Colonoscopy practice in South Africa: The way forward.
Authors: Katsidzira L, Thomson S PMID: 33403949 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Reporting of studies based on the analysis of routinely collected health data.
Authors: Abratt RP, Macbeth F PMID: 33403950 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

COVID-19 collateral damage: Alcohol rub dermatitis as an emerging problem.
Authors: Alves SM, Arendse AJ, Kannenberg SMH PMID: 33403951 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Trends in paediatric tuberculosis diagnoses in two South African hospitals early in the COVID-19 pandemic.
Authors: Lebina L, Dube M, Hlongwane K, Brahmbatt H, Lala SG, Reubenson G, Martinson N PMID: 33403952 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

The challenges of maintaining non-COVID medicine services at Groote Schuur Hospital, Cape Town, South Africa, during COVID-19.
Authors: Sonderup M, Spearman W, Ross I, Gogela N, Combrinck M, Setshedi M, Symons G, Wearne N, Hoosain S, Kruger JJ, Mbena B, Boayke D, Muchenje T, Masikati M, Okeyo E, Makhura B, Botha J, Hlongwane L, Ntusi N PMID: 33403953 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

The economics of poisoning: The role of telemedicine and toxicovigilance.
Authors: Balme K, Stephen C, Curling L, Mohamed F, Du Plessis C, Marks C, Pillay-Fuentes Lorente V, Van Rensburg R, Voigt G PMID: 33403954 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Protecting healthcare workers: A critical part of the COVID-19 response.
Authors: Bekker LG, Delany-Moretlwe S, Biccard B, Du Toit L, Lovat LB, Dehbi HM, Moonesinghe R, Rees H, Avidan MS PMID: 33403955 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Access to novel therapies for COVID-19 - distributive justice and Russian roulette?
Authors: Pepper MS PMID: 33403956 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
CONCLUSIONS: According to moderate- to high-certainty evidence, short-chain fatty acids and LCn3 have little or no effect on mortality or cardiovascular health. However, omega-3 ALA slightly reduces the risk of CVD events and arrhythmias. PMID: 33403957 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Opportunities from a new disease for an old threat: Extending COVID-19 efforts to address tuberculosis in South Africa.
Authors: Loveday M, Cox H, Evans D, Furin J, Ndjeka N, Osman M, Naidoo For The National Tb Think Tank 'Optimising Tb Treatment Outcomes' Task Team K Abstract The COVID-19 pandemic and phased nationwide lockdown have impacted negatively on individuals with tuberculosis (TB) and routine TB services. Through a literature review and the perspective of members of a national TB Think Tank task team, we describe the impact of the pandemic and lockdown on TB patients and services as well as the potential long-term setback to TB control in South Africa (SA). Strategies to mitigate risk and impact are explored, together with...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Prolonged treatment of COVID-19 pneumonia with high-flow nasal oxygen: A story of oxygen and resilience.
Authors: Audley GG, Frankenfeld P, Dlamini S, Raubenheimer P, Hoare J, Cairncross L, Van den Berg R, Gule MV, Calligaro G Abstract The COVID-19 pandemic has placed significant strain on the oxygen delivery infrastructure of health facilities in resource-constrained health systems. In this case report, we describe a patient with severe COVID-19 pneumonia who was managed with high-flow nasal oxygen for 40 days, with an eventual successful outcome. We discuss the oxygen delivery infrastructure needed to offer this intervention, as well as the psychosocial impact on those undergoing treatment. PMID: ...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Age discrimination in critical care triage in South Africa: The law and the allocation of scarce health resources in the COVID-19 pandemic.
Authors: Erasmus N Abstract No one may be refused emergency medical treatment in South Africa (SA). Yet score-based categorical exclusions used in critical care triage guidelines disproportionately discriminate against older adults, the cognitively and physically impaired, and the disabled. Adults over the age of 60, who make up 9.1% of the SA population, are most likely to present with disabilities and comorbidities at triage. Score-based models, drawn from international precedents, deny these patients admission to an ICU when resources are constrained, such as during influenza and COVID-19 outbreaks. The Critical...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Critical care triage during the COVID-19 pandemic in South Africa: A constitutional imperative!
Authors: Morrow BM, Gopalan PD, Joubert I, Paruk F, Pope A Abstract Triage and rationing of scarce intensive care unit (ICU) resources are an unavoidable necessity. In routine circumstances, ICU triage is premised on the best interests of an individual patient; however, when increased demand exceeds capacity, as during an infectious disease outbreak, healthcare providers need to make difficult decisions to benefit the broader community while still respecting individual interests. We are currently living through an unprecedented period, with South Africa (SA) facing the challenges of the global COVID-19 pandemic. Th...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Rapid evolution of our understanding of the pathogenesis of COVID-19: Implications for therapy.
Authors: Mustafa F, Giles R, Pepper MS Abstract COVID-19 severity appears to lie in its propensity to cause a hyperinflammatory response, attributed to the cytokine release syndrome (CRS) or 'cytokine storm', although the exact role of the CRS remains to be fully elucidated. Hyperinflammation triggers a hypercoagulable state, also thought to play a key role in COVID-19 pathogenesis. Disease severity is linked to age, sex and comorbid conditions, which in turn may be linked to oxidative stress and pre-existing depletion of nicotinamide adenine dinucleotide (NAD+). There is increasing evidence that the host genome ma...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

