Revisit three “I” model: a novel five “I” model of fracture liaison service
(Source: Osteoporosis International)
Source: Osteoporosis International - September 11, 2019 Category: Orthopaedics Source Type: research

Fracture liaison service and mortality in elderly hip fracture patients: a prospective cohort study
AbstractSummaryOsteoporosis is a metabolic disorder that results in increased bone fragility and risk of fractures. Hip fracture is the most important fragility fracture. Fracture Liaison Service (FLS) is a secondary prevention model which identifies patients at risk for fragility fractures. The introduction of an intensive FLS model could decrease 1-year-mortality of hip fracture patients.IntroductionHip fractures are a clinical manifestation of osteoporosis, and these patients are at risk of premature death and suffering subsequent fractures. FLS is an approach for secondary facture prevention by identifying patients wit...
Source: Osteoporosis International - September 11, 2019 Category: Orthopaedics Source Type: research

Correction to: CD4 T cell count is positively associated with lumbar spine bone mass in HIV-infected men under the age of 50  years
Discussion section were incorrect. (Source: Osteoporosis International)
Source: Osteoporosis International - September 10, 2019 Category: Orthopaedics Source Type: research

The association between sarcopenia and osteoporotic vertebral compression refractures
In this study, we reported for the first time that sarcopenia was an independent risk predictor of osteoporotic vertebral compression refractures (OVCRFs). Other risk factors of OVCRFs are low bone mass density T-scores, female sex, and advanced age.IntroductionThe purpose of this study was to investigate the association between osteoporotic vertebral compression refractures (OVCRFs) and sarcopenia, and to identify other risk factors of OVCRFs.MethodsWe evaluated 237 patients with osteoporotic vertebral compression fracture who underwent percutaneous kyphoplasty (PKP) in our hospital from August 2016 to December 2017. To d...
Source: Osteoporosis International - September 3, 2019 Category: Orthopaedics Source Type: research

Elderly males with or without existing osteoporotic vertebral fracture have much lower future vertebral fracture risk than elderly females: the MrOS (Hong Kong) year-4 follow-up spine radiograph study
ConclusionVD progression/new VD is much less common in elderly men than in elderly women. Vertebrae with VD had a higher risk of developing ECF. (Source: Osteoporosis International)
Source: Osteoporosis International - September 2, 2019 Category: Orthopaedics Source Type: research

Bone mineral density in diabetes and impaired fasting glucose
This study aimed to determine whether individuals with IFG have elevated or normal BMD.MethodsWomen (n = 858) and men (n = 970) (aged 20–80 years) from the Geelong Osteoporosis Study were included. IFG was defined as fasting plasma glucose (FPG) 5.5–6.9 mmol/L and diabetes as FPG ≥ 7.0 mmol/L, use of antihyperglycaemic medication and/or self-report. Using multivariable linear regression, the relation ships between glycaemia and BMD at the femoral neck and lumbar spine were examined, and adjusted for age, body mass index (BMI), and other variables. In w...
Source: Osteoporosis International - August 30, 2019 Category: Orthopaedics Source Type: research

Bone material strength in normoglycemic and hyperglycemic black and white older adults
AbstractSummaryThis cross-sectional study assessed cortical bone properties via impact microindentation in adults with normoglycemia, prediabetes, and early-stage T2D. Bone material strength index was stable across the glycemia categories in whites but it declined in blacks. Blacks may be more susceptible than whites to impaired cortical bone properties in early diabetes.IntroductionIndividuals with long-standing type 2 diabetes (T2D) have altered cortical bone material properties as determined by impact microindentation. This cross-sectional study was done to determine whether altered cortical bone material properties cou...
Source: Osteoporosis International - August 28, 2019 Category: Orthopaedics Source Type: research

Rate of drop in serum calcium as a predictor of hypocalcemic symptoms post total thyroidectomy
ConclusionThe rate of drop of serum calcium post total thyroidectomy significantly and independently correlated with the development of hypocalcemic symptoms. Patients with a rate of drop
Source: Osteoporosis International - August 28, 2019 Category: Orthopaedics Source Type: research

