Fusobacterium nucleatum carcinogenesis and drug delivery interventions
This article presents a comprehensive review of microbial communities especially F. nucleatum in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated F. nucleatum is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.PMID:38643839 | DOI:10.1016/j.addr.2024.115319 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Zhenzhen Chen Leaf Huang Source Type: research
CX-6258 hydrochloride hydrate: A potential non-nucleoside inhibitor targeting the RNA-dependent RNA polymerase of norovirus
Virology. 2024 Apr 17;595:110088. doi: 10.1016/j.virol.2024.110088. Online ahead of print.ABSTRACTHuman norovirus (HuNoV), a primary cause of non-bacterial gastroenteritis, currently lacks approved treatment. RdRp is vital for virus replication, making it an attractive target for therapeutic intervention. By application of structure-based virtual screening procedure, we present CX-6258 hydrochloride hydrate as a potent RdRp non-nucleoside inhibitor, effectively inhibiting HuNoV RdRp activity with an IC50 of 3.61 μM. Importantly, this compound inhibits viral replication in cell culture, with an EC50 of 0.88 μM. In vitro b...
Source: Virology - April 21, 2024 Category: Virology Authors: Yang Liu Quanjie Li Huihan Shao Yang Mao Lufei Liu Dongrong Yi Zhaojun Duan Huiqing Lv Shan Cen Source Type: research
KPC-2-producing Enterobacterales from ready-to-eat food to hospitalized patients
Infect Genet Evol. 2024 Apr 19:105596. doi: 10.1016/j.meegid.2024.105596. Online ahead of print.ABSTRACTFoodstuffs are a well-documented source of multidrug-resistant bacteria, and hospitalized patients are usually susceptible to hospital infections owing to their immune status. Therefore, this study aimed to investigate the presence of beta-lactamase-producing Enterobacterales in ready-to-eat foods consumed by hospitalized patients. For this purpose, 51 vegetable and meat samples were collected over 2 months and analyzed. Enterobacterales isolates were identified and subjected to antimicrobial susceptibility testing, foll...
Source: Infection, Genetics and Evolution - April 21, 2024 Category: Genetics & Stem Cells Authors: Bianca Lara Ven âncio de Godoy Marlon do Valle Barroso Yasmin Fontoura de Azeredo Louren ção Let ícia Kellen de Andrade Vit ória Gabriela Tosta Rodrigues Caroline Atu í Ana Caroline do Valle Ta ís Paulino Ferreira Mara Corr êa Lelles Nogueira Tiag Source Type: research
Usefulness of the C-Reactive Protein (CRP)-Albumin-Lymphocyte (CALLY) Index as a Prognostic Indicator for Patients With Gastric Cancer
CONCLUSIONS: The CALLY index may be associated with a poor prognosis for gastric cancer, highlighting the utility of a comprehensive assessment using inflammatory, nutritional, and immunological statuses.PMID:38644521 | DOI:10.1177/00031348241248693 (Source: The American Surgeon)
Source: The American Surgeon - April 21, 2024 Category: Surgery Authors: Keigo Nakashima Koichiro Haruki Teppei Kamada Junji Takahashi Masashi Tsunematsu Hironori Ohdaira Kenei Furukawa Yutaka Suzuki Toru Ikegami Source Type: research
Evaluation of expression level of BANCR, MALAT1 and FER1L4 and their target genes in coumarin-treated AGS cell line
In this study, we investigated the expression level of selected cellular lncRNAs (BANCR, MALAT1 and FER1L4) and their target genes (PTEN, p-PI3K and p-AKT) in coumarin-treated AGS cell line. The expressions of the three lncRNAs: BANCR, MALAT1 and FER1L4, as well as their specified targets, PTEN, PI3K and AKT, were measured by qRT-PCR. To gauge the impact of coumarin on the AGS cells, a MTT assay was utilized. A Western blot has been employed to assess variations in PTEN, p-PI3K, and p-AKT expression. The experiment's results showed that AGS viability diminished with increasing doses of coumarin. Compared to the control cel...