The 'ins and outs' of colonoscopy at Wits Donald Gordon Medical Centre, South Africa: A practice audit of the outpatient endoscopy unit.
CONCLUSIONS: The WDGMC OEU performed reasonably well against the international guidelines, despite some inadequacy in bowel preparation and lower than recommended median withdrawal times on negative-result colonoscopy. Annual auditing of clinical practice and availability of these data in the public domain will become standard of care, making this audit a baseline for longitudinal observation, assessing the impact of interventions, and contributing to the development of local guidelines. PMID: 33403963 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Prevalence and characteristics of incidental colorectal polyps in patients undergoing colonoscopy at a South African tertiary institution.
CONCLUSIONS: This study provides a benchmark ADR for our catchment population and potentially across Africa. There is evidence of a continuing differential colorectal neoplasia risk according to ethnicity, with fewer adenomas being detected in black South Africans. PMID: 33403964 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Postmortem lung biopsies from four patients with COVID-19 at a tertiary hospital in Cape Town, South Africa.
CONCLUSIONS: The pulmonary findings we observed are in keeping with those described in the international literature. However, the pathology was surprisingly heterogeneous between cases, and was only deemed severe enough to be the cause of death in 1 of 4 cases. While lung-targeted, standardised postmortem biopsies may be safe, easy to perform and provide useful insights into the disease, they are not suitable to replace full autopsies in determining cause of death. PMID: 33403965 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

The impact of COVID-19 on routine patient care from a laboratory perspective.
CONCLUSIONS: This study, focusing on the short-term consequences of the SA response to the COVID-19 pandemic, found that routine follow-up of patients with communicable and non-communicable diseases was affected. Future studies are necessary to evaluate the long-term consequences of the pandemic for these patient groups. PMID: 33403966 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Use of the antenatal antiretroviral (ARV) tracking form in maternity case records to improve ARV management.
CONCLUSIONS: Uptake of use of the tracking form increased markedly after implementation. Use of the form significantly improved the taking and retrieval of blood tests and the management of ARVs. The form has since been printed as part of the new maternity case records in KZN. PMID: 33403967 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Two-year viral load suppression among adolescents receiving antiretroviral therapy in the Cape Metropole, South Africa, 2013 - 2015: A retrospective cohort analysis.
CONCLUSIONS: Targeted interventions are required to improve retention in care and VLS among adolescents on ART, with specific focus on older (15 - 19-year-olds) and pregnant adolescents. PMID: 33403968 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Repeat injuries in childhood.
CONCLUSIONS: Repeat presentations were substantial and associated with male gender. They occurred less commonly after fluid burn injuries, foreign body ingestion and moderate to severe injuries. Children with intentional injuries were also less likely to have a repeat presentation. Further research is indicated for childhood injuries with greater propensity to repeat, including non-height falls and sport-related injuries. Secondary injury prevention education should not neglect patients with unintentional and minor injuries. These results strengthen the hypothesis that injuries arise as a result of sustained exposure to ag...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Adverse drug reactions reported to a provincial public health sector pharmacovigilance programme in South Africa.
CONCLUSIONS: Enalapril and etonogestrel were responsible for a significant proportion of ADRs reported to this provincial programme. Future work should include quantification of preventability aspects to better inform gaps in healthcare worker knowledge that can be addressed in order to improve patient care. PMID: 33403970 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

A retrospective review of the adverse effects of biological therapy and reasons for its discontinuation in a resource-limited setting.
CONCLUSIONS: Recurrent uveitis occurred in almost half of the patients with AS and was also the main reason for discontinuation of biological therapy. We did not document an increased risk of PTB. Disease activity scores showed significant improvement. The study is limited by the small number of patients on biological therapy, a reflection of the impact of severe resource constraints. PMID: 33403971 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

