Orthogeriatric co-management reduces incidence of delirium in hip fracture patients
ConclusionOrthogeriatric co-management as an integrated care model reduced the incidence of SSD/delirium in hip fracture patients. (Source: Osteoporosis International)
Source: Osteoporosis International - May 8, 2021 Category: Orthopaedics Source Type: research

Preoperative severe vitamin D deficiency is a significant independent risk factor for poorer functional outcome and quality of life 6 months after surgery for fragility hip fractures
ConclusionPreoperative severe vitamin D deficiency is an independent risk factor for poorer recovery of function and quality of life after hip fracture surgery. (Source: Osteoporosis International)
Source: Osteoporosis International - May 7, 2021 Category: Orthopaedics Source Type: research

Association between outdoor particulate air pollution and the risk of osteoporosis: a systematic review and meta-analysis
AbstractAir pollution is a major threat to global health, which is associated with several adverse health outcomes and increased mortality. Few studies have investigated the association between air pollution and osteoporosis, and their findings were inconclusive. Our objective is to determine whether exposure to outdoor air pollution is causally associated with risk of osteoporosis. A systematic literature search of PubMed, Web of Science, Embase, and Cochrane Library for publications up to December 2020 was conducted for studies reporting the association between air pollution and osteoporosis. Meta-analysis was performed ...
Source: Osteoporosis International - May 6, 2021 Category: Orthopaedics Source Type: research

One-year outcomes of an osteoporosis liaison services program initiated within a healthcare system
This study aimed to evaluate 1-year outcomes of an osteoporosis liaison service (OLS) program that includes two independent components: medication management services (MMS) to improve medication adherence and fracture liaison services (FLS) for secondary prevention.MethodsPatients with new hip fracture or untreated vertebral fractures enrolled in the FLS program (n = 600), and those with osteoporosis medication management issues but not necessarily fragility fractures enrolled in the MMS program (n = 499) were included. To evaluate outcomes, care coordinators assessed baseline items adapted from the 13 Best Practices Frame...
Source: Osteoporosis International - May 6, 2021 Category: Orthopaedics Source Type: research

Internal medicine inpatients ’ prevalence of misdiagnosed severe osteoporosis
AbstractSummaryVertebral fractures (VF) related to osteoporosis (i.e., severe OP) increase the risk of disability and mortality, but they are often neglected. We observed a severe OP misdiagnosis in 28.9% of inpatients with previous spinal imaging positive for VFs. Diagnosing severe OP is crucial to reduce the health care costs of inpatients.IntroductionVertebral fractures (VFs) related to osteoporosis (OP) increase the risk of additional fractures and death. In inpatients, VFs are often neglected with consequent delay in OP treatments, prolongation of hospitalization, and reduction of life expectancy. The aim of this stud...
Source: Osteoporosis International - May 5, 2021 Category: Orthopaedics Source Type: research

Vitamin D status and complications, readmissions, and mortality after hip fracture
ConclusionLow vitamin D at admission for hip fracture increased the risk of delirium, a new hip fracture, and medical readmissions, but not orthopedic complications. The role of vitamin D supplementation to prevent orthopedic complications requires further study. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Cross-sectional and longitudinal associations between sleep duration, sleep quality, and bone stiffness in European children and adolescents
ConclusionThe positive associations between nocturnal sleep, daytime napping and SI depended on total sleep duration. Long-term detrimental effect of extreme sleep duration on SI only existed in individuals with poor sleep quality. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

