A longitudinal histologic evaluation of vitamin D receptor expression in the skeletal muscles of patients with a distal radius fracture
We examined the changes in VDR expression and CSA by immunohistochemistry.ResultsThe median serum 25-hydroxyvitamin D [25(OH)D] increased from 14.3 to 32.1 ng/mL (P = 0.001). The median VDR expression increased from 0.72 to 0.78 (P = 0.002), and the median CSA increased from 1290.0 to 1685.8 μm2 (P = 0.022). Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D]
Source: Osteoporosis International - January 16, 2021 Category: Orthopaedics Source Type: research

Cost-effectiveness of buffered soluble alendronate 70 mg effervescent tablet for the treatment of postmenopausal women with osteoporosis in Italy
ConclusionThis study suggests that buffered soluble ALN represents a cost-effective strategy compared with relevant alternative treatments for postmenopausal osteoporosis women in Italy aged 60 years and over. (Source: Osteoporosis International)
Source: Osteoporosis International - January 14, 2021 Category: Orthopaedics Source Type: research

Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study
ConclusionsThis pilot suggests longer TT  + RT interventions may be a viable rehabilitation technique to combat bone loss following SCI.Clinical trial registrationRegistered withclinicaltrials.gov: NCT01652040 (07/27/2012). (Source: Osteoporosis International)
Source: Osteoporosis International - January 14, 2021 Category: Orthopaedics Source Type: research

Estimates of the effects of physical activity on osteoporosis using multivariable Mendelian randomization analysis
ConclusionsHabitual vigorous PA could increase LS BMD. Individuals with higher overall acceleration average would have a higher FA BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - January 13, 2021 Category: Orthopaedics Source Type: research

Postpartum bilateral sacral stress fracture without osteoporosis —a case report and literature review
ConclusionSacral stress fractures in the absence of osteoporosis are rare complications of pregnancy that can present with lumbar radiculopathy. Conservative management often produces good clinical outcomes. (Source: Osteoporosis International)
Source: Osteoporosis International - January 13, 2021 Category: Orthopaedics Source Type: research

Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study
ConclusionInfrequent infusions of zoledronic acid, initiated early in menopause, are expected to reduce long-term fracture risk and result in a substantial reduction in the proportion of women with densitometric osteoporosis after age 65. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2021 Category: Orthopaedics Source Type: research

Circulating MiR-21 expression is upregulated after 30  days of head-down tilt bed rest
Conclusionc-miR-21-5p has potential as a biomarker of bone resorption and bone loss in an unloading condition. The upregulation of miR-21-5p may reflect an increase in osteoclast activity after bed rest, which is corroborated by the increase in TRAP5b. (Source: Osteoporosis International)
Source: Osteoporosis International - January 11, 2021 Category: Orthopaedics Source Type: research

Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial
In this study, a salacinol-type α-GI increased GLP-1 and markedly reduced postprandial bone resorption compared to placebo, suggesting it could h ave implications for bone health.IntroductionAnimal and clinical trials indicate that α-glucosidase inhibitors attenuate postprandial glycemic indices and increase secretion of GLP-1. In addition, GLP-1 acts on bone by inhibiting resorption. The goal in this study was to determine if a salacinol α-GI alters postprandial bone turnover and can be explained by changes in serum GLP-1.MethodsIn this double-blind, placebo-controlled crossover study, healthy overweight...
Source: Osteoporosis International - January 11, 2021 Category: Orthopaedics Source Type: research

Vitamin D and bone health status in beta thalassemia patients —systematic review
AbstractThalassemia is a chronic congenital disease characterized by a combination of endocrine and metabolic disorders. Bone disease is a very common complication related to the poor absorption of calcium, the secondary chronic renal disease with low vitamin D, as well as multiple endocrine risk factors. The aim of this systematic review was to estimate the prevalence of vitamin D deficiency in thalassemia, as well as its association with osteoporosis/low bone mass. A systematic review was carried out using PubMed/Medline, Cochrane, and EBSCO databases. The methodological quality of the included studies was assessed with ...
Source: Osteoporosis International - January 9, 2021 Category: Orthopaedics Source Type: research

