Metastasis-directed therapy for oligometastatic urological tumours: still no second-hand news.
Authors: Berghen C, Joniau S, Vulsteke C, Albersen M, Devos G, Rans K, Haustermans K, De Meerleer G Abstract For patients presenting with limited metastatic disease burden, known as the oligometastatic state of disease, a more aggressive treatment approach targeting the new or progressive metastatic lesions might improve patient outcome, with no or only limited toxicity to be expected from the treatment. This review provides an overview of the existing evidence and on-going trials on oligometastatic disease and metastasis-directed therapy in the field of renal, bladder and prostate cancer. PMID: 32565889 [PubMe...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Anal canal cancer in Brazil: why should we pay more attention to the epidemiology of this rare disease?
Authors: Donadio MD, Riechelmann RP Abstract Anal canal cancer is one of the human papilloma virus (HPV)-associated diseases with increasing incidence. High-risk sexual behaviour and the resurgence of human immunodeficiency virus (HIV) infection, associated with low HPV vaccine coverage, are risk factors for the increased incidence of this cancer. In this paper, the authors point out pertinent questions regarding the greater exposure of the population to some risk factors and discuss the latest epidemiological data of these factors, particularly those of concern to emerging countries like Brazil. The authors also d...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Concomitant use of antibiotics and immune checkpoint inhibitors in patients with solid neoplasms: retrospective data from real-world settings.
Conclusions: This study shows that the judicious use of antibiotics is required in patients on ICI or scheduled to be started on ICI. PMID: 32565891 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The impact of armed conflict on cancer among civilian populations in low- and middle-income countries: a systematic review.
Authors: Jawad M, Millett C, Sullivan R, Alturki F, Roberts B, Vamos EP Abstract Background: Armed conflicts are increasingly impacting countries with a high burden of cancer. The aim of this study is to systematically review the literature on the impact of armed conflict on cancer in low- and middle-income countries (LMICs). Methods: In November 2019, we searched five medical databases (Embase, Medline, Global Health, PsychINFO and the Web of Science) without date, language or study design restrictions. We included studies assessing the association between armed conflict and any cancer among civilian populatio...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Treatment of cancer patients during the COVID-19 pandemic in the Philippines.
Authors: Ting FI, Sacdalan DB, Abarquez HS, Uson AJ Abstract The COVID-19 pandemic has caused disruptions in cancer care around the world due to logistical and psychosocial reasons. This paper was written with the primary objective of providing a guide for medical oncologists in addressing concerns in the management of adult patients with solid tumours in the Philippines and for those working under similar circumstances. These recommendations are divided into prioritisation of cancer care, ensuring a safe work environment, organising the transition of cancer care, and maintaining cohesion in a time of isolation. ...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Should breast reconstruction and breast oncoplastic procedures be performed during the coronavirus pandemic?
Authors: Vidya R, Rubio IT, Paulinelli RR, Rancati A, Kolacinska-Voytkuv A, Salgarello M, Becker H Abstract The onset of the COVID-19 pandemic has changed the face of the treatment of breast cancer and breast reconstruction globally. Mastectomy with immediate implant-based breast reconstruction was on the rise due to advances in meshes and implants. However, due to the prioritisation of the critically ill and diversion of the work force, breast cancer treatment has drastically changed. This is an opinion paper written by the authors with experience and importance in the scenario of breast reconstructive surgery. Th...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The CAPRA score versus sub-types of minimal residual disease to predict biochemical failure after external beam radiotherapy.
Conclusions: The MRD prognostic classification is based on the biological characteristics of the tumour cell-microenvironment interaction, to give three groups, MRD negative, only bone marrow micro-metastasis and CPC positive prostate cancer. Differing from the CAPRA score classification the risk of treatment failure changes with time, differentiating between early and late treatment failures and incorporates the concept of dormancy. It proved to be superior to the CAPRA score in predicting biochemical failure and the results need to be confirmed in larger studies. PMID: 32565895 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cervical carcinoma in the setting of uterovaginal prolapse: comparing standard versus tailored management.
Conclusions: Cervical cancer in the setting of stage III-IV uterovaginal prolapse can be managed successfully with standard treatment strategies (primary surgery with adjuvant therapy as necessary versus chemoradiation). When patients are surgical candidates, techniques to address the underlying prolapse can be used for symptomatic improvement. PMID: 32565896 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina.
