Health resource utilisation by patients with neuroendocrine tumours with or without carcinoid heart disease: a multinational study.
Authors: Tanaka H, Uema D, Rego JFM, Weschenfelder RF, D'Agustini N, Filho DRR, O'Connor JM, Luca R, Nuñez JER, de Barros E Silva MJ, Riechelmann RP Abstract Background: Carcinoid heart disease (CHD) is a rare and severe complication from carcinoid syndrome which may be associated with high health resource utilisation (HRU). We aimed to compare HRU between patients with and without CHD. Methods: Multicentre retrospective study of 137 consecutive patients with neuroendocrine tumours (NET) and elevated urinary 5-hydroxyindoleacetic acid treated in seven large hospitals in Latin America. We used the chi-squ...
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Trends in the crossover of patients in phase III oncology clinical trials in the USA.
Conclusions: The proportion of identified clinical trials with crossover compared to those without is extremely small. Crossover in clinical trials studying cancer treatment does not appear to be a widespread practice. Even though statistical approaches to mitigate confounding exist, crossover can still skew accurate reporting of the impact of experimental therapies on overall survival. PMID: 33343701 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Histological subtype of gastric adenocarcinoma: two cases of mixed fundic and pyloric mucosa-type adenocarcinoma.
Authors: Takahashi H, Yao K, Ueo T, Nagahama T, Imamura K, Chuman K, Tanabe H, Iwashita A, Ueki T Abstract Adenocarcinomas with differentiation towards fundic or pyloric glands are rare histological subtypes. We herein describe two cases of new histological subtypes: mixed fundic and pyloric mucosa-type adenocarcinoma detected in Helicobacter pylori uninfected patients. The first patient was a woman in her 40s. A glossy, reddish, nodular lesion with a flat elevated whitish area was detected at the gastric fundus. When the nodular lesion was visualised with magnifying narrow-band imaging (M-NBI), an absent microvasc...
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer care and COVID-19: tailoring recommendations for the African radiation oncology context.
Authors: Kochbati L, Vanderpuye V, Moujahed R, Rejeb MB, Naimi Z, Olasinde T Abstract Africa is the second most populous continent after Asia comprising 54 countries. Given the healthcare system deficiencies in Africa, the impact of the COVID-19 pandemic was expected to be disastrous. The first case of COVID-19 on the continent was reported in Egypt on 14 February 2020. By 13 May, cases had been reported in all 54 countries. Several practice guidelines specific to radiation oncology departments have been published, including prioritisation criteria for postponing radiotherapy, continuation of treatment, hypofractio...
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Prognostic factors and outcomes of nonseminomatous germ cell tumours of testis-experience from a tertiary cancer centre in India.
We report the outcomes of patients with nonseminomatous germ cell tumours of testis treated at a tertiary cancer centre in South India over a period of 10 years. Patients with a histopathological diagnosis of nonseminomatous germ cell tumours of the testis from 1 January 2006 to 31 December 2016 were included in the study. Patient demographics, tumour characteristics and treatment details were retrieved from case records. Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression model was used to analyse the prognostic factors. One hundred and nineteen patients with ...
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

A review of barriers and facilitators to mammography in Asian women.
Conclusion: Knowing the barriers and facilitators to access mammography is the first step in the development of a successful screening program. Awareness and various personal, professional and social factors have emerged as the major barriers to access to mammography in most Asian countries. PMID: 33343705 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Impact of COVID-19 on oncology education and training in India.
Authors: Rao SR, Gurram L, K VB, Lewis S Abstract Coronavirus disease-19 was declared a pandemic and global emergency in March 2020. Oncology education and training has been on a rollercoaster ride ever since. Despite major changes in the work environment, training for postgraduates in oncology has continued with various challenges. We discuss the changes brought about in education, training and assessments for oncology residents. PMID: 33343706 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Research on lung cancer and its funding, 2004-2018.
We examined the amount, types, geographical origins and funding of research on lung cancer as revealed by papers in the Web of Science over the 15 years, 2004-2018. The annual number of lung cancer research papers increased over the study period from 2,157 to 8,202, but as a percentage of all biomedical research in Western Europe and North America they only accounted for one-eighth of the percentage of the disease burden. Lung cancer increased its share of cancer research from 4.4% to 6.5%, mainly because of the greatly expanded output from China in 2014-2018 which published almost one-third of the world's total on a fract...
