Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
MicroRNAs in hepatocellular carcinoma treatment: Charting the path forward
World J Gastroenterol. 2024 Mar 21;30(11):1470-1474. doi: 10.3748/wjg.v30.i11.1470.ABSTRACTMicroRNAs (miRNAs) are recognized for their involvement in the regulation of gene expression and exhibit significant potential in both the prognostic assessment and treatment of hepatocellular carcinoma (HCC). HCC, like other tumors, seldom occurs in isolation; instead, it evolves within a microenvironment featuring oncogenic and tumor-suppressive elements. When combined with suitable delivery vehicles, miRNA technology provides the capability to directly engage with these elements, thereby hindering tumor formation and progression. ...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Hong T Lin Antonio F Alvarez Castaneda Somashekar G Krishna Khalid Mumtaz Source Type: research
Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope
World J Gastroenterol. 2024 Mar 28;30(12):1670-1675. doi: 10.3748/wjg.v30.i12.1670.ABSTRACTThis editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-p...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Somdatta Giri Jayaprakash Sahoo Source Type: research
Liquid biopsy for gastric cancer: Techniques, applications, and future directions
World J Gastroenterol. 2024 Mar 28;30(12):1680-1705. doi: 10.3748/wjg.v30.i12.1680.ABSTRACTAfter the study of circulating tumor cells in blood through liquid biopsy (LB), this technique has evolved to encompass the analysis of multiple materials originating from the tumor, such as nucleic acids, extracellular vesicles, tumor-educated platelets, and other metabolites. Additionally, research has extended to include the examination of samples other than blood or plasma, such as saliva, gastric juice, urine, or stool. LB techniques are diverse, intricate, and variable. They must be highly sensitive, and pre-analytical, patient...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Cristina D íaz Del Arco M Jes ús Fernández Aceñero Luis Ortega Medina Source Type: research
Oral iron supplementation: new formulations, old questions
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2024.284967. Online ahead of print.ABSTRACTIron deficiency anemia and pre-anemic iron deficiency are the most frequent pathologies. The first line of treatment involves oral iron supplementation. The simplest, least expensive, and most frequently prescribed drug is ferrous sulfate, while other ferrous salts and ferric complexes with polysaccharides or succinylated milk proteins are also widely used. In recent years, novel iron formulations have been developed, such as the lipophilic iron donor ferric maltol, or nanoparticle encapsulated sucrosomial® iron. Oral iron supplem...
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Kostas Pantopoulos Source Type: research
Impact Analysis of a new, Cross-sector Service Provision of Gastroenterologic Endoscopic Services in Accordance with 115f SGB V (Hybrid-DRG): Allocation Matrix and Cost Analysis
CONCLUSION: Based on clearly defined structural, procedural and personnel requirements, services from suitable DRGs can be transferred to a hybrid DRG. Assigning services without the involvement of clinical experts seems extremely difficult. Case assignment based on arbitrary contextual factors increases complexity without demonstrably increasing the quality of the assignment and needs to be further developed. A cost analysis can be derived from the known inpatient costs and must serve as the basis for the 2025 Hybrid DRG catalog.PMID:38621703 | DOI:10.1055/a-2292-9766 (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 15, 2024 Category: Gastroenterology Authors: Markus Rathmayer Sebastian Belle Wolfgang Heinlein Markus Dollhopf Martin Braun J örg G Albert Source Type: research
Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy
Nutr Cancer. 2024 Apr 15:1-10. doi: 10.1080/01635581.2024.2340782. Online ahead of print.ABSTRACTPost-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) and survival of the patient undergoing gastrectomy. We have introduced perioperative and post-discharge continuous nutritional counseling (CNC) to prevent BWL and improve QOL after gastrectomy. In the present study, we evaluated the effect of CNC on QOL using the Post-gastrectomy Syndrome Assessment Scale-45 (PGSAS-45). Eighty-three patients with gastric cancer (GC) who underwent curative gastrectomy between March 2018 and July 2019 were r...