Conclusions: The scientific evidence available on this topic worldwide is in progress. This together with the epidemiologically shifting scenario poses unprecedented challenges in the management of cancer amidst this global pandemic. Furthermore, the key role of the healthcare structural organisation appears evident, such as the drafting of clear guidelines for all the stakeholders, adaptability to constant change and an interdisciplinary shared vision through consensus to provide adequate care to our cancer patients in the light of uncertainty and fast-paced change. PMID: 32565897 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Tumour-infiltrating Langerhans cells in non-melanoma skin cancer, a clinical and immunohistochemical study.
Authors: Maraee A, Farag AGA, Gadallah MM, Abdou AG Abstract Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and SCC and to correlate this percentage with their clinicopathological features. The current study was performed on surgically excised specimens of 41 patients pr...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Reactions and countermeasures of medical oncologists towards the incoming COVID-19 pandemic: a WhatsApp messenger-based report from the Italian College of Chief Medical Oncologists.
Conclusion: In our experience, the WhatsApp instant-messaging system seems to be a useful tool to share news and reactions between medical oncologists to rapidly implement necessary health measures and answers to most cancer patients' needs and queries in the COVID-19 pandemic scenario. PMID: 32565899 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer is associated with severe disease in COVID-19 patients: a systematic review and meta-analysis.
Authors: Ofori-Asenso R, Ogundipe O, Agyeman AA, Chin KL, Mazidi M, Ademi Z, De Bruin ML, Liew D Abstract Cancer patients are vulnerable to complications of respiratory viruses. This systematic review and meta-analysis sought to examine the prevalence of cancer and its association with disease severity in patients with novel coronavirus disease 2019 (COVID-19). Searches were performed in MEDLINE, EMBASE and ScienceDirect from their inception until 28 April 2020. Severe disease was considered to encompass cases resulting in death or as defined by the primary study authors. Meta-analysis was performed using random-ef...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group.
Conclusions: Our recommendations emphasise the importance of treating cancer patients, using the best evidence available, while simultaneously taking into consideration the world-wide health resource hyperutilisation to treat non-cancer COVID-19 patients. PMID: 32565901 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The recurrence of the melanotic neuroectodermal tumour of infancy: an unusual presentation of a rare tumour.
Authors: Pereira AAC, de Jesus Rozante MM, Doveinis RB, Salvarani CP, Anegawa TH, da Costa Souza P, Brat DJ, de Oliveira Borges AC Abstract The melanotic neuroectodermal tumour of infancy (MNTI), also known as melanotic progonoma, is a rare neoplasm derived from neural crest cells. Although it is fundamentally benign, the tumour may present a locally aggressive behaviour, characterised by a rapid progression and a destructive invasion of adjacent structures, hence causing deformities. Unfortunately, perhaps due to the low incidence of this type of tumour, the published cases in the literature do not characterise th...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Breast cancer and the black swan.
Authors: Retsky M, Demicheli R, Hrushesky W, James T, Rogers R, Baum M, Vaidya JS, Erhabor O, Forget P Abstract Most current research in cancer is attempting to find ways of preventing patients from dying after metastatic relapse. Driven by data and analysis, this project is an approach to solve the problem upstream, i.e., to prevent relapse. This project started with the unexpected observation of bimodal relapse patterns in breast and a number of other cancers. This was not explainable with the current cancer paradigm that has guided cancer therapy and early detection for many years. After much analysis using comp...
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Zambia's National Cancer Centre response to the COVID-19 pandemic-an opportunity for improved care.
This article reports the response of a comprehensive cancer centre in a lower-middle income country to prevent COVID-19 transmission and how the implementation of pragmatic strategies have served as a springboard to improve cancer services beyond the COVID-19 pandemic. The strategies included establishment of a local taskforce, increased education and facilitation of good hygiene practices, staff training, patient triaging, improved patient scheduling, remote review of patients and establishing a virtual platform for meetings. PMID: 32565904 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

COVID-19: hypofractionation in the Radiation Oncology Department during the 'state of alarm': first 100 patients in a private hospital in Spain.
We report the results of the first 100 patients who have experienced radiotherapy treatment since the state of alarm (66 women and 34 men). In these patients, the FI is 12.12-lower than previous years. PMID: 32565905 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Oncofertility and COVID-19-cancer does not wait.
