Hyperphosphatemic familial tumoral calcinosis secondary to fibroblast growth factor 23 (FGF23) mutation: a report of two affected families and review of the literature
We describe young Lebanese cousins presenting with HFTC, based on a retrospective chart review and a prospective case study. In addition, we present a comprehensive review on the topic, based on a literature search conducted in PubMed and Google Scholar, in 2014 and updated in December 2017. While the patients had the same previously reportedFGF23 gene mutation (homozygous c.G367T variant in exon 3 leading to a missense mutation), they presented with variable severity and age of disease onset (at 4  years in patient 1 and at 23 years in patient 2). A review of the literature revealed several potential patho-physi...
Source: Osteoporosis International - June 20, 2018 Category: Orthopaedics Source Type: research

Risk of fracture and low bone mineral density in adults with inflammatory bowel diseases. A systematic literature review with meta-analysis
AbstractInflammatory bowel diseases (IBDs) are associated with a decreased bone mineral density, but the impact on fractures is unknown. In our study, global risk of fracture is increased for patients with IBDs versus controls. This result will help to determine the appropriate assessment with early screening and management of osteoporosis. Inflammatory bowel diseases (IBDs), such as Crohn ’s disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density (BMD). However, the impact on fracture risk is unknown and data are contradictory across studies. In this systematic review and meta-...
Source: Osteoporosis International - June 16, 2018 Category: Orthopaedics Source Type: research

Association of renal function with bone mineral density and fracture risk in the Longitudinal Aging Study Amsterdam
ConclusionsIn men and women, early decreased renal function (eGFR
Source: Osteoporosis International - June 15, 2018 Category: Orthopaedics Source Type: research

Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK
ConclusionsBone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children ’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life. (Source: Osteoporosis International)
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Dietary fat, saturated fatty acid, and monounsaturated fatty acid intakes and risk of bone fracture: a systematic review and meta-analysis of observational studies
AbstractTotal dietary fat intake might influence the risk of fracture; however, conflicting findings have been reported to date. Moreover, the type of fatty acids is also of vital importance. We aimed to conduct a comprehensive review of the literature on the association between dietary fat intake, saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and the risk of fracture. PubMed and Scopus were used to conduct a comprehensive search for articles published up to 7 January 2018. To pool effect sizes, random effects models (the DerSimonian-Laird method) were applied. The CochraneQ test was used to trace the ...
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Characteristics of recurrent fractures
ConclusionHigh fracture risks and utility loss immediately after fracture suggest that treatment given as soon as possible after fracture would avoid a higher number of new fractures compared with treatment given later. This provides the rationale for very early intervention immediately after a sentinel fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Abnormal bone turnover in individuals with low serum alkaline phosphatase
AbstractThe clinical spectrum of hypophosphatasia (HPP) is broad and variable within families. Along severe infantile forms, adult forms with mild manifestations may be incidentally discovered by the presence of low alkaline phosphatase (ALP) activity in serum. However, it is still unclear whether individuals with persistently low levels of ALP, in the absence of overt manifestations of HPP, have subclinical abnormalities of bone remodeling or bone mass. The aim of this study was to obtain a better understanding of the skeletal phenotype of adults with low ALP by analyzing bone mineral density (BMD), bone microarchitecture...
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Progression of frailty and prevalence of osteoporosis in a community cohort of older women —a 10-year longitudinal study
AbstractSummaryIn community dwelling, 75-year-old women followed 10  years, a frailty index was created at each of three visits. Frailty score increased by ~ 6–7% annually. A higher frailty score was equivalent to being 5–10 years chronologically older. Frailty was associated with low bone density and higher risk of dying.IntroductionTo understand the distribution of frailty among a population-based sample of older community-dwelling women, progression over 10  years, and association with mortality and osteoporosis.MethodsThe study is performed in a cohort designed to investigate osteoporo...
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Issues of trial selection and subgroup considerations in the recent meta-analysis of Zhao and colleagues on fracture reduction by calcium and vitamin D supplementation in community-dwelling older adults
ConclusionBased on the four concerns raised in this letter and the fact that there will be a manyfold increase in the data on vitamin D supplementation in community-dwelling senior adults from large ongoing trials, we believe that it is too early to recommend the cessation of vitamin D with or without calcium for the prevention of fractures among community-dwelling adults. (Source: Osteoporosis International)
Source: Osteoporosis International - June 12, 2018 Category: Orthopaedics Source Type: research

Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease
ConclusionsThese results provide new data regarding how reduced kidney function affects drug accumulation in rat bone. (Source: Osteoporosis International)
Source: Osteoporosis International - June 11, 2018 Category: Orthopaedics Source Type: research

Abnormal microarchitecture and stiffness in postmenopausal women using chronic inhaled glucocorticoids
AbstractSummaryPostmenopausal (PM) women using inhaled glucocorticoids (IGCs) had substantial abnormalities in volumetric BMD (vBMD), microarchitecture, and stiffness using high resolution peripheral computed tomography (HRpQCT) compared to age- and race-matched controls. Abnormalities were most severe at the radius. These preliminary results suggest that there may be major, heretofore unrecognized, skeletal deficits in PM women using IGCs.IntroductionWhile oral glucocorticoids are well recognized to have destructive skeletal effects, less is known about the effects of IGCs. The detrimental skeletal effects of IGCs may be ...
Source: Osteoporosis International - June 11, 2018 Category: Orthopaedics Source Type: research

Cost-effective but clinically inappropriate: new NICE intervention thresholds in osteoporosis (Technology Appraisal 464)
ConclusionCost-effectiveness thresholds for low-cost interventions should not be used to set intervention thresholds but rather to validate the implementation of clinically driven intervention thresholds. (Source: Osteoporosis International)
Source: Osteoporosis International - June 8, 2018 Category: Orthopaedics Source Type: research

Rush Fracture Liaison Service for capturing “missed opportunities” to treat osteoporosis in patients with fragility fractures
We report the results of the first 12 months of operation in patients admitted to the hospital.ResultsFirst acute fragility fracture(s) were identified in 36% (80/223), only historical fragility fracture(s) in 28% (63/223) and both acute and historical fragility fracture(s) in 36% (80/223). The cumulative subgroup with historical fragility fractures with/without new fractures included 67% (96/143) without a previous diagnosis of osteoporosis. First acute fragility fracture group included 83.8% (67/80) without a previous diagnosis of osteoporosis. Rush FLS “captured missed opportunities” in 73.1% (163/223) ...
Source: Osteoporosis International - June 4, 2018 Category: Orthopaedics Source Type: research

Review of the guideline of the American College of Physicians on the treatment of osteoporosis
ConclusionsThe ACP guideline appears outdated. (Source: Osteoporosis International)
Source: Osteoporosis International - June 4, 2018 Category: Orthopaedics Source Type: research

Long-term effects of functional impairment on fracture risk and mortality in postmenopausal women
AbstractSummaryOur findings imply that simple functional tests can predict both hip fracture risk and excess mortality in postmenopausal women. Since the tests characterize general functional capacity (one-legged stance, squatting down, and grip strength), these simple measures should have clinical utility in the assessment of women at risk of falls and fragility fracture.IntroductionFunctional impairment is associated with the risk of fall, which is the leading cause of hip fracture. We aimed to determine how clinical assessments of functional impairment predict long-term hip fracture and mortality.MethodsA population-bas...
Source: Osteoporosis International - June 2, 2018 Category: Orthopaedics Source Type: research

Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case –control study
ConclusionsInsulin monotherapy was associated with an increased fracture risk compared to MTF monotherapy in T2DM patients. Fracture risk should be taken into account when starting a glucose-lowering drug as part of T2DM treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - June 2, 2018 Category: Orthopaedics Source Type: research

Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress condition via activating the endogenous antioxidant system
ConclusionsThe results suggested that Vd3 could not only promote the osteogenic differentiation of osteoblastic cells under normal condition but also partly protect the cell from oxidative stress damage by activating endogenous antioxidant system. The study shed light on the new roles of Vd3 in bone modeling and remodeling regulation. (Source: Osteoporosis International)
Source: Osteoporosis International - June 2, 2018 Category: Orthopaedics Source Type: research

The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys
AbstractSummaryAdipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN- γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values.IntroductionThis longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB).MethodsTwenty-six OWB and 29 normal-weight boys were followed y...
Source: Osteoporosis International - June 1, 2018 Category: Orthopaedics Source Type: research

The American Orthopaedic Association ’s Own the Bone ® database: a national quality improvement project for the treatment of bone health in fragility fracture patients
ConclusionOTB is the first and largest multi-center voluntary fragility fracture registry in the USA. The data collected through the OTB program is comparable to that collected in international studies. Thus, the OTB registry functions as an externally valid cohort for further studies assessing the clinical characteristics, interventions, and outcomes achieved in patients who present with a fragility fracture in the USA. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2018 Category: Orthopaedics Source Type: research

Constitutive melanin density is associated with higher 25-hydroxyvitamin D and potentially total body BMD in older Caucasian adults via increased sun tolerance and exposure
This study aimed to describe the relationship between spectrophotometrically determined constitutive melanin density, osteoporotic risk factors and potential intermediaries in a cohort of exclusively older Caucasian adults.MethodsOne thousand seventy-two community-dwelling adults aged 50 –80 years had constitutive melanin density quantified using spectrophotometry. Sun exposure, skin phenotype, non-melanoma skin cancer (NMSC) prevalence and smoking status were assessed by questionnaire. Bone mineral density (BMD), falls risk, physical activity and 25-hydroxyvitamin D were measure d using DXA, the short form Phys...
Source: Osteoporosis International - June 1, 2018 Category: Orthopaedics Source Type: research

Is calcium phosphate augmentation a viable option for osteoporotic hip fractures?
AbstractSummaryThe use of calcium phosphate bone cement has been described to allow for retention of reduction. Therefore, we evaluated whether augmentation with resorbable calcium phosphate could improve fracture stability in osteoporotic hip fractures. The results showed that augmentation with calcium phosphate cement significantly improved the stability of intertrochanteric fractures.IntroductionThe aim with this study was to measure whether augmentation with resorbable calcium phosphate cement could improve fracture stability in osteoporotic hip fractures.MethodsWe retrospectively reviewed 82 patients who underwent clo...
Source: Osteoporosis International - June 1, 2018 Category: Orthopaedics Source Type: research

Association of trabecular bone score (TBS) and prior fracture differs among minorities in NHANES 2005-2008
ConclusionsThe association of fracture and TBS varies by race/ethnicity and gender with weaker association observed in AA and MA women. More research is needed to define the proper use of TBS for predicting fractures in minority groups. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2018 Category: Orthopaedics Source Type: research

Volumetric bone mineral density of the spine predicts mortality in African-American men with type 2 diabetes
ConclusionsLower vBMD was associated with increased all-cause mortality in African-American men with T2D, independent of other risk factors for mortality including subclinical atherosclerosis. (Source: Osteoporosis International)
Source: Osteoporosis International - May 31, 2018 Category: Orthopaedics Source Type: research

Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene
ConclusionsOur evidence supported the significant role ofSQRDL in the etiology of PMOP and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women. (Source: Osteoporosis International)
Source: Osteoporosis International - May 31, 2018 Category: Orthopaedics Source Type: research

Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study
AbstractSummaryAmong 365 Hertfordshire Cohort Study participants (aged 59 –71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by ch anges in immune phenotype and alterations in adipokine homeostasis.IntroductionThe aim of this study was to examine the association between indices of inflammation and BMD in a population-based cohort of older adults in the UK.MethodsAnalyses were...
Source: Osteoporosis International - May 28, 2018 Category: Orthopaedics Source Type: research

