Postprandial syncope : Incidence, mechanism & hemodynamics.
Syncope is one of the common, yet difficult symptoms to evaluate especially in the elderly. Post-prandial syncope is one condition likely to be missed out.As the name suggests It has a distinct relationship with food intake. Mild fall in postprandial BP is an expected response but if it exceeds a limit* syncope is triggered. (*Highly variable)
Hemodynamics of Postprandial state
Normally splanchnic circulation demands up to a 25% increase in blood volume after a moderately large meal.
When this happens there must be compensatory vasoconstriction elsewhere especially in muscles. Lack of this respon...
Source: Dr.S.Venkatesan MD - June 24, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Cardiology -Clinical signs Cardiology -Definitions Cardiology -Hemodynamics Cardiology -Mechnisms of disease Syncope gastrointestinal cause for syncope orthostatic vs postprandial hypotension post prandial hypotension post-prandial hypoten Source Type: blogs
Idarucizumab for reversal of direct thrombin inhibitor dabigatran
Idarucizumab is a monoclonal antibody fragment used to reverse the anticoagulant effect of direct thrombin inhibitor dabigatran. RE-VERSE AD (Reversal of Dabigatran Anticoagulant Effect With Idarucizumab) clinical trial evaluated the safety and efficacy of 5 g idarucizumab given intravenously [1]. An article on interim analysis of 90 patients was published first. In that report, 51 patients in group A of the study had serious bleeding while 39 patients in group B required an urgent procedure. Primary end point of the study was the maximum percentage reversal of the anticoagulant effect of dabigatran within four hours of a...
Source: Cardiophile MD - June 18, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Kirigami Stent for Localized Drug Delivery
Researchers at MIT have developed a kirigami-style stent that can provide localized drug delivery through needle-like projections that pop out when the stent is extended. The ‘spines’ on the stent’s surface deliver drug-loaded microparticles into the surrounding tissue, allowing for sustained drug release for an extended period. The technology is well suited to administering drugs within tubular structures, such as those found in the GI tract, the respiratory system, and blood vasculature.
Treating inflammatory gastrointestinal conditions, such as inflammatory bowel disease, is frequently performed through the...
Source: Medgadget - June 15, 2021 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Medicine Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gr...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
A few years back, researchers noted that a common growth hormone receptor gene variant was associated with greater life expectancy in humans. There was some theorizing as to possible mechanisms at the time, following the usual paths for anything that touches on growth hormone or its receptor. In short-lived mammals such as mice, loss of function in growth hormone or its receptor produces small body size and increased healthy longevity. The present record for mouse longevity is held by a growth hormone receptor knockout lineage. In humans, members of the small Laron syndrome population exhibit an analogous disruption of gro...
Source: Fight Aging! - June 11, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Highly Active Tsimane People Exhibit Slower Neurodegeneration with Age
You may recall the data on cardiovascular health published in recent years for the Tsimane population in Bolivia, characterized by a physically active lifestyle and a diet that lacks most of the problem components found in wealthier parts of the world. The rates of cardiovascular disease are far lower in the Tsimane than in US populations. While there are certainly inevitable processes of aging that can only be addressed by the development of new medical biotechnologies, it is also the case that a sizable fraction of cardiovascular and muscle degeneration in the wealthier populations of the world appears to be self-inflict...
Source: Fight Aging! - June 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Off Our Chests: No Secrets Left Behind
By CHADI NABHAN
She was a successful corporate lawyer turned professional volunteer and a housewife.
He was a charismatic, successful, and world-renowned researcher in gastrointestinal oncology. He was jealous of all breast cancer research funding and had declared that disease his nemesis.
They were married; life was becoming a routine, and borderline predictable. Both appeared to have lost some appreciation of each other and their sacrifices.
Then, she saw a lump, and was diagnosed with breast cancer. Not any breast cancer, but triple negative breast cancer. The kind that is aggressive and potentially lethal. ...