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities.
Authors: Azzam P, Mroueh M, Francis M, Daher AA, Zeidan YH Abstract Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Despite the substantial advances in RT contouring and dosage delivery, patients suffer from various radiation-induced complications, among which are toxicities to the nervous tissues in the head and neck area. Radiation-mediated neuropathies manifest as a result of increased oxidative stress-mediated apoptosis, neuroi...
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer and COVID-19: economic impact on households in Southeast Asia.
Authors: Kong YC, Sakti VV, Sullivan R, Bhoo-Pathy N Abstract The ongoing COVID-19 pandemic may worsen the existing financial vulnerabilities of cancer survivors who may be experiencing a double financial hit, both from cancer-induced financial toxicity as well as economic strains arising from loss of income and prolonged unemployment following the pandemic. The impact of the pandemic is likely to be more pronounced on cancer survivors living in resource-limited settings, such as in Southeast Asia. As health care systems in the region try to streamline resources and accommodate the influx of patients from COVID-19,...
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

A case of adrenocortical oncocytic carcinoma arising in ectopic adrenal tissue: a multidisciplinary diagnostic challenge.
We report a case of a 26-year-old female who presented with vague left-sided abdominal pain and a large left retroperitoneal mass. She underwent exploratory laparotomy and resection of the mass and was diagnosed with extra-adrenal adrenocortical oncocytic carcinoma. PMID: 33281927 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Multidisciplinary brain metastasis clinic: is it effective and worthwhile?
Conclusion: Multidisciplinary management of difficult brain metastasis cases in specialised clinics has a significant impact on treatment decisions. PMID: 33281928 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Adjuvant radiochemotherapy in locally advanced gastric cancer: from evidence to daily clinical practice in a single institution.
Conclusion: In patients with locoregionally advanced gastric cancer treated with curative intent with surgery and adjuvant radiochemotherapy, the overall 5-year survival reported from local clinical practice is similar to that reported in randomised series and supports its use as an effective treatment for this type of patients in our country. PMID: 33281929 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Adherence to triage among women with HPV-positive self-collection: a study in a middle-low income population in Argentina.
We reported odds ratios, 95% confidence intervals and p-value of 0.05, which was considered the threshold for p-values). Results: We analysed data of 2,389 HPV+ women. The overall adherence to triage at 18 months was 42.9%. The percentage of women completing cytology triage within the recommended timeframe of 120 days was lower (25.2%). Women with the record of a previous Pap-based screening had 1.86 times the odds of having a triage compared to women without a record of a previous Pap-based screening (95% CI: 1.64-2.64, p
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Gastrointestinal stromal tumour of the rectum and intestinal obstruction: case report.
We report the case of a 75-year-old female patient with a big tumour in the lower rectum with intestinal obstruction and lower gastrointestinal bleeding history who underwent a tumour biopsy under laparotomy and end colostomy at another hospital in Peru. She came to our institution for clinical evaluation with a pathology result of a rectal gastrointestinal stromal tumour. An extra elevator abdominoperineal resection was performed with tumour-free margins. The histology confirmed a high-grade (G2) rectal gastrointestinal stromal tumour with a mitotic index of 27/50. DOC-1 (+) and CD117 (+) in immunohistochemistry. Genomic ...
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Experiences and challenges in the management of pregnancy-associated breast cancer at the Korle Bu Teaching Hospital: a review of four cases.
Authors: Nsaful J, Vanderpuye V, Scott AA, Dedey F, Oppong SA, Appiah-Danquah R, Damale N, Fenu B, Wordui T, Yarney J, Clegg-Lamptey JN Abstract Breast cancer is the commonest female cancer worldwide and the most common malignancy during pregnancy. The current management of breast cancer is based on patient and tumour characteristics, preferences and disease stage. In pregnancy-associated breast cancer, the gestational age influences treatment options. Sequencing of therapies is guided by safe imaging options, timing of delivery and prognosis. Systemic therapy options in the neoadjuvant, adjuvant and palliative set...
