The superiority of blue-light imaging and narrow-band imaging over white-light imaging in the detection of proximal colonic lesions
I read with interest the article by Leung et al1 entitled “Blue-light imaging or narrow-band imaging for proximal colonic lesions: a prospective randomized tandem colonoscopy study.” The aim of this study was to evaluate and compare the efficacy of blue-light imaging (BLI) and narrow-band imaging (NBI) in detecting proximal colonic lesio ns and minimizing miss rates, in comparison with white-light imaging (WLI). The findings of the authors indicate that both BLI and NBI outperformed WLI in detecting proximal colonic lesions. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Liqi Li Tags: Letter to the Editor Source Type: research
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management
Each tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed preclinically. Their translation into clinics is underway with 4 clinical trials recruiting participants with...
Source: PET Clinics - April 21, 2024 Category: Radiology Authors: Simone Dalm, Heying Duan, Andrei Iagaru Source Type: research
A case of refractory severe pyoderma gangrenosum successfully treated with upadacitinib
A 59-year-old woman affected by colonic Crohn's disease and perianal disease underwent colectomy and end ileostomy. Persistently active luminal disease was associated with severe pyoderma gangrenosum localized to the upper and lower limbs. Previous treatments with intravenous steroids and infliximab were not effective on pyoderma gangrenosum lesions. The image shows the evolution of a large and deep lesion localized on the right hand, after starting upadacitinib 45 mg once a day, with clear improvement and almost complete healing in 6 weeks of treatment (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Marco Mendolaro, Enrico Morello, Paola Salacone, Rodolfo Rocca Tags: Image of the Month Source Type: research
Author's reply: “Assessing ChatGPT and perplexity AI performance”
None. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Raffaele Pellegrino, Antonietta Gerarda Gravina Tags: Correspondence Source Type: research
Artificial intelligence-assisted colonoscopy to identify histologic remission and predict the outcomes of patients with ulcerative colitis: A systematic review
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Yasuharu Maeda, Shin-ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci Tags: Alimentary Tract Source Type: research
Application of Deep Learning Model and Machine Learning Detection Algorithm for Gastric Cancer Patients Undergoing Chemotherapy
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Huang, Xiaohui Fu, Jing Wang, Xiaoyan Yu, Chaoxiu Tags: research-article Source Type: research
Early identification of patients at risk for iron-deficiency anemia using deep learning techniques
CONCLUSIONS: Our results showcase the feasibility of employing deep learning techniques for early prediction of IDA in the outpatient setting based on sequences of laboratory data, offering a substantial lead time for clinical intervention.PMID:38642073 | DOI:10.1093/ajcp/aqae031 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 20, 2024 Category: Pathology Authors: Nelly Estefanie Garduno-Rapp Yee Seng Ng Jenny L Weon Sameh N Saleh Christoph U Lehmann Chenlu Tian Andrew Quinn Source Type: research
Gastrodin alleviates the deterioration of depressive-like behavior and glucolipid metabolism promoted by chronic stress in type 2 diabetic mice
In this study, we performed 5 weeks CUMS intervention and simultaneously administered gastrodin (140 mg/kg, once daily) on T2DM mice, to investigate the potential protective effects of gastrodin. The protective effect of gastrodin was evaluated by behavioral tests, biochemical analysis, histopathological examination, RT-qPCR and gut microbiota analysis. We found that the depressive-like behavior and glucolipid metabolism could be deteriorated by chronic stress in type 2 diabetic mice, while gastrodin showed a protective effect against these exacerbations by regulating HPA hormones, activating FXR and Cyp7a1, reducing infla...