Source: Nutrition and Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Shunya Hanzawa Satoru Kikuchi Shinji Kuroda Ryohei Shoji Hajime Kashima Yuki Matsumi Ayako Takahashi Yoshihiko Kakiuchi Kosei Takagi Shunsuke Tanabe Kazuhiro Noma Shunsuke Kagawa Kenichi Shikata Toshiyoshi Fujiwara Source Type: research
High-Flow Nasal Oxygen versus Conventional Nasal Cannula in Preventing Hypoxemia in Elderly Patients Undergoing Gastroscopy with Sedation: A Randomized Controlled Trial
Conclusions: The HFNO system was determined to be a safe and highly effective method for oxygen delivery, leading to a reduction in the occurrence of hypoxemia in elderly patients undergoing gastroscopy with sedation. It is recommended that HFNO be considered as the standard approach for management in this population.PMID:38617012 | PMC:PMC11008486 | DOI:10.7150/ijms.91607 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Xin Yin Wen Xu Jianlei Zhang Mingyue Wang Zhen Chen Songbin Liu Yan Xu Shaowen Xu Danian Ji Jingwen Wang Weidong Gu Source Type: research
Radiographic identification of challenging gastrointestinal tract foreign bodies: a descriptive study of how appearance varies in air versus water to aid interpretation
Am J Vet Res. 2024 Apr 16:1-4. doi: 10.2460/ajvr.23.10.0237. Online ahead of print.ABSTRACTOBJECTIVE: To provide veterinarians with updated radiographic descriptions of select radiolucent foreign material in a simulated gastrointestinal environment.SAMPLE: 368 veterinarian respondents from the US.METHODS: An online survey was administered between June 18, 2023, and July 2, 2023, through a private veterinarian-based social media group. Representative commonly ingested foreign bodies were radiographed surrounded by air and water to simulate being within the gastrointestinal tract. Two examiners evaluated and qualified the op...
Source: American Journal of Veterinary Research - April 15, 2024 Category: Veterinary Research Authors: Franco Yuen Sophie Dennison Source Type: research
Harnessing gastrointestinal organoids for cancer therapy
Trends Mol Med. 2024 Apr 13:S1471-4914(24)00065-0. doi: 10.1016/j.molmed.2024.03.010. Online ahead of print.ABSTRACTGastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.PMID:38616435 | DOI:10.1016/j.molmed.2024.03.010 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Gunter Maubach Michael Naumann Source Type: research
Harnessing gastrointestinal organoids for cancer therapy
Trends Mol Med. 2024 Apr 13:S1471-4914(24)00065-0. doi: 10.1016/j.molmed.2024.03.010. Online ahead of print.ABSTRACTGastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.PMID:38616435 | DOI:10.1016/j.molmed.2024.03.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Gunter Maubach Michael Naumann Source Type: research
Evaluation of the Genetic Background of Patients with Niemann-Pick Disease
CONCLUSIONS: In this study, disease-causing variants were identified in three probands suspected of Niemann-Pick disease. Such results show the relatively high power of molecular techniques to assist clinicians with disease management, therapeutic strategies, and preventive options such as preimplantation genetic diagnosis and prenatal diagnosis.PMID:38618260 | PMC:PMC11015928 | DOI:10.61186/rbmb.12.3.386 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Fatemeh Alipouran Ehsan Ghayoor Karimiani Jina Khayatzadeh Source Type: research
The advent of the first electric driven EUS-guided 17 gauge core needle biopsy - A pilot study on subepithelial lesions
CONCLUSIONS: By using an electric driven 17-G biopsy device, a true cylinder of core tissue can be obtained in one single puncture from the area of interest reducing the need for a second sampling. The absolute benefit of EUS-guided CNB is that the sample can be handled and histologically prepared in the same manner as standard percutaneous core needle sample, e.g., breast and prostate cancer.PMID:38618997 | DOI:10.1080/00365521.2024.2336611 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Fredrik Swahn Robert Glavas Lucin Hultin Malin Wickbom Source Type: research
Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research