A study of dynamic contrast-enhanced MR imaging features and influence factors of pelvic bone marrow in adult females
AbstractSummaryPerfusion of the pelvic bone marrow is reduced in the postmenopausal group and with age. Quantitative dynamic contrast-enhanced MRI could reflect the blood supply characteristics and hemodynamic changes of the pelvic bone marrow. These results contribute to the description of osteoporosis in the postmenopausal females and the elderly.IntroductionTo investigate the effect of menstrual status and age on the perfusion of pelvic bone marrow in adult females using quantitative dynamic contrast-enhanced MRI (DCE-MRI).MethodsIn total, 96 adult females who underwent DCE-MRI between September 2017 and December 2017 w...
Source: Osteoporosis International - August 26, 2019 Category: Orthopaedics Source Type: research

Comorbidity as the dominant predictor of mortality after hip fracture surgeries
ConclusionOur analysis showed that CCI is the dominant predictor of both short- and long-term mortality compared with delay in surgery. The effect of CCI is vital in the prognostication of mortality in patients surgically treated for hip fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - August 26, 2019 Category: Orthopaedics Source Type: research

Test systems for the biomechanical evaluation of hip protectors: a systematic review
This article provides a systematic review of various test systems employed in the determination of the biomechanical efficacy of hip protectors. A systematic literature search was carried out, and 28 relevant articles were included to demonstrate the effect of test systems in the evaluation of the biomechanical effectiveness of hip protectors. Methodological studies illustrated the appropriate use of impact testing systems for the simulation of hip anatomy and fall dynamics in evaluating the effectiveness of hip protectors in preventing a hip fracture. This systematic review has demonstrated the effect of the variability o...
Source: Osteoporosis International - August 24, 2019 Category: Orthopaedics Source Type: research

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men
We describe the time course of bone formation marker (P1NP) decline in men exposed to ~  3 weeks of sleep restriction with concurrent circadian disruption. P1NP declined within 10 days and remained lower with ongoing exposure. These data suggest even brief exposure to sleep and circadian disruptions may disrupt bone metabolism.IntroductionA serum bone formation marker (procollagen type 1 N-terminal, P1NP) was lower after ~  3 weeks of sleep restriction combined with circadian disruption. We now describe the time course of decline.MethodsThe ~  3-week protocol included two segments: &ldqu...
Source: Osteoporosis International - August 24, 2019 Category: Orthopaedics Source Type: research

Fracture-induced changes in biomarkers CTX, PINP, OC, and BAP —a systematic review
This study searched for articles in PUBMED, CINAHL, Medline, EM-BASE, and Cochrane, and identified 3486 unique articles. These articles were screened based on predefined inclusion and exclusion criteria. Seven articles addressing time to normalization of either CTX, PINP, osteocalcin, or bone-specific alkaline phosphatase after a recent fracture were identified and these were analyzed qualitatively. CTX appeared to return to baseline within 6  months. PINP appeared to return to baseline within 6 months and interestingly dip below baseline after a year. Osteocalcin was elevated throughout the first year after a fr...
Source: Osteoporosis International - August 24, 2019 Category: Orthopaedics Source Type: research

Bone health in estrogen-free contraception
This article reviews the effect of estrogens and progestogens on bone and presents new data of the currently approved drospirenone-only pill. The use of progestin-only contraceptives leading to an estradiol level between 30 and 50 pg/ml does not seem to lead to an acc elerate bone loss. (Source: Osteoporosis International)
Source: Osteoporosis International - August 24, 2019 Category: Orthopaedics Source Type: research

The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis
ConclusionT2DM individuals are at increased risk of hip fracture, post-hip fracture mortality, and hip fracture –free death. After adjustment, T2DM men were at a 28% higher risk of dying after suffering a hip fracture and women had 57% excess risk of post-hip fracture mortality. (Source: Osteoporosis International)
Source: Osteoporosis International - August 23, 2019 Category: Orthopaedics Source Type: research

Natural history of incomplete atypical femoral fractures in patients after a prolonged and variable course of bisphosphonate therapy —a long-term radiological follow-up
ConclusionsIn FSF, there is natural progression from normal bone, to focal cortical thickening, to dreaded black line and eventually to displaced fracture. Most lesions persist, remaining static or progressing, especially if a dreaded black line is present and bisphosphonates are continued. Regression is uncommon and more frequent when bisphosphonates are discontinued. Despite stopping bisphosphonates, there remains a 10.9% risk of progression to displaced fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - August 21, 2019 Category: Orthopaedics Source Type: research