High-Intensity Physical Activity with High Serum Vitamin D Levels is Associated with a Low Prevalence of Osteopenia and Osteoporosis: A Population-Based Study
AbstractSummaryWe found that combination of high-intensity PA and high 25(OH)D levels was associated with low prevalence of osteoporosis/osteopenia. In addition, the prevalence of osteoporosis was lower in the low PA with high 25(OH)D levels than in the moderate or high PA with low 25(OH)D levels.IntroductionThe aim of this study was to explore the association of physical activity (PA) and serum 25-hydroxyvitamin D (25[OH]D) levels with osteopenia/osteoporosis.MethodsThe Korean National Health and Nutrition Examination Survey data from 2008 to 2011 were used in this study. Data from 6868 individuals were selected. Each ind...
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Real-world bone turnover marker use: impact on treatment decisions and fracture
ConclusionIn this large, heterogeneous population of patients with presumed osteoporosis, BTM testing was associated with treatment decision-making, likely leading to fragility fracture reduction following use. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Efficacy of methotrexate in reducing the risk of bone erosion in patients with rheumatoid arthritis: a systematic review of randomized controlled trials
AbstractEven though new drugs for the treatment of rheumatoid arthritis (RA) have been developed, methotrexate (MTX) remains a commonly used drug for RA management. In addition to monitoring disease activity during RA treatment, bone erosion should be closely assessed throughout long-term RA management. In this review article, we present a systematic review of MTX effectiveness in reducing the risk of bone erosion. We reviewed randomized controlled trial studies that involved MTX monotherapy or MTX in combination with placebo. Evaluation of the progression of bone erosion was examined by radiographic assessment such as tot...
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Contribution of elevation and residential proximity to the coast in explaining geographic variations in hip fracture incidence. A Norwegian Epidemiologic Osteoporosis Studies (NOREPOS) study
ConclusionWe found a somewhat higher incidence of hip fracture in inland residents living in areas of high elevation, as compared to those living in more coastal proximity; however, the geographic variation did not explain county and seasonal differences in fracture incidence in Norway. More in-depth analyses on temperature and climate factors may give further clues. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

The diagnostic value of phase angle, an integrative bioelectrical marker, for identifying individuals with dysmobility syndrome: the Korean Urban-Rural Elderly study
AbstractSummaryLow phase angle, a non-invasive bioimpedance marker, is associated with elevated odds of dysmobility syndrome and its components. Phase angle (estimated cutoffs:
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

High-impact exercise stimulated localised adaptation of microarchitecture across distal tibia in postmenopausal women
ConclusionWe demonstrated that it was possible to detect exercise-related bone adaptation with 3D registration of HR-pQCT scan data. Regular hopping exercise increased Tb.N and possibly BV/TV across the whole distal tibia. A novel finding of the study was that tBFR and tBRR responses to loading were localised: changes were achieved by formation rate exceeding resorption rate in the exercise leg, both globally and at the anterior region where turnover was greatest.Trial registrationclinicaltrials.gov: NCT03225703 (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Pregnancy- and lactation-associated vertebral compression fractures: MRI prevalence and characteristics
This study showed that MRI prevalence of PLVCFs was approximately 0.5% in females ≥ 15 and
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Effect of compression fracture on trabecular bone score at lumbar spine
This study aimed to investigate whether lumbar spine TBS was affected by fractured vertebrae.MethodsWe studied postmenopausal women and men above 50 years old who underwent DXA between January 1, 2017, and May 31, 2019. By calculating the difference of BMD and TBS between L1 and the mean of L2-3, the study compared the difference of values between the control group and fracture group to determine the effects of fractured vertebrae on BMD and TBS.ResultsA total of 377 participants were enrolled with 202 in the control group (157 females; age: 68.06  ± 6.47 years) and 175 in the fracture group (147 females; ...
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Frequency, diagnosis, pathogenesis and management of osteoporosis in alkaptonuria: data analysis from the UK National Alkaptonuria Centre
AbstractSummaryOsteoporosis and fractures are common features of alkaptonuria.IntroductionA large cohort of alkaptonuria (AKU) patients was studied to better recognise and characterise osteoporosis and fractures in AKU.MethodsAssessments including questionnaire analysis, DEXA and CT densitometry at the neck of femur (FN), total hip (TH) and lumbar spine (LS) were performed on patients at baseline when 2 mg nitisinone was commenced, and yearly thereafter. Blood and urine samples were collected for chemical measurement. CT BMD Z-scores were generated.ResultsBetween June 2007 and March 2020, 87 AKU patients attended the NAC. ...
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Racial and gender differences in the relationship between sarcopenia and bone mineral density among older adults
ConclusionsIn this older cohort, sarcopenia is significantly related to low regional/whole-body BMD, and these associations vary by race and sex. Consideration in race and sex is warranted when developing strategies to maintain or minimize BMD loss. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2021 Category: Orthopaedics Source Type: research