Sex-specific associations of serum insulin-like growth factor-1 with bone density and risk of fractures in Chinese patients with type 2 diabetes
The objective was to investigate the associations of serum insulin-like growth factor-1 (IGF-1) with bone mineral density (BMD) and risk of fractures in Chinese patients with type 2 diabetes (T2D) in each gender.MethodsThis was a cross-sectional, retrospective study that included men over 50 years and postmenopausal women with T2D without medical conditions or medications known to significantly affect BMD or serum IGF-I levels. Data of IGF-1, bone metabolism markers, lumbar spine (LS), femoral neck (FN), and total hip (TH) BMD were obtained; 10-year probability of major osteoporotic fractures (MOFs) and hip fractures (HFs)...
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Comparing three machine learning approaches to design a risk assessment tool for future fractures: predicting a subsequent major osteoporotic fracture in fracture patients with osteopenia and osteoporosis
ConclusionWe show that predicting the risk of MOF in patients who already sustained a fracture can be done with adequate discriminative performance. We developed a user-friendly tool for risk calculation of subsequent MOF in patients with osteopenia. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Situational risk factors for fall-related vertebral fractures in older men and women
ConclusionsThe combination of predisposing and situational risk factors may display a more comprehensive risk profile for the occurrence of VFs, and thus, interventions that add both types of risk factors may result in greater risk reduction of VFs, although those specifically targeted at situational risk factors during falls are limited and their effectiveness and efficiency remained to be explored. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Over half of seniors who start oral bisphosphonate therapy are exposed for 3 or more years: novel rolling window approach and patterns of use
ConclusionsAmong seniors initiating oral bisphosphonates, we found that 60% receive at least 3  years of therapy when using an extended follow-up. Studies are needed to examine the benefits and harms of continuing bisphosphonate therapy beyond 3 years. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Evolution in fracture risk assessment: artificial versus augmented intelligence
(Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Risk factors for imminent fractures: a substudy of the FRISBEE cohort
AbstractSummaryMultiple factors increase the risk of an imminent fracture, including a recent fracture, older age, osteoporosis, comorbidities, and the fracture site. These findings could be a first step in the development of a model to predict an imminent fracture and select patients most at need of immediate treatment.IntroductionThe risk of a recurrent fragility fracture is maximal during the first 2 years following an incident fracture. In this prospective cohort study, we looked at the incidence of recurrent fractures within 2 years after a first incident fracture and we assessed independent clinical risk factors (CRF...
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

A novel economic framework to assess the cost-effectiveness of bone-forming agents in the prevention of fractures in patients with osteoporosis
ConclusionIncorporating imminent fracture risk in economic evaluations has a significant impact on the cost-effectiveness when evaluating fracture prevention treatments in patients with osteoporosis who sustained a recent fracture. Bone-forming treatment followed by antiresorptive therapy can be cost-effective compared to antiresorptive therapy alone depending on treatment acquisition costs. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Comparative effectiveness of denosumab, teriparatide, and zoledronic acid among frail older adults: a retrospective cohort study
ConclusionsDenosumab and ZA may be as effective as teriparatide for hip fracture prevention in frail older adults. Given their lower cost and easier administration, denosumab and ZA are likely preferable non-oral treatments for most frail, older adults. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Association between body mass index and the risk of falls: a nationwide population-based study
This study examined the sex-specific association between body mass index (BMI) and falls in Korean adults using data from a large population-based survey.MethodsWe analyzed 113,805 men and women (age ≥ 50 years) who participated in the Korean Community Health Survey in 2013. Logistic regression was used to assess the relationship between BMI and falls.ResultsThe mean ( ± standard deviation) age and BMI of all participants were 63.8 ± 9.6 years and 23.2 ± 2.9 kg/m2, respectively. Among the 113,805 subjects, 19.1% and 6.7% had histories of falls and recurrent falls, respectively. The association of BM...
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Hospital admissions of patients with osteogenesis imperfecta in the English NHS
ConclusionThe treatment of patients with OI is associated with a significant number of hospital admissions at an important cost for the NHS, with both number of admissions and costs increasing over time. Children below the age of 14 years had more admissions at a greater total cost than other ages, while the oldest adults had longer average stays and higher costs per admission. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