Different surgical outcomes in a patient with bilateral atypical femoral fracture related to bisphosphonate use with or without teriparatide treatment
We report a case of bilateral AFFs. The surgical treatments were the same, but the final treatment outcomes were different with or without teriparatide treatment. We investigated the potential causes of the different outcomes of AFFs between the two sides to inform the clinical treatment of AFFs. (Source: Osteoporosis International)
Source: Osteoporosis International - August 19, 2019 Category: Orthopaedics Source Type: research

Effects of anti-osteoporosis medications on radiological and clinical results after acute osteoporotic spinal fractures: a retrospective analysis of prospectively designed study
AbstractSummaryEffects of anti-osteoporosis medications such as anti-resorptive and anabolic agents on healing of osteoporotic spinal fracture were retrospectively investigated. The use of anabolic agent significantly enhanced fracture healing, reduced progressive collapse, and presented good pain relief. These findings suggest that proper selection of medication could improve initial management of acute osteoporotic spinal fractures (OSFs).IntroductionAlthough anti-osteoporosis medications have beneficial effects on prevention of osteoporotic spinal fractures (OSFs), few studies have compared effects of medications on fra...
Source: Osteoporosis International - August 17, 2019 Category: Orthopaedics Source Type: research

Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010
ConclusionsWe observed declining trends in MOF and hip fracture for both sexes. However, a lower rate of decrease of hip fracture and an increasing trend in vertebral fracture was noticed among men. Considering our observations and the major economic burden that accompanies this devastating disease, more attention should be paid to MOF, especially in men. (Source: Osteoporosis International)
Source: Osteoporosis International - August 15, 2019 Category: Orthopaedics Source Type: research

Laboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders
ConclusionsScreening for secondary causes of osteoporosis, particularly for hypogonadism and hypovitaminosis D, should be considered in patients with a SCI/D. (Source: Osteoporosis International)
Source: Osteoporosis International - August 13, 2019 Category: Orthopaedics Source Type: research

FGF23 and bone microarchitecture
(Source: Osteoporosis International)
Source: Osteoporosis International - August 12, 2019 Category: Orthopaedics Source Type: research

FGF 23 and trabecular microarchitecture
(Source: Osteoporosis International)
Source: Osteoporosis International - August 12, 2019 Category: Orthopaedics Source Type: research

Vitamin D and cardiovascular disorders
In conclusion, preclinical data generated a plausible hypothesis of a link between vitamin D status and extra-skeletal events, including cardiovascular endpoints. Whether the vitamin D endocrine system is redundant for the human vascular system or whether the RCTs have not been optimally designed to answer the research question is thus not yet settled. (Source: Osteoporosis International)
Source: Osteoporosis International - August 11, 2019 Category: Orthopaedics Source Type: research

Prediction of lumbar vertebral strength of elderly men based on quantitative computed tomography images using machine learning
ConclusionsThis study provided an effective approach to predict vertebral strength and showed that it may have great potential in clinical applications for noninvasive assessment of vertebral fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - August 10, 2019 Category: Orthopaedics Source Type: research

Study of twice-weekly injections of Teriparatide by comparing efficacy with once-weekly injections in osteoporosis patients: the TWICE study
AbstractSummaryA 48-week, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial (the TWICE study) conducted in Japanese primary osteoporosis patients with a high risk of fractures demonstrated that a 28.2- μg twice-weekly regimen of teriparatide can provide comparable efficacy to a 56.5-μg once-weekly regimen of teriparatide, while also improving safety.IntroductionWhile a 56.5- μg once-weekly regimen of teriparatide has high efficacy for osteoporosis, treatment continuation rates are low, with one of the major causes being adverse drug reactions such as nausea or vomiting. ...
Source: Osteoporosis International - August 8, 2019 Category: Orthopaedics Source Type: research

Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank
AbstractSummaryWe conducted a phenome-wide Mendelian randomization analysis (MR-PheWAS) to survey health effects associated with high normal serum calcium. We found causal evidence for conditions related to renal function, bone and joint health, and cardiovascular risk. These conditions collectively suggest that tissue calcification may be a key mechanism through which serum calcium influences health.IntroductionCalcium is essential for the normal functioning of the cardiovascular system, muscles, and nerves. In this MR-PheWAS study, we sought to capture the totality of health effects associated with high normal serum calc...
Source: Osteoporosis International - August 8, 2019 Category: Orthopaedics Source Type: research

