Hit-hard and early versus step-up treatment in severe sarcoidosis
Purpose of review The treatment of sarcoidosis remains uncertain, despite 70 years of study. The conventional approach is to initiate corticosteroids in individuals who require treatment. The position of more aggressive regimes is unknown. Recent findings Recent recognition that many patients will require prolonged therapy, and the observation that corticosteroids lead to overt and insidious toxicities, have led to suggestions that steroid-sparing medications be used earlier in the management of sarcoidosis. Individuals with poor prognostic features, designated as ‘high-risk’ sarcoidosis may, especially bene...
Source: Current Opinion in Pulmonary Medicine - August 9, 2022 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Ogugua Ndili Obi and Mareye Voortman Source Type: research

Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice
High-calorie intake has become one of the most common causes of dietary obesity, which eventually develops into type 2 diabetes mellitus (T2DM). Microbiota, along with the length of the gastrointestinal tract, is related to metabolic disorders, but its shifts and following impact on metabolic disorders due to external perturbation are still unclear. To evaluate shifts of microbiota from the proximal to the distal intestine and their impact on metabolic disorders, we profiled jejunal and colonic microbiota with the perturbation using high salt (HS) and antibiotic-induced microbiota depletion (AIMD) in diet-induced obesity (...
Source: Frontiers in Endocrinology - August 9, 2022 Category: Endocrinology Source Type: research

Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report
Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease affecting over 71 million people worldwide. An increased incidence of atherothrombotic events [e.g. coronary artery disease (CAD), atrial fibrillation (AF)] has been observed in HCV seropositive patients. On the other hand, an increased bleeding risk is another clinical issue, particularly in subjects with liver cirrhosis, gastroesophageal varices, portal hypertension, thrombocytopenia and alcohol consumption. The introduction and progressively greater use of direct-acting antivirals (DAAs) (instead of protease and polymerase inhibitors) during t...
Source: Frontiers in Pharmacology - August 9, 2022 Category: Drugs & Pharmacology Source Type: research

Identification of molecular patterns and prognostic models of epithelial –mesenchymal transition- and immune-combined index in the gastric cancer
Conclusion: EIRG_score may be used as a biomarker to assess prognosis and guide precise treatment. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 9, 2022 Category: Drugs & Pharmacology Source Type: research

Growth hormone associated with treatment efficacy of immune checkpoint inhibitors in gastric cancer patients
ConclusionsThe post-treatment GH level might be a predictor for ICIs treatment in AGC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 9, 2022 Category: Cancer & Oncology Source Type: research

Impact of baseline body mass index on the outcomes of patients with  neuroendocrine neoplasms
ConclusionsLower BMI is associated with worse overall survival among patients with NENs. This finding was demonstrable regardless of the tumor ’s stage or histology. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 8, 2022 Category: Endocrinology Source Type: research

Two-year outcomes of Roux ‐en‐Y gastric bypass vs medical treatment in type 2 diabetes with a body mass index lower than 32.5 kg/m2: a multicenter propensity score-matched analysis
ConclusionsAmong T2D patients with a BMI between 25.0 and 32.5  kg/m2, RYGB was more effective than medical treatment in resolving metabolic disorders and also resulted in more complications. The risk for complications should be considered in the clinical decision-making process for T2D patients with a low BMI. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 8, 2022 Category: Endocrinology Source Type: research

Molecular determinants of peritoneal dissemination in gastric adenocarcinoma
Peritoneal dissemination represents a poor prognostic indicator in gastric cancer. Despite a comprehensive molecular characterization of this disease, no peritoneal dissemination-specific signature has been identified, limiting the tailoring of the surgical and oncological treatments. In this review, we outline the available literature focusing on the role of the different molecular pathways involved in the acquisition of peritoneal metastatic dissemination. According to our results, several molecular determinants are associated with peritoneal carcinomatosis and are involved in several cellular and molecular carcinogeneti...
Source: Digestive Diseases - August 8, 2022 Category: Gastroenterology Source Type: research

Clinical research review: usefulness of bovine lactoferrin in child health
Biometals. 2022 Aug 9. doi: 10.1007/s10534-022-00430-4. Online ahead of print.ABSTRACTLactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted considering these properties, which reported the usefulness of bLF. This review was aimed to provide an overview of the clinical evidence in children. We searched clinical reports investigating the effects of bLF in children and identified 36 studies on the role of bLF in infections, iron me...
Source: Biometals - August 8, 2022 Category: Biochemistry Authors: Momoko Miyakawa Hirotsugu Oda Miyuki Tanaka Source Type: research

