Frailty is Associated with Increased 30-day Adverse Events and Hospitalization Costs after Primary Total Hip Arthroplasty
Frailty can predict adverse outcomes for multiple medical conditions and surgeries, but is not well-studied in total hip arthroplasty (THA). We evaluate the association between Hospital Frailty Risk Score (HFRS) and postoperative events and costs after primary THA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - January 24, 2022 Category: Orthopaedics Authors: Michael K. Tram, Casey M. O ’Connor, Alex S. Qian, Jennifer T. Tram, Matthew W. Tetreault Source Type: research

Spatiotemporal association of rapid urbanization and water-body distribution on hemorrhagic fever with renal syndrome: A case study in the city of Xi ’an, China
by Li Shen, Minghao Sun, Xiao Wei, Yao Bai, Qingwu Hu, Shuxuan Song, Boxuan Gao, Weilu Zhang, Jifeng Liu, Zhongjun Shao, Kun Liu Hemorrhagic fever with renal syndrome (HFRS) is a zoonosis characterized by clinical features of high fever, hemorrhage, and renal damage. China has the largest number of HFRS cases worldwide, accounting for over 90% of the total reported cases. In this paper, we used surveyed HFRS data and satell ite imagery to conduct geostatistical analysis for investigating the associations of rapid urbanization, water bodies, and other factors on the spatiotemporal dynamics of HFRS from year 2005 to 2018 in...
Source: PLoS Neglected Tropical Diseases - January 10, 2022 Category: Tropical Medicine Authors: Li Shen Source Type: research

Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review
Infect Disord Drug Targets. 2022 Jan 5. doi: 10.2174/1871526522666220105110819. Online ahead of print.ABSTRACTHantaviruses are rodent viruses that have been identified as etiologic agents of 2 diseases of humans: hemorrhagic fever with renal syndrome (HFRS) and nephropathiaepidemica (NE) in the Old World and Hantavirus pulmonary syndrome (HPS) in the New World. Orthohantavirus is a genus of sin- gle-stranded, enveloped, negative-sense RNA viruses in the family Hantaviridae of the order Bunyavi- rales. The important reservoir of Hantaviruses is rodents. Each virus serotype has its unique rodent host species and is transmitt...
Source: Infectious Disorders Drug Targets - January 6, 2022 Category: Infectious Diseases Authors: Sumel Ashique Navjot K Sandhu Supratim Das Sk Niyamul Haque Kartick Koley Source Type: research

Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
This study evaluated the utility of a code-based frailty score in registry data by comparing it to a gold-standard frailty score to understand how frailty can be quantified in population data and perhaps better addressed in healthcare.METHODS: We compared the Hospital Frailty Risk Score (HFRS), a frailty measure based on 109 ICD codes, to a modified version of the Frailty Index (FI) Frailty Index (FI), a self-report frailty measure, and their associations with all-cause mortality both cross-sectionally and longitudinally (follow-up = 36 years) in a Swedish cohort study (n = 1368).RESULTS: The FI and HFRS were weakly correlated (rho = 0.11, p
Source: Scandinavian Journal of Public Health - December 14, 2021 Category: International Medicine & Public Health Authors: Alexandra M Wennberg Weiyao Yin Fang Fang Nancy L Pedersen Sara H ägg Juulia Jylh ävä Karin Modig Source Type: research

Dissection of the NKG2C NK cell response against < i > Puumala Orthohantavirus < /i >
Conclusions/SignificanceOur results corroborate the substantial impact of the NKG2C/HLA-E axis on PUUV-specific NK cell responses. A weak NKG2C+ NK cell response, as reflected by NKG2Cwt/del variant, may be associated with a higher risk for a severe hantavirus infections. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 6, 2021 Category: Tropical Medicine Authors: Hannes Vietzen Source Type: research

Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT
Hantaviruses are globally emerging zoonotic viruses that can cause hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe, which is primarily caused by Hantaan virus (HTNV) infection, results in profound morbidity and mortality. However, no specific treatment is available for this disease. Coumarin derivatives have been reported as antiviral molecules, while studies about the bioactivity of coumarin derivatives against HTNV infection are limited. To study the potential antiviral activity of coumarin derivatives, 126 coumarin derivatives are synthesized, and their inhibitory activity against HTNV is analyzed in vit...
Source: Frontiers in Pharmacology - December 6, 2021 Category: Drugs & Pharmacology Source Type: research

The Hospital Frailty Risk Score Identifies Fewer Cases of Frailty in a Community-Based Cohort of Older Men Than the FRAIL Scale and Frailty Index
The recently developed Hospital Frailty Risk Score (HFRS) allows ascertainment of frailty from administrative data. We aimed to compare the HFRS against the widely used FRAIL Scale and Frailty Index. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - November 2, 2021 Category: Health Management Authors: Derrick Lopez, Kevin Murray, David B. Preen, Frank M. Sanfilippo, Michelle Trevenen, Graeme J. Hankey, Bu B. Yeap, Jonathan Golledge, Osvaldo P. Almeida, Leon Flicker Tags: Original Study Source Type: research

ECM algorithm for estimating vector ARMA model with variance gamma distribution and possible unbounded density
SummaryThe simultaneous analysis of several financial time series is salient in portfolio setting and risk management. This paper proposes a novel alternating expectation conditional maximisation (AECM) algorithm to estimate the vector autoregressive moving average (VARMA) model with variance gamma (VG) error distribution in the multivariate skewed setting. We explain why the VARMA-VG model is suitable for high-frequency returns (HFRs) because VG distribution provides thick tails to capture the high kurtosis in the data and unbounded central density further captures the majority of near-zero HFRs. The distribution can also...
Source: Australian and New Zealand Journal of Statistics - October 18, 2021 Category: Statistics Authors: Thanakorn Nitithumbundit, Jennifer S.K. Chan Tags: Original Article Source Type: research

Association between haemorrhagic fever with renal syndrome and cancers
Haemorrhagic fever with renal syndrome (HFRS) is a clinical syndrome characterized by fever, capillary haemorrhage and acute renal impairment. HFRS is an infectious disease associated with severe acute renal impairment and mortality. One-third of cases of HFRS include stage 3 acute kidney injury according to Kidney Disease: Improving Global Outcomes, with overall case fatality of 5 –10% (Muranyi et al., 2005). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 12, 2021 Category: Infectious Diseases Authors: Yong Jin Yi, Minsun Kang, Won-Keun Kim, Kyungmin Huh, Jonas Klingstr öm, Jin-Won Song, Jaehun Jung Source Type: research

Halogenated flame retardants in wild, prey-sized mud carp from an e-waste recycling site in South China, 2006-2016: Residue dynamics and ecological risk assessment
Environ Pollut. 2021 Sep 30:118270. doi: 10.1016/j.envpol.2021.118270. Online ahead of print.ABSTRACTThe crude e-waste recycling has been regulated in China since the late 2000s; however, information on the recent levels and the ecological risks of e-waste derived contaminants such as halogenated flame retardants (HFRs) in the e-waste sites are limited. We therefore examined the concentrations of several HFRs in wild, prey-sized mud carps collected from a typical e-waste site in 2006, 2011 and 2016, to understand the exposure dynamics and ecological risk of these chemicals. Several ecological and biological parameters incl...
Source: Environmental Pollution - October 3, 2021 Category: Environmental Health Authors: Jiang-Ping Wu Wen-Lu Feng Lin Tao Xiao Li You-Tian Nie Ya-Chun Xu Yan-Hong Zeng Xiao-Jun Luo Bi-Xian Mai Source Type: research

ZIF-8/nitrogen-doped reduced graphene oxide as thin film microextraction adsorbents for simultaneous determination of novel halogenated flame retardants in crayfish-aquaculture water systems
This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.PMID:34597646 | DOI:10.1016/j.chemosphere.2021.132408 (Source: Chemosphere)
Source: Chemosphere - October 1, 2021 Category: Chemistry Authors: Lingshuai Zeng Danqi Cheng Zhenxing Mao Yikai Zhou Tao Jing Source Type: research