Evaluating RANKL and OPG levels in patients with Duchenne muscular dystrophy
AbstractSummaryRANKL-OPG should be explored in DMD patients to potentially provide targeted therapy. We quantified RANKL and OPG levels in DMD patients compared with controls. RANKL, OPG, and RANKL:OPG significantly declined with age in DMD patients suggesting some bone turnover markers are difficult to assess or use as therapeutic indicators.IntroductionOsteoporosis in Duchenne muscular dystrophy (DMD) is multi-factorial in nature with high prevalence of fractures. RANKL-OPG should be explored to potentially provide targeted therapy for these patients. We quantified RANKL, OPG, and RANKL:OPG levels in DMD patients compare...
Source: Osteoporosis International - August 7, 2019 Category: Orthopaedics Source Type: research

Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF)
ConclusionThese recommendations are intended for clinicians to manage adherence of their patients and to researchers and policy makers to design, facilitate and appropriately use adherence interventions. (Source: Osteoporosis International)
Source: Osteoporosis International - August 7, 2019 Category: Orthopaedics Source Type: research

Serum fibroblast growth factor 23 and mineral metabolism in patients with euthyroid Graves ’ diseases: a case-control study
ConclusionSerum phosphorus and FGF23 levels remain higher in GD patients even after euthyroid status has been achieved for a median of 1.6  years. Serum FGF23 was negatively correlated with serum phosphorus in euthyroid GD patients. Underlying mechanisms warrant further investigations.Trial registrationRegistration number: NCT01660308 and NCT02620085 (Source: Osteoporosis International)
Source: Osteoporosis International - August 5, 2019 Category: Orthopaedics Source Type: research

Systematic review of the effects of bisphosphonates on bone density and fracture incidence in childhood acute lymphoblastic leukaemia
ConclusionsThis systematic review identified that there is insufficient evidence to support routine use of prophylactic bisphosphonate therapy in childhood ALL for prevention of fracture and improvement of bone mass. Future well-designed clinical trials in those at highest risk of fractures in ALL are now needed. (Source: Osteoporosis International)
Source: Osteoporosis International - August 3, 2019 Category: Orthopaedics Source Type: research

Influence of fall environment and fall direction on risk of injury among pre-frail and frail adults
AbstractSummaryIn this prospective study, half of all falls resulted in injury. Pre-frail adults sustained more injuries, while more frail adults had injuries requiring hospitalization or fractures. Pre-frail adults fell more often when in movement compared with frail adults who fell more often when standing and in indoor public spaces.PurposeTo assess prospectively how fall environment and direction are related to injury among pre-frail and frail adults.MethodsWe included 200 community-dwelling adults with a prior fall (pre-frail, mean age 77  years) and 173 adults with acute hip fracture (frail, mean age 84 yea...
Source: Osteoporosis International - August 3, 2019 Category: Orthopaedics Source Type: research

Percutaneous vertebroplasty versus non-operative treatment for osteoporotic vertebral compression fractures: a meta-analysis of randomized controlled trials
ConclusionsApplication of PVP was effective and safe only in patients with acute OVCFs having persistent and severe pain. No benefits were recorded, among patients with older fractures or those bearing non-severe symptoms. (Source: Osteoporosis International)
Source: Osteoporosis International - August 3, 2019 Category: Orthopaedics Source Type: research

Effects of milk powder intervention on bone mineral density and indicators related to bone metabolism in Chinese adolescents
AbstractSummaryThe study is to determine the effects of milk powder on bone density and metabolism in healthy adolescents. Vitamin D and calcium supplements increased IGF-1 but did not affect bone mineralization or turnover. Higher vitamin D in combination with sufficient calcium supplementation in such populations requires attention.IntroductionBoth calcium and vitamin D play an important role in bone mineralization in adolescents.MethodsIn this one and a half-year randomized controlled trial, 232 participants (aged 12 –15 years) were randomly assigned to three intervention groups receiving milk powder fortifie...
Source: Osteoporosis International - August 2, 2019 Category: Orthopaedics Source Type: research