The diabetes-fracture association in women with type 1 and type 2 diabetes is partially mediated by falls: a 15-year longitudinal study
ConclusionWomen with T1D and T2D have an increased risk of fracture, which may be partially explained by increased falls, and to a lesser extent by shorter reproductive lifespan, in T1D. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

The association between overweight/obesity and vertebral fractures in older adults: a meta-analysis of observational studies
ConclusionsOverweight aged adults tend to have a lower vertebral fracture risk. When gender and ethnicity were taken into consideration, the inverse relationship between overweight and vertebral fracture risk were only observed in female and non-Asian populations. Besides, there is insufficient data to conclude the relationship between obesity and the risk of vertebral fractures, and thus, further studies are needed. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Long-term direct and indirect economic burden associated with osteoporotic fracture in US postmenopausal women
ConclusionsA considerable and sustained economic burden after a non-traumatic fracture underscores the need for early patient identification and continued management. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Fracture rates in patients discontinuing alendronate treatment in real life: a population-based cohort study
ConclusionIn a real-world setting, less than 50% continued ALN treatment for 5 years. We found no difference in the risk of fractures in patients discontinuing versus continuing ALN after 5 years. (Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Calcification of lower extremity arteries is related to the presence of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a cross-sectional observational study
AbstractSummaryIt is unknown whether there is any relationship between extremity arterial macroangiopathy and osteoporosis in type 2 diabetic mellitus (T2DM) patients. We provide evidence to show the association between lower extremity arterial calcification and the presence of osteoporosis in postmenopausal T2DM women, but not in T2DM men of similar age.PurposeTo investigate the relationship between lower extremity arterial calcification and the presence of osteoporosis in type 2 diabetic mellitus (T2DM) patients.MethodsWe performed a retrospective cross-sectional study in patients with T2DM. They were assigned into two g...
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Increasing fasting glucose and fasting insulin associated with elevated bone mineral density —evidence from cross-sectional and MR studies
ConclusionFindings from our cross-sectional and MR studies revealed the associations between the studied diabetic indices and BMD measurements in the US and European adults. (Source: Osteoporosis International)
Source: Osteoporosis International - January 6, 2021 Category: Orthopaedics Source Type: research

Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden
ConclusionThe results of this study indicate that sequential romosozumab-to-alendronate can be a cost-effective treatment option for postmenopausal women with severe osteoporosis at high risk of fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - January 6, 2021 Category: Orthopaedics Source Type: research

Association between type 1 diabetes mellitus and reduced bone mineral density in children: a meta-analysis
ConclusionThis meta-analysis suggests that T1DM may play a role in decreasing BMD Z-scores in the whole body and lumbar spine in children. (Source: Osteoporosis International)
Source: Osteoporosis International - January 6, 2021 Category: Orthopaedics Source Type: research

Social deprivation predicts adverse health outcomes after hospital admission with hip fracture in England
We examined the effect of area-level social deprivation on outcomes following hospital admission for hip fracture in England.MethodsWe used English Hospital Episodes Statistics linked to the National Hip Fracture Database (April 2011 –March 2015) and Office for National Statistics mortality database, to identify patients aged 60+ years admitted with hip fracture. Deprivation was measured using Index of Multiple Deprivation quintiles; Q1-least deprived; Q5-most deprived, and outcomes by mortality over 1-year, length-of-stay in NHS acute and rehabilitation hospitals (‘superspell’), and emergency 30-day read...
Source: Osteoporosis International - January 5, 2021 Category: Orthopaedics Source Type: research

Retraction Note to: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients
This article has been retracted. Please see the Retraction Notice for more detail:https://doi.org/10.1007/s00198-020-05777-3 (Source: Osteoporosis International)
Source: Osteoporosis International - January 4, 2021 Category: Orthopaedics Source Type: research