ZIF-8/nitrogen-doped reduced graphene oxide as thin film microextraction adsorbents for simultaneous determination of novel halogenated flame retardants in crayfish-aquaculture water systems
This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.PMID:34597646 | DOI:10.1016/j.chemosphere.2021.132408 (Source: Chemosphere)
Source: Chemosphere - October 1, 2021 Category: Chemistry Authors: Lingshuai Zeng Danqi Cheng Zhenxing Mao Yikai Zhou Tao Jing Source Type: research

ZIF-8/nitrogen-doped reduced graphene oxide as thin film microextraction adsorbents for simultaneous determination of novel halogenated flame retardants in crayfish-aquaculture water systems
This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.PMID:34597646 | DOI:10.1016/j.chemosphere.2021.132408 (Source: Chemosphere)
Source: Chemosphere - October 1, 2021 Category: Chemistry Authors: Lingshuai Zeng Danqi Cheng Zhenxing Mao Yikai Zhou Tao Jing Source Type: research

ZIF-8/nitrogen-doped reduced graphene oxide as thin film microextraction adsorbents for simultaneous determination of novel halogenated flame retardants in crayfish-aquaculture water systems
This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.PMID:34597646 | DOI:10.1016/j.chemosphere.2021.132408 (Source: Chemosphere)
Source: Chemosphere - October 1, 2021 Category: Chemistry Authors: Lingshuai Zeng Danqi Cheng Zhenxing Mao Yikai Zhou Tao Jing Source Type: research

Viruses Run: The Evasion Mechanisms of the Antiviral Innate Immunity by Hantavirus
Hantavirus can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in America, with high mortality and unknown mechanisms. Innate immunity is the host’s first-line defense to bridge the acquired immunity against viral infections. However, hantavirus has evolved various strategies in both molecular and cellular aspects to evade the host’s natural immune surveillance. The Interferon-I (IFN-I) signaling pathway, a central link of host defense, induces various antiviral proteins to control the infection. This paper summarizes the molecular mechanisms of hantavirus e...
Source: Frontiers in Microbiology - September 30, 2021 Category: Microbiology Source Type: research

Concentrations of Halogenated Flame Retardants and Polychlorinated Biphenyls in house dust from Lagos, Nigeria
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Olumide Emmanuel Akinrinade, William A. Stubbings, Mohamed Abdallah, Olusegun Ayejuyo, Rose Anthony Alani, Stuart Harrad Manufacture of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecane (HBCDD) is banned; with concerns emerging about alternative halogenated flame retardants (alt-HFRs). While the presence in indoor dust of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Environ. Monit. latest articles)
Source: RSC - J. Environ. Monit. latest articles - September 28, 2021 Category: Environmental Health Authors: Olumide Emmanuel Akinrinade Source Type: research

Urinary genome detection and tracking of Hantaan virus from hemorrhagic fever with renal syndrome patients using multiplex PCR-based next-generation sequencing
Conclusion/SignificanceOur results suggest that whole or partial genome sequences of HTNV from the urine enabled to track the putative infection sites of patients with HFRS by phylogeographically linking to the zoonotic HTNV from the reservoir host captured at endemic regions. This report raises awareness among physicians for the presence of HTNV in the urine of patients with HFRS. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 28, 2021 Category: Tropical Medicine Authors: Seungchan Cho Source Type: research

Viruses, Vol. 13, Pages 1818: Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
ukka Mustonen Pia Jaatinen Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS have not been studied yet. Forty-two patients diagnosed with Puumala virus (PUUV) infection were examined during the acute phase and on a follow-up visit approximately one month later. Hormonal defects were common during acute PUUV infection. Overt (clinical) hypogonadism was identified in 80% of ...
Source: Viruses - September 13, 2021 Category: Virology Authors: Marlene Tarvainen Satu M äkelä Outi Laine Ilkka P örsti Sari Risku Onni Niemel ä Jukka Mustonen Pia Jaatinen Tags: Article Source Type: research