Poor Gastric Emptying in Patients with Paraesophageal Hernias: Pyloroplasty, Per-Oral Pyloromyotomy, BoTox, or Wait and See?
J Laparoendosc Adv Surg Tech A. 2022 Aug 8. doi: 10.1089/lap.2022.0342. Online ahead of print.ABSTRACTGastric emptying delay may be caused with both functional and anatomic derangements. Gastroparesis is suspected in patients presenting with certain foregut symptoms without anatomic obstruction. Data are still emerging regarding the best treatment of this condition. In cases where large paraesophageal hernias alter the upper gastrointestinal anatomy, it is difficult to know if gastroparesis also exists. Management of hiatal hernias is also still evolving, with various strategies to reduce recurrence being actively investig...
Source: Adv Data - August 8, 2022 Category: Epidemiology Authors: Dimitrios N Varvoglis Timothy M Farrell Source Type: research

Impact of diabetes, obesity, and dyslipidemia on the risk of HCC in patients with chronic liver diseases
Clin Mol Hepatol. 2022 Aug 8. doi: 10.3350/cmh.2021.0383. Online ahead of print.ABSTRACTDespite the increasing prevalence of metabolic disorders, the potential effects of metabolic factors on hepatocellular carcinoma (HCC) development in individuals with chronic liver diseases (CLDs) are not well understood. For a metabolic factor to be identified as a risk factor for HCC in patients with CLDs, such as hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, there should be a strong synergistic interaction between the carcinogenic mechanisms of the metabolic factor and the CLD itself. This review aims to comprehensiv...
Source: Clinical and molecular hepatology - August 8, 2022 Category: Gastroenterology Authors: Hwang Sik Shin Baek Gyu Jun Sang-Wook Yi Source Type: research

Epidemiology of Gastric Cancer in Korea: Trends in Incidence and Survival Based on Korea Central Cancer Registry Data (1999-2019)
This study investigated the trends of gastric cancer in Korea by adding the latest updated gastric cancer data from 2019. Gastric cancer incidence between 1999 and 2019 was reviewed using data from the Korea Central Cancer Registry. The study period was divided into 3 periods: period I (1999-2005), period II (2006-2012), and period III (2013-2019). The incidence, mortality, tumor location, histology, stage, and treatment were analyzed. Between 1999 and 2019, 577,502 patients were newly diagnosed with gastric cancer in Korea, accounting for 33.2% of patients aged ≥70 years. The age-standardized incidence rate (per 100,000...
Source: Journal of Gastric Cancer - August 8, 2022 Category: Gastroenterology Authors: Sin Hye Park Mee Joo Kang E Hwa Yun Kyu-Won Jung Source Type: research

Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening to < em > Helicobacter pylori < /em > Eradication in Korea
J Gastric Cancer. 2022 Jul;22(3):169-183. doi: 10.5230/jgc.2022.22.e22.ABSTRACTGastric cancer is prevalent in Korea and ranked as the third most common cancer in 2019, followed by lung and thyroid cancers. The National Cancer Screening Program (NCSP) for gastric cancer has been implemented in adults aged ≥40 since 1999 and involves endoscopic screening every 2 years. The beneficial effects of the current NCSP on early cancer detection, cost-effectiveness, and mortality reduction are evident. However, the screening program results in a large socioeconomic burden and the consumption of medical resources, as it focuses sole...
Source: Journal of Gastric Cancer - August 8, 2022 Category: Gastroenterology Authors: Young-Il Kim Il Ju Choi Source Type: research

Surgical Outcomes of Patients Undergoing Gastrectomy for Gastric Cancer: Does the Age Matter?
J Gastric Cancer. 2022 Jul;22(3):157-159. doi: 10.5230/jgc.2022.22.e20.NO ABSTRACTPMID:35938362 | DOI:10.5230/jgc.2022.22.e20 (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - August 8, 2022 Category: Gastroenterology Authors: Bang Wool Eom Source Type: research

Potential Applicability of Local Resection With Prophylactic Left Gastric Artery Basin Dissection for Early-Stage Gastric Cancer in the Upper Third of the Stomach
CONCLUSIONS: More than 95% of the patients with u-EGC might be eligible for LR + LGA-BD. This function-preserving procedure may contribute to the development of u-EGC without pathological LN metastases, especially for tumors located at the lesser curvature.PMID:35938365 | DOI:10.5230/jgc.2022.22.e17 (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - August 8, 2022 Category: Gastroenterology Authors: Yoshimasa Akashi Koichi Ogawa Katsuji Hisakura Tsuyoshi Enomoto Yusuke Ohara Yohei Owada Shinji Hashimoto Kazuhiro Takahashi Osamu Shimomura Manami Doi Yoshihiro Miyazaki Kinji Furuya Shoko Moue Tatsuya Oda Source Type: research