Causal relationships of Helicobacter pylori and related gastrointestinal diseases on Type 2 diabetes: Univariable and Multivariable Mendelian randomization
ConclusionOur study found that H. pylori IgG antibody, H. pylori GroEL antibody, gastroduodenal ulcer and chronic gastritis are all related to t T2DM, and blood glucose level and obesity mediate the development of H. pylori GroEL antibody and gastroduodenal ulcer on T2DM, respectively. These findings may inform new prevention and intervention strategies for T2DM. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Mei Sun Source Type: research
Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid
Oncogene, Published online: 23 April 2024; doi:10.1038/s41388-024-03034-zImproving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid (Source: Oncogene)
Source: Oncogene - April 23, 2024 Category: Cancer & Oncology Authors: Karen van der Sluis Johanna W. van Sandick Marieke A. Vollebergh Jolanda M. van Dieren Niek Hugen Koen J. Hartemink Alexander A. F. A. Veenhof Els Verhoeven Jos é G. van den Berg Petur Snaebjornsson Michael Noe Tom van Wezel Mirjam C. Boelens Liudmila L. Source Type: research
A Prospective Multimodal Education Intervention for Providers Does Not Increase Hepatic Encephalopathy Treatment Rates
ConclusionThis MMEI did not increase HE treatment rates, suggesting that alternative strategies are needed to identify and address barriers to treatment. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Cardiopulmonary Resuscitation Outcomes and Trainee Perception of Code Status Discussions in Patients with Cirrhosis
ConclusionsWe identified significant trainee uncertainty about outcomes in patients with cirrhosis. These deficits improved after an educational intervention and gave providers more confidence in holding informed code status conversations with patients with cirrhosis, a population that faces barriers to adequate code discussions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Metabolomic Analysis of Human Cirrhosis and Hepatocellular Carcinoma: A Pilot Study
ConclusionOur findings give promising insides into the metabolic changes during HCC carcinogenesis and provide candidate biomarkers for future studies. Campesterol and furoylglycine in particular were identified as possible biomarkers for HCC progression. Moreover, eight metabolites were detected as predictors for poor overall survival.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Statewide Survey of Primary Care and Subspecialty Providers on Hepatocellular Carcinoma Risk-Stratification and Surveillance Practices
ConclusionsIn this statewide survey, there were great knowledge gaps in HCC surveillance among PCPs and most respondents expressed interest in strategies to increase appropriate HCC surveillance. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Spatial genomics: mapping human steatotic liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 23 April 2024; doi:10.1038/s41575-024-00915-2This Perspective discusses single-cell and single-nuclei RNA sequencing in metabolic dysfunction-associated steatotic liver disease and explains how our understanding of the pathology of the disease will accelerate following the advances in spatial transcriptomics. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Kylie P. Matchett Jasmin Paris Sarah A. Teichmann Neil C. Henderson Source Type: research
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research
Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan
ConclusionsThe GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
ConclusionThese findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs + PANTO. Markers of oxidative stress, inflammation and apoptosis were assessed. The current data indicated that PANTO-, ADSCs- and ADSCs + PANTO-treated groups showed significant drop (p < 0.05) in serum adva...
Source: Inflammopharmacology - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Cancers, Vol. 16, Pages 1617: Interaction of Colorectal Neoplasm Risk Factors and Association with Metabolic Health Status Focusing on Normal Waist-to-Hip Ratio in Adults
Conclusions: An increase in FRS and HbA1c or a positive H. pylori infection still warrants vigilance for colorectal adenoma risk when WHR is 0.9. These factors interacted with each other and were found to have a minimal decline in adenoma risk when considering the interaction between WHR and FRS. (Source: Cancers)
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Ying-Chun Lin Hung-Ju Ko Lo-Yip Yu Ming-Jen Chen Horng-Yuan Wang Shou-Chuan Shih Chuan-Chuan Liu Yang-Che Kuo Kuang-Chun Hu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1620: Short-Term Outcomes Analysis Comparing Open, Laparoscopic, Laparoscopic-Assisted, and Robotic Distal Gastrectomy for Locally Advanced Gastric Cancer: A Randomized Trials Network Analysis
Conclusions. LapAs-DG, Lap-DG, and Rob-DG performed in referral centers by dedicated surgeons have comparable short-term outcomes to Op-DG for locally AGC. (Source: Cancers)
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Michele Manara Alberto Aiolfi Andrea Sozzi Matteo Cal ì Federica Grasso Emanuele Rausa Gianluca Bonitta Luigi Bonavina Davide Bona Tags: Systematic Review Source Type: research
Correction: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
A gastric sarcoma from 3000 years ago: paleopathological diagnosis at the field
ConclusionsMalignant diseases are seldom described in Paleopathology; to our knowledge, this is the oldest and most unique case of this type of pathology in mummies worldwide. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
