Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor: A Pilot Study on Comparable Efficacy in the Treatment of Gastroesophageal Reflux-Related Cough
In conclusion, vonoprazan may be comparable to esomeprazole in cough symptom relief in GERC during the 2-month treatment period, but possibly provides better gains on classic reflux symptoms and quality-of-life. The long-term efficacy of P-CABs on GERC may be worth further exploration. Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR2200067089.PMID:38528386 | DOI:10.4168/aair.2024.16.2.191 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 26, 2024 Category: Allergy & Immunology Authors: Shuxin Zhong Mingyu Zhong Liman Fang Haopeng Zhi Xiaolong Ji Kailun Tang Chen Zhan Xu Shi Mo Xian Wanjun Wang Jing Li Wei Luo Kefang Lai Ruchong Chen Source Type: research

The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study
CONCLUSIONS: The evidence suggests that UC is associated with an elevated risk of AP and IBS, and IL-6 may be responsible in AP. CD is associated with an increased risk of developing CeD. Implementing a proactive monitoring program for assessing the risk of gastrointestinal diseases in UC patients, particularly those with elevated IL-6 levels, may be of interest. In addition, the presence of AP and IBS may indicate the presence of UC. Preventing CeD is an essential consideration in the therapeutic management of patients with CD.PMID:38529201 | PMC:PMC10963109 | DOI:10.1155/2024/1266139 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Shu Zhou Qi Sun Ning Gao Zekai Hu Junjun Jia Jiangwei Song Guocong Xu Aiqiang Dong Weiliang Xia Jiafeng Wu Source Type: research

A Meta-Analysis of MiRNA-497 and Prognosis of Hepatocellular Carcinoma
CONCLUSIONS: MiR-497 might serve as a prognostic biomarker in HCC, but more clinical studies are needed to confirm this view.PMID:38529202 | PMC:PMC10963114 | DOI:10.1155/2024/2211179 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Zhiqiang Xie Qingzhi Hao Rongrong Zhu Ruiping Ma Source Type: research

Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research

PELI1: key players in the oncogenic characteristics of pancreatic Cancer
CONCLUSION: PELI1 is overexpressed in PC, which increased ubiquitination of RPS3 proteins and activates the PI3K/Akt/GSK3β signaling pathway, as well as reduces the protective effect of RPS3 on p53 and promotes the degradation of the p53 protein, which facilitates the progression of PC and leads to a poor prognosis for patients. Therefore, PELI1 is a potential target for the treatment of PC.PMID:38528516 | PMC:PMC10962118 | DOI:10.1186/s13046-024-03008-9 (Source: Cell Research)
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Xiaobin Fei Changhao Zhu Peng Liu Songbai Liu Likun Ren Rishang Lu Junyi Hou Yongjia Gao Xing Wang Yaozhen Pan Source Type: research

A review on the traditional applications, phytochemistry, and pharmacology of the genus Physochlaina G. Don
Chem Biodivers. 2024 Mar 26:e202400394. doi: 10.1002/cbdv.202400394. Online ahead of print.ABSTRACTPhysochlaina is a genus of flowering plants belonging to the family Solanaceae and consists of 10 species distributed in various Asian countries. The species of the genus have been traditionally used to cure a variety of illnesses due to their highly valuable medicinal properties, including cancer, asthma, cough, weakness, stomachache, diarrhea, swelling, spasms, toothache, boils, ulcers, rheumatic pain, chronic bronchitis, gastric problems, abdominal pain, palpitation, and insomnia. The species have gained significant attent...
Source: Chemistry and Biodiversity - March 26, 2024 Category: Biochemistry Authors: Younas Rasheed Tantray Ishrat Jan Irshad Mohiuddin Preeti Gorla Charul Anand Jagdesh Chandra Arya Shahnawaz Ahmad Bhat Vijay Kumar Shiddamallayya Nagayya Rabinaryana Acharya Source Type: research

Discovery of cinnamylaldehyde-derived mono-carbonyl curcumin analogs as anti-gastric cancer agents via suppression of STAT3 and AKT pathway
Bioorg Chem. 2024 Mar 24;146:107306. doi: 10.1016/j.bioorg.2024.107306. Online ahead of print.ABSTRACTThe structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells). Mo...
Source: Bioorganic Chemistry - March 26, 2024 Category: Chemistry Authors: Xi Chen Peiqin Zhang Huating Zhang Xueqiang Ma Ye Zhang Yajie Wu Kaiwen Jin Jiabing Wang Jianzhang Wu Source Type: research

Safety and efficacy of myofascial release therapy in the treatment of patients with hemophilic ankle arthropathy. Single-blind randomized clinical trial
CONCLUSION: Myofascial release therapy is a safe form of physical therapy for patients with hemophilia. Myofascial release therapy can effectively complement prophylactic pharmacological treatment in patients with hemophilic arthropathy, improving range of motion in dorsal flexion, functional capacity and gastrocnemius strength.PMID:38530214 | DOI:10.1080/09593985.2024.2334752 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - March 26, 2024 Category: Physiotherapy Authors: Elena Donoso- Úbeda Roberto Ucero-Lozano Javier Mero ño-Gallut Rub én Cuesta-Barriuso Ra úl Pérez-Llanes Source Type: research