Health care utilization and excess costs after pelvic fractures among older people in Germany
ConclusionPelvic fractures come along with high excess costs and should be considered when planning and allocating health care resources. (Source: Osteoporosis International)
Source: Osteoporosis International - April 10, 2021 Category: Orthopaedics Source Type: research

The impact of fracture liaison services on subsequent fractures and mortality: a systematic literature review and meta-analysis
ConclusionThis systematic review and meta-analysis suggests that FLS care is associated with a significantly lower probability of subsequent fractures and mortality although the latter was only found in studies comparing outcomes before and after the introduction of an FLS. The quality assessment revealed that some important methodological issues were unmet in the currently available studies. Recommendations to guide researchers to design high-quality studies for evaluation of FLS outcomes in the future were provided. (Source: Osteoporosis International)
Source: Osteoporosis International - April 7, 2021 Category: Orthopaedics Source Type: research

Osteoporotic hip and vertebral fractures in the Arab region: a systematic review
AbstractAsia is projected to account for the largest proportion of the rising burden of osteoporotic fractures worldwide. Data from the Middle East is scarce. We performed a systematic review on the epidemiology of vertebral and hip osteoporotic fractures in 22 Arab League countries, using Scopus, PubMed, and Embase. We identified 67 relevant publications, 28 on hip and 39 on vertebral fractures. The mean age of patients was 70 –74 years, female to male ratio 1.2:2.1. Age-standardized incidence rates, to the UN 2010 population, were 236 to 290/100,000 for women from Kuwait and Lebanon, lower in Morocco. Risk factors ...
Source: Osteoporosis International - April 7, 2021 Category: Orthopaedics Source Type: research

High prevalence of vertebral fractures in seizure patients with normal bone density receiving chronic anti-epileptic drugs
ConclusionsBy performing a VFA in addition to standard bone densitometric studies, we disclosed a large prevalence of compression fractures in individuals with epilepsy chronically treated with AEDs who had BMDs in the normal and osteopenic ranges. The addition of VFA or other imaging methods to evaluate VF should be included in the evaluation of bone health in individuals with epilepsy receiving AEDs since it may modify treatment recommendations to prevent future osteoporotic fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - April 6, 2021 Category: Orthopaedics Source Type: research

Height loss in postmenopausal women —do we need more for fracture risk assessment? Results from the GO Study
AbstractSummaryHuman body height loss of 3 –4 cm or more may be considered a simple indicator of increasing fracture risk, where the information is very similar to the results from fracture risk assessments by available online calculators, all of them based on a multiple variable approaches.IntroductionThe aim of the study was to assess the relationship between body height loss (HL) and fracture risk in postmenopausal women from the Gliwice Osteoporosis (GO) Study.MethodsThe study sample included 1735 postmenopausal women, aged over 55 years and recruited at the Osteoporotic Outpatient Clinic. The mean age of the stu...
Source: Osteoporosis International - April 5, 2021 Category: Orthopaedics Source Type: research

Higher latitude and lower solar radiation influence on hip fracture admissions in Chilean older population
ConclusionRegional solar radiation and latitude were associated with hip fracture admission rates in men aged 65 years or older in Chile, with highest admission rates at higher latitudes and lower solar radiation. (Source: Osteoporosis International)
Source: Osteoporosis International - April 5, 2021 Category: Orthopaedics Source Type: research

An assessment of intervention thresholds for very high fracture risk applied to the NOGG guidelines
ConclusionsProposals for FRAX-based criteria for very high risk for the NOGG hybrid model categorise a small proportion of women age 50 years or more (10%) in this highest risk stratum. The level of risk identified was comparable to that of women enrolled in trials of anabolic agents. (Source: Osteoporosis International)
Source: Osteoporosis International - April 4, 2021 Category: Orthopaedics Source Type: research

