Characteristics of canine oral tumors: Insights into prevalence, types, and lesion distribution
CONCLUSION: Gingiva was the primary site for oral tumors, and mainly classified as stage III. These findings emphasize the increasing occurrence of oral tumors in senior and geriatric dogs and provide insights into the prevalent types and distribution.PMID:37969809 | PMC:PMC10636079 | DOI:10.5455/javar.2023.j709 (Source: Cell Research)
Source: Cell Research - November 16, 2023 Category: Cytology Authors: Chakkarin Satthathum Supreeya Srisampane Pollawat Jariyarangsrirattana Pitak Anusorn Panpicha Sattasathuchana Naris Thengchaisri Source Type: research
GSE218062 BCL2 inhibition reveals a dendritic cell-specific immune checkpoint that controls tumor immunosurveillance
In conclusion, genetic and pharmacological BCL2 inhibition unveils a DC-specific immune checkpoint that restrains tumor immunosurveillance (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Angiotensin-(1-7) Improves Islet β-cell Dedifferentiation by Activating PI3K/Akt/FoxO1 Pathway
CONCLUSION: Ang-(1-7) may prevent high glucose-induced pathological dedifferentiation of pancreatic β-cell by activating the PI3K/Akt/FoxO1 signaling pathway.PMID:37953618 | DOI:10.2174/0109298665257646231020054036 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 13, 2023 Category: Biochemistry Authors: Hao Guo Dandan Guo Min An Ruonan Zhang Caixia Wang Junhua He Source Type: research
Angiotensin-(1-7) Improves Islet β-cell Dedifferentiation by Activating PI3K/Akt/FoxO1 Pathway
CONCLUSION: Ang-(1-7) may prevent high glucose-induced pathological dedifferentiation of pancreatic β-cell by activating the PI3K/Akt/FoxO1 signaling pathway.PMID:37953618 | DOI:10.2174/0109298665257646231020054036 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 13, 2023 Category: Biochemistry Authors: Hao Guo Dandan Guo Min An Ruonan Zhang Caixia Wang Junhua He Source Type: research
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
CONCLUSION: SOX71, a succinylated derivative of OX071 was synthesized, characterized, and applied for in vivo EPR tumor oxygen imaging. SOX71 is highly biocompatible, and shows decreased sensitivity to oxygen and self-relaxation. This first report suggests that SOX71 is superior to OX071 for absolute oxygen mapping under a broad range of pO2 values.PMID:37945971 | DOI:10.1007/s11307-023-01869-8 (Source: Mol Biol Cell)
Source: Mol Biol Cell - November 9, 2023 Category: Molecular Biology Authors: Misa A Shaw Martin Poncelet Navin Viswakarma Gian Paolo Vallerini Safa Hameed Teresa D Gluth Werner J Geldenhuys Emily H Hoblitzell Timothy D Eubank Boris Epel Mrignayani Kotecha Benoit Driesschaert Source Type: research
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
ConclusionSOX71, a succinylated derivative of OX071 was synthesized, characterized, and applied forin vivo EPR tumor oxygen imaging. SOX71 is highly biocompatible, and shows decreased sensitivity to oxygen and self-relaxation. This first report suggests that SOX71 is superior to OX071 for absolute oxygen mapping under a broad range ofpO2 values. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 9, 2023 Category: Molecular Biology Source Type: research
Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer ’s Disease
This study was to investigate the potential molecular mechanisms of rapidly accelerated fibrosarcoma-1 (RAF-1) in AD through bioinformatics analysis. Differential gene expression analysis was performed in GSE 132903 dataset. We used weight gene correlation network analysis (WGCNA) to evaluate the relations among co-expression modules and construct global regulatory network. Cross-talking pathways of RAF-1 in AD were identified by functional enrichment analysis. Totally, 2700 differentially expressed gene s (DEGs) were selected between AD versus non-dementia control and RAF-1-high versus low group. Among them, DEGs in turqu...
Source: Molecular Neurobiology - November 8, 2023 Category: Neurology Source Type: research
Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance
We examined whether loss of TREM1 signaling can abrogate the immunosuppressive TME and enhance cancer immunity. To investigate the therapeutic potential of TREM1 in cancer, we used mice deficient in Trem1 and developed a novel small molecule TREM1 inhibitor, VJDT. We demonstrated that genetic or pharmacological TREM1 silencing significantly delayed tumor growth in murine melanoma (B16F10) and fibrosarcoma (MCA205) models. Single-cell RNA-Seq combined with functional assays during TREM1 deficiency revealed decreased immunosuppressive capacity of myeloid-derived suppressor cells (MDSCs) accompanied by expansion in cytotoxic ...
Source: Journal of Clinical Investigation - November 1, 2023 Category: Biomedical Science Authors: Ashwin Ajith, Kenza Mamouni, Daniel D. Horuzsko, Abu Musa, Amiran K. Dzutsev, Jennifer R. Fang, Ahmed Chadli, Xingguo Zhu, Iryna Lebedyeva, Giorgio Trinchieri, Anatolij Horuzsko Source Type: research
Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models
CONCLUSION: This study confirms that EPROI locates resistant tumor hypoxic regions for radiation boost, increasing clonogenic LTCP, with potential enhanced therapeutic index in three tumor types. Preclinical absolute EPROI may provide correction for clinical hypoxia images using additional clinical physiologic MRI.PMID:37904839 | PMC:PMC10613495 | DOI:10.3389/fmed.2023.1269689 (Source: Cancer Control)
Source: Cancer Control - October 31, 2023 Category: Cancer & Oncology Authors: Inna Gertsenshteyn Boris Epel Mihai Giurcanu Eugene Barth John Lukens Kayla Hall Jenipher Flores Martinez Mellissa Grana Matthew Maggio Richard C Miller Subramanian V Sundramoorthy Martyna Krzykawska-Serda Erik Pearson Bulent Aydogan Ralph R Weichselbaum Source Type: research
The mechanism of acrolein exposure inhibited the release of neutrophil extracellular traps: By reducing respiratory burst and Raf/MEK/ERK pathway and promote cell apoptosis
In this study, chicken peripheral blood neutrophils were pretreated with 20 μM AC and treated with 5 μM Phorbol 12-myristate 13-acetate (PMA) to stimulate the release of NETs. The results showed that AC exposure significantly inhibited the release of NETs induced by PMA, respiratory burst, and the expression levels of phospho-rapidly accelerated fibrosarcoma (p-Raf), phospho-mitogen-activated extracellular signal-regulated kinase (p-MEK) and phospho-extracellular regulated protein kinases (p-ERK). In addition, AC exposure significantly inhibited the expression of B-cell lymphoma-2 (Bcl-2) and promoted the expression of a...
Source: Chemico-Biological Interactions - October 8, 2023 Category: Molecular Biology Authors: Dongliu Luo Yiming Lu Jintao Zhang Xixi Wang Yixuan Wang Shiping Li Shu Li Source Type: research
The mechanism of acrolein exposure inhibited the release of neutrophil extracellular traps: By reducing respiratory burst and Raf/MEK/ERK pathway and promote cell apoptosis
In this study, chicken peripheral blood neutrophils were pretreated with 20 μM AC and treated with 5 μM Phorbol 12-myristate 13-acetate (PMA) to stimulate the release of NETs. The results showed that AC exposure significantly inhibited the release of NETs induced by PMA, respiratory burst, and the expression levels of phospho-rapidly accelerated fibrosarcoma (p-Raf), phospho-mitogen-activated extracellular signal-regulated kinase (p-MEK) and phospho-extracellular regulated protein kinases (p-ERK). In addition, AC exposure significantly inhibited the expression of B-cell lymphoma-2 (Bcl-2) and promoted the expression of a...
Source: Chemico-Biological Interactions - October 8, 2023 Category: Molecular Biology Authors: Dongliu Luo Yiming Lu Jintao Zhang Xixi Wang Yixuan Wang Shiping Li Shu Li Source Type: research
Genes, Vol. 14, Pages 1883: Exploring Large MAF Transcription Factors: Functions, Pathology, and Mouse Models with Point Mutations
hashi
Large musculoaponeurotic fibrosarcoma (MAF) transcription factors contain acidic, basic, and leucine zipper regions. Four types of MAF have been elucidated in mice and humans, namely c-MAF, MAFA, MAFB, and NRL. This review aimed to elaborate on the functions of MAF transcription factors that have been studied in vivo so far, as well as describe the pathology of human patients and corresponding mouse models with c-MAF, MAFA, and MAFB point mutations. To identify the functions of MAF transcription factors in vivo, we generated genetically modified mice lacking c-MAF, MAFA, and MAFB and analyzed their phenotypes. Fu...
Source: Genes - September 27, 2023 Category: Genetics & Stem Cells Authors: Mitsunori Fujino Masami Ojima Satoru Takahashi Tags: Review Source Type: research
Effectiveness and cost-effectiveness of combination therapy versus monotherapy in malignant melanoma
ConclusionCombination therapy is more effective compared to monotherapy. While combined ICIs are cost-effective compared to monotherapy, this is not the case for the combination of BRAF and MEK inhibitors. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - September 25, 2023 Category: Pharmaceuticals Source Type: research
Diclofenac and metformin synergistic dose dependent inhibition of hamster fibrosarcoma, rescued with mebendazole
In conclusion, diclofenac and metformin combination may be recommended for potential use in oncology, due to synergistic anticancer effect in doses achievable in humans.PMID:37738800 | DOI:10.1016/j.biopha.2023.115528 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 22, 2023 Category: Drugs & Pharmacology Authors: Du šica J Popović Kosta J Popovi ć Dejan Miljkovi ć Jovan K Popovi ć Du šan Lalošević Mihalj Po ša Zana Doli ćanin Ivan Čapo Source Type: research
KMT2A-rearranged sarcoma with unusual fusion gene CBX6::KMT2A::PYGO1
We report the case of a 47-year-old man with a spindle cell tumor arising from the subcutaneous tissue of the right anterior chest. The tumor harbored an unusual novel fusion gene,CBX6::KMT2A::PYGO1. Histologically, the tumor consisted of proliferating spindle-shaped cells with uniform nuclei, which varied in cell density and the amount of intervening collagen fibers. After 2 years and 8 months without postoperative treatment, the patient showed no recurrence or metastasis. Although highly likely irreproducible, tumors with theCBX6::KMT2A::PYGO1 fusion gene were morphologically somewhat different from those containing theY...
Source: Virchows Archiv - September 15, 2023 Category: Pathology Source Type: research