Source: Ecancermedicalscience - December 9, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Management of non-invasive tumours, benign tumours and breast cancer during the COVID-19 pandemic: recommendations based on a Latin American survey.
Conclusion: The management of patients with BC presents unique challenges during the current world health situation produced by COVID-19 pandemic. Breast care specialists (surgical oncologists, breast care clinicians, clinical oncologists, radiation oncologists and radiologists) from 18 countries in Central and South America submitted through their responses and recommendations for the treatment of BC during the COVID-19 pandemic. PMID: 33209106 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Prostate cancer clinical characteristics and outcomes in Central Sudan.
Conclusion: The findings suggest that Sudanese men who are living in Central Sudan present at diagnosis with large tumours at late stages, and high PSA levels and Gleason scores. Improving awareness and building up the treatment capacity are key to achieving better outcomes. PMID: 33209107 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Axillary surgical approach in metastatic breast cancer patients: a systematic review and meta-analysis.
Authors: Lisboa A FCAP, Silva RB, de Andrade KRC, Veras LPC, Figueiredo ACMG, Pereira MG Abstract A systematic review and meta-analysis were conducted to evaluate the benefit of an axillary surgical approach on overall survival and secondarily of breast surgery amongst patients with metastatic breast cancer which is considered to be an incurable disease. However, an axillary surgical approach showed no association with overall survival in patients with metastatic breast cancer. The true impact of locoregional therapies on long-term outcomes remains unknown, and randomised clinical trials are needed. PMID: 33209...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Can post-treatment oral cancer patients' concerns reflect their cancer characteristics, HRQoL, psychological distress level and satisfaction with consultation?
This study aimed to determine post-treatment oral cancer patients' concerns and its relationship with patients' clinical characteristics, health-related quality of life (HRQoL), psychological distress and patient satisfaction with the follow-up consultation. Methods: A total of 85 oral cancer patients were recruited from a three-armed pragmatic RCT study on the patient concerns inventory for head and neck cancer (PCI-H&N), which was conducted at six hospital-based oral maxillofacial specialist clinics throughout Malaysia. Malaysians aged 18 years and above and on follow-ups from 1 month to 5 years or more were elig...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Subtypes of minimal residual disease and outcome for stage II colon cancer treated by surgery alone.
Conclusions: MRD subtypes define relapse patterns and may be useful to define the risk of relapse in stage II CC patients, in which patients may benefit or not from additional therapy and warrants further studies with a larger number of patients. PMID: 33209110 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Synchronous invasive ductal carcinoma of the breast and clear cell renal carcinoma with rare presentation and behaviour: a case report with a literature review.
Authors: Hassan MA, Fakhrudiin N, Farhat F Abstract The presence of two or more primary tumours is a relatively uncommon phenomenon. Recently with the improvement of diagnostic modalities, such cases are increasingly reported in the literature. This paper presents a rare case of synchronous breast and renal tumour with unusual features including RCC metastasis to the duodenum and stomach, rapid recurrence of the tumour at the nephrectomy site, rapid renal cell carcinoma growth rate and the rare presence of syncytial-type giant cells in the renal cell tumour. PMID: 33209111 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Lack of association between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and pain improvement in patients with oral cancer.
Conclusions: When compared to no treatment, ARBs and ACEis are not associated with significant analgesic effect or decreased inflammatory scores (NLR, PLR and MLR). PMID: 33209112 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Recurrent cervical cancer treated with palliative chemotherapy: real-world outcome.
Authors: Mailankody S, Dhanushkodi M, Ganesan TS, Radhakrishnan V, Christopher V, Ganesharajah S, Sagar TG Abstract Introduction: Cervical cancer is the third most common cancer in India. There is limited data on the treatment of relapsed cervical cancer from India; therefore, we report the outcomes of patients with recurrent cervical cancer who were treated with palliative chemotherapy (CT). Materials and methods: This was a retrospective study of patients with recurrent cervical cancer who received palliative CT from January 2012 to December 2016. The demographic details, clinical profile and survival outcome...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review.