FXR/Menin-mediated epigenetic regulation of E2F3 expression controls β-cell proliferation and is increased in islets from diabetic GK rats after RYGB
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 24:167136. doi: 10.1016/j.bbadis.2024.167136. Online ahead of print.ABSTRACTFarnesoid X receptor (FXR) improves the function of islets, especially in the setting of Roux-en-Y gastric bypass (RYGB). Here we investigated how FXR activation regulates β-cell proliferation and explored the potential link between FXR signaling and the menin pathway in controlling E2F3 expression, a key transcription factor for controlling adult β-cell proliferation. Stimulation with the FXR agonist GW4064 or chenodeoxycholic acid (CDCA) increased E2F3 expression and β-cell proliferation. Consistent...
Source: Biochimica et Biophysica Acta - March 26, 2024 Category: Biochemistry Authors: Xiangchen Kong Chenxi Yang Bingfeng Li Dan Yan Yanhui Yang Cuihua Cao Bowen Xing Xiaosong Ma Source Type: research

Glucagon-like peptide-1 analogs: Miracle drugs are blooming?
Eur J Med Chem. 2024 Mar 17;269:116342. doi: 10.1016/j.ejmech.2024.116342. Online ahead of print.ABSTRACTGlucagon-like peptide-1 (GLP-1), secreted by L cells in the small intestine, assumes a central role in managing type 2 diabetes mellitus (T2DM) and obesity. Its influence on insulin secretion and gastric emptying positions it as a therapeutic linchpin. However, the limited applicability of native GLP-1 stems from its short half-life, primarily due to glomerular filtration and the inactivating effect of dipeptidyl peptidase-IV (DPP-IV). To address this, various structural modification strategies have been developed to ex...
Source: European Journal of Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Binbin Gong Zhihong Yao Chenxu Zhou Wenxi Wang Lidan Sun Jing Han Source Type: research

Phase 1 Trial of the Safety, Pharmacokinetics, and Antiviral Activity of EDP-514 in Untreated Viremic Chronic Hepatitis B Patients
CONCLUSIONS: In treatment-naïve viremic patients, oral EDP-514 was generally safe and well-tolerated, displayed PK profile supportive of once-daily dosing, and markedly reduced HBV DNA and HBV RNA.PMID:38528825 | DOI:10.3350/cmh.2023.0535 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 26, 2024 Category: Gastroenterology Authors: Man-Fung Yuen Wan-Long Chuang Cheng-Yuan Peng Wen-Juei Jeng Wei-Wen Su Ting-Tsung Chang Chi-Yi Chen Yao-Chun Hsu Guy De La Rosa Alaa Ahmad Ed Luo Annie L Conery Source Type: research

Prucalopride and Bowel Function Post Gastrointestinal Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials
DISCUSSION: Current RCT evidence suggests that prucalopride may enhance postoperative return of bowel function. Larger RCTs assessing patient important outcomes and associated costs are needed before routine use of this agent.PMID:38530772 | DOI:10.1177/00031348241241683 (Source: The American Surgeon)
Source: The American Surgeon - March 26, 2024 Category: Surgery Authors: Gaurav Talwar Sahil Sharma Tyler McKechnie Shuling Yang Jigish Khamar Dennis Hong Aristithes Doumouras Cagla Eskicioglu Source Type: research

The Impact of Transcriptional Profiling Cadherin Family and Therapeutic Approaches of Gastric Cancer: A Translational Outlook on Multi-omics Data Analysis
This study used multi-omics data to examine the cadherin genes that were differentially regulated in gastric cancer. Differential expression of genes, epigenetic, molecular alterations, and protein expression analyses was conducted. Male SD rats were given N-methyl-N-nitrosourea (MNU) to induce stomach carcinoma in order to verify the activation of cadherin genes. CDH5, CDH6, CDH11, and CDH24 levels were found to be considerably higher in gastric cancer and may serve as useful indicators of stomach adenocarcinoma (STAD). Cadherin genes with variable expression had considerably more promoter methylation in cancers than in n...
Source: Applied Biochemistry and Biotechnology - March 26, 2024 Category: Biochemistry Authors: Huan Wang Baomin Zhang Source Type: research

A randomized controlled study to assess the effect of mosapride citrate on intestinal recovery following gastrectomy
Sci Rep. 2024 Mar 25;14(1):7030. doi: 10.1038/s41598-024-57870-w.ABSTRACTThe enhanced recovery after surgery (ERAS) protocol, including prokinetic medications, is commonly used to prevent postoperative ileus. Prospective studies evaluating the effectiveness of mosapride citrate, a prokinetic 5-hydroxytryptamine 4 receptor agonist, in patients undergoing gastrectomy within the ERAS framework are lacking. This double-blind randomized trial included patients who were scheduled for laparoscopic or robotic gastrectomy for gastric cancer. Participants were randomly assigned to either a control (placebo) or experimental (mosaprid...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Shiyeol Jun Seyeol Oh Ji Eun Jung In Gyu Kwon Sung Hoon Noh Source Type: research

The Association Between Appetite and Quality of Life in Adults with Obesity or Severe Obesity Post-Sleeve Gastrectomy Procedure: A Cross-Sectional Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 26, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research