Hantavirus infections in Italy: not reported doesn't mean inexistent
CONCLUSIONS: In the last decade, no human cases of hantavirus infection have been officially reported in Italy. However, our analysis stresses the actual occurrence of Hantavirus among general population and in selected population groups. Further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans are needed to prevent outbreaks in the future.PMID:34487097 | DOI:10.23750/abm.v92i4.10661 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - September 6, 2021 Category: General Medicine Authors: Matteo Ricc ò Simona Peruzzi Silvia Ranzieri Federica Balzarini Marina Valente Federico Marchesi Nicola Luigi Bragazzi Source Type: research

Hantavirus infections in Italy: not reported doesn't mean inexistent
CONCLUSIONS: In the last decade, no human cases of hantavirus infection have been officially reported in Italy. However, our analysis stresses the actual occurrence of Hantavirus among general population and in selected population groups. Further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans are needed to prevent outbreaks in the future.PMID:34487097 | DOI:10.23750/abm.v92i4.10661 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - September 6, 2021 Category: General Medicine Authors: Matteo Ricc ò Simona Peruzzi Silvia Ranzieri Federica Balzarini Marina Valente Federico Marchesi Nicola Luigi Bragazzi Source Type: research

Hantavirus infections in Italy: not reported doesn't mean inexistent
CONCLUSIONS: In the last decade, no human cases of hantavirus infection have been officially reported in Italy. However, our analysis stresses the actual occurrence of Hantavirus among general population and in selected population groups. Further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans are needed to prevent outbreaks in the future.PMID:34487097 | DOI:10.23750/abm.v92i4.10661 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - September 6, 2021 Category: General Medicine Authors: Matteo Ricc ò Simona Peruzzi Silvia Ranzieri Federica Balzarini Marina Valente Federico Marchesi Nicola Luigi Bragazzi Source Type: research

Environmental occurrence and remediation of emerging organohalides: A review
Environ Pollut. 2021 Aug 27;290:118060. doi: 10.1016/j.envpol.2021.118060. Online ahead of print.ABSTRACTAs replacements for "old" organohalides, such as polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), "new" organohalides have been developed, including decabromodiphenyl ethane (DBDPE), short-chain chlorinated paraffins (SCCPs), and perfluorobutyrate (PFBA). In the past decade, these emerging organohalides (EOHs) have been extensively produced as industrial and consumer products, resulting in their widespread environmental distribution. This review comprehensively summarizes ...
Source: Environmental Pollution - September 3, 2021 Category: Environmental Health Authors: Haozheng He Yiyang Li Rui Shen Hojae Shim Yanhong Zeng Siyan Zhao Qihong Lu Bixian Mai Shanquan Wang Source Type: research

IJERPH, Vol. 18, Pages 8495: Epidemiological Characteristics and Regional Risk Prediction of Hemorrhagic Fever with Renal Syndrome in Shandong Province, China
Conclusions: HFRS in Shandong Province has shown seasonal and spatial clustering characteristics. Middle-aged and elderly farmers are a high-risk population. The BRT model has satisfactory predictive capability in stratifying the regional risk of HFRS at a county level in Shandong Province, which could serve as an important tool for risk assessment of HFRS to deploy prevention and control measures. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - August 11, 2021 Category: Environmental Health Authors: Kaili She Chunyu Li Chang Qi Tingxuan Liu Yan Jia Yuchen Zhu Lili Liu Zhiqiang Wang Ying Zhang Xiujun Li Tags: Article Source Type: research

Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome
AbstractTo assess the relationship between the expression of CD38 and the progression of hemorrhagic fever with renal syndrome (HFRS), we determined the levels of CD38 during different phases of HFRS and evaluated the relationship between changes in CD38 expression and the progression of HFRS. The expression of CD38 in 68 patients with HFRS was analyzed by flow cytometry, and this method was also used to determine the levels of CD4+T, CD8+T, and B lymphocytes and NK cells. Furthermore, creatinine (Cr), uric acid (UA), and urea in serum at each stage of HFRS were measured using commercial kits. The basic clinical reference ...
Source: Archives of Virology - August 9, 2021 Category: Virology Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - August 9, 2021 Category: Infectious Diseases Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - August 9, 2021 Category: Tropical Medicine Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - August 9, 2021 Category: Infectious Diseases Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - August 9, 2021 Category: Tropical Medicine Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - August 9, 2021 Category: Infectious Diseases Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

