Haemorrhagic Fever With Renal Syndrome (HFRS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor
In this study, we discovered that benidipine hydrochloride, a calcium channel blocker, inhibits the entry of hantaviruses in vitro. Moreover, an array of calcium channel inhibitors, such as cilnidipine, felodipine, amlodipine, manidipine, nicardipine, and nisoldipine, exhibit similar antiviral properties. Using pseudotyped vesicular stomatitis viruses harboring the different hantavirus glycoproteins, we demonstrate that benidipine hydrochloride inhibits the infection by both HFRS- and HPS-causing hantaviruses. The results of our study indicate the possibility of repurposing FDA-approved calcium channel blockers for the tre...
Source: Frontiers in Pharmacology - August 29, 2022 Category: Drugs & Pharmacology Source Type: research

Leveraging HFRS to Assess How Frailty Affects Healthcare Resource Utilization after Elective ACDF for CSM
: Frailty is a common comorbidity associated with worsening outcomes in various medical and surgical fields. The Hospital Frailty Risk Score (HFRS) is a recently developed tool which assesses frailty using 109 International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) comorbidity codes to assess severity of frailty. However, there is a paucity of studies utilizing the HFRS with patients undergoing anterior cervical discectomy and fusion (ACDF) for cervical spondylotic myelopathy (CSM). (Source: The Spine Journal)
Source: The Spine Journal - August 18, 2022 Category: Orthopaedics Authors: Aladine A. Elsamadicy, Andrew B. Koo, Margot Sarkozy, Wyatt B. David, Benjamin C. Reeves, Saarang Patel, Justice Hansen, Mani Ratnesh S. Sandhu, Astrid C. Hengartner, Andrew Hersh, Luis Kolb, Sheng-Fu Larry Lo, John H. Shin, Ehud Mendel, Daniel M. Sciubba Tags: Clinical Study Source Type: research

Comprehensive characterization of halogenated flame retardants and organophosphate esters in settled dust from informal e-waste and end-of-life vehicle processing sites in Vietnam: Occurrence, source estimation, and risk assessment
In this study, OPEs and HFRs including polybrominated diphenyl ethers (PBDEs), novel brominated flame retardants (NBFRs), and chlorinated flame retardants (CFRs) were determined in settled dust from Vietnamese e-waste recycling (WR) and vehicle processing (VP) workshops. Pollutant concentrations decreased in the order: OPEs (median 1500; range 230-410,000 ng/g) ≈ PBDEs (1200; 58-250,000) > NBFRs (140; not detected - 250,000) > CFRs (13; 0.39-2200). HFR and OPE levels in the WR workshops for e-waste and obsolete plastic were significantly higher than in the VP workshops. Decabromodiphenyl ether and decabromodiphenyl...
Source: Environmental Pollution - August 5, 2022 Category: Environmental Health Authors: Anh Quoc Hoang Ryogo Karyu Nguyen Minh Tue Akitoshi Goto Le Huu Tuyen Hidenori Matsukami Go Suzuki Shin Takahashi Pham Hung Viet Tatsuya Kunisue Source Type: research

Halogenated flame retardants in Irish waste polymers: Concentrations, legislative compliance, and preliminary assessment of temporal trends
Environ Pollut. 2022 Jul 18;309:119796. doi: 10.1016/j.envpol.2022.119796. Online ahead of print.ABSTRACTHalogenated flame retardants (HFRs) were measured in 470 waste plastic articles from Ireland between 2019 and 2020. We identified articles containing concentrations of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD), and tetrabromobisphenol-A (TBBP-A) exceeding European Union limits. Enforcement of existing limits of 1000 mg/kg will render an estimated 3.1% (2800 t) of articles in the waste categories studied unrecyclable, increasing to: 4.0, 4.9, and 5.6% if limits were reduced to 500, 200, and 1...
Source: Environmental Pollution - July 21, 2022 Category: Environmental Health Authors: Daniel Drage Martin Sharkey Layla Salih Al-Omran William A Stubbings Harald Berresheim Marie Coggins Andr é Henrique Rosa Stuart Harrad Source Type: research

Halogenated flame retardants in Irish waste polymers: Concentrations, legislative compliance, and preliminary assessment of temporal trends
Environ Pollut. 2022 Jul 18:119796. doi: 10.1016/j.envpol.2022.119796. Online ahead of print.ABSTRACTHalogenated flame retardants (HFRs) were measured in 470 waste plastic articles from Ireland between 2019 and 2020. We identified articles containing concentrations of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD), and tetrabromobisphenol-A (TBBP-A) exceeding European Union limits. Enforcement of existing limits of 1000 mg/kg will render an estimated 3.1% (2800 t) of articles in the waste categories studied unrecyclable, increasing to: 4.0, 4.9, and 5.6% if limits were reduced to 500, 200, and 100 m...
Source: Environmental Pollution - July 21, 2022 Category: Environmental Health Authors: Daniel Drage Martin Sharkey Layla Salih Al-Omran William A Stubbings Harald Berresheim Marie Coggins Andr é Henrique Rosa Stuart Harrad Source Type: research

Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors in Frail People With Diabetes Who Were Recently Hospitalized
Conclusion: SGLT-2Is may be preferred to DPP-4Is for preventing MACE, HF hospitalizations and mortality in frail people with type 2 diabetes. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 12, 2022 Category: Drugs & Pharmacology Source Type: research

Hyperamylasemia Caused by the Hantaan Virus: A Retrospective Study of 101 Patients with Hemorrhagic Fever with Renal Syndrome in West China
CONCLUSION: HTNV-induced HA is a common clinical presentation of HFRS patients in West China. It can increase the severity, the hospitalization days of patients, and the incidence of AP in HFRS. Age and T OA constituted independent risk factors for HA caused by HTNV.PMID:35789642 | PMC:PMC9250431 | DOI:10.1155/2022/4942697 (Source: Biomed Res)
Source: Biomed Res - July 5, 2022 Category: Research Authors: Sumei Zhang Lei Shi Xiaoqian Jiang Xiaoling Yang Libo Wu Chuan Wang Fuchun Jing Tianyan Chen Source Type: research

In vitro Anti-Hantavirus Activity of Protein Kinase Inhibitor 8G1 Targeting AKT/mTOR/eIF4E Signaling Pathway
Hantaan virus (HTNV) is the main cause of hemorrhagic fever with renal syndrome (HFRS) around the world, which results in profound morbidity and mortality. However, there are currently no FDA-approved therapeutics or vaccines against HFRS. To find new anti-HTNV drugs, the inhibitory activity of 901 small molecule kinase inhibitors against HTNV is analyzed. Among these compounds, compound 8G1 inhibits HTNV with a relatively high inhibition rate and lower toxicity. The viral titer and nucleocapsid protein of HTNV are reduced after compound 8G1 treatment in a dose-dependent manner at concentrations ranging from 1 to 20 μM. I...
Source: Frontiers in Microbiology - June 30, 2022 Category: Microbiology Source Type: research

Emerging hantavirus infection in wild rodents captured in suburbs of Gwangju Metropolitan City, South Korea
Conclusions/SignificanceHantaviruses were detected in all three wild rodent species ofA.agrarius,C.lasiura, andM.regulus captured in the suburbs of Gwangju Metropolitan City, South Korea, and it was demonstrated that they were various strains of hantaviruses such as the Hantaan, Jeju, and Imjin viruses. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - June 23, 2022 Category: Tropical Medicine Authors: Mi hee Seo Source Type: research

Utility of hospital frailty risk score for predicting postoperative outcomes in craniopharyngioma
ConclusionIn patients undergoing any surgery for craniopharyngioma, frailty is predictive of increased hospital length of stay and overall care costs. HFRS failed to independently predict mortality because the incidence of mortality is too low in this population to analyze. The HFRS is a valuable tool to identify post-operative outcomes following surgery for craniopharyngioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 20, 2022 Category: Cancer & Oncology Source Type: research

Viruses, Vol. 14, Pages 1258: Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan
Yeraliyeva Guenter Froeschl Michael Hoelscher Stefan Frey Edith Wagner Lukas Peintner Sandra Essbauer Orthohantaviruses are zoonotic pathogens that play a significant role in public health. These viruses can cause haemorrhagic fever with renal syndrome in Eurasia. In the Republic of Kazakhstan, the first human cases were registered in the year 2000 in the West Kazakhstan region. Small mammals can be reservoirs of orthohantaviruses. Previous studies showed orthohantavirus antigens in wild-living small mammals in four districts of West Kazakhstan. Clinical studies suggested that there might be further regions...
Source: Viruses - June 9, 2022 Category: Virology Authors: Nur Tukhanova Anna Shin Nurkeldi Turebekov Talgat Nurmakhanov Karlygash Abdiyeva Alexandr Shevtsov Toktasyn Yerubaev Gulnara Tokmurziyeva Almas Berdibekov Vitaliy Sutyagin Nurbek Maikanov Andrei Zakharov Ilmars Lezdinsh Lyazzat Yeraliyeva Guenter Froeschl Tags: Article Source Type: research

Fatal cases of hemorrhagic fever with renal syndrome in Udmurtia, Russia, 2010 to 2019
AbstractHemorrhagic fever with renal syndrome (HFRS) continues to be a cause of death in Europe. Our aim was to describe the clinical and histopathological features of fatal HFRS in the Udmurt Republic (Udmurtia), located in the European part of Russia. This retrospective observational study included all fatal cases of HFRS that occurred in Udmurtia from January 2010 through December 2019. The most relevant clinical and autopsy data of these cases were recorded through a review of the patients ’ medical records and autopsy reports. During 2010–2019, Udmurtia had 41 fatal cases of HFRS of a total of 10,312 confirmed cas...
Source: European Journal of Clinical Microbiology and Infectious Diseases - June 6, 2022 Category: Microbiology Source Type: research

Analysis of the effect of meteorological factors on hemorrhagic fever with renal syndrome in Taizhou City, China, 2008 –2020
Hemorrhagic fever with renal syndrome (HFRS) is endemic in Zhejiang Province, China, while few studies have concentrated on the influence of meteorological factors on HFRS incidence in the area. (Source: BMC Public Health)
Source: BMC Public Health - June 1, 2022 Category: Consumer Health News Authors: Rong Zhang, Ning Zhang, Wanwan Sun, Haijiang Lin, Ying Liu, Tao Zhang, Mingyong Tao, Jimin Sun, Feng Ling and Zhen Wang Tags: Research Source Type: research

Analysis of the relationship between replication of the Hokkaido genotype of Puumala orthohantavirus and autophagy
In this study, we examined the role of autophagy in PUUV-Hok replication. PUUV-Hok infection induced the expression of LC3-II, an autophagosome marker, and the nucleocapsid protein (NP) of PUUV-Hok was colocalized with punctate structures of LC3. Inhibition of autophagy using an siRNA for Atg5, an autophagy-related gene, increased the replication of PUUV-Hok, whereas an autophagy inducer decreased its replication. Inhibition of lysosomal degradation increased the expression of NP and LC3-II. In summary, autophagy was induced by PUUV-Hok infection, which inhibited PUUV-Hok replication in a manner related to the degradation ...
Source: Virus Research - May 31, 2022 Category: Virology Authors: Kazuma Tamiya Shintaro Kobayashi Kentaro Yoshii Hiroaki Kariwa Source Type: research