Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2024 Category: Physiology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2024 Category: Physiology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.NO ABSTRACTPMID:38626403 | DOI:10.1152/ajpgi.00075.2024 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2024 Category: Physiology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Cadherin-17 as a target for the immunoPET of adenocarcinoma
CONCLUSION: Taken together, these data underscore that [89Zr]Zr-DFO-D2101 is a highly promising probe for the non-invasive visualization of CDH17 expression in PDAC. We contend that this radioimmunoconjugate could have a significant impact on the clinical management of patients with both PDAC and gastrointestinal adenocarcinoma, most likely as a theranostic imaging tool in support of CDH17-targeted therapies.PMID:38625402 | DOI:10.1007/s00259-024-06709-7 (Source: Molecular Medicine)
Source: Molecular Medicine - April 16, 2024 Category: Molecular Biology Authors: Samantha Delaney Outi Kein änen Dennis Lam Andrew L Wolfe Takao Hamakubo Brian M Zeglis Source Type: research
Rapid and multi-target genotyping of Helicobacter pylori with digital microfluidics
Biosens Bioelectron. 2024 Apr 11;256:116282. doi: 10.1016/j.bios.2024.116282. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection correlates closely with gastric diseases such as gastritis, ulcers, and cancer, influencing more than half of the world's population. Establishing a rapid, precise, and automated platform for H. pylori diagnosis is an urgent clinical need and would significantly benefit therapeutic intervention. Recombinase polymerase amplification (RPA)-CRISPR recently emerged as a promising molecular diagnostic assay due to its rapid detection capability, high specificity, and mild reaction...
Source: Biosensors and Bioelectronics - April 16, 2024 Category: Biotechnology Authors: Jinsong Liu Rongxin Fu Shuailong Zhang Jialu Hou Hanbin Ma Siyi Hu Hang Li Yanli Zhang Weian Wang Bokang Qiao Baisheng Zang Xun Min Feng Zhang Jie Du Shengkai Yan Source Type: research
Characteristics of the Digestive Tract of Dogs and Cats
Adv Exp Med Biol. 2024;1446:15-38. doi: 10.1007/978-3-031-54192-6_2.ABSTRACTAs for other mammals, the digestive system of dogs (facultative carnivores) and cats (obligate carnivores) includes the mouth, teeth, tongue, pharynx, esophagus, stomach, small intestine, large intestine, and accessory digestive organs (salivary glands, pancreas, liver, and gallbladder). These carnivores have a relatively shorter digestive tract but longer canine teeth, a tighter digitation of molars, and a greater stomach volume than omnivorous mammals such as humans and pigs. Both dogs and cats have no detectable or a very low activity of salivar...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Wenliang He Erin D Connolly Guoyao Wu Source Type: research
The effect of serum triglyceride levels and different lipid-lowering methods on the prognosis of hypertriglyceridemic acute pancreatitis: a single-center 12-year retrospective study by propensity score matching
CONCLUSION: The severity of HTG-AP is not associated with the triglyceride levels at admission. However, rapid reduction of triglyceride levels can lower the incidence of local complications and respiratory failure. Compared with conservative treatment, insulin and LMWH + bezafibrate can both reduce the incidence of IPN in patients with HTG-AP.PMID:38625376 | DOI:10.1080/00365521.2024.2342406 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Yang Liu Jian-Ping Cheng Xiao-Lin Zhao Source Type: research
Beyond the Bowl: Understanding Amino Acid Requirements and Digestibility to Improve Protein Quality Metrics for Dog and Cat Foods
Adv Exp Med Biol. 2024;1446:99-134. doi: 10.1007/978-3-031-54192-6_5.ABSTRACTThe determination of amino acid (AA) requirements for mammals has traditionally been done through nitrogen (N) balance studies, but this technique underestimates AA requirements in adult animals. There has been a shift toward researchers using the indicator amino acid oxidation (IAAO) technique for the determination of AA requirements in humans, and recently in dogs. However, the determination of AA requirements specific to adult dogs and cats at maintenance is lacking and the current requirements outlined by the National Research Council are base...
Source: Adv Data - April 16, 2024 Category: Epidemiology Authors: Pawanpreet Singh Sydney Banton Guido Bosch Wouter H Hendriks Anna K Shoveller Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against non-alcoholic fatty liver disease
CONCLUSIONS: Ursolic acid could improve immune inflammation in NAFLD by modulating SPP1-mediated Th17 cell differentiation via the ERK signaling pathway, which is orchestrated jointly by ITGB1 and CD44, emerging as a linchpin in this molecular cascade.PMID:38623614 | DOI:10.3350/cmh.2024.0047 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Yiyuan Zheng Lina Zhao Zhekun Xiong Chaoyuan Huang Qiuhong Yong Dan Fang Yugang Fu Simin Gu Chong Chen Jiacheng Li Yingying Zhu Jing Liu Fengbin Liu Yong Li Source Type: research