Vertebroplasty for vertebral fragility fractures in the ‘very elderly’: experience from a regional UK spine unit
(Source: Osteoporosis International)
Source: Osteoporosis International - January 4, 2021 Category: Orthopaedics Source Type: research

Reproducibility of total and regional body composition using dual-energy X-ray absorptiometry in rheumatoid arthritis and ankylosing spondylitis
ConclusionTotal body tissue mass, FM percentage, FM, LM, and BMC measurements obtained by DXA are highly reproducible in RA and AS. (Source: Osteoporosis International)
Source: Osteoporosis International - January 2, 2021 Category: Orthopaedics Source Type: research

The efficacy and safety of bisphosphonate analogs for treatment of osteoporosis after spinal cord injury: a systematic review and meta-analysis of randomized controlled trials
ConclusionEarly bisphosphonate administration after SCI was safe and beneficial to the BMD of the total hip and lumbar spine at 12 months. (Source: Osteoporosis International)
Source: Osteoporosis International - January 2, 2021 Category: Orthopaedics Source Type: research

Forearm bone mineral density and fracture incidence in postmenopausal women with osteoporosis: results from the ACTIVExtend phase 3 trial
AbstractSummaryAbaloparatide increased ultradistal radius bone mineral density (BMD) in the Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) trial. Over the subsequent 24  months in ACTIVExtend, ultradistal radius BMD gains were maintained with alendronate. Conversely, 1/3 radius BMD remained stable during ALN treatment in ACTIVExtend after decreasing during ACTIVE.IntroductionAbaloparatide (ABL) increased femoral neck, total hip, and lumbar spine bone mineral density (BMD) in postmenopausal women with osteoporosis and decreased the risk of vertebral and nonvertebral fractures in ACTIVE. Effects on fract...
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Burden of disease associated with X-linked hypophosphataemia in adults: a systematic literature review
ConclusionXLH in adults is associated with considerable disease burden and unmet needs. Forthcoming studies and increased awareness of the impact of XLH in adulthood should help to improve management of XLH in adulthood and patient outcomes. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Fragility fractures and health-related quality of life: does socio-economic status widen the gap? A population-based study
ConclusionFractures of the spine and hip are associated with clinically important deficits in physical HRQoL up to 5  years post-fracture. Low educational attainment widened the gap in mental but not in physical post-fracture HRQoL. However, due to low pre-fracture PCS and MCS, people with a low educational attainment and fractures were more likely to report very low HRQoL post-fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Prediction of osteoporotic fragility re-fracture with lumbar spine DXA-based derived bone strain index: a multicenter validation study
ConclusionsBSI appears to be a valid DXA index of prediction of re-fracture, and it can be used for a more refined risk assessment of osteoporotic patients. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Upper gastrointestinal safety of oral bisphosphonate in hospitalized patients
ConclusionThe incidence of adverse reaction was similar to that reported in community trials. The administration of oral bisphosphonate in hospitalized patients does not represent an additional risk for upper gastrointestinal adverse events. Treatment should be optimized during the hospital stay to improve the pharmacological management of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture
ConclusionThe 10-year probability of fractures is the appropriate metric to capture the impact of the recency of sentinel fractures. The probability ratios provide adjustments to conventional FRAX estimates of fracture probability for recent sentinel fractures, adjustments which can readily inform clinical decision-making. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Global impact of COVID-19 on non-communicable disease management: descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures
ConclusionThis study documents a marked global impact of the COVID-19 pandemic on the management of osteoporosis as reflected by FRAX online fracture risk assessments. The analysis suggests that impact may relate to the societal and healthcare measures taken to ameliorate the pandemic. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Fragility fracture discriminative ability of radius quantitative ultrasound: a systematic review and meta-analysis
This study aimed to provide a comprehensive evaluation of the association between radius QUS and fracture risk. A detailed article search was carried out on PubMed, EMBASE, Cochrane Libraries, CNKI, Wan-Fang database, VIP, and SinoMed for studies published between January 1980 and February 2020. We determined the estimated relative risk (RR) for fracture per each radial SOS SD decrease. A meta-analysis of studies was performed under the random-effects model. A total of 16,681 individuals were included in this review. Among the participants, 5892 were male and 10,789 were female. A total of 1296 cases of fragility fracture ...
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Disruption of bone densitometry practice in a Northern Italy Orthopedic Hospital during the COVID-19 pandemic
ConclusionCOVID-19 pandemic had a disruptive effect on the daily practice of bone densitometry with DXA. After reopening, we observed a persistence of DXA examination reduction, confirming the fact that returning to normality will probably be a slow process. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density
ConclusionThe TUG time predicts the risk of MOF and hip fracture independently of clinical risk factors and BMD and has a substantial impact on fracture probabilities, indicating that inclusion of the TUG test in patient evaluation should be considered in order to improve fracture prediction in older women. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

