Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease
CONCLUSIONS: The fecal microbiota in IBD patients with EIMs is distinct from that in IBD patients without EIM and could be important for EIM pathogenesis.PMID:38648495 | DOI:10.1080/07853890.2024.2338244 (Source: Annals of Medicine)
Source: Annals of Medicine - April 22, 2024 Category: Internal Medicine Authors: Sandra Hertz Jacqueline Moltzau Anderson Hans Linde Nielsen Claire Schachtschneider Kathryn E McCauley Mustafa Özçam Lone Larsen Susan V Lynch Henrik Nielsen Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Colorectal Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants
CONCLUSIONS: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.PMID:38649672 | DOI:10.1007/s10120-024-01499-1 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Dan Huang Minkyo Song Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Katherine De la Torre Norie Sawada Akiko Tamakoshi Xiao-Ou Shu Hui Cai Atsushi Hozawa Seiki Kanemura Jeongseon Kim Yu Chen Hidemi Ito Yumi Sugawara Sue K Park Myung-Hee S Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
CONCLUSION: These findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer.PMID:38649530 | DOI:10.1007/s00595-024-02845-7 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Katsutoshi Shoda Takeshi Kubota Yoshihiko Kawaguchi Hidenori Akaike Suguru Maruyama Yudai Higuchi Takashi Nakayama Ryo Saito Koichi Takiguchi Shinji Furuya Kensuke Shiraishi Hidetake Amemiya Hiromichi Kawaida Daisuke Ichikawa Source Type: research
< em > BCAT1 < /em > , < em > IKZF1 < /em > and < em > SEPT9 < /em > : methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas
DISCUSSION: Existing CRC methylated ctDNA blood tests for BCAT1/IKZF1 and SEPT9 might be usefully repurposed for use in other gastrointestinal adenocarcinomas and warrant further prospective ctDNA studies.PMID:38644767 | DOI:10.1080/1354750X.2024.2340663 (Source: Biomarkers)
Source: Biomarkers - April 22, 2024 Category: Research Authors: Geraldine Laven-Law Ganessan Kichenadasse Graeme P Young Erin L Symonds Jean M Winter Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Lung Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
Impact of Geospatial Food Access on Acute Pancreatitis Outcomes
ConclusionLow food access had a significant association with 30-day AP-related readmissions and AP severity. However, mortality and LOS lacked significant association with food access. The association between nutrition, lifestyle, and AP outcomes warrants further prospective investigation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 22, 2024 Category: Gastroenterology Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo and Hong Xu Tags: Research Source Type: research
Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation
This study aimed to examine the endoscopic characteristics of patients diagnosed with ... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Masaya Iwamuro, Daisuke Ennishi, Nobuharu Fujii, Ken-ichi Matsuoka, Takehiro Tanaka, Toshihiro Inokuchi, Sakiko Hiraoka and Motoyuki Otsuka Tags: Research Source Type: research
Heavy alcohol use and the HIV care continuum in Kenya: a population-based study
. (Source: AIDS Care)
Source: AIDS Care - April 22, 2024 Category: Infectious Diseases Authors: Edom WakeJoseph G. Rosena Division of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USAb Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA Source Type: research
Clinicopathologic and endoscopic characteristics of ten patients with gastric hamartomatous inverted polyp: a single center case series
Gastric hamartomatous inverted polyps (GHIPs) are not well characterized and remain diagnostically challenging due to rarity. Therefore, this study aims to investigate the clinicopathologic and endoscopic char... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Ningning Dong, Fandong Meng, Bing Yue and Junzhen Hou Tags: Research Source Type: research
Management of malignant Gastric Outlet Obstruction (mGOO) due to pancreatic cancer in the era of EUS-Gastrojejunostomy: an international practice survey and case vignette study by Pancreas 2000 from the European Pancreatic Club
ConclusionsThis survey revealed significant differences in the management of mGOO, depending on specialties, local expertise and treatment volume, suggesting the lack of standardized algorithms. Life expectancy and patients ’ frailty are the main decision drivers. Regarding EUS-GJ, its availability remains suboptimal, with learning curve as the main perceived barrier. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 22, 2024 Category: Surgery Source Type: research
Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma
In conclusion, targeting Claudin proteins offers a novel clinical opportunity for the treatment of patients with advanced liver fibrosis and HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Saviano, Antonio Roehlen, Natascha Baumert, Thomas F. Tags: Review Article Source Type: research
Changing fate: how EGFRs "pit" cell vs cell in the stomach
(Source: Gastroenterology)
Source: Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Sumimasa Arimura, Sarah To, Jason C. Mills Tags: Editorials Source Type: research
