Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass
ConclusionThis study deepened the understanding of the clinical characteristics, treatment, and follow-up of OPPG and LRP5-HBM; expanded the pathogenic gene spectrum of OPPG; and confirmed that bisphosphonates were effective for OPPG. Additionally, it was found that Ala242Thr mutation could not protect LRP5-HBM patients from age-related bone loss. This phenomenon deserves further study. (Source: Osteoporosis International)
Source: Osteoporosis International - April 16, 2024 Category: Orthopaedics Source Type: research
Family/caregiver influence on osteoporosis management for older people: an integrative review
This study applied an integrative literature review methodology to key literature findings on family/caregiver influence on osteoporosis management for older people. Key findings include caregivers’ tendency to overprotect persons who experience hip fracture by limiting mobil ization, thus impeding recovery, caregivers’ risks for their own fragility fractures due to the demands of their caregiving role, risks of poor bone health in caregivers, and caregivers’ experience of significant burden for which facilitators have been identified. Family caregivers of older peop le with osteoporosis have unique needs and require...
Source: Osteoporosis International - April 15, 2024 Category: Orthopaedics Source Type: research
The cost-effectiveness of osteoporosis medications for preventing periprosthetic fractures following femoral neck fracture indicated hip arthroplasty: a break-even analysis
ConclusionThe utilization of lower cost osteoporosis medications such as oral bisphosphonates and estrogen hormonal therapy as PPF prophylaxis in this patient population would be economically viable if they reduce the PPF rate by 1.8% and 1.5%, respectively. For IV bisphosphonates and newer agents to be economically viable as PPF prophylaxis in the USA, their costs need to be significantly reduced. (Source: Osteoporosis International)
Source: Osteoporosis International - April 15, 2024 Category: Orthopaedics Source Type: research
Delayed and significant hypercalcaemia due to teriparatide therapy: a case report and review
We report the case of a female who developed significant delayed hypercalcaemia after teriparatide treatment for osteoporosis and review other cases in the literature to date.Case reportA 72-year-old female on teriparatide for the treatment of osteoporosis was found to have hypercalcaemia (3.30 mmol/l) on routine testing approximately 3 months after starting therapy. Serum calcium pretreatment was normal at 2.39 mmol/l. She was admitted to the hospital for investigations which identified a serum 25-hydroxyvitamin D of 94 nmol/l, a low parathyroid hormone of 6.0 pg/ml, and normal test results for 1,25 dihydroxyvitamin D (11...
Source: Osteoporosis International - April 13, 2024 Category: Orthopaedics Source Type: research
Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007 –2010
ConclusionHigher prevalence of thyroid-specific autoantibodies may lead to decreased BMD. In females, higher prevalence of TgAb and TPOAb significantly associated with fractures and TPOAb especially relating to the fractures of hip and spine. Males patients with vitamin D deficiency or insufficiency associated a higher possibility of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2024 Category: Orthopaedics Source Type: research
Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review
ConclusionOverall, there appears to be no deleterious effect of osteoporosis medications on fracture healing. The benefit of treating osteoporosis and the urgent necessity to mitigate imminent refracture risk after a fracture should be given prime consideration. It is imperative that new radiological and biological markers of fracture healing be identified. It is also important to synthesize clinical and basic science methodologies to assess fracture healing, so that a convergence of the two frameworks can be achieved. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2024 Category: Orthopaedics Source Type: research
Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study
ConclusionsThis study suggested that people whose BMI slightly increased from normal weight to low-level overweight during 30 years of middle adulthood confer a significantly lower risk of fracture in later life than those whose BMI declined from overweight to normal weight. This result implies the potentially beneficial effects of avoiding weight loss to normal weight during middle adulthood for overweight persons, with reduced fracture risk in late life. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2024 Category: Orthopaedics Source Type: research
Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review
ConclusionOverall, there appears to be no deleterious effect of osteoporosis medications on fracture healing. The benefit of treating osteoporosis and the urgent necessity to mitigate imminent refracture risk after a fracture should be given prime consideration. It is imperative that new radiological and biological markers of fracture healing be identified. It is also important to synthesize clinical and basic science methodologies to assess fracture healing, so that a convergence of the two frameworks can be achieved. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2024 Category: Orthopaedics Source Type: research
Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study
ConclusionsThis study suggested that people whose BMI slightly increased from normal weight to low-level overweight during 30 years of middle adulthood confer a significantly lower risk of fracture in later life than those whose BMI declined from overweight to normal weight. This result implies the potentially beneficial effects of avoiding weight loss to normal weight during middle adulthood for overweight persons, with reduced fracture risk in late life. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2024 Category: Orthopaedics Source Type: research
Follow-up in Fracture Liaisons Services: the involvement of general practitioners and fracture nurses is urgently needed
(Source: Osteoporosis International)
Source: Osteoporosis International - April 6, 2024 Category: Orthopaedics Source Type: research
Romosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials
ConclusionData suggest support for the efficacy and safety of continuing romosozumab treatment following fracture.Trial registrationsNCT01575834; NCT01631214. (Source: Osteoporosis International)
Source: Osteoporosis International - April 4, 2024 Category: Orthopaedics Source Type: research