Prediction of insufficient serum vitamin D status in older women: a validated model
AbstractSummaryWe developed an externally validated simple prediction model to predict serum 25(OH)D levels
Source: Osteoporosis International - May 28, 2018 Category: Orthopaedics Source Type: research

Genetic study of eight Egyptian patients with pycnodysostosis: identification of novel CTSK mutations and founder effect
ConclusionOur findings expand the mutational spectrum ofCTSK gene and emphasize the importance of full clinical examination of all body systems including thorough orodental evaluation in patients with pycnodysostosis. (Source: Osteoporosis International)
Source: Osteoporosis International - May 23, 2018 Category: Orthopaedics Source Type: research

Biomarkers of muscle damage increased in anterolateral compared to direct lateral approach to the hip in hemiarthroplasty: no correlation with clinical outcome
In this study, we found elevated levels of serum CK in the anterolateral approach to the hip compared to the direct lateral approach in patients with a displaced femoral neck fracture. No correlation was found between levels of CK and functional outcomes.IntroductionTo compare increase in serum creatine kinase (CK) and its association with functional outcome between the muscle-sparing anterolateral approach and the direct lateral approach to the hip in patients with displaced femoral neck fracture (FNF).MethodsIn this randomized trial, we enrolled eligible patients between 70 and 90  years of age with FNF. Patients we...
Source: Osteoporosis International - May 22, 2018 Category: Orthopaedics Source Type: research

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse
AbstractBone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogen...
Source: Osteoporosis International - May 18, 2018 Category: Orthopaedics Source Type: research

Quality indicators for hip fracture care, a systematic review
AbstractQuality indicators are used to measure quality of care and enable benchmarking. An overview of all existing hip fracture quality indicators is lacking. The primary aim was to identify quality indicators for hip fracture care reported in literature, hip fracture audits, and guidelines. The secondary aim was to compose a set of methodologically sound quality indicators for the evaluation of hip fracture care in clinical practice. A literature search according to the PRISMA guidelines and an internet search were performed to identify hip fracture quality indicators. The indicators were subdivided into process, structu...
Source: Osteoporosis International - May 17, 2018 Category: Orthopaedics Source Type: research

Subtrochanteric and diaphyseal femoral fractures in hypophosphatasia —not atypical at all
ConclusionsIncreased risk for subtrochanteric and diaphyseal femoral fractures in HPP appears to result from both compromised bone metabolism as well as disease-associated bone deformities. In severe HPP, generous screening for such fractures seems advisable. Bisphosphonates and Hypovitaminosis D should be avoided. Healing is compromised and requires mindful consideration of both pharmacological and surgical options. (Source: Osteoporosis International)
Source: Osteoporosis International - May 17, 2018 Category: Orthopaedics Source Type: research

Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway
AbstractSummaryUse of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50 –85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men.IntroductionTo examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions.MethodsData were obtained from the Nord-Tr øndelag Health Study (HUNT3) performed in 2006–2008 and the Norwegian Prescription Database, in...
Source: Osteoporosis International - May 17, 2018 Category: Orthopaedics Source Type: research

Cost-effectiveness of osteoporosis screening strategies for hip fracture prevention in older Chinese people: a decision tree modeling study in the Mr. OS and Ms. OS cohort in Hong Kong
ConclusionsOsteoporosis screening strategies based on DXA with or without pre-screening are more cost-effective compared to no screening for Chinese people aged 65 or over in Hong Kong. (Source: Osteoporosis International)
Source: Osteoporosis International - May 17, 2018 Category: Orthopaedics Source Type: research

High levels of serum sclerostin and DKK1 in a case of Klippel-Tr énaunay syndrome
We report a case of a 67-year-old postmenopausal Caucasian women with KTS that shows elevated levels of sclerostin and Dickkopf-related protein 1 (DKK1). Dual-energy X-ray absorptiometry (DXA) BMD T-scores at lumbar spine and femur were normal. Serum calcium and phosphorus levels were consistently normal, 25-hydroxyvitamin D (25OHD)
Source: Osteoporosis International - May 17, 2018 Category: Orthopaedics Source Type: research

