Limb salvage of an infant with infantile fibrosarcoma using TRK inhibitor larotrectinib
We report the case of a male infant from Bangladesh with a locally advanced IFS of the leg which was partially resected. The patient received adjuvant chemotherapy which was complicated by the development of chemotherapy-related veno-occlusive disease and had to be discontinued. Thereafter he was referred to our dedicated sarcoma oncology clinic in India for further management. The parents of the child refused amputation of the limb. The tumour tested positive for NTRK3-ETV6 gene fusion and after discussion in multidisciplinary clinic, targeted therapy using oral NTRK inhibitor larotrectinib was started. The patient had co...
Source: Ecancermedicalscience - August 3, 2023 Category: Cancer & Oncology Authors: Shubham Sahni Sameer Rastogi Richa Yadav Adarsh Barwad Source Type: research
