Confronting colon cancer: a daughter ’ s regretful journey
My mother. 63 years old. Colon cancer. She first noticed rectal bleeding. She made excuses. Maybe it’s hemorrhoids. She put her physician on a pedestal. He said, “You’re too young to die,” and there was no need for further tests. Her daughters, both RNs (one an ICU nurse, the other an anesthetist), pleaded with her
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Confronting colon cancer: a daughter’s regretful journey originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 6, 2024 Category: General Medicine Authors: Debbie Moore-Black, RN Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Addressing physician workforce shortages [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join William E. Fox, chair-elect of the ACP Board of Regents, as we delve into the pressing issue of physician workforce shortages in primary care. William sheds light on recent alarming statistics, including the declining interest among medical students in pursuing
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Addressing physician workforce shortages [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 26, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Gastroenterology Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity-Associated BPIFB4 Variant is Anti-Inflammatory
A variant in the gene BPIFB4 has been found to correlate with longevity in humans. In these matters it is worth noting that even small effects on mortality risk result in noticeable correlations with sustained over decades, and indeed all of the known human associations between longevity and genetic variation identified in large study populations are thought to have only modest effect sizes. What are the underlying mechanisms for BPIFB4, however? Researchers here make an argument for suppression of the chronic inflammation of aging as the reason for the association between BPIFB4 and longevity. Certainly chronic inflammato...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Beyond the workout: the hidden struggle of diabetic gastroparesis
The final three minutes of my hour-long elliptical workout were not easy. Pain spread across my stomach, causing me to row in a half-sitting motion, and my chest vacillated between violent coughs and the sorts of deep breaths people take when they think they’ve seen a ghost. Perspiration fell from my shirtless torso to the
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Beyond the workout: the hidden struggle of diabetic gastroparesis originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 21, 2024 Category: General Medicine Authors: Ryan Ritchie Tags: Conditions Endocrinology Gastroenterology Source Type: blogs
What Is the Microbiome?
Have you ever noticed a skin care product advertised as “microbiome friendly” and wondered what that meant? The microbiome is the collection of all the microbes—including bacteria, viruses, and fungi—that live in a specific environment, such as on the skin or in the digestive tract.
Escherichia coli (E. coli) is a bacterial species commonly found in the human intestine. While some strains of E. coli cause foodborne illness, others are helpful members of the gut microbiome.Credit: Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego.
It’s ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 20, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Common questions Microbes Microbiome Source Type: blogs
Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
This study provides some insight into how these relationships play out in practice by sabotaging telomerase and p53, and observing the results.
Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Similarly, zebrafish have restricted telomerase expression, and telomeres shorten to critical length during their lifesp...
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Searching for a Causal Link Between Gut Microbiome Populations and Pace of Aging
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
Link: https://doi.org/10.3390/microorganisms12020370 (Source: Fight Aging!)
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
When the conventional algorithm diagnoses the ECG as COMPLETELY NORMAL, but there is in fact OMI, what does the Queen of Hearts PM Cardio AI app say? (with 10 case examples)
Conclusions Need Scrutiny.Proximal LAD Occlusion with STE in I and aVL, and hyperacute T-waves in V2-V6.Algorithm: Marquette 12 SL (GE)The Queen gets it rightCase 9 (prehospital and ED ECGs). Echocardiography, even (or especially) with Speckle Tracking, can get you in trouble. The ECG told the story. 30 yo woman with trapezius pain. HEART Pathway = 0. Computer " Normal " ECG. Reality: ECG is Diagnostic of LAD Occlusion.Prehospital ECG:There are hyperacute T-waves in V3-V5.The Queen gets it rightFirst ED ECG:Hyperacute T-waves persist. Called normal again! Algorithm: Veritas (on Mortara...
Source: Dr. Smith's ECG Blog - March 4, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Microbiome and Alzheimer's Disease
The balance of microbial populations making up the gut microbiome changes with age, both a loss of microbes generating beneficial metabolites and an increase in the number of inflammatory microbes. Separately from this harmful process, a number of studies have shown that that aged gut microbiome is distinctly different in patients with Alzheimer's disease, suggesting that there may be a meaningful contribution to disease onset and progression arising from the gut. The precise mechanisms involved have yet to be identified. While inflammation has an important role in Alzheimer's disease, the contribution of an Alzheimer's-li...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How a ruptured spleen saved a life
Of the many thousand operations I did in my surgical career, most were life-improving rather than life-saving. To me, life-saving implies immediate or imminent risk of death: gunshot wounds, stabbings, gastrointestinal bleeding or perforations, punctured lungs, and cracking a chest in the ER for a stab wound to the heart. Potentially life-saving but less dramatic
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How a ruptured spleen saved a life originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 17, 2024 Category: General Medicine Authors: Sid Schwab, MD Tags: Physician Surgery Source Type: blogs
From popcorn to peril: a C. difficile survivor ’ s tale [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with Carol Raye, a patient advocate who shares her personal journey with a life-threatening C. difficile infection. Join us as Carol sheds light on the challenges she faced, the importance of responsible antibiotic use, and her mission to raise awareness about
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From popcorn to peril: a C. difficile survivor’s tale [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 14, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Gastroenterology Source Type: blogs
Decoding digestive discomfort: the science behind FODMAPs
FODMAPs are Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols.
Digestive discomfort – excessive flatulence, “bloating”, loose stool, or constipation – is a prevalent issue for many, and it often finds its roots in a group of fermentable carbohydrates collectively known as FODMAPs. Understanding the science behind FODMAPs could help in establishing a more comfortable and gratifying relationship with food.
In the realm of our digestive system, envision a system akin to an intricate ecosystem, teeming with activity. Various nutrients act as its constituents, powering this intern...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 5, 2024 Category: Science Authors: David Bradley Tags: Food Health and Medicine Source Type: blogs