Efficiently stratifying mid-term death risk in femoral fractures in the elderly: introducing the ASAgeCoGeCC Score
ConclusionThe ASAgeCoGeCC Score is a predictive tool for mortality after hip fracture with good calibration and excellent discrimination properties. It is the first scoring system stratifying hip fracture patients ’ mortality at 4 years from fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - April 3, 2021 Category: Orthopaedics Source Type: research

Long-term evaluation of anabolic and anti-resorptive agents in adults with familial osteoporosis due to pro205ala variant of the col1a1 gene
We report the results of BMD of a family harbouring C 613 C>G substitution in exon 8 of Col1A1 gene leading to Pro205Ala missense variant, as  well as the results of long term treatment of a mother and daughter with this mutation. (Source: Osteoporosis International)
Source: Osteoporosis International - April 2, 2021 Category: Orthopaedics Source Type: research

Trends in hip fracture care in the Republic of Ireland from 2013 to 2018: results from the Irish Hip Fracture Database
ConclusionWhile some hip fracture standards have improved, further improvements are required to compare favourably internationally. Reduction of surgical delay and ensuring early mobilisation post-operatively are immediate priorities for the IHFD. (Source: Osteoporosis International)
Source: Osteoporosis International - April 1, 2021 Category: Orthopaedics Source Type: research

Denosumab for craniofacial fibrous dysplasia: duration of efficacy and post-treatment effects
We report a case of successful treatment of aggressive craniofacial FD with denosumab, highlighting novel insights into the duration of efficacy, surrogate treatment markers, and discontinuation effects. A 13-year-old girl presented with persistent pain and expansion of a maxillary FD lesion, which was not responsive to repeated surgical procedures or bisphosphonates. Pre-treatment biopsy showed high RANKL expression and localization with proliferation markers. Denosumab therapy was associated with improved pain, decreased bone turnover markers, and increased lesion density on computed tomography scan. During 3.5 years of ...
Source: Osteoporosis International - March 27, 2021 Category: Orthopaedics Source Type: research

Cost effectiveness of romosozumab versus teriparatide for severe postmenopausal osteoporosis in Japan
ConclusionResults show that romosozumab/alendronate produces greater health benefits at a lower total cost than teriparatide/alendronate. (Source: Osteoporosis International)
Source: Osteoporosis International - March 27, 2021 Category: Orthopaedics Source Type: research

Early clinical effects, safety, and predictors of the effects of romosozumab treatment in osteoporosis patients: one-year study
ConclusionRomosozumab is an effective treatment for spine osteoporosis because it significantly increases the percent change in the spine BMD at 12 months. The percent change in the spine BMD is higher in patients not previously treated with other anti-osteoporosis medications. (Source: Osteoporosis International)
Source: Osteoporosis International - March 26, 2021 Category: Orthopaedics Source Type: research

Sedentary behaviour and bone health in older adults: a systematic review
AbstractOlder adults spend more than 8 h/day in sedentary behaviours. Detrimental effects of sedentary behaviour (SB) on health are established, yet little is known about SB and bone health (bone mineral density; BMD) in older adults. The purpose of this review is to examine associations of SB with BMD in older adults. Five electronic databases were searched: Web of Science (Core Collection); PubMed; EMBASE; Sports Medicine and Education and PsycInfo. Inclusion criteria were healthy older adults mean age ≥ 65 years; measured SB and measured BMD using dual-energy X-ray absorptiometry. Quality was assessed using National ...
Source: Osteoporosis International - March 25, 2021 Category: Orthopaedics Source Type: research

Geographical variation in surgical care and mortality following hip fracture in England: a cohort study using the National Hip Fracture Database (NHFD)
ConclusionsWe have identified regional differences in operation type and 30-day mortality amongst hip fracture patients in England. The relationship between surgical approach and mortality has been explored, but the extent to which differential mortality reflects variation in approach to medical assessment, anaesthesia and other aspects of care warrants further investigation. (Source: Osteoporosis International)
Source: Osteoporosis International - March 25, 2021 Category: Orthopaedics Source Type: research