This article briefly highlights what patients, oncologists and fertility specialists need to keep in mind during oncofertility counseling at the time of the COVID-19 outbreak. PMID: 32565906 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Mortality prediction in women with corpus uteri cancer in Brazil: a 21-year analysis.
Authors: Dantas DB, Rodrigues LFG, de Campos Gomes F, de Melo-Neto JS Abstract Mortality data obtained from the Mortality Information System identified a total of 19,499 deaths in women caused by corpus uteri cancer in Brazil. However, the association between mortality and sociodemographic factors in these women is not fully understood. A study based on the secondary data on deaths caused by corpus uteri cancer recorded in the SIM-DATASUS was conducted. Deaths reported from 1996 to 2016 in the health information system were included. Sociodemographic factors were analysed to determine their association with mortali...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fertility preservation in endometrial cancer patients: options, challenges and perspectives.
Authors: Terzic M, Norton M, Terzic S, Bapayeva G, Aimagambetova G Abstract Several different approaches have been designed by physicians in order to preserve fertility in younger patients with endometrial carcinoma. There are various options offering different advantages, but hysteroscopic resection of pathologic endometrial tissue with placement of a Levonorgestrel Intrauterine Device has proven to be the most successful in allowing patients to conceive and give birth afterwards. However, conservative treatments should only be considered in patients with low-grade and low-stage endometrial tumours. There are many...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Borderline ovarian tumours: management in the era of fertility-sparing surgery.
Authors: Maramai M, Barra F, Menada MV, Stigliani S, Moioli M, Costantini S, Ferrero S Abstract Borderline ovarian tumours (BOTs) are ovarian neoplasms characterised by epithelial proliferation, variable nuclear atypia and no evidence of destructive stromal invasion. BOTs account for approximately 15% of all epithelial ovarian cancers. Due to the fact that the majority of BOTs occur in women under 40 years of age, their surgical management often has to consider fertility-sparing approaches. The aim of this mini-review is to discuss the state of the art of fertility-sparing surgery for BOTs with a specific focus on ...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Uterine irradiation as a determinant of infertility and pregnancy losses in young cancer survivors.
Authors: Buonomo B, Orecchia R, Tomao F, Pup LD, Garcia-Faura A, Peccatori FA Abstract Several concerns exist regarding the impact of anticancer treatments on fertility and pregnancy outcome. The detrimental effects of both chemotherapy and radiotherapy on the ovaries are well reported in the available literature. Fewer data are focused on the importance of a functioning uterus to conceive and carry on a healthy pregnancy. The aim of this paper is to provide a narrative review of the current literature to assess the role of uterine irradiation as a potential determinant of infertility and poor obstetrical outcomes....
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fertility preservation in patients with BRCA mutation.
Authors: Ghunaim S, Ghazeeri G, Khalife D, Azim HA Abstract Evidence suggests a likely negative impact of deleterious BRCA mutations on female fertility. Hence, different studies have aimed to address the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients with a prime focus on their safety and efficacy. However, several uncertainties exist in many domains of this field. The aim of the current paper is to overview the reproductive potential and fertility preservation options in breast and ovarian cancer patients harbouring a BRCA mutation. We also discu...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The role of magnetic resonance-guided focused ultrasound in fertility-sparing treatment of uterine fibroids-current perspectives.
Authors: Ciebiera M, Łoziński T Abstract Uterine fibroids (UFs) are the most common benign tumours of the female reproductive system and the most frequent reason for hysterectomy worldwide. UFs are reported in 20%-70% of women of reproductive age depending on a study group. Although most women with UFs are asymptomatic, over 30% of them will present with different symptoms. Abnormal uterine bleeding, pain, pressure and infertility are the most common. Lesions that cause these kinds of symptoms may require medical intervention. Trends in UF treatment change along with patient awareness and the introduction of new ...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fertility preservation in women affected by gynaecological cancer: the importance of an integrated gynaecological and psychological approach.
Authors: Rosa VL, Garzon S, Gullo G, Fichera M, Sisti G, Gallo P, Riemma G, Schiattarella A Abstract Gynaecological cancer treatment significantly affects the fertility of women in reproductive age. Surgery, chemotherapy and radiotherapy are the mainstays of ovarian, cervical and endometrial cancers and anatomically or functionally impact the uterus and ovaries. Moreover, the sexual function and psychological wellbeing of patients are highly weakened after a cancer diagnosis: depression, anxiety and impairment of quality of life represent a relevant concern for patient care. The potential loss of fertility could be...