Low rates of osteoporosis treatment after hospitalization for hip fracture in Hawaii
ConclusionThe use of osteoporosis medication for secondary prevention after admission for hip fracture in Hawaii is low. Efforts need to be made to improve treatment rates, especially among males. (Source: Osteoporosis International)
Source: Osteoporosis International - May 9, 2018 Category: Orthopaedics Source Type: research

Benefits and safety of dietary protein for bone health —an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporosis Foundation
AbstractA summary of systematic reviews and meta-analyses addressing the benefits and risks of dietary protein intakes for bone health in adults suggests that dietary protein levels even above the current RDA may be beneficial in reducing bone loss and hip fracture risk, provided calcium intakes are adequate. Several systematic reviews and meta-analyses have addressed the benefits and risks of dietary protein intakes for bone health in adults. This narrative review of the literature summarizes and synthesizes recent systematic reviews and meta-analyses and highlights key messages. Adequate supplies of dietary protein are r...
Source: Osteoporosis International - May 8, 2018 Category: Orthopaedics Source Type: research

Reduced bone mineral density in human immunodeficiency virus-infected individuals: a meta-analysis of its prevalence and risk factors: supplementary presentation
AbstractA meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary. (Source: Osteoporosis International)
Source: Osteoporosis International - May 8, 2018 Category: Orthopaedics Source Type: research

Assessment of bone quality in patients with diabetes mellitus
AbstractSubstantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased bone fragility in diabetes. Bone density and quality are important determinants of bone strength. Although bone mineral density (BMD) and the fracture risk assessment tool (FRAX) are very useful clinical tools in assessing bone strength, they may underestimate the fracture risk in diabetes mellitus. Through advances in new technologies such as trabecular bone score (TBS) and peripheral quantitative computed t...
Source: Osteoporosis International - May 7, 2018 Category: Orthopaedics Source Type: research

Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women
ConclusionIn this prospective cohort of healthy postmenopausal women, age-related Ct bone loss was attenuated at non-bearing bone sites in FDP consumers, not in milk or ripened cheese consumers, independently of total energy, calcium, or protein intakes.Study registrationISRCTN11865958 (http://www.isrctn.com) (Source: Osteoporosis International)
Source: Osteoporosis International - May 3, 2018 Category: Orthopaedics Source Type: research

Reply to “At what price decreased mortality risk?”
(Source: Osteoporosis International)
Source: Osteoporosis International - May 3, 2018 Category: Orthopaedics Source Type: research

At what price decreased mortality risk?
(Source: Osteoporosis International)
Source: Osteoporosis International - May 3, 2018 Category: Orthopaedics Source Type: research

Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells
ConclusionsOur results indicate that iron impacts the S1P/S1PR signalizing axis in the MG-63 cell line and suggest that iron can affect the bone-associated S1P pathway and favor the occurrence of osteoporosis during chronic iron overload. (Source: Osteoporosis International)
Source: Osteoporosis International - May 3, 2018 Category: Orthopaedics Source Type: research

Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976 –2013—supplementary presentation
AbstractIncidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age- and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with a hazard ratio (HR) of 2.18. (Source: Osteoporosis International)
Source: Osteoporosis International - May 1, 2018 Category: Orthopaedics Source Type: research

Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women
This study found that a large percentage of Caucasian women have a high genetic risk of osteoporosis, and genetic risk scores are significantly associated with BMD variation in a bone healthy sample of Caucasian women.IntroductionWe aimed to examine the distribution of risk alleles in an independent sample and to determine if such genetic components are associated with bone mineral density (BMD) variation in the sample.MethodsExisting genotype data of 1205 women in the cross-sectional Genomic Wide Scans for Female Osteoporosis Gene Study (GWSFO) were analyzed. Multi-loci genetic risk scores (GRSs) based on 62 BMD-associate...
Source: Osteoporosis International - May 1, 2018 Category: Orthopaedics Source Type: research