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Canye Li Jinming Cao Zhicong Chen Zuanjun Su Huimin Bao Xue Li Luping Liu Zhijun Xiao Jingjing Duan Ting Zhou Feng Xu Source Type: research
Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China
CONCLUSION: Patients with lung cancer require more ICU care due to critical complications and the overall survival prognosis is poor. Colorectal cancer may benefit more from ICU management. This information may be considered in ICU admission and treatment strategies.PMID:38642154 | PMC:PMC11032264 | DOI:10.1007/s00432-024-05727-0 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Wensheng Liu Dongmin Zhou Li Zhang Mingguang Huang Rongxi Quan Rui Xia Yong Ye Guoxing Zhang Zhuping Shen Cancer Critical Care Medicine Committee of the Chinese Anti-Cancer Association Source Type: research
Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China
CONCLUSION: Patients with lung cancer require more ICU care due to critical complications and the overall survival prognosis is poor. Colorectal cancer may benefit more from ICU management. This information may be considered in ICU admission and treatment strategies.PMID:38642154 | PMC:PMC11032264 | DOI:10.1007/s00432-024-05727-0 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Wensheng Liu Dongmin Zhou Li Zhang Mingguang Huang Rongxi Quan Rui Xia Yong Ye Guoxing Zhang Zhuping Shen Cancer Critical Care Medicine Committee of the Chinese Anti-Cancer Association Source Type: research
The Role of the Gut Microbiome in Health and Disease in the Elderly
AbstractPurpose of ReviewGrowing evidence supports the contribution of age in the composition and function of the gut microbiome, with specific findings associated with health in old age and longevity.Recent FindingsCurrent studies have associated certain microbiota, such asButyricimonas,Akkermansia, andOdoribacter, with healthy aging and the ability to survive into extreme old age. Furthermore, emerging clinical and pre-clinical research have shown promising mechanisms for restoring a healthy microbiome in elderly populations through various interventions such as fecal microbiota transplant (FMT), dietary interventions, a...
Source: Current Gastroenterology Reports - April 20, 2024 Category: Gastroenterology Source Type: research
Primary thromboprophylaxis in cancer outpatients – real-world evidence
ConclusionPrimary thromboprophylaxis in medium-to-high-risk cancer outpatients is a safe and effective practice in real-world settings. This study is the first Portuguese RWE on primary thromboprophylaxis, highlighting evidence for improving prophylactic strategies in this population.Graphical abstract (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - April 20, 2024 Category: Hematology Source Type: research
Integrated clinical and genomic models using machine-learning methods to predict the efficacy of paclitaxel-based chemotherapy in patients with advanced gastric cancer
Paclitaxel is commonly used as a second-line therapy for advanced gastric cancer (AGC). The decision to proceed with second-line chemotherapy and select an appropriate regimen is critical for vulnerable patien... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Yonghwa Choi, Jangwoo Lee, Keewon Shin, Ji Won Lee, Ju Won Kim, Soohyeon Lee, Yoon Ji Choi, Kyong Hwa Park and Jwa Hoon Kim Tags: Research Source Type: research
Evaluating the Preferences and Willingness-to-Pay for Oral Antidiabetic Drugs Among Patients with Type 2 Diabetes Mellitus in China: A Discrete Choice Experiment
ConclusionThe results suggest that Chinese patients with T2DM prioritized better efficacy, less frequency of medication, lower gastrointestinal side effects, no dose adjustment required for patients with hepatic or renal insufficiency, and less out-of-pocket expense of OAD treatment. (Source: The Patient - Patient-Centered Outcomes Research)
Source: The Patient - Patient-Centered Outcomes Research - April 20, 2024 Category: International Medicine & Public Health Source Type: research
The Role of the Gut Microbiome in Health and Disease in the Elderly
AbstractPurpose of ReviewGrowing evidence supports the contribution of age in the composition and function of the gut microbiome, with specific findings associated with health in old age and longevity.Recent FindingsCurrent studies have associated certain microbiota, such asButyricimonas,Akkermansia, andOdoribacter, with healthy aging and the ability to survive into extreme old age. Furthermore, emerging clinical and pre-clinical research have shown promising mechanisms for restoring a healthy microbiome in elderly populations through various interventions such as fecal microbiota transplant (FMT), dietary interventions, a...
Source: Current Gastroenterology Reports - April 20, 2024 Category: Gastroenterology Source Type: research