Source: Ecancermedicalscience - May 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic.
Authors: Martí C, Sánchez-Méndez JI Abstract The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or postponing their attendance at clinics, as well as avoiding surgeries. In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. ...
Source: Ecancermedicalscience - May 7, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Liver failure due to relapsed myeloma and hepatic iron overload.
We present a case of a 49-year-old female with relapsed/refractory multiple myeloma who presented with rapid onset liver failure, due to both iron deposition and malignant plasma cell infiltration of the liver as a terminal event. A review of the literature on hepatic complications in multiple myeloma patients is presented. PMID: 32368253 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - May 7, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Epidemiological and histopathological characteristics of head and neck cancers in Bhutan from 2011 to 2017: a retrospective descriptive study.
Conclusion: Head and neck cancers are the third most common cancer in Bhutan after stomach cancer and cervical cancer. Thyroid, oral cavity and hypopharynx are the top three anatomical sites for head and neck cancers in Bhutan. The current epidemiological and histopathological profile of head and neck cancers will form a baseline of information and basis for further research on head and neck cancers in Bhutan. PMID: 32346390 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - May 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012.
Conclusions: Young adults represent a highly unique group, characterised by little diagnostic suspicion, distribution and aggressiveness of the neoplasms that occur in them. Assessing and reporting incidence and mortality ratios in this age group can contribute to decision making. PMID: 32346391 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - May 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer care in the time of COVID-19-a perspective from Pakistan.
Authors: Yusuf A Abstract Across much of the world, cancer care has been sidelined to a variable degree by the global effort against the coronavirus pandemic. This paper discusses the impact of coronavirus infection on cancer diagnosis and treatment in two leading cancer centres in Pakistan. It also describes the effect that preparations for the expected surge in cases in Pakistan over the next few weeks have had on cancer care. There is an urgent need to evaluate the effect of delays in diagnosis and treatment on cancer stage and treatment, and to decide how to minimise these during likely future cycles of lockdow...
Source: Ecancermedicalscience - May 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

COVID-19 and its ramifications for cancer patients in low-resource settings: Ghana as a case study.
Authors: Kugbey N, Ohene-Oti N, Vanderpuye V Abstract The impact of COVID-19 on healthcare in low- and middle-income countries (LMICs) is a major challenge requiring urgent measures. Cancer care in LMICs, including Ghana, is faced with inadequate numbers of skilled healthcare professionals and essential material resources which negatively impacts the quality of healthcare and wellbeing of patients. In the face of COVID-19, cancer patients are likely to be affected in three key ways: access to healthcare, increased financial toxicity and increased mental health burden as a consequence of strict measures being implem...
Source: Ecancermedicalscience - May 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Additional challenges faced by cancer patients in Gaza due to COVID-19.
Authors: AlWaheidi S, Sullivan R, Davies EA Abstract Cancer patients in conflict settings experience significant barriers in accessing chemotherapy and radiotherapy as well as palliative care and psychosocial support. Now they face an additional possible risk of infection by SARS-CoV-2 novel coronavirus and the indirect impact of the COVID-19 pandemic on movement restrictions and their access to care. In this commentary, we highlight that despite the low COVID-19 burden in conflict settings like Gaza, COVID-19 could lead to further inequity in cancer care and poorer outcomes for Palestinians with cancer. This is du...
Source: Ecancermedicalscience - May 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Upheaval in cancer care during the COVID-19 outbreak.
Authors: Salako O, Okunade K, Allsop M, Habeebu M, Toye M, Oluyede G, Fagbenro G, Salako B Abstract On Monday, 23 March 2020, Nigeria recorded its first mortality from the novel global COVID-19 outbreak. Before this, the country reported 36 confirmed cases (at the time of writing) and has discharged home two cases after weeks of care at a government-approved isolation centre in Lagos State. This first mortality was that of a 67-year-old man with a history of multiple myeloma, a type of blood cancer. He was undergoing chemotherapy and had just returned to Nigeria following medical treatment in the United Kingdom. Th...
Source: Ecancermedicalscience - April 11, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say?