Utility of Nested Reverse-Transcriptase Polymerase Chain Reaction of Clinical Specimens for Early Diagnosis of Hemorrhagic Fever with Renal Syndrome
We report eight HFRS cases diagnosed using urine and serum, but not using saliva, with RT-nPCR targeting the L-segment. Hantavirus RNA detection by RT-nPCR in urine and serum may aid the rapid diagnosis of HFRS during the early phase of the disease. In particular, HFRS should not be ruled out based on negative RT-PCR results in serum, and RT-PCR should be performed using urine as well as serum during the early phase of symptoms.PMID:34370707 | DOI:10.4269/ajtmh.21-0185 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - August 9, 2021 Category: Tropical Medicine Authors: Jun-Won Seo Da Young Kim Choon-Mee Kim Na-Ra Yun Yu-Mi Lee Merlin Jayalal Lawrence Panchali Dong-Min Kim Source Type: research

The changing epidemiology of hemorrhagic fever with renal syndrome in Southeastern China during 1963 –2020: A retrospective analysis of surveillance data
ConclusionsWe observed dynamic changes in the seasonal distribution, geographical distribution, and demographic features of HFRS, which should be well considered in the development of control and prevention strategies in future. Additional researches are warranted to elucidate the environmental, meteorological, and social factors associated with HFRS incidence in different decades. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 6, 2021 Category: Tropical Medicine Authors: Rong Zhang Source Type: research

Viruses, Vol. 13, Pages 1553: Coagulopathy in Acute Puumala Hantavirus Infection
Jukka Mustonen Outi Laine Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and th...
Source: Viruses - August 6, 2021 Category: Virology Authors: Sirpa Koskela Satu M äkelä Tomas Strandin Antti Vaheri Tuula Outinen Lotta Joutsi-Korhonen Ilkka P örsti Jukka Mustonen Outi Laine Tags: Review Source Type: research

Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)
Exp Ther Med. 2021 Sep;22(3):984. doi: 10.3892/etm.2021.10416. Epub 2021 Jul 12.ABSTRACTHantavirus infection belongs to a group of zoonoses rare in the Balkan Peninsula, causing two major syndromes, depending on the viral serotype involved: Hemorrhagic fever with renal syndrome (HFRS) also known as endemic nephropathy and cardiopulmonary syndrome (CPS). Because there is no specific treatment or vaccine for this condition approved in the USA or Europe, the key to minimizing the risk of adverse progression to chronic kidney disease, secondary hypertension or even death is primarily the recognition and early diagnosis of this...
Source: Experimental and Therapeutic Medicine - August 4, 2021 Category: General Medicine Authors: Gabriela Lupu şoru Mircea Lupu şoru Ioana Ailinc ăi Lavinia Bernea Andreea Berechet Radu Sp ătaru Gener Ismail Source Type: research

Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome
AbstractTo assess the relationship between the expression of CD38 and the progression of hemorrhagic fever with renal syndrome (HFRS), we determined the levels of CD38 during different phases of HFRS and evaluated the relationship between changes in CD38 expression and the progression of HFRS. The expression of CD38 in 68 patients with HFRS was analyzed by flow cytometry, and this method was also used to determine the levels of CD4+T, CD8+T, and B lymphocytes and NK cells. Furthermore, creatinine (Cr), uric acid (UA), and urea in serum at each stage of HFRS were measured using commercial kits. The basic clinical reference ...
Source: Archives of Virology - July 30, 2021 Category: Virology Source Type: research

Interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) for flame retardant analysis in biological matrices: Results from the HBM4EU project
Environ Res. 2021 Jul 20:111705. doi: 10.1016/j.envres.2021.111705. Online ahead of print.ABSTRACTThe European Human Biomonitoring Initiative (HBM4EU) is coordinating and advancing human biomonitoring (HBM). For this purpose, a network of laboratories delivering reliable analytical data on human exposure is fundamental. The analytical comparability and accuracy of laboratories analysing flame retardants (FRs) in serum and urine were investigated by a quality assurance and control (QA/QC) scheme comprising interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs). This paper presents t...
Source: Environmental Research - July 23, 2021 Category: Environmental Health Authors: Darina Dvorakova Jana Pulkrabova Tomas Gramblicka Andrea Polachova Martina Buresova Marta Esteban L ópez Argelia Casta ño Stefanie N übler Karin Haji-Abbas-Zarrabi Nadine Klausner Thomas G öen Hans Mol Holger M Koch Vincent Vaccher Jean-Philippe Antig Source Type: research

Interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) for flame retardant analysis in biological matrices: Results from the HBM4EU project
Environ Res. 2021 Jul 20:111705. doi: 10.1016/j.envres.2021.111705. Online ahead of print.ABSTRACTThe European Human Biomonitoring Initiative (HBM4EU) is coordinating and advancing human biomonitoring (HBM). For this purpose, a network of laboratories delivering reliable analytical data on human exposure is fundamental. The analytical comparability and accuracy of laboratories analysing flame retardants (FRs) in serum and urine were investigated by a quality assurance and control (QA/QC) scheme comprising interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs). This paper presents t...
Source: Environmental Research - July 23, 2021 Category: Environmental Health Authors: Darina Dvorakova Jana Pulkrabova Tomas Gramblicka Andrea Polachova Martina Buresova Marta Esteban L ópez Argelia Casta ño Stefanie N übler Karin Haji-Abbas-Zarrabi Nadine Klausner Thomas G öen Hans Mol Holger M Koch Vincent Vaccher Jean-Philippe Antig Source Type: research

Integrative Analysis of HTNV Glycoprotein Derived MHC II Epitopes by In Silico Prediction and Experimental Validation
Hantaan virus (HTNV), the causative pathogen of hemorrhagic fever with renal syndrome (HFRS), is a negative RNA virus belonging to the Orthohantaviridae family. HTNV envelope glycoprotein (GP), encoded by the genomic medium segment, is immunogenic and is therefore a promising vaccine candidate. Major histocompatibility complex class I (MHC-I) epitopes derived from HTNV has been extensively studied, but little is known of MHC-II epitopes. In silico predictions based on four databases indicated that the full-length HTNV GP has 1121 15-mer epitopes, of which 289 had a high score for binding to the human and murine MHC-II supe...
Source: Frontiers in cellular and infection microbiology - July 19, 2021 Category: Microbiology Source Type: research

Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection
Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome (HFRS). The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the susceptibility of Nlrc3−/− mice to HTNV infection in order to establish a new model of HFRS. Nlrc3−/− mice developed weight loss, renal hemorrhage, and tubule dilation after HTNV infection, recapitulating many clinical symptoms of human HFRS. ...
Source: Frontiers in Immunology - July 16, 2021 Category: Allergy & Immunology Source Type: research

Acute Appendicitis Associated with Hantaan Virus Infection
Am J Trop Med Hyg. 2021 Jul 6:tpmd201468. doi: 10.4269/ajtmh.20-1468. Online ahead of print.ABSTRACTHantaviruses are Bunyaviridae viruses that cause hemorrhagic fever with renal syndrome (HFRS). Appendicitis caused by Hantaan virus has not been reported previously. An 81-year-old man who underwent laparoscopic appendectomy for suspected appendicitis based on abdominal pain, fever, hypotension, and computed tomography findings. Based on a suspicion of hemorrhagic fever with renal syndrome, the patient's plasma was simultaneously analyzed using an indirect immunofluorescent antibody assay and nested reverse transcription-pol...
Source: The American Journal of Tropical Medicine and Hygiene - July 6, 2021 Category: Tropical Medicine Authors: Sung-Chul Lim Young Min Lee Choon-Mee Kim Na Ra Yun Dong-Min Kim Source Type: research

