A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease
Cell Calcium. 2024 Apr 6;120:102886. doi: 10.1016/j.ceca.2024.102886. Online ahead of print.ABSTRACTNeurodevelopment, a complex and highly regulated process, plays a foundational role in shaping the structure and function of the nervous system. The transient receptor potential melastatin 7 (TRPM7), a divalent cation channel with an α-kinase domain, mediates a wide range of cellular functions, including proliferation, migration, cell adhesion, and survival, all of which are essential processes in neurodevelopment. The global knockout of either TRPM7 or TRPM7-kinase is embryonically lethal, highlighting the crucial role of ...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Zhengwei Luo Xinyang Zhang Andrea Fleig Daniel Romo Kenneth G Hull F David Horgen Hong-Shuo Sun Zhong-Ping Feng Source Type: research
Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers
Eur J Cell Biol. 2024 Apr 15;103(2):151415. doi: 10.1016/j.ejcb.2024.151415. Online ahead of print.ABSTRACTThe 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now. Therefore, we focused on the determination of function of MPST in colon (HCT116 cells)/colorectal (DLD1 cells) cancers. In silico analysis revealed that in gastrointestinal cancers, MPST together with its binding partners can be either of a high risk or might have a protective effect. Silenc...
Source: European Journal of Cell Biology - April 17, 2024 Category: Cytology Authors: Katarina Matyasova Andrea Soltysova Petr Babula Olga Krizanova Veronika Liskova Source Type: research
Heat strain in professional firefighters: physiological responses to a simulated smoke dive in extremely hot environments and the subsequent recovery phase
This study investigated the effect of a single simulated smoke dive and the following recovery phase on physiological and perceptual responses. Nineteen professional male firefighters (43 ± 8 yr) performed a 2-min stair walk and a15-min simulated smoke dive in a two-floor heat chamber (110 °C to 272°C) (HEAT), followed by a 5-min stair walk outside the heat chamber. Heart rate (HR), gastrointestinal temperature (Tgi) and skin temperatures were registered continuously during the test. The Tgi increased significantly from the start (37.5 ± 0.3°C) to the end of HEAT (38.4 ± 0.4°C) and further increased after the heat e...
Source: Industrial Health - April 17, 2024 Category: Occupational Health Authors: Mariann Sandsund Edvard Aamodt Julie Renberg Source Type: research
Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research
Gut microbiota plays a significant role in gout
J Med Microbiol. 2024 Apr;73(4). doi: 10.1099/jmm.0.001824.ABSTRACTWith the development of social economy, the incidence of gout is increasing, which is closely related to people's increasingly rich diet. Eating a diet high in purine, fat, sugar and low-fibre for a long time further aggravates gout by affecting uric acid metabolism. The renal metabolism mechanism of uric acid has been thoroughly studied. To find a new treatment method for gout, increasing studies have recently been conducted on the mechanism of intestinal excretion, metabolism and absorption of uric acid. The most important research is the relationship bet...
Source: Journal of Medical Microbiology - April 17, 2024 Category: Microbiology Authors: Zhi-Peng Feng Xiao-Yan Wang Hong-Yi Xin Shao-Li Huang Hong-Yu Huang Qiang Xin Xi-He Zhang Hong-Wu Xin Source Type: research
Safety and efficacy of thalidomide in treatment of gastrointestinal bleeding secondary to angioectasias: a systematic review and meta-analysis
DISCUSSION: In patients with angioectasias-related refractory/recurrent GIB, the use of thalidomide results in significantly decreased bleeding risk and may play a role in the management of such patients.PMID:38629130 | DOI:10.1080/00365521.2024.2342404 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 17, 2024 Category: Gastroenterology Authors: Sahib Singh Babu P Mohan Omid Sanaei Rakesh Vinayek Sudhir Dutta Dushyant Singh Dahiya Ishfaq Bhat Neil Sharma Douglas G Adler Source Type: research
The Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease
Ann Hepatol. 2024 Apr 15:101501. doi: 10.1016/j.aohep.2024.101501. Online ahead of print.ABSTRACTMetabolic Dysfunction-Associated Fatty Liver Disease and Diabetes Mellitus are two prevalent metabolic disorders that often coexist and synergistically contribute to the progression of each other. Several pathophysiological pathways are involved in the association, including insulin resistance, inflammation, and lipotoxicity, providing a foundation for understanding the complex interrelationships between these conditions. The presence of MASLD has a significant impact on diabetes risk and the development of microvascular and ma...