Authors: Russell B, Moss C, Rigg A, Hopkins C, Papa S, Van Hemelrijck M Abstract There have been several reports noting anosmia and ageusia as possible symptoms of COVID-19. This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. The purpose of this report was to summarise the evidence on the existence of anosmia and ageusia an emerging COVID-19 symptoms in order to better inform both oncology patients and clinicians. Currently, there is no published evidence or case reports noting anosmia or...
Source: Ecancermedicalscience - April 11, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Multiple malignant transformations of an ovarian mature cystic teratoma.
Conclusion: Malignant transformations of MCTs are exceedingly rare with no guidelines on management. We use this case to demonstrate an approach for the workup and management of malignantly transformed MCTs. PMID: 32256692 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Slowly developing toxic epidermal necrolysis-like reaction associated with pemetrexed and carboplatin.
Authors: Eichhoff G Abstract Most cutaneous adverse drug reactions reported in association with chemotherapy, such as a limited maculopapular rash, are considered mild and do not affect the continuation of the treatment. Toxic epidermal necrolysis (TEN), however, is a life-threatening reaction that needs treatment discontinuation. The present case shows the slow progression from a pemetrexed and carboplatin-associated maculopapular rash to a TEN-like reaction. PMID: 32256693 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The development of T-cell malignancies in patients with pre-existing myeloproliferative neoplasms: a report of three cases.
We present two cases of angioimmunoblastic T-cell lymphoma (AITL) and one case of T-cell acute lymphoblastic leukaemia (T-ALL) that developed in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), respectively. All malignancies were advanced at diagnosis and exhibited disease progression, regardless of the mutational status of the underlying ET/PMF, presence of cytogenetic abnormalities, type of T-cell neoplasm or systemic chemotherapy utilised. The median time to diagnosis of AITL or T-ALL from the onset of MPN was 4.5 years (range: 6 months-10 years). This single institutional case series demons...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Multiple myeloma with concurrent immune thrombocytopenic purpura.
We present a case of MM with concurrent ITP which was refractory of steroids and intravenous immunoglobulin but had a response with anti-neoplastic therapy for MM. We also review all the cases of ITP with MM described in the literature. If conventional treatment for ITP associated with MM fails to improve platelet count, anti-neoplastic therapy for MM should be considered. PMID: 32256695 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Histopathologic patterns of cutaneous malignancies in individuals with oculocutaneous albinism in Anambra state, Nigeria: a paradigm swing?
Conclusion: Contrary to previous reports, it would appear that the pattern of cutaneous malignancies in albinos shows the same trend as that seen in Caucasians and fair-skinned Africans. PMID: 32256696 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Clinical factors related to severe enterocolitis after adjuvant CAPOX for colorectal cancer: a retrospective analysis.
Conclusion: Our data showed that adjuvant CAPOX induced severe enterocolitis in 13.1% of patients. In addition, we found that advanced age, right colectomy and concurrent use of ARB were statistically associated with these events. Awareness of these factors could be easily incorporated into the treatment decision and patient orientation. PMID: 32256697 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Progress in acute myeloid leukaemia: small molecular inhibitors with small benefits.
Authors: Hilal T Abstract The use of small molecule inhibitors in acute myeloid leukaemia (AML) has become ubiquitous with the US Food and Drug Administration approval of multiple agents between 2017 and 2018. Despite the promise, some of these indications are based on early efficacy data (phase I/II), and single-arm studies, and have not been tested in randomised trials. Furthermore, there are important limitations in the evidence that exists in randomised trials. This perspective aims to summarise the data that formed the basis for approval of gilteritinib, glasdegib, ivosidenib, enasidenib and venetoclax. It als...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fertility sparing strategies for pre- and peripubertal male cancer patients.
Authors: Stukenborg JB, Wyns C Abstract Genetic parenthood following cancer therapy is considered to be a major factor of quality of life. Given the rising proportion of patients surviving cancer due to improved therapeutic protocols, it is an issue of growing importance. Hence, the efforts to preserve fertility have motivated researchers to develop options for the paediatric population facing fertility-threatening cancer therapies. In prepubertal boys who do not yet produce sperm, cryo-banking of testicular tissue containing spermatogonial stem cells (SSCs) is the only viable option for future fertility preservati...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences.