Acute Appendicitis Associated with Hantaan Virus Infection
Am J Trop Med Hyg. 2021 Jul 6:tpmd201468. doi: 10.4269/ajtmh.20-1468. Online ahead of print.ABSTRACTHantaviruses are Bunyaviridae viruses that cause hemorrhagic fever with renal syndrome (HFRS). Appendicitis caused by Hantaan virus has not been reported previously. An 81-year-old man who underwent laparoscopic appendectomy for suspected appendicitis based on abdominal pain, fever, hypotension, and computed tomography findings. Based on a suspicion of hemorrhagic fever with renal syndrome, the patient's plasma was simultaneously analyzed using an indirect immunofluorescent antibody assay and nested reverse transcription-pol...
Source: Am J Trop Med Hyg - July 6, 2021 Category: Infectious Diseases Authors: Sung-Chul Lim Young Min Lee Choon-Mee Kim Na Ra Yun Dong-Min Kim Source Type: research

Acute Appendicitis Associated with Hantaan Virus Infection
Am J Trop Med Hyg. 2021 Jul 6:tpmd201468. doi: 10.4269/ajtmh.20-1468. Online ahead of print.ABSTRACTHantaviruses are Bunyaviridae viruses that cause hemorrhagic fever with renal syndrome (HFRS). Appendicitis caused by Hantaan virus has not been reported previously. An 81-year-old man who underwent laparoscopic appendectomy for suspected appendicitis based on abdominal pain, fever, hypotension, and computed tomography findings. Based on a suspicion of hemorrhagic fever with renal syndrome, the patient's plasma was simultaneously analyzed using an indirect immunofluorescent antibody assay and nested reverse transcription-pol...
Source: The American Journal of Tropical Medicine and Hygiene - July 6, 2021 Category: Tropical Medicine Authors: Sung-Chul Lim Young Min Lee Choon-Mee Kim Na Ra Yun Dong-Min Kim Source Type: research

Edging on Mutational Bias, Induced Natural Selection From Host and Natural Reservoirs Predominates Codon Usage Evolution in Hantaan Virus
The molecular evolutionary dynamics that shape hantaviruses’ evolution are poorly understood even now, besides the contribution of virus-host interaction to their evolution remains an open question. Our study aimed to investigate these two aspects in Hantaan virus (HTNV)—the prototype of hantaviruses and an emerging zoonotic pathogen that infects humans, causing hemorrhagic fever with renal syndrome (HFRS): endemic in Far East Russia, China, and South Korea—via a comprehensive, phylogenetic-dependent codon usage analysis. We found that host- and natural reservoir-induced natural selection is the primary d...
Source: Frontiers in Microbiology - July 2, 2021 Category: Microbiology Source Type: research

Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score
CONCLUSION: Adjusting for the HFRS in addition to other patient and procedural risk factors provided greater discrimination of outcomes in this cohort of older patients undergoing vascular surgery.PMID:34157089 | DOI:10.1002/bjs.12043 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - June 22, 2021 Category: Surgery Authors: S J Aitken S Lujic D A Randall N Noguchi V Naganathan F M Blyth Source Type: research

Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score
CONCLUSION: Adjusting for the HFRS in addition to other patient and procedural risk factors provided greater discrimination of outcomes in this cohort of older patients undergoing vascular surgery.PMID:34157089 | DOI:10.1002/bjs.12043 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - June 22, 2021 Category: Surgery Authors: S J Aitken S Lujic D A Randall N Noguchi V Naganathan F M Blyth Source Type: research

Organophosphate (OP) diesters and a review of sources, chemical properties, environmental occurrence, adverse effects, and future directions
Environ Int. 2021 Jun 16;155:106691. doi: 10.1016/j.envint.2021.106691. Online ahead of print.ABSTRACTOver the course of the continual phase-outs of toxic halogenated flame retardants (HFRs), there has been an increasing demand for organophosphate esters (OPEs) in global FR markets. OPE-FRs have largely been identified as OP triesters, which have a basic chemical structure of O = P(OR)3. In addition to OP triesters, OPEs can refer to another class of related substances, namely, OP diesters that have a typical chemical structure of O = P(OR)2(OH)). OP diesters are known as biotic or abiotic degradation products of OP triest...
Source: Environment International - June 19, 2021 Category: Environmental Health Authors: Yaxin Liu Shuai Gong Langjie Ye Jianhua Li Chunsheng Liu Da Chen Mingliang Fang Robert J Letcher Guanyong Su Source Type: research