A scorecard for osteoporosis in Canada and seven Canadian provinces
ConclusionGovernment-backed action plans are needed to address provincial inequities in patients ’ access to diagnosis, treatment, and FLS programs in Canada. Further characterization of the treatment gap and the establishment of fracture registries are critical next steps in providing high-quality osteoporosis care. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women
ConclusionBacteroides andRikenellaceae may be involved in bone metabolism and fracture risk. Further investigations of the underlying microbiota-related pathways in bone metabolism may reveal treatment strategies, and facilitate the prevention of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Physical function in UK adults with osteogenesis imperfecta: a cross-sectional analysis of the RUDY study
We describe the physical function in adults with osteogenesis imperfecta (OI) and explored clinical and non-clinical factors related to its impairment. Our data showed that physical dysfunction is a common feature of adults with OI, varying by OI severity, and mediated by the presence and quality of pain and fatigue symptoms.IntroductionThere is a paucity of data describing physical function in adults with osteogenesis imperfecta (OI). We investigated the effects of OI and its severity on physical function and explored the relationship between physical function and number of fractures and symptomatology.MethodsAdults with ...
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

Coexistence of brown tumors due to secondary hyperparathyroidism and prostate cancer in a patient
In this report, we present a case of a 65-year-old man with brown tumors due to secondary hyperpar athyroidism and prostate cancer. In this setting, histologic confirmation is recommended. (Source: Osteoporosis International)
Source: Osteoporosis International - December 22, 2020 Category: Orthopaedics Source Type: research

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort
AbstractSummaryIn elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin.PurposeBlood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers.MethodsWe anal...
Source: Osteoporosis International - December 11, 2020 Category: Orthopaedics Source Type: research

Osteoporosis case ascertainment strategies in European and Asian countries: a comparative review
This article provides an overview of the current case-finding strategies in the UK, Germany (including Austria and German-speaking regions of Switzerland), China, Japan, and Korea. We conducted a review of current treatment guidelines in each country and included expert opinions from key opinion leaders. Most countries define osteoporosis among patients with a radiographically identified fracture of the hip or the vertebrae. However, for other types of fractures, or in the absence of a fracture, varying combinations of risk-factor assessment and areal bone mineral density (aBMD) assessed by dual X-ray absorptiometry are us...
Source: Osteoporosis International - December 10, 2020 Category: Orthopaedics Source Type: research

Is a treat-to-target strategy in osteoporosis applicable in clinical practice? Consensus among a panel of European experts
ConclusionsAccording to a panel of European experts, the main goals of fracture management are to recover pre-fracture functional level and reduce fracture risk. Total hip BMD seems to be the most clinically appropriate treatment target within a T2T strategy. (Source: Osteoporosis International)
Source: Osteoporosis International - November 12, 2020 Category: Orthopaedics Source Type: research

Frequency of normal bone measurement in postmenopausal women with fracture: a registry-based cohort study
This study included all women age 50+ with a first DXA from February 1999 to March 2018 with valid BMD, TBS, and fracture data. Bone status was defined as Normal = BMD T-score of the spine, femoral neck, and total femur ≥ − 1.0 AND TBS>  1.31; Abnormal = BMD T-score ≤ − 2.5 OR TBS
Source: Osteoporosis International - November 12, 2020 Category: Orthopaedics Source Type: research