Empowering physicians: the benefits of personalized coaching [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Kim Downey, a physical therapist, and Michael Hersh, a gastroenterologist, and discover how coaching can help physicians navigate challenges, change their lives, and find personal and professional growth. Don’t miss their insights on finding the right coach, the impact of thoughts on feelings,
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Empowering physicians: the benefits of personalized coaching [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 11, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Evaluation of Prosthetic Aortic Valve Obstruction
This discussion will focus beyond the basic clinical evaluation, ECG, chest X-ray and hematological workup. Hematological workup is important in aortic valve obstruction because of likelihood of associated hemolytic anemia and acquired von Willebrand Syndrome. Former is due to destruction of red blood cells across the narrowed aortic valve, and latter due to loss of the largest multimers of von Willebrand factor. High shear stress across the narrowed aortic valve exposes a region of the von Willebrand factor which is susceptible to a specific von Willebrand protease. This can lead on to gastrointestinal angiodysplasia (He...
Source: Cardiophile MD - August 9, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, beta-blockers serve as an indispensable tool in the realm of modern medical treatment, particularly in managing a broad range of cardiovascular conditions.
Their unique mechanism of action, which includes decreasing heart rate and blood pressure, confers a significant cardio-protective effect.
This, combined with their versatility and the extensive clinical experience with their use, has cemented beta-blockers as a first-line treatment for various conditions, from hypertension and heart failure to anxiety and migraines.
Although beta-blockers present unique benefits, it’s crucial...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Chronic constipation treatment with pulsed irrigation evacuation [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! In this episode, we delve into the serious consequences of fecal impaction and chronic constipation on patients’ well-being and health care costs. Our guest, Mahesh Moolani, an internal medicine physician and author of Tough Decisions In Care Of Elderly Loved Ones, sheds light on
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Chronic constipation treatment with pulsed irrigation evacuation [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 17, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Gastroenterology Source Type: blogs
Answer to Case 722
Answer to theParasite Case of the Week 722: anisakid larvae, one of the members of theAnisakis simplex, Pseudoterranova decipiens,or Contracecum osculatumcomplex. Humans can become transiently infected with the larvae when they are ingested in undercooked fish, such as this salmon. The larvae may embed in the gastric or intestinal mucosa, causing intense pain. Endoscopic removal is curative. In less severe cases, the larvae will migrate back up the esophagus and out the mouth - a much preferred (but disturbing!) alternative. They can also be passed in the stool. In these settings, the larvae have to be differenti...
Source: Creepy Dreadful Wonderful Parasites - July 15, 2023 Category: Parasitology Source Type: blogs
The surprising truth behind virtual visits
We live in an era now when workers have leverage over their employers. Nearly every establishment is struggling to hire employees. It’s mysterious not only why so many folks have chosen not to return to work but also how they are paying their living expenses. Remote work, particularly for younger workers, has become a non-negotiable
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The surprising truth behind virtual visits originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 14, 2023 Category: General Medicine Authors: Michael Kirsch, MD Tags: Physician Gastroenterology Source Type: blogs
Fiber Probes to Investigate Brain-Gut Relationship
Engineers at MIT have developed a microelectronic probe that can measure and influence the behavior of neurons involved in the brain-gut axis. Neural communication between the brain and GI tract has been implicated in a range of conditions as varied as autism and Parkinson’s disease. However, studying the interplay between these neurons was difficult, until now. The new microelectronic probes are thin polymer filaments that contain sensors and other microelectronic components, including microfluidic channels to deliver drugs and light sources to perform optogenetics. The probes can be advanced into gastrointestinal or ne...
Source: Medgadget - July 10, 2023 Category: Medical Devices Authors: Conn Hastings Tags: GI Neurology Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Surgical Patch Alerts to Intestinal Leaks
Scientists at the Swiss Federal Laboratories for Materials Science and Technology (EMPA) have developed an advanced surgical sealant that can alert clinicians to the presence of an intestinal leak after gastrointestinal surgery. Such leaks can be very dangerous, but until now clinicians had few ways to detect them before they start causing symptoms. This new polymer patch reacts to pH changes in the presence of leaked intestinal fluid, and produces small bubbles within its structure in response, often within minutes or hours of a leak starting. This physical change in the patch can be visualized using ultrasound or CT scan...
Source: Medgadget - July 6, 2023 Category: Medical Devices Authors: Conn Hastings Tags: GI Surgery EMPA Source Type: blogs
The Aging of the Enteric Nervous System
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome and the brain. One of the more interesting parts of this review paper is the discussion regarding relationships between the gut microbiome and enteric nervous system. All too little is known in detail, even while it is possible to find reports of specific associations and points of communication between gut microbiome and nervous system. Given the attention to measuring and altering the balance of populations in the gut microbiome, one might hope that the advent of ways to sizeably...
Source: Fight Aging! - July 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ensuring medication safety: a shocking incident that exposed a dangerous flaw
At six-week intervals, I replenish my supply of omeprazole. Initially, I took it for symptomatic relief of GERD, becoming symptomatic again within a week or two during periodic self-directed suspensions. An esophagogastroduodenoscopy, done for another reason, disclosed Barrett’s esophagus, shifting that daily pill of personal comfort to a more essential intervention. It falls within several
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Ensuring medication safety: a shocking incident that exposed a dangerous flaw originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 28, 2023 Category: General Medicine Authors: Richard Plotzker, MD Tags: Meds Gastroenterology Medications Source Type: blogs
If Probiotics in their Present Form Were a Truly Effective Intervention, We Would Already Know
There is an increasing focus in the research community on the role of the gut microbiome in aging. This is in large part driven by the ability to accurately, cost-effectively measure the composition of the gut microbiome from a stool sample, using 16S rRNA sequencing. The 16S rRNA gene is differs between bacterial species, without being subject to a high rate of mutation and change. Using low-cost modern techniques, researchers can thus read out the relative numbers of different species in the gut microbiome, a service now available to the public at large as well. This allows researchers to see exactly how the balance of p...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