Organophosphate (OP) diesters and a review of sources, chemical properties, environmental occurrence, adverse effects, and future directions
Environ Int. 2021 Jun 16;155:106691. doi: 10.1016/j.envint.2021.106691. Online ahead of print.ABSTRACTOver the course of the continual phase-outs of toxic halogenated flame retardants (HFRs), there has been an increasing demand for organophosphate esters (OPEs) in global FR markets. OPE-FRs have largely been identified as OP triesters, which have a basic chemical structure of O = P(OR)3. In addition to OP triesters, OPEs can refer to another class of related substances, namely, OP diesters that have a typical chemical structure of O = P(OR)2(OH)). OP diesters are known as biotic or abiotic degradation products of OP triest...
Source: Environment International - June 19, 2021 Category: Environmental Health Authors: Yaxin Liu Shuai Gong Langjie Ye Jianhua Li Chunsheng Liu Da Chen Mingliang Fang Robert J Letcher Guanyong Su Source Type: research

Severe contamination and time trends of legacy and novel halogenated flame retardants in multiple environmental media from Lake Shihwa, Korea: Effectiveness of regulatory action
Chemosphere. 2021 Sep;279:130620. doi: 10.1016/j.chemosphere.2021.130620. Epub 2021 Apr 22.ABSTRACTNovel halogenated flame retardants (HFRs) were introduced to industrial markets as alternatives to legacy brominated FRs (BFRs), such as polybrominated diphenyl ethers (PBDEs). In the present study, PBDEs and their brominated and chlorinated alternatives, novel BFRs (NBFRs) and dechlorane plus (DP), were measured in multiple environmental matrices in a highly industrialized lake in Korea. Legacy and novel HFRs were detected in multiple samples, indicating ubiquitous contamination. Concentrations of HFRs in water and sediment ...
Source: Chemosphere - June 17, 2021 Category: Chemistry Authors: Sunggyu Lee Kongtae Ra Hyo-Bang Moon Source Type: research

Severe contamination and time trends of legacy and novel halogenated flame retardants in multiple environmental media from Lake Shihwa, Korea: Effectiveness of regulatory action
Chemosphere. 2021 Sep;279:130620. doi: 10.1016/j.chemosphere.2021.130620. Epub 2021 Apr 22.ABSTRACTNovel halogenated flame retardants (HFRs) were introduced to industrial markets as alternatives to legacy brominated FRs (BFRs), such as polybrominated diphenyl ethers (PBDEs). In the present study, PBDEs and their brominated and chlorinated alternatives, novel BFRs (NBFRs) and dechlorane plus (DP), were measured in multiple environmental matrices in a highly industrialized lake in Korea. Legacy and novel HFRs were detected in multiple samples, indicating ubiquitous contamination. Concentrations of HFRs in water and sediment ...
Source: Chemosphere - June 17, 2021 Category: Chemistry Authors: Sunggyu Lee Kongtae Ra Hyo-Bang Moon Source Type: research

Severe contamination and time trends of legacy and novel halogenated flame retardants in multiple environmental media from Lake Shihwa, Korea: Effectiveness of regulatory action
Chemosphere. 2021 Sep;279:130620. doi: 10.1016/j.chemosphere.2021.130620. Epub 2021 Apr 22.ABSTRACTNovel halogenated flame retardants (HFRs) were introduced to industrial markets as alternatives to legacy brominated FRs (BFRs), such as polybrominated diphenyl ethers (PBDEs). In the present study, PBDEs and their brominated and chlorinated alternatives, novel BFRs (NBFRs) and dechlorane plus (DP), were measured in multiple environmental matrices in a highly industrialized lake in Korea. Legacy and novel HFRs were detected in multiple samples, indicating ubiquitous contamination. Concentrations of HFRs in water and sediment ...
Source: Chemosphere - June 17, 2021 Category: Chemistry Authors: Sunggyu Lee Kongtae Ra Hyo-Bang Moon Source Type: research