Source: Pathology, Research and Practice - April 21, 2024 Category: Pathology Authors: Shirin Shafaee Arani Majid Nejati Sepide Rastgoufar Arash Raisi Reza Eshraghi Amirreza Ostadian Amir Hassan Matini Neda Rahimain Hamed Mirzaei Source Type: research
The trends of pediatric duodenal ulcer and predictors of recurrence
CONCLUSIONS: Hp-positive DU seems to wane. Patients with male sex, lower Hb level, or perforation at diagnosis carried a higher risk of recurrence, which may warrant active surveillance and endoscopic follow-up.PMID:38644127 | DOI:10.1016/j.jfma.2024.04.011 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 21, 2024 Category: General Medicine Authors: Pai-Jui Yeh Chien-Chang Chen Hsun-Chin Chao Jin-Yao Lai Yung-Ching Ming Mi-Chi Chen Ming-Wei Lai Source Type: research
Green synthesis of silver nanoparticles based on using Croton urucurana and their toxicity against freshwater snail species Biomphalaria glabrata
Acta Trop. 2024 Apr 19:107224. doi: 10.1016/j.actatropica.2024.107224. Online ahead of print.ABSTRACTGreen plant-based silver nanoparticles (GP-Ag NPs) have contributed to the development of ecological technologies with low environmental impact and safer for human health, as well as demonstrating potential for the control of vectors and intermediate hosts. However, knowledge about its toxicity in the early stages of gastropod development remains scarce. Therefore, the current study aimed to investigate the toxicity of GP-Ag NPs synthesized from Croton urucurana leaf extracts in snail species Biomphalaria glabrata, which is...
Source: Acta Tropica - April 21, 2024 Category: Infectious Diseases Authors: Paula Sampaio Ara újo Maxwell Batista Caixeta Eloiza da Silva Nunes Bruno Bastos Gon çalves Thiago Lopes Rocha Source Type: research
Fusobacterium nucleatum carcinogenesis and drug delivery interventions
This article presents a comprehensive review of microbial communities especially F. nucleatum in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated F. nucleatum is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.PMID:38643839 | DOI:10.1016/j.addr.2024.115319 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Zhenzhen Chen Leaf Huang Source Type: research
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management: Preclinical and Clinical Developments of the Past 5 Years
PET Clin. 2024 Apr 20:S1556-8598(24)00019-1. doi: 10.1016/j.cpet.2024.03.004. Online ahead of print.ABSTRACTEach tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed p...
Source: Clinical Prostate Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Simone Dalm Heying Duan Andrei Iagaru Source Type: research
Improving colonoscopy quality: growing evidence to support adenomas per colonoscopy as a standard quality indicator
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death in the United States, with nearly 150,000 individuals with diagnoses of CRC and an estimated 53,200 CRC deaths in 2020.1 CRC screening has been effective at reducing the incidence and mortality of CRC by an estimated 30% to 60%, and tremendous efforts have been aimed at improving screening rates. Screening by colonoscopy is estimated to decrease CRC incidence and mortality by 69% and 68%, respectively. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Jennifer Maranki Tags: Editorial Source Type: research
Response
We sincerely thank Wu et al1 for their interest in our article entitled “Impact of direct-acting oral anticoagulants and warfarin on postendoscopic GI bleeding and thromboembolic events in patients undergoing elective endoscopy.”2 We are pleased that their study has found concordant results of thromboembolic events. O ur ERCP cohort was too small for subgroup analysis and did not include indomethacin data. As such, the size of the authors’ ERCP cohort of individuals who had received antithrombotic agents is impressive and fills a current gap in the literature. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Andy Tien, Karl Kwok Tags: Letter to the Editor Source Type: research
Phase analysis: a novel and useful application of artificial intelligence in endoscopy
“What gets measured, gets managed.”– Peter Drucker (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: David L. Diehl Tags: Editorial Source Type: research
Contents
(Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Source Type: research
Editors
(Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Source Type: research
Focus On...
(Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Source Type: research