Impact of population-based or targeted BMD interventions on fracture incidence
ConclusionsBoth strategies reduced the numbers of expected incident fractures, with contrasting relative impacts by age and fracture site. Whilst the current analysis used UK/European anthropometric/risk factor distributions, further analyses calibrated to the distributions in other settings globally may be readily undertaken. Overall, these findings support the investigation of both population level interventions and those targeted at high fracture risk groups. (Source: Osteoporosis International)
Source: Osteoporosis International - March 23, 2021 Category: Orthopaedics Source Type: research

Skeletal characterization in a patient with Hajdu-Cheney syndrome undergoing total knee arthroplasty
We report a 38-year-old male HCS patient with a history of multiple pathologic fractures, poor bone stock under intermittent antiresorptive therapy, and secondary osteoarthritis (OA) of the knee, in which we successfully performed total knee arthroplasty (TKA). Next to a detailed skeletal assessment including laboratory bone metabolism markers, dual energy X-ray absorptiometry (DXA), and high-resolution peripheral quantitative computed tomography (HR-pQCT), undecalcified histologic and histomorphometric analysis was performed on intraoperatively obtained tibial cut sections. This multiscale assessment revealed a severe, co...
Source: Osteoporosis International - March 19, 2021 Category: Orthopaedics Source Type: research

Alendronate use in older patients with reduced renal function: challenges and opportunities in clinical practice
AbstractSummaryIn this retrospective cohort study, alendronate use among older osteoporosis patients (age>65 years) with reduced renal function (creatinine clearance
Source: Osteoporosis International - March 15, 2021 Category: Orthopaedics Source Type: research

The treatment gap after major osteoporotic fractures in Denmark 2005-2014: a combined analysis including both prescription-based and hospital-administered anti-osteoporosis medications
ConclusionA significant treatment gap among patients sustaining a major osteoporotic fracture was present throughout our analysis, and including hospital-administered AOM did not significantly improve the treatment gap assessment. Improved secondary fracture prevention is urgently needed. (Source: Osteoporosis International)
Source: Osteoporosis International - March 15, 2021 Category: Orthopaedics Source Type: research

Regional and gender-specific analyses give new perspectives for secular trend in hip fracture incidence
ConclusionIncidence of hip fracture has converged significantly between regions and genders. Especially factors related with socioeconomic development and increased frailty and longevity seem to be important. The hip fracture incidence rate ratio between women and men has systematically decreased in time, and more attention should be paid to hip fracture risk in men in the future. (Source: Osteoporosis International)
Source: Osteoporosis International - March 12, 2021 Category: Orthopaedics Source Type: research

Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis
This study aimed to assess the association between serum 25(OH)Vit-D and the risk of fractures in children, and to explore the sources of heterogeneity and investigate their impact on results.MethodsSystematic review and meta-analysis were conducted for observational studies comparing serum 25(OH)Vit-D levels between fracture and non-fracture pediatric cases. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS).ResultsAnalysis on 17 case-control and 6 cross-sectional studies (2929 fracture cases and 5000 controls) suggested that 25(OH)Vit-D was lower in fracture cases than in controls (po...
Source: Osteoporosis International - March 11, 2021 Category: Orthopaedics Source Type: research

Correction to: How has COVID-19 affected the treatment of osteoporosis? An IOF-NOF-ESCEO global survey
A Correction to this paper has been published:https://doi.org/10.1007/s00198-021-05905-7 (Source: Osteoporosis International)
Source: Osteoporosis International - March 9, 2021 Category: Orthopaedics Source Type: research

Clinical and molecular characterization of Chilean patients with X-linked hypophosphatemia
We report the most comprehensive clinical and molecular characterization of XLH patients performed in Chile. We show high prevalence of musculoskeletal burden and pain, associated with significantly impaired physical capacity and quality of life, with many relevant complications presenting more frequently than previously reported in cohorts from developed countries.IntroductionOur current understanding of the clinical presentation and natural history of X-linked hypophosphatemia (XLH) comes mainly from cohorts from developed countries, with limited data on the clinical and genetic abnormalities of XLH patients in South Ame...
Source: Osteoporosis International - March 5, 2021 Category: Orthopaedics Source Type: research