Source: The Health Care Blog - May 27, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Physicians Book Review Breast cancer Chadi Nabhan illness narratives John Marshall Liza Marshall Off Our Chests triple negative breast cancer Source Type: blogs
Raising the awareness of celiac disease in the medical community
May is Celiac Disease Awareness Month. Physicians and others in the medical community need to be more aware of celiac disease. Celiac disease is an autoimmune disease triggered by the ingestion of gluten that affects approximately 1 percent of the U.S. population. However, most physicians didn’t learn much about it in medical school or duringRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 26, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/christina-tennyson" rel="tag" > Christina Tennyson, MD < /a > < /span > Tags: Conditions Gastroenterology Source Type: blogs
GI Genius Polyp Detection System: Interview with Giovanni Di Napoli, President, Gastrointestinal at Medtronic
We recently reported on the de novo FDA clearance received by Medtronic for its GI Genius AI polyp detection system. The product is hugely flexible as it works with any video colonoscope and provides AI powered assistance for clinicians in identifying colorectal polyps during colonoscopies.
Medtronic reports that the system has significantly improved polyp detection rates, which should translate to better colorectal cancer patient outcomes through prompt diagnosis and early treatment.
As a clinician performs a colonoscopy the system analyzes the video data and highlights suspected polyps using a green box on the vid...
Source: Medgadget - May 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Source Type: blogs
Is IBD an underrecognized health problem in minority groups?
As many people know, inflammatory bowel disease (IBD) is a complex condition affecting the intestine, which is the part of the digestive tract that helps digest food and remove water, salt, and waste.
But you might not know this: in recent years in the US, IBD is being diagnosed more often among people who are Black, Hispanic/Latinx, East and Southeast Asian, or from other minority groups than it was in past decades.
Is this a true rise in cases? Is IBD underrecognized in minority populations? While we don’t have all the answers yet, exploring health disparities in IBD and explaining its symptoms may encourage more peopl...
Source: Harvard Health Blog - May 7, 2021 Category: Consumer Health News Authors: Adjoa Anyane-Yeboa, MD, MPH Tags: Digestive Disorders Health Health care disparities Inflammation Source Type: blogs
How reviewing medical malpractice claims made me a better gastroenterologist [PODCAST]
“When a patient is dissatisfied with his or her care, he or she can consult an attorney, who will enlist a physician‘expert’ to determine if a doctor has deviated from the standard of care and whether that deviation caused a negative outcome. Over the past decade of reviewing cases involving medical malpractice, I have […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 5, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Physician Gastroenterology Malpractice Source Type: blogs
Understanding the link between reflux and cancer can save lives
People who find themselves reaching for antacid several times a month, might consider reaching out to their doctor instead. Gastroesophageal reflux disease (GERD), the same condition that causes heartburn, is also linked to a deadly form of esophageal cancer, adenocarcinoma. Lack of awareness about the link between reflux and cancer has contributed to a 733 […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 30, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/hoag-memorial-hospital-presbyterian" rel="tag" > Hoag Memorial Hospital Presbyterian < /a > < /span > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
3D Printed Shields Protect Guts During Radiotherapy
Researchers at Brigham and Women’s Hospital and MIT have developed 3D printed shields to protect the gastrointestinal tract from the side effects of radiotherapy. Using CT scans, the devices can be custom printed to suit each patient’s anatomy. The materials they’re made of contain high atomic number elements that help to shield tissues from gamma and X-rays.
Radiotherapy can be highly effective at targeting tumors and helping to shrink them. However, it can also have significant consequences for nearby healthy tissues. The side effects can be particularly pronounced in the delicate tissues of the mouth and g...
Source: Medgadget - April 27, 2021 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Radiation Oncology Radiology Source Type: blogs
Non-Surgical Solution for Fecal Incontinence: Interview with Miles Rosen, CEO of Pelvalon
Fecal incontinence can be extremely challenging for those who suffer it. The condition can be embarrassing, making it difficult for people to tell others or even their doctor about it, and it is more common than you might think. Fecal incontinence can affect anyone, but a key group of patients includes women during menopause, in whom it is often associated with previous pelvic trauma, such as that which occurs during child-birth.
Treatment options are relatively limited and either tend to be minimalist, such as lifestyle changes, or pretty intense, such as expensive surgical implants. There was a gap for a low-risk and ...
Source: Medgadget - April 21, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Ob/Gyn Source Type: blogs