New cholesterol targets for patients at high or very high cardiovascular risk and the indications for PCSK9 inhibitors.
Authors: Klug EQ, Raal FJ PMID: 33403972 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Metabolic alkalosis in hospitalised COVID-19 patients: A window to the pathogenesis?
Authors: Rood J, Davids R, Le Roux A, Du Plessis M, Parker A, Allwood BW, Prozesky HW, Koegelenberg CFN, Taljaard JJ PMID: 33403973 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Modified full-face snorkel masks as personal protective equipment for COVID-19 in South Africa.
Authors: Van Wyk L, Goussard P, Meintjes WAJ PMID: 33403974 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Maximising health science student volunteers for the COVID-19 response: A valuable resource.
Authors: Verhage S, Kim I, Ndereya S, Begg K, Zweigenthal V, Fieggen K, Wallis L, Reid S, Irlam J, Ntusi N, Peter J PMID: 33403975 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Clinical v. laboratory-based screening for COVID-19 in asymptomatic patients requiring acute cardiac care.
Authors: Joubert LH, Herbst PG, Doubell AF, Pecoraro AJK PMID: 33403976 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Dangers of smoking cigarettes and drinking alcohol during pregnancy.
Authors: Odendaal HJ, Kruger M, Botha MH PMID: 33403977 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Research imperialism resurfaces in South Africa in the midst of the COVID-19 pandemic - this time, via a digital portal.
Authors: Moodley K PMID: 33403978 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Reflections for global public health research and evidence-based medicine during the COVID-19 pandemic.
Authors: Davids EL PMID: 33403979 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Implementing malaria control in South Africa, Eswatini and southern Mozambique during the COVID-19 pandemic.
Authors: Brooke BD, Raman J, Frean J, Rundle J, Maartens F, Misiani E, Mabuza A, Barnes KI, Moonasar DP, Dlamini Q, Charles S, Blumberg L Abstract The COVID-19 pandemic has strained healthcare delivery systems in a number of southern African countries. Despite this, it is imperative that malaria control and elimination activities continue, especially to reduce as far as possible the number and rate of hospitalisations caused by malaria. The implementation of enhanced malaria control/elimination activities in the context of COVID-19 requires measures to protect healthcare workers and the communities t...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory.
Authors: Leong TD, McGee SM, Gray AL, De Waal R, Kredo T, Cohen K, Reubenson G, Blockman M, Nel J, Maartens G, Rees H, Wiseman R, Jamaloodien K, Parrish AG Abstract The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Opportunistic pathogenic fungal co-infections are prevalent in critically ill COVID-19 patients: Are they risk factors for disease severity?
Authors: Ezeokoli OT, Pohl CH Abstract Fungal co-infections, especially with Aspergillus and Candida species, are prevalent in hospitalised COVID-19 patients, and could influence patient outcomes and hamper treatment efforts. However, information about and elucidation of the causal relationship between fungal co-infections and COVID-19 disease outcomes or severity in patients are still lacking. Such information, if and when available, will help facilitate appropriate case management. PMID: 33403982 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Is the COVID-19 regulation that prohibits parental visits to their children who are patients in hospital invalid in terms of the Constitution? What should hospitals do?
This article deals with whether the COVID-19 regulation that prohibits parental visits to their children who are patients in hospital is invalid in terms of the Constitution of South Africa. The article contends that the ban on visits by parents to their children in hospital is a violation of the children's rights provisions of the Constitution regarding the 'best interests of the child', and the 'best interests standard' in the Children's Act 38 of 2005. The article also points out that the regulations are not saved by the limitations clause of the Constitution, because the restriction is not 'reasonable and justifiable' ...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Handmaidens and pioneers: Three female anaesthetists and their contribution to anaesthesia in South Africa.
This article offers an account of three South African (SA) women who trained in anaesthetics before and during the War and participated in these changes. By the mid-1960s, they presided over the three independent anaesthetic departments at Johannesburg's three main teaching hospitals, teaching generations of junior doctors. The first woman to register as a specialist anaesthetist in SA, Miriam (Mollie) Barlow, broke the glass ceiling in her own career by lobbying for the professional rights of medical women, although working within the constraints of the medical and political establishment. She also contributed to importan...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

COVID deaths in South Africa: 99 days since South Africa's first death.
CONCLUSIONS: Data collection for COVID-19 deaths in provinces must be standardised. Even though the data had limitations, these findings can be used by the SA government to manage the pandemic and identify individuals who are at high risk of dying from COVID-19. PMID: 33403985 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Smoking and drinking habits of women in subsequent pregnancies after specific advice about the dangers of these exposures during pregnancy.
CONCLUSIONS: Detailed information on the adverse effects of smoking and drinking during pregnancy was not effective in the population studied. Other methods to reduce or stop these toxic exposures should therefore be investigated. A short inter-pregnancy interval, as demonstrated by three enrolments in 7.5 years, is associated with preterm labour and fetal growth restriction, and is probably indicative of the role played by confounders such as poor socioeconomic conditions and drug exposure during pregnancy. PMID: 33403986 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

