Haemorrhagic Fever With Renal Syndrome (HFRS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Frailty Assessment and Perioperative Adverse Cardiovascular Events After Noncardiac Surgery
Dr. Chandler Clinical question: Can a frailty assessment tool be used to identify patients at higher risk for major adverse cardiac events (MACE) prior to noncardiac surgery? Background: Studies have outlined the risk of increasing frailty on overall health outcomes and hospitalizations and as a possible risk factor for complications after noncardiac surgery. The association between frailty scores and perioperative MACE is limited. Study design: Retrospective cohort study Setting: Administrative data of patients aged ≥45 hospitalized for noncardiac surgeries between 2004 and 2014 in the U.S. Synopsis: Using the Nati...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Cardiology In the Literature Source Type: research

Hepatic Dysfunction Quantified by HepQuant DuO Outperforms Child-Pugh Classification in Predicting the Pharmacokinetics of Ampreloxetine
Clin Pharmacol Ther. 2024 Apr 23. doi: 10.1002/cpt.3265. Online ahead of print.ABSTRACTHepQuant tests quantify liver function from clearance of deuterium- and 13C-labeled cholates administered either intravenously and orally (SHUNT) or orally (DuO). Hepatic impairment studies have relied on clinical or laboratory criteria like Child-Pugh classification to categorize the degree of hepatic dysfunction. We compared HepQuant tests with Child-Pugh classification in predicting the pharmacokinetics of ampreloxetine. Twenty-one subjects with hepatic impairment (8 Child-Pugh A, 7 Child-Pugh B, and 6 Child-Pugh C), and 10 age- and s...
Source: Clinical Pharmacology and Therapeutics - April 24, 2024 Category: Drugs & Pharmacology Authors: Jitendra Kanodia Hugh Giovinazzo Wayne Yates David L Bourdet Michael P McRae Steve M Helmke Gregory T Everson Source Type: research

Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016 –2022
This study was... (Source: BMC Public Health)
Source: BMC Public Health - April 13, 2024 Category: Consumer Health News Authors: Qing Duan, Yao Wang, Xiaolin Jiang, Shujun Ding, Yuwei Zhang, Mingxiao Yao, Bo Pang, Xueying Tian, Wei Ma, Zengqiang Kou and Hongling Wen Tags: Research Source Type: research

Prevalence of frailty according to the Hospital Frailty Risk Score and related factors in older patients with acute coronary syndromes in Vietnam
CONCLUSIONS: The HFRS was an effective tool for stratifying frailty and predicting adverse health outcomes in older patients with ACS. Further research is needed to compare the HFRS with other frailty assessment tools in this population.PMID:38576179 | DOI:10.1111/ajag.13307 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 5, 2024 Category: Geriatrics Authors: Tan Van Nguyen Huy Minh Tran Ha Bich Thi Trinh Vu Hoang Vu Vien Ai Bang Source Type: research

Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells
In this study, host responses to SEOV infection in primary human and rat LMECs were directly compared on a transcriptional level. As infection of rat LMECs was more efficient than human LMECs, the majority of anti-viral defense responses were observed earlier in rat LMECs. Most prominently, SEOV-induced processes in both species included responses to cytokine stimulus, negative regulation of innate immune responses, responses to type I and II interferons, regulation of pattern recognition receptor signaling and MHC-I signaling. However, over time, in the rat LMECs, responses shifted from an anti-viral state towards a more ...
Source: PLoS Neglected Tropical Diseases - March 27, 2024 Category: Tropical Medicine Authors: Danny Noack Source Type: research

GSE245916 Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells
In this study, host responses to SEOV infection in primary human and rat LMECs were directly compared on a transcriptional level. As infection of rat LMECs was more efficient than human LMECs, most anti-viral defense responses were also observed earlier in rat LMECs. Most prominently SEOV-induced processes in both species included responses to cytokine stimulus, negative regulation of innate immune responses, responses to type I and II interferons, regulation of pattern recognition receptor signaling and MHC-I signaling. However, over time, in the rat LMECs, responses shifted from an anti-viral towards a more immunotolera...
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Rattus norvegicus Source Type: research

Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease
CONCLUSIONS: The HFRS is an efficient and effective tool for stratifying frailty in patients with CVD and predicting adverse health outcomes.PMID:38425103 | DOI:10.2174/011573403X276647240217112151 (Source: Current Cardiology Reviews)
Source: Current Cardiology Reviews - March 1, 2024 Category: Cardiology Authors: Balamrit Singh Sokhal Sowmya Prasanna Kumar Menon Charles Willes Nadia Corp Andrija Mateti ć Christian Mallen Mamas Mamas Source Type: research

Partly unequal receipt of healthcare in last month of life in amyotrophic lateral sclerosis: a retrospective cohort study of the Stockholm region
CONCLUSIONS: The results indicate partly unequal distribution of palliative care, however the actual, individual preferences cannot be deducted from registry studies. All patients with ALS should be offered SPC when needed.KEY MESSAGE: This register study shows that receipt of SPC in patients with ALS is equal in relation to gender, socioeconomic standing, frailty, and age <75 years, while those ≥75 years, with dementia, or residing in NH were somewhat less likely to receive SPC. Receipt of SPC reduces ER visits and acute hospital admissions.PMID:38371486 | PMC:PMC10870957 | DOI:10.48101/ujms.v129.9856 (Source: Upsala...
Source: Upsala Journal of Medical Sciences - February 19, 2024 Category: General Medicine Authors: Peter Strang Torbj örn Schultz Anneli Ozanne Source Type: research