Evaluation of bone texture imaging parameters on panoramic radiographs of patients with Sheehan ’s syndrome: a STROBE-compliant case-control study
AbstractSummarySheehan ’s syndrome (SHS) is a rare condition related to the risk of osteoporosis and evaluation of bone texture imaging features on panoramic radiographs would be suitable for this condition, which was the aim of the present study. Fractal dimension, lacunarity, and trabecular morphologic aspects were si gnificantly altered in these patients.IntroductionSHS is an important public health problem particularly in developing countries. It is characterized as postpartum hypopituitarism secondary to obstetric complications-related ischemic pituitary necrosis that shows significant systemic metabolic repercu...
Source: Osteoporosis International - August 2, 2019 Category: Orthopaedics Source Type: research

Fracture prediction from self-reported falls in routine clinical practice: a registry-based cohort study
We examined the independent effects of falls on subsequent fractures in a large clinical registry of bone mineral density (BMD) results for the Province of Manitoba, Canada that has been systematically collecting self-reported falls information since September 1, 2012.MethodsThe study population consisted of 24,943 women and men aged 40  years and older (mean age 65.5 ± 10.2 years) with fracture probability assessment (FRAX), self-reported falls for the previous year (categorized as none, 1, 2, or> 3) and fracture outcomes. Adjusted hazard ratios (HR) with 95 confidence intervals (CI)...
Source: Osteoporosis International - August 2, 2019 Category: Orthopaedics Source Type: research

Letter to the Editor about the article “A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk”
(Source: Osteoporosis International)
Source: Osteoporosis International - August 2, 2019 Category: Orthopaedics Source Type: research

Oral vitamin D 3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis
AbstractStudies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. This systematic review and meta-analysis was conducted to summarize all available data. A systematic review was conducted using MEDLINE and EMBASE database from inception to February 2019 to identify studies that provided oral vitamin D3 supplement to vitamin D-deficient participants (25-hydroxyvitamin D  
Source: Osteoporosis International - August 1, 2019 Category: Orthopaedics Source Type: research

FRAX-based intervention and assessment thresholds for osteoporosis in Iran
ConclusionIntervention thresholds based on BMD alone do not effectively target women at high fracture risk, particularly in the elderly. In contrast, intervention thresholds based on fracture probabilities equivalent to a “fracture threshold” target women at high fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - August 1, 2019 Category: Orthopaedics Source Type: research

Effects of calcium supplementation on circulating osteocalcin and glycated haemoglobin in older women
AbstractSummaryOne year of calcium supplementation in older women led to modest reductions in total osteocalcin and undercarboxylated osteocalcin (ucOC), with no changes in muscle or fat mass, or glycated haemoglobin. Future studies should explore whether treatments with more profound effects of suppressing ucOC may lead to impaired glycaemic control.IntroductionTotal osteocalcin (TOC) is a marker of bone turnover, while its undercarboxylated form has beneficial effects on glucose metabolism in mice. This post hoc analysis of a randomised double-blind, placebo-controlled trial examined whether 1  year of calcium suppl...
Source: Osteoporosis International - July 24, 2019 Category: Orthopaedics Source Type: research

Future hospital service utilisation in older adults living in long-term residential aged care or the community hospitalised with a fall-related injury
ConclusionsIdentifying trajectories of ongoing hospital use informs targeting of strategies to reduce hospital admissions and design of services to allow community-living individuals to remain as long as possible within their own residence. (Source: Osteoporosis International)
Source: Osteoporosis International - July 24, 2019 Category: Orthopaedics Source Type: research

Tea consumption and risk of fractures: an updated meta-analysis
ConclusionsThe current meta-analysis indicates that tea consumption may be associated with a reduced the risk of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - July 23, 2019 Category: Orthopaedics Source Type: research

WNT3A accelerates delayed alveolar bone repair in ovariectomized mice
ConclusionsAlveolar bone injuries heal slower in OVX mice that exhibit an osteoporotic-like phenotype. The rate of alveolar bone repair in OVX mice can be significantly promoted with local delivery of L-WNT3A. (Source: Osteoporosis International)
Source: Osteoporosis International - July 23, 2019 Category: Orthopaedics Source Type: research