Source: Annals of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Francisco Barrera Javier Uribe Nixa Olvares Paula Huerta Daniel Cabrera Manuel Romero-G ómez Source Type: research
Closure of a Gastropleural Fistula Using Advanced Endoscopy
Am Surg. 2024 Apr 17:31348241248697. doi: 10.1177/00031348241248697. Online ahead of print.ABSTRACTGastropleural fistulas are rare complications with significant mortality and morbidity. There are limited reports on the successful management of gastropleural fistulas with advanced endoscopic procedures. The following case of a 75-year-old woman with a history of recurrent pseudomyxoma peritonei secondary to ruptured low-grade appendiceal mucinous neoplasm status post cytoreductive surgery highlights the successful treatment of a gastropleural fistula with endoscopic suturing.PMID:38631338 | DOI:10.1177/00031348241248697 (S...
Source: The American Surgeon - April 17, 2024 Category: Surgery Authors: Deep P Vakil Jennifer Palacio Monique Motta Zaineb N Shatawi Juliana L Colvin Omar H Llaguna Source Type: research
A Case of Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3412-23. Online ahead of print.ABSTRACTA 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappeara...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Takahito Harada Yoshikazu Hirata Hayato Kawamura Yuki Yamamoto Yuka Kobayashi Daisuke Kumai Akihisa Adachi Yoshihito Nagura Hirokazu Ikeuchi Noriyuki Hayashi Hiroki Takada Satoshi Sobue Megumi Yoshida Source Type: research
Gut microbiota-generated metabolites: missing puzzles to hosts' health, diseases, and aging
BMB Rep. 2024 Apr 17:6194. Online ahead of print.ABSTRACTThe gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate imp...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Yan Zhang Shibo Wei Hang Zhang Yunju Jo Jong-Sun Kang Ki-Tae Ha Jongkil Joo Hyun Joo Lee Dongryeol Ryu Source Type: research
Enhanced environmental stress resistance and functional properties of the curcumin-shellac nano-delivery system: Anti-flocculation of poly- γ-glutamic acid
Int J Biol Macromol. 2024 Apr 15:131607. doi: 10.1016/j.ijbiomac.2024.131607. Online ahead of print.ABSTRACTCurcumin was widely designed as nanoparticles to remove application restrictions. The occurrence of flocculation is a primary factor limiting the application of the curcumin nano-delivery system. To enhance the environmental stress resistance and functional properties of shellac-curcumin nanoparticles (S-Cur-NPs), γ-polyglutamic acid (γ-PGA) was utilized as an anti-flocculant. The encapsulation efficiency and loading capacity of S-Cur-NPs were also improved with γ-PGA incorporation. FTIR and XRD analysis confirmed...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Di Zhuang Yafang Wang Shancan Wang Rui Li Hafiz Nabeel Ahmad Jie Zhu Source Type: research
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer
CONCLUSIONS: This study identified a multi-protein signature with the potential to benefit clinical GC diagnosis, especially for Asian and early GC patients, which may contribute to the development of a less-invasive, convenient, and efficient early screening tool, promoting early diagnosis and treatment of GC and ultimately improving patient survival.PMID:38631604 | DOI:10.1016/j.cca.2024.119675 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 17, 2024 Category: Chemistry Authors: Tong Feng Minwen Jie Kai Deng Jinlin Yang Hao Jiang Source Type: research
Current and emerging pharmacotherapy for the treatment of gastroparesis
Expert Opin Pharmacother. 2024 Apr 17. doi: 10.1080/14656566.2024.2344646. Online ahead of print.ABSTRACTINTRODUCTION: Gastroparesis is a chronic disorder characterized by decreased gastric emptying and presents with nausea, vomiting, and abdominal pain which impacts patients' quality of life greatly. The treatment modalities available for gastroparesis have been expanding over the past 2 decades. Currently there are multiple options available for gastroparesis albeit with only one FDA approved medication until June of 2021.AREAS COVERED: We review the different treatments available for gastroparesis and discuss the recent...
Source: Expert Opinion on Pharmacotherapy - April 17, 2024 Category: Drugs & Pharmacology Authors: M Ammar Kalas Irene Sarosiek Richard W McCallum Source Type: research
Gastrointestinal disorders in hyperkinetic movement disorders and ataxia
Nervenarzt. 2024 Apr 17. doi: 10.1007/s00115-024-01655-z. Online ahead of print.ABSTRACTDisorders of the gastrointestinal tract in patients suffering from hypokinetic movement disorders, and in particular Parkinson's disease, have increasingly been the subject of more intensive neuromedical research. So far, few data are available for patients with hyperkinetic movement disorders and ataxias. This review article summarizes the currently available and relevant publications on this topic. The particular focus is on essential tremor, restless legs syndrome, Huntington's disease and the group of hereditary ataxias. Further int...
Source: Der Nervenarzt - April 17, 2024 Category: Neurology Authors: Inga Claus Tobias Warnecke Source Type: research
