services, most reported that DXA access met needs. However, adherence to basic DXA quality and reporting procedures was confirmed by only around 50% of institutions and many required education for operators/interpreters. Overall, there is significant variability in the access to, and quality of, DXA services worldwide.IntroductionWhile the use of dual-energy X-ray absorptiometry (DXA) has been widely adopted worldwide for the assessment of bone mineral density, the quality of DXA facilities is unknown. To address this, a global survey of fracture liaison services (FLS) ...
Source: Osteoporosis International - May 6, 2020 Category: Orthopaedics Source Type: research