BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 23, 2024 Category: Physiology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Extent of Virulence and Antibiotic Resistance Genes in Helicobacter pylori and Campylobacteria
Curr Microbiol. 2024 Apr 23;81(6):154. doi: 10.1007/s00284-024-03653-5.ABSTRACTHelicobacter pylori, a member of the clade campylobacteria, is the leading cause of chronic gastritis and gastric cancer. Virulence and antibiotic resistance of H. pylori are of great concern to public health. However, the relationship between virulence and antibiotic resistance genes in H. pylori in relation to other campylobacteria remains unclear. Using the virulence and comprehensive antibiotic resistance databases, we explored all available 354 complete genomes of H. pylori and compared it with 90 species of campylobacteria for virulence an...
Source: Current Microbiology - April 23, 2024 Category: Microbiology Authors: R Shyama Prasad Rao Sudeep D Ghate Larina Pinto Prashanth Suravajhala Prakash Patil Praveenkumar Shetty Nagib Ahsan Source Type: research
Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis
This study aimed to investigate the changes in oxidative stress, adenosine monophosphate-activated protein kinase (AMPK), connexin43 (Cx43), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression, and extracellular matrix (ECM) in the gastric smooth muscle tissues of rats with diabetic gastroparesis (DGP) and high glucose-cultured gastric smooth muscle cells, determine the existence of oxidative stress-AMPK-Cx43-NLRP3 pathway under high glucose condition, and the involvement of this pathway in ECM remodeling in DGP rats. The results showed that with increasing duration of diabetes, oxidation s...
Source: Cell Stress and Chaperones - April 23, 2024 Category: Cytology Authors: Baihui Song Gaoyuan Zhang Yitegele Bao Mohan Zhang Source Type: research
Hedonic hunger, eating behavior, and food reward and preferences 1 year after initial weight loss by diet or bariatric surgery
CONCLUSIONS: Continued WL with bariatric surgery is paralleled by favorable changes in eating behavior and food reward and preferences. By contrast, controls experienced weight regain at 1Y follow-up and no changes in eating behavior. These striking differences are likely to be important in the long-term WL management of individuals with severe obesity.PMID:38653583 | DOI:10.1002/oby.24021 (Source: Obesity)
Source: Obesity - April 23, 2024 Category: Eating Disorders & Weight Management Authors: Marthe Isaksen Aukan Graham Finlayson Catia Martins Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research
Impact of Straight Stomach Reconstruction on Delayed Gastric Emptying and Nutritional Recovery After Pancreaticoduodenectomy
CONCLUSION: Straight stomach reconstruction is able to reduce DGE in patients after PD and also improves their postoperative nutritional recovery.PMID:38652272 | DOI:10.1177/00031348241248688 (Source: The American Surgeon)
Source: The American Surgeon - April 23, 2024 Category: Surgery Authors: Naoki Iwanaga Yuzuru Ito Shozo Miyano Michio Machida Ikuo Watanobe Hiroyuki Sugo Source Type: research
Helicobacter pylori impacts the expression of immune checkpoint molecules in gastric cancer via up-regulating SERPINE1
Asian J Surg. 2024 Apr 22:S1015-9584(24)00728-0. doi: 10.1016/j.asjsur.2024.04.068. Online ahead of print.NO ABSTRACTPMID:38653693 | DOI:10.1016/j.asjsur.2024.04.068 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 23, 2024 Category: Surgery Authors: Qijia Zhang Ze Yu Ling Hu Source Type: research
Short-term trends in gastric cancer incidence after insurance coverage expansion for Helicobacter pylori eradication in Japan
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00170-5. doi: 10.1016/j.ejim.2024.04.010. Online ahead of print.NO ABSTRACTPMID:38653632 | DOI:10.1016/j.ejim.2024.04.010 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Yusaku Kajihara Source Type: research
Enhanced recovery after surgery improves clinical outcomes in adolescent bariatric surgery
CONCLUSIONS: The described ERAS protocol is safe and effective in adolescents undergoing laparoscopic VSG and is associated with shorter time to oral intake, reduced opioid requirements, and shorter hospital lengths of stay with no increase in return ED visits or readmissions.PMID:38653653 | DOI:10.1016/j.soard.2024.03.016 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 23, 2024 Category: Surgery Authors: Nicholas Schmoke Christopher Nemeh Tania Gennell Dana Schapiro Ashley Hiep-Catarino Matthew Alexander Alexander V Chalphin Robert W Crum Leign Holynskyj Tatiana Kubacki William S Schechter Jeffrey Zitsman Source Type: research
BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
Incidence of dreaming during ciprofol anesthesia for painless gastroscopy
CONCLUSIONS: The postoperative dream recall incidence in this study was 27.5% among patients undergoing painless gastroscopy under ciprofol sedation anesthesia.PMID:38652450 | DOI:10.23736/S0375-9393.24.17845-5 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 23, 2024 Category: Anesthesiology Authors: Xinyu Cao Jiejie Zhou Miaomiao Xu Bin Wang Chongya Yang Jingwei Xiong Kangli Hui Source Type: research
Pancreatitis after Percutaneous Transhepatic Biliary Intervention
A 50-year-old man who had undergone distal gastrectomy and adjuvant chemotherapy for gastric adenocarcinoma presented with new hyperbilirubinemia and biliary ductal dilation (Fig 1a, black arrow) secondary to a common bile duct (CBD) mass (Fig 1a, white arrow). Owing to his gastrojejunostomy (Fig 1a, open arrow), he was not a candidate for endoscopic retrograde cholangiopancreatography. A percutaneous transhepatic cholangiogram confirmed abrupt truncation of the CBD (Fig 1b, white arrow), and a brush biopsy (Cellebrity Cytology Brush; Boston Scientific, Marlborough, Massachsetts) was performed (Fig 1b, black arrow) bef...
Source: Journal of Vascular and Interventional Radiology : JVIR - April 23, 2024 Category: Radiology Authors: Jacob DePolo, Alexander Miller, Joseph Buchholz, James Ronald Tags: Lessons in IR: M & Source Type: research
Buttressed pancreaticogastrostomy for a soft pancreas and/or small pancreatic duct in pancreaticoduodenectomy: A retrospective cohort study
ConclusionButtressing PG represents a simple and safe reconstruction technique following PD, particularly for patients with a soft pancreas and/or small pancreatic duct. This approach is associated with a low incidence of POPF. However, prospective randomised trials with large sample sizes are required to confirm these results. (Source: Surgical Practice)
Source: Surgical Practice - April 23, 2024 Category: Surgery Authors: Mostafa M. Sayed,
Mohamad Raafat,
Abdallah M. Taha Tags: ORIGINAL ARTICLE Source Type: research