Reply to Comment on “Osteoporosis in the Age of COVID-19”
(Source: Osteoporosis International)
Source: Osteoporosis International - March 4, 2021 Category: Orthopaedics Source Type: research

In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures
ConclusionFrail elderly women are at immediate risk of fracture, regardless of bone density and continue to be at risk over subsequent years compared to identically aged nonfrail women. Incorporating regular frailty assessment into fracture management could improve identification of women at high fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - March 4, 2021 Category: Orthopaedics Source Type: research

Bone resorption and dietary calcium in pregnancy —a window to future maternal bone health
AbstractBackgroundPregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established.ObjectiveWe aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum.DesignThis is a prospective, longitudinal study of 107 women recruited to the ROLO low glycemic index dietary intervention trial in pregnancy and followed-up at 13, 28, and 34 &n...
Source: Osteoporosis International - March 4, 2021 Category: Orthopaedics Source Type: research

Author response: bone health in men: still suffer the gender gap
(Source: Osteoporosis International)
Source: Osteoporosis International - March 4, 2021 Category: Orthopaedics Source Type: research

The French multicentre elevated bone mass study: prevalence and causes
ConclusionsThe prevalence of EBM was approximately 1 in 100. These findings suggest that degenerative disease of the spine is the main cause of EBM, but that acquired or hereditary diseases are also causal factors. (Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2021 Category: Orthopaedics Source Type: research

Persistent phosphaturic mesenchymal tumor causing tumor-induced osteomalacia treated with image-guided ablation
We present a 60-year-old patient with a PMT that was persistently hypophosphatemic after resection, who was then successfully treated with cryoablation of the tumor. Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia characterized by vague symptoms of gradual muscle weakness and diffuse bone pain with pathologic fractures that often lead to a delayed diagnosis. This condition is usually caused by benign phosphaturic mesenchymal tumors (PMTs). Here, we present a case of persistent PMT after surgical resection treated with image-guided ablation. We present the patient ’s clinical examinations and labo...
Source: Osteoporosis International - March 2, 2021 Category: Orthopaedics Source Type: research

Current status and distribution of hip fractures among older adults in China
ConclusionsChina should no longer be regarded as a low-risk country for hip fracture. By 2050, the total number of hip fractures in people older than 65 years in China is predicted to be 1.3 million. Higher altitude areas had higher hip fracture rates than lower altitude, higher urbanized areas. (Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2021 Category: Orthopaedics Source Type: research

Bone health in men: still suffer the gender gap
(Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2021 Category: Orthopaedics Source Type: research

Serum non-esterified fatty acid levels and hip fracture risk: The Cardiovascular Health Study
AbstractSummaryAmong elderly participants from the Cardiovascular Health Study, we found that non-esterifiedtrans fatty acid levels had a significant prospective association with hip fracture risk. Other non-esterified fatty acid classes were not associated with hip fracture risk.IntroductionSerum non-esterified fatty acids (NEFAs) are bioactive metabolic intermediates that can be taken up by bone tissue. Their associations with hip fracture risk have not been previously examined.MethodsThirty-five individual NEFAs in five classes (saturated [SFA], mono-un-saturated [MUFA], poly-unsaturated n-6 and n-3 [PUFA], andtrans-FA)...
Source: Osteoporosis International - March 2, 2021 Category: Orthopaedics Source Type: research

Therapeutic efficacy of zoledronic acid combined with calcitriol in elderly patients receiving total hip arthroplasty or hemiarthroplasty for osteoporotic femoral neck fracture
ConclusionsA single infusion of ZOL shows promise in improving BMD of the healthy side of the femoral neck, lumbar spine, and total hip and decreasing the level of bone markers, which may improve the clinical outcome of patients with osteoporotic femoral neck fractures receiving THA/HA. (Source: Osteoporosis International)
Source: Osteoporosis International - March 1, 2021 Category: Orthopaedics Source Type: research