A rapid review of the effectiveness of screening practices at airports, land borders and ports to reduce the transmission of respiratory infectious diseases such as COVID-19.
CONCLUSIONS: There is insufficient evidence to support entry and exit screening at points of entry, as these strategies detect just over half of the infected cases, missing almost half at entry points. The benefits of airport screening therefore need to be context specific and weighed against the resources and cost of implementation, the contribution of imported cases to total cases, and the benefits of identifying 50% of cases in the South African context with the country's high HIV and tuberculosis prevalence and limited resources to deal with a pandemic of this nature. PMID: 33403987 [PubMed - in process] (Source: S...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Trauma patterns during the COVID-19 lockdown in South Africa expose vulnerability of women.
CONCLUSIONS: The study showed that during the period of lockdown in SA there was a significant decrease in MVAs, PVAs and interpersonal violence. Assaults involving a knife seemed to decrease dramatically, but the rate of GSWs remained constant. PMID: 33403988 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

A descriptive analysis of the effect of the national COVID-19 lockdown on the workload and case mix of patients presenting to a district-level emergency centre in Cape Town, South Africa.
CONCLUSIONS: The SA national COVID-19 lockdown resulted in a substantial decrease in the number of patients presenting to the emergency centre. It is yet to be seen how quickly emergency centre volumes will recover as lockdown measures are eased. PMID: 33403989 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

The effect of lockdown regulations on SARS-CoV-2 infectivity in Gauteng Province, South Africa.
CONCLUSIONS: The findings of this study testify to the rapid increase in ARs resulting from easing of the lockdown regulations, especially to level 3 in June. Of concern is the upward trend in the AR across all age groups, especially <20 years (15.9%), which was not reported in other parts of the world. Population age dynamics should therefore be considered when taking future decisions about lockdown regulations. PMID: 33403990 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Let's get physical:  A prospective pedometer study of doctors working in a South African emergency department.
CONCLUSIONS: Doctors working in an SA ED are not achieving the daily recommended number of steps while at work. The increased risk of ill health and burnout in an already high-risk specialty heightens the importance of exercise and physical activity that needs to be achieved outside the workplace. PMID: 33403991 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Vitamin D levels in patients admitted to the intensive care unit and the association with organ dysfunction and glutamine levels.
CONCLUSIONS: Vitamin D deficiency is common in ICU patients in SA. Deficient patients were more severely ill and required more respiratory support. No significant relationship between deficiency and median glutamine levels was noted. PMID: 33403992 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Unrecognised postoperative residual curarisation in developing countries remains a common problem.
CONCLUSIONS: PORC is more common in practice than currently recognised. This deduction is supported by the low rate of intraoperative neuromuscular monitoring conducted and the high pass rate on clinical assessment. Routine use of quantitative monitoring of neuromuscular function should be encouraged to minimise the risk of this serious yet preventable condition. PMID: 33403993 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

HLA and disease: Missing clinical data on laboratory request forms - a missed opportunity.
Authors: Janse van Rensburg WJ, De Kock A, Bester C, Kloppers JF PMID: 33403994 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Extraintestinal pathogenic Escherichia coli  (ExPEC) ST221 isolated in the micro-biome of swine in South Africa.
Extraintestinal pathogenic Escherichia coli (ExPEC) ST221 isolated in the micro-biome of swine in South Africa. S Afr Med J. 2020 Dec 14;111(1):5-6 Authors: Founou LL, Founou RC, Allam M, Ismail A, Essack SY PMID: 33403995 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Importance of genetic diagnosis in the management of early-onset epilepsies.
Authors: Esterhuizen AI, Carvill GL, Fieggen K, McIntosh C, Ramesar RS, Wilmshurst JM PMID: 33403996 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Long-COVID: An evolving problem with an extensive impact.
Authors: Mendelson M, Nel J, Blumberg L, Madhi SA, Dryden M, Stevens W, Venter FWD Abstract Persistence of symptoms or development of new symptoms relating to SARS-CoV-2 infection late in the course of COVID-19 is an increasingly recognised problem facing the globally infected population and its health systems. 'Long-COVID' or 'COVID long-haulers' generally describes those persons with COVID-19 who experience symptoms for >28 days after diagnosis, whether laboratory confirmed or clinical. Symptoms are as markedly heterogeneous as seen in acute COVID-19 and may be constant, fluctuate, or appear and be replace...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic.
Authors: Raman J, Barnes KI, Baker L, Blaylock M, Blumberg L, Frean J, Misiani E, Ukpe IS Abstract As September marks the start of the malaria season in South Africa (SA), it is essential that healthcare professionals consider both COVID- 19 and malaria when a patient who lives in or has recently travelled to a malaria area presents with acute febrile illness. Early diagnosis of malaria by either a rapid diagnostic test or microscopy enables prompt treatment with the effective antimalarial, artemether-lumefantrine, preventing progression to severe disease and death. Intravenous artesunate is the preferred treatment...
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research