This study aims to increase the knowledge about the characteristics of cutaneous melanoma in Argentina, their association with the risk of having Breslow ≥1 mm and mortality trends for the period 2002-2017. Patients and methods: Descriptive statistics and regression analyses were done for 10.199 cases within the Argentine Melanoma Registry in the period 2002-2018. Trends in age-standardised mortality rates (ASMR) were analysed using the Join point Regression Model. Results: Cases showed lesions mainly located in males' trunk (37%) and in females' lower limbs (29%). The level of invasion was higher in males who a...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer care in times of conflict: cross border care in Pakistan of patients from Afghanistan.
Authors: Yusuf MA, Hussain SF, Sultan F, Badar F, Sullivan R Abstract Armed conflict in Afghanistan has continued for close to 40 years and has devastated its health infrastructure. The lack of a cancer care infrastructure has meant that many Afghans seek cancer care in neighbouring countries, like Pakistan. There remains a significant lack of empirical data on the new therapeutic geographies of cancer in contemporary conflicts. This retrospective single centre study explores the therapeutic and clinical geographies of Afghan cancer patients who were treated at the Shaukat Khanum Memorial Cancer Hospital and Resear...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Sequential chemotherapy followed by radical thoracic radiotherapy (50 Gy in 25 fractions) in limited stage small cell lung cancer.
Conclusions: Most of the literature reporting outcome from sequential treatment in LS-SCLC is old and used a variety of radiotherapy regimens. Our data shows inferior outcomes to the gold standard concurrent chemoradiotherapy but support its usage in less fit patients with reasonable outcome observed. PMID: 32256702 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Impact of HER2 status in resected gastric or gastroesophageal junction adenocarcinoma in a Western population.
Authors: Lago NM, Villar MV, Ponte RV, Nallib IA, Alvarez JJC, López JRA, López RL, Iruegas MEP Abstract Background: HER2 status is a predictive biomarker of response to trastuzumab in advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, there is relatively little known about the role of HER2 in resected gastric or GEJ adenocarcinoma in the Western population. Methods: Retrospective, observational, single centre study of patients with gastric or GEJ adenocarcinoma undergoing surgery with curative intent between January 2007 and June 2014 in the University Hospital Complex o...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Prospective study to assess the survival outcomes of planned irradiation of ipsilateral subventricular and periventricular zones in glioblastoma.
Conclusion: Planned irradiation of potential stem cell niches in the ipsilateral cerebral hemisphere did not result in improved survival as suggested by retrospective studies. Doses to contralateral or bilateral PVZ or SVZ also did not influence survival. PMID: 32256704 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence.
Conclusion: The COVID-19 pandemic has led to challenging decision-making about treatment of critically unwell patients. Low-dose prednisolone and tacrolimus may have beneficial impacts on COVID-19. The mycophenolate mofetil picture is less clear, with conflicting data from pre-clinical studies. There is no definitive evidence that specific cytotoxic drugs, low-dose methotrexate for auto-immune disease, NSAIDs, JAK kinase inhibitors or anti-TNFα agents are contraindicated. There is clear evidence that IL-6 peak levels are associated with severity of pulmonary complications. PMID: 32256705 [PubMed - as supplied by ...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting?
Authors: Russell B, Moss C, Rigg A, Van Hemelrijck M Abstract Given the current SARS-CoV-2 (COVID-19) pandemic, the availability of reliable information for clinicians and patients is paramount. There have been a number of reports stating that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. Therefore, this review aimed to collate information available in published articles to identify any evidence behind these claims with the aim of advising clinicians on how best to treat patients. This review found no published evidence for or against the use of NSA...
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The emerging role of radiation therapists in the contouring of organs at risk in radiotherapy: analysis of inter-observer variability with radiation oncologists for the chest and upper abdomen.
Authors: Arculeo S, Miglietta E, Nava F, Morra A, Leonardi MC, Comi S, Ciardo D, Fiore MS, Gerardi MA, Pepa M, Gugliandolo SG, Livi L, Orecchia R, Jereczek-Fossa BA, Dicuonzo S Abstract Aims: To compare the contouring of organs at risk (OAR) between a clinical specialist radiation therapist (CSRT) and radiation oncologists (ROs) with different levels of expertise (senior-SRO, junior-JRO, fellow-FRO). Methods: On ten planning computed tomography (CT) image sets of patients undergoing breast radiotherapy (RT), the observers independently contoured the contralateral breast, heart, left anterior descending artery (...
Source: Ecancermedicalscience - March 12, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research