Promoting mobility and healthy aging in men: a narrative review
AbstractMaintaining mobility is an important aspect of health and well-being in older men. This literature review describes several modifiable and nonmodifiable risk factors impacting bone, muscle, and joint health. Exercise and nutritional interventions may help to prevent the progressive deterioration in bones, muscles, and joints impacting mobility in later life. Limitations in mobility are increasingly recognized as a major public health problem due to an aging population and growing number of older individuals affected by disabling comorbidities. Despite increasing numbers and debilitating consequences, there are no g...
Source: Osteoporosis International - July 19, 2019 Category: Orthopaedics Source Type: research

How well do the FRAX (Australia) and Garvan calculators predict incident fractures? Data from the Geelong Osteoporosis Study
This study reports that both FRAX and Garvan calculators underestimated fractures in Australian men and women, particularly in those with osteopenia or osteoporosis. Major osteoporotic fractures were poorly predicted, while both calculators performed acceptably well for hip fractures.IntroductionThis study assessed the ability of the FRAX (Australia) and Garvan calculators to predict fractures in Australian women and men.MethodsWomen (n = 809) and men (n = 821) aged 50–90 years, enrolled in the Geelong Osteoporosis Study, were included. Fracture risk was estimated using FRAX and Garva...
Source: Osteoporosis International - July 18, 2019 Category: Orthopaedics Source Type: research

Two-year persistence with teriparatide improved significantly after introduction of an educational and motivational support program
This study evaluated the 2-year persistence with teriparatide in the Netherlands. Analyses showed that the risk of non-persistence was 28% lower in patients who were followed according to an additional educational and motivational support program.IntroductionUntil recently, teriparatide (TPTD) was a third-line treatment option for severe osteoporosis in the Netherlands, which could only be prescribed by medical specialists based on a specific medical statement. We aimed to determine whether an educational and motivational support program (EMSP) increased 2-year treatment persistence with TPTD in patients with severe osteop...
Source: Osteoporosis International - July 18, 2019 Category: Orthopaedics Source Type: research

Denosumab utilization among older adults in Ontario: patient characteristics, persistence with therapy, and return to therapy after an extended gap
ConclusionsDenosumab utilization is increasing at a steady rate in Ontario. However, persistence remains a concern given the highly reversible pharmacokinetic profile of denosumab that results in a rapid increased fracture risk following discontinuation. Over 80% of patients had a history of oral bisphosphonate therapy, which may persist in bone despite discontinuing denosumab. Consequently, better understanding of denosumab safety and effectiveness among real-world users is important. (Source: Osteoporosis International)
Source: Osteoporosis International - July 17, 2019 Category: Orthopaedics Source Type: research

Time trends in oral bisphosphonate initiation in Ontario, Canada over 20  years reflect drug policy and healthcare delivery changes
ConclusionsThe characteristics of patients starting oral bisphosphonate therapy have changed over time. Consideration must be given to these time trends when designing studies that examine osteoporosis drug effects. (Source: Osteoporosis International)
Source: Osteoporosis International - July 17, 2019 Category: Orthopaedics Source Type: research

Correction to: Prevalent vertebral fractures and minor vertebral deformities analyzed by vertebral fracture assessment (VFA) increases the risk of incident fractures in postmenopausal women: the FRODOS study
Figure 1 as published in the original version of this article was unfortunately incomplete. (Source: Osteoporosis International)
Source: Osteoporosis International - July 17, 2019 Category: Orthopaedics Source Type: research

The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service
ConclusionThis study indicates that the presence and severity of prevalent VFs reflect generalized bone deterioration in women with a recent NVF, independently of FN aBMD. (Source: Osteoporosis International)
Source: Osteoporosis International - July 17, 2019 Category: Orthopaedics Source Type: research

The combined effect of Parathyroid hormone (1 –34) and whole-body Vibration exercise in the treatment of postmenopausal OSteoporosis (PaVOS study): a randomized controlled trial
ConclusionTwelve months of WBV and teriparatide had a significant clinically relevant treatment effect in lumbar spine BMD compared to teriparatide alone in postmenopausal osteoporotic women.ClinicalTrials.gov:(NCT02563353). (Source: Osteoporosis International)
Source: Osteoporosis International - July 15, 2019 Category: Orthopaedics Source Type: research