Whole egg consumption and cortical bone in healthy children
This study examined the relationships between egg consumption and cortical bone in children.MethodsThe cross-sectional study design included 294 9 –13-year-old black and white males and females. Three-day diet records determined daily egg consumption. Peripheral quantitative computed tomography measured radius and tibia cortical bone. Body composition and biomarkers of bone turnover were assessed using dual-energy X-ray absorptiometry and EL ISA, respectively.ResultsEgg intake was positively correlated with radius and tibia cortical bone mineral content (Ct.BMC), total bone area, cortical area, cortical thickness, pe...
Source: Osteoporosis International - April 30, 2018 Category: Orthopaedics Source Type: research

Is calcifediol better than cholecalciferol for vitamin D supplementation?
AbstractModest and even severe vitamin D deficiency is widely prevalent around the world. There is consensus that a good vitamin D status is necessary for bone and general health. Similarly, a better vitamin D status is essential for optimal efficacy of antiresorptive treatments. Supplementation of food with vitamin D or using vitamin D supplements is the most widely used strategy to improve the vitamin status. Cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are the most widely used compounds and the relative use of both products depends on historical or practical reasons. Oral intake of calcifediol (25OHD3) r...
Source: Osteoporosis International - April 30, 2018 Category: Orthopaedics Source Type: research

Hypocalcemia and bone mineral density changes following denosumab treatment in end-stage renal disease patients: a meta-analysis of observational studies
AbstractThe incidence of hypocalcemia and bone mineral density (BMD) changes in end-stage renal disease (ESRD) patients on denosumab remains unclear. We performed this meta-analysis to assess the incidence of denosumab-associated hypocalcemia and effects of denosumab on BMD in ESRD patients. A literature search was conducted using MEDLINE, EMBASE, and Cochrane Database from inception through November 2017 to identify studies evaluating incidence of denosumab-associated hypocalcemia and changes in serum calcium, phosphate, alkaline phosphatase (ALP), parathyroid hormone (PTH), and BMD from baseline to post-treatment course ...
Source: Osteoporosis International - April 30, 2018 Category: Orthopaedics Source Type: research

Implementation of the Western Australian Osteoporosis Model of Care: a fracture liaison service utilising emergency department information systems to identify patients with fragility fracture to improve current practice and reduce re-fracture rates: a 12-month analysis
This study evaluates the efficacy of a FLS linked to a tertiary hospital emergency department information system (EDIS) in reducing recurrent fractures.MethodsPatients aged ≥ 50 years with MTF identified from EDIS were invited to the FLS. Patient outcomes were compared to routine care (retrospective group—same hospital, and prospective group—other hospital) at 3- and 12-month follow-up.ResultsTwo hundred forty-one of 376 (64.1%) eligible patients participated in the FLS with 12  months of follow-up. Absolute risk of recurrent MTF at 12 months was reduced by 9.2 and 10.2% compared with t...
Source: Osteoporosis International - April 27, 2018 Category: Orthopaedics Source Type: research

The relation of low levels of bone mineral density with coronary artery calcium and mortality
This study investigated the relation of BMD levels with CAC and mortality in both genders across ethnicities.MethodsThis study consisted of 5590 consecutive at-risk subjects without known coronary artery disease (CAD), age 57  ± 12, and 69% male, who underwent non-enhanced cardiac computed tomography, and were followed for mean of 8 years. The subjects’ CAC (Agatston score) and thoracic BMD levels (mg/cm3) were measured. CAC stratified based on the severity to CAC 0, 1 –100, 101–400, and 400+. Low-BMD levels defined as BMD levels below median (180 mg/cm3). Physician verified...
Source: Osteoporosis International - April 27, 2018 Category: Orthopaedics Source Type: research

A proposal for an atypical femur fracture treatment and prevention clinical practice guideline
ConclusionsClinical practice guidelines for the treatment and prevention of AFF will benefit clinicians who are frequently faced with having to make clinical decisions in patients requiring antiresorptive medications. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2018 Category: Orthopaedics Source Type: research