Conclusion: Breast lesions from extramammary primary often pose a diagnostic challenge, since a breast nodule can be the first and often the only presentation of the disease. However, differentiating between primary and secondary NEN breast lesions is essential, owing to different clinical management and prognosis. PMID: 33209114 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Impact of the 8th edition of the AJCC TNM classification on gastric cancer prognosis-study of a western cohort.
Conclusion: The 8th edition of the AJCC TNM classification allows for a better prognostic refinement, namely in the new stage III groups after the stratification of lymph node disease in N3a and N3b. Factors that evaluate the biological behaviour of the disease remain excluded from this edition, such as extracapsular extension, which had a prognostic impact in our series. PMID: 33209115 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Tamoxifen exposure in pregnancy after synchronous breast and thyroid cancer.
In conclusion, oncologists should be aware of breast and thyroid cancer co-occurrence and examinations should be conducted together in diagnosis and follow-up. Also, pregnancy is feasible and can be considered after synchronous breast and thyroid cancer diagnosis. Physicians need to emphasise the use of barrier contraceptives to patients undergoing endocrine therapy. However, the optimum timing for pregnancy after breast cancer and the safety of endocrine therapy interruption in hormonal-positive patients should be discussed and managed by a multidisciplinary team. PMID: 33209116 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Brazilian Group of Gastrointestinal Tumours' consensus guidelines for the management of gastric cancer.
Authors: Peixoto RD, Rocha-Filho DR, Weschenfelder RF, Rego JFM, Riechelmann R, Coutinho AK, Fernandes GS, Jacome AA, Andrade AC, Murad AM, Mello CAL, Miguel DSCG, Gomes DBD, Racy DJ, Moraes ED, Akaishi EH, Carvalho ES, Mello ES, Filho FM, Coimbra FJF, Capareli FC, Arruda FF, Vieira FMAC, Takeda FR, Cotti GCC, Pereira GLS, Paulo GA, Ribeiro HSC, Lourenco LG, Crosara M, Toneto MG, Oliveira MB, de Lourdes Oliveira M, Begnami MD, Forones NM, Yagi O, Ashton-Prolla P, Aguillar PB, Amaral PCG, Hoff PM, Araujo RLC, Filho RPDP, Gansl RC, Gil RA, Pfiffer TEF, Souza T, Jr UR, Jesus VHF, Jr WLC, Prolla G Abstract Gastric canc...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Patients' experience with MRI-guided in-bore biopsy versus TRUS-guided biopsy in prostate cancer: a pilot study.
Conclusion: These preliminary results indicate that the MRGB is likely to be more tolerable and acceptable to patients than TRUS-Bx. PMID: 33209118 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Updated general recommendations in cancer management during the COVID-19 pandemic in the Philippines.
The objective of this update is to provide answers to the questions pertaining to the diagnostic testing of SARS-CoV-2 for both cancer patients and healthcare professionals caring for cancer patients, as well as the recommended protective measures and practices that may be instituted in healthcare facilities. PMID: 33209119 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Mapping breast cancer journal publications in conflict settings in the MENA region: a scoping review.
Conclusion: This scoping review has identified key areas in breast cancer research that lack significant research activity in conflict MENA settings. These areas, including but are not limited to palliative care, mental health, and education, can be prioritised and developed through regional collaboration and contextualised capacity strengthening initiatives. PMID: 33209120 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The prognostic influence of tumour budding in Western patients with stage II colorectal cancer.
Conclusion: In this series of Western patients, TB grade was associated with perineural invasion and increased risk of disease relapse. PMID: 33209121 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis.
Authors: Thinggaard AB, Liposits G, Fristrup N Abstract Chronic neutropenia is a rare but important challenge with substantial clinical implications for patients receiving antineoplastic treatment. Treatment-induced neutropenia is a well-known adverse event during chemotherapy and some targeted treatments. Guidelines for administering chemotherapy are rather strict to protect the patient from severe and life-threatening complications. Consequently, patients with chronic neutropenia may receive suboptimal antineoplastic treatment. Autoimmune neutropenia or chronic idiopathic neutropenia (CIN) may affect the antineop...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Antibiotics, cancer risk and oncologic treatment efficacy: a practical review of the literature.
Authors: Martins Lopes MS, Machado LM, Ismael Amaral Silva PA, Tome Uchiyama AA, Yen CT, Ricardo ED, Mutao TS, Pimenta JR, Shimba DS, Hanriot RM, Peixoto RD Abstract Antibiotics have been extensively used to treat infectious diseases over the past century and have largely contributed to increased life expectancy over time. However, antibiotic use can impose profound and protracted changes to the diversity of the microbial ecosystem, affecting the composition of up to 30% of the bacterial species in the gut microbiome. By modifying human microbiota composition, antibiotics alter the action of several oncologic drugs...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.
Authors: Usman M, Hameed Y, Ahmad M Abstract The role of human papillomavirus (HPV) in human colorectal cancer (CRC) has already been widely investigated worldwide with conflicting results. Although researchers have tried to establish the link between HPV and CRC through a statistical meta-analysis of the previous studies associating HPV with CRC, they failed to establish a more reliable link due to the shortcomings of the statistical meta-analysis. In the present study, we identified population-wide studies relating HPV with CRC through the PubMed search engine. Then, we examined the available data of HPV prevalen...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Highlights from the 4th PALOP-AORTIC Conference on Cancer, 29-31 July 2020, Luanda, Angola.
Authors: Santos LL, Miguel F, Túlsidas S, Spencer HB, Rodrigues B, Lopes LV, Freitas H Abstract The 4th Países Africanos de Língua Oficial Portuguesa (PALOP)-African Organisation for Research and Training in Cancer (AORTIC) Conference on Cancer was held in July 2020 in Luanda, Angola, under the theme: 'Training to better care'. It was hosted by the Ministry of Health of Angola and AORTIC. It was held virtually using an online platform. The PALOP organisation comprises Lusophone African countries. The conference brought together 360 delegates from 12 countries. Key themes covered during the conf...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Lymphopenia during chemoradiation-foe or friend.
Conclusion: The occurrence of severe lymphopenia was not significantly associated with the outcomes. Gender is the only risk factor significantly linked to severe lymphopenia. PMID: 33144877 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

COVID-19 and haematology services in a cancer centre from a middle-income country: adapting service delivery, balancing the known and unknown during the pandemic.
Authors: Radhakrishnan VS, Nair RKS, Goel G, Ramanan V, Chandy M, Nair R Abstract The COVID-19 pandemic has caused major disruptions in multiple spheres of healthcare delivery in the world. Developing nations have had to tackle this unanticipated crisis in the midst of various other healthcare delivery issues and resource constraints. As a tertiary level cancer care provider located in an eastern Indian city, a COVID-19 hotspot, we share our experience from the perspective of haematology and haematopoietic stem cell transplantation (HSCT) services. The primary challenges related to infection control included infect...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cervical cancer: a meta-analysis, therapy and future of nanomedicine.
Authors: Venkatas J, Singh M Abstract Cervical cancer is one of the leading causes of female death, with an annual mortality rate exceeding 200,000 in developing communities. Despite the past decade bearing witness to a reduction in cervical cancer cases throughout developed countries, the prevalence in developing countries continues to rapidly rise. The increase in cervical cancer cases is attributed to the lack of financial resources and the unavoidable risk factors of the disease. Traditional means of anticancer therapy are compromised by reduced drug potency, non-specificity, negative side effects and the devel...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Dyspnoea at rest predictor of increased in-hospital mortality in metastatic cancer patients undergoing emergent surgery in United States.
In this study, we decided to analyse post-operative outcomes to understand if dyspnoea is a significant prognostic predictor of in-hospital mortality in patients with stage IV cancer who underwent emergent surgery in the United States. Methods: We performed a search of the 2014 National Surgical Quality Improvement Program database (NSQIP) for patients with a diagnosis of malignancy (ICD-9 Codes 145.00-200.00). Cases were divided into two groups: metastatic cancer and non-metastatic cancer. Demographical data including preoperative, intraoperative and postoperative factors, as well as data regarding complications and c...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Metronomic oral vinorelbine in patients with advanced non-small cell lung cancer progressing after nivolumab immunotherapy: a retrospective analysis.
Conclusