Haemorrhagic Fever With Renal Syndrome (HFRS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Case Report: Multiple Organ Failure Caused by Hemorrhagic Fever with Renal Syndrome
This report describes the case of a 55-year-old man with complaints of fever, vomiting, and diarrhea. His symptoms showed no significant improvement after routine anti-infective, antipyretic, and other symptomatic supportive treatments administered at a local clinic. During these treatments, the patient had progressive oliguria; after 3 days, he also developed multiple organ failures, such as the liver and kidney, and was examined for positive serum IgM antibodies to hemorrhagic fever during treatment at our hospital. The patient was finally diagnosed with HFRS followed by multiple organ failure. After antiviral therapy, i...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rui Wang Xiang-Yang Zhao Xiao-Jun Liu Miao Zhang Yan-Ting Sun Xiao Ning Jian Xu Chan-Yuan Bu Source Type: research

Case Report: Multiple Organ Failure Caused by Hemorrhagic Fever with Renal Syndrome
This report describes the case of a 55-year-old man with complaints of fever, vomiting, and diarrhea. His symptoms showed no significant improvement after routine anti-infective, antipyretic, and other symptomatic supportive treatments administered at a local clinic. During these treatments, the patient had progressive oliguria; after 3 days, he also developed multiple organ failures, such as the liver and kidney, and was examined for positive serum IgM antibodies to hemorrhagic fever during treatment at our hospital. The patient was finally diagnosed with HFRS followed by multiple organ failure. After antiviral therapy, i...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rui Wang Xiang-Yang Zhao Xiao-Jun Liu Miao Zhang Yan-Ting Sun Xiao Ning Jian Xu Chan-Yuan Bu Source Type: research

Discovering common pathogenic processes between COVID-19 and HFRS by integrating RNA-seq differential expression analysis with machine learning
This study is attributed to the identification of common genes and perturbed pathways by combining differential expression analysis with bioinformatics and machine learning approaches. Initially, the transcriptomic data of hantavirus-infected peripheral blood mononuclear cells (PBMCs) and SARS-CoV-2 infected PBMCs were analyzed through differential gene expression analysis for identification of common differentially expressed genes (DEGs). The functional annotation by enrichment analysis of common genes demonstrated immune and inflammatory response biological processes enriched by DEGs. The protein–protein interaction (P...
Source: Frontiers in Microbiology - May 5, 2023 Category: Microbiology Source Type: research

Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics
Antiviral Res. 2023 May 3;214:105619. doi: 10.1016/j.antiviral.2023.105619. Online ahead of print.ABSTRACTSeoul virus (SEOV) is an emerging global health threat that can cause hemorrhagic fever with renal syndrome (HFRS), which results in case fatality rates of ∼2%. There are no approved treatments for SEOV infections. We developed a cell-based assay system to identify potential antiviral compounds for SEOV and generated additional assays to characterize the mode of action of any promising antivirals. To test if candidate antivirals targeted SEOV glycoprotein-mediated entry, we developed a recombinant reporter vesicular ...
Source: Antiviral Research - May 4, 2023 Category: Virology Authors: Punya Shrivastava-Ranjan Shilpi Jain Payel Chatterjee Joel M Montgomery Mike Flint C ésar Albariño Christina F Spiropoulou Source Type: research

Hospital Frailty Risk Score (HFRS) Predicts Adverse Outcomes Among Hospitalized Patients with Chronic Pancreatitis
ConclusionsFrailty is independently associated with higher mortality, readmission rates, and healthcare utilization among patients with chronic pancreatitis in the US. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 4, 2023 Category: Gastroenterology Source Type: research

Spatiotemporal variations and potential influencing factors of hemorrhagic fever with renal syndrome: A case study in Weihe Basin, China
ConclusionWe suggested that the temporal and spatial variations in the HFRS epidemics, as well as their dominant influencing factors should be adequately considered for making and/or adjusting the targeted prevention and control strategies on this disease in Weihe Basin. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 24, 2023 Category: Tropical Medicine Authors: Lingli Zhu Source Type: research

Viruses, Vol. 15, Pages 1034: Construction of a Hantaan Virus Phage Antibody Library and Screening for Potential Neutralizing Activity
ihua Chen China is one of the main epidemic areas for hemorrhagic fever with renal syndrome (HFRS). Currently, there is no human antibody specific to Hantaan virus (HTNV) for the emergency prevention and treatment of HFRS. To prepare human antibodies with neutralizing activity, we established an anti-HTNV phage antibody library using phage display technology by transforming peripheral blood mononuclear cells (PBMCs) of patients with HFRS into B lymphoblastoid cell lines (BLCLs) and extracting cDNA from BLCLs that secreted neutralizing antibodies. Based on the phage antibody library, we screened HTNV-specific Fab antibo...
Source: Viruses - April 23, 2023 Category: Virology Authors: Zhuo Li Huiyuan Zhang Xiaxia Yu Yusi Zhang Lihua Chen Tags: Article Source Type: research

The role of glomerular lesions in the prognosis of patients with acute kidney injury during hemorrhagic fever with renal syndrome
CONCLUSIONS: Patients with AKI during HFRS can have glomerular lesions or glomerulonephritis. Patients with AKI during HFRS who have glomerular lesions or moderate renal tubulointerstitial injury proven by kidney biopsy have a relatively poor kidney prognosis. A kidney biopsy can help determine long-term prognosis in patients with AKI during HFRS.PMID:37013434 | DOI:10.1080/0886022X.2023.2196349 (Source: Renal Failure)
Source: Renal Failure - April 4, 2023 Category: Urology & Nephrology Authors: Min Min Meiling Liu Chunyu Lu Lina Zhu Jiong Zhang Jinquan Wang Source Type: research

The role of glomerular lesions in the prognosis of patients with acute kidney injury during hemorrhagic fever with renal syndrome
CONCLUSIONS: Patients with AKI during HFRS can have glomerular lesions or glomerulonephritis. Patients with AKI during HFRS who have glomerular lesions or moderate renal tubulointerstitial injury proven by kidney biopsy have a relatively poor kidney prognosis. A kidney biopsy can help determine long-term prognosis in patients with AKI during HFRS.PMID:37013434 | PMC:PMC10075516 | DOI:10.1080/0886022X.2023.2196349 (Source: Renal Failure)
Source: Renal Failure - April 4, 2023 Category: Urology & Nephrology Authors: Min Min Meiling Liu Chunyu Lu Lina Zhu Jiong Zhang Jinquan Wang Source Type: research

GSE148518 TBBPA, TBBPS and TCBPA disrupt hESCs hepatic differentiation and promote the proliferation of differentiated cells seemingly via up-regulating the FGF10 signaling pathway
Contributors : Renjun Yang ; Shaojun Liang ; Shuyu Liu ; Xiaoxing Liang ; Linshu Jiang ; Nuoya Yin ; Francesco FaiolaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHalogenated flame retardants (HFRs) Tetrabromobisphenol A (TBBPA), Tetrabromobisphenol S (TBBPS) and Tetrachlorobisphenol (TCBPA) are wildly applied in manufacturing industry to improve the fire safety of the products. Recent reports demonstrated that TBBPA, TBBPS and TCBPA can be detected in pregnant women serum at nanomolar-level. Considering TBBPA have also been detected in the cord serum and the structural simil...
Source: GEO: Gene Expression Omnibus - April 3, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Viruses, Vol. 15, Pages 872: Hantavirus Infection in Children & mdash;A Pilot Study of Single Regional Center
Conclusions: HFRS should always be considered as a differential diagnosis when faced with a patient with AKI and thrombocytopenia. Dobrava serotype is the most common hantavirus subtype in the Balkans. For the specific prevention of human infections, mainly in high-risk groups, vaccines are needed. As far as we know, this is the first study on HFRS in Romanian children. (Source: Viruses)
Source: Viruses - March 29, 2023 Category: Virology Authors: Adriana Mocanu Ana-Maria Cajvan Tudor Ilie Lazaruc Vasile Valeriu Lupu Laura Florescu Ancuta Lupu Roxana Alexandra Bogos Ileana Ioniuc Georgiana Scurtu Felicia Dragan Iuliana Magdalena Starcea Tags: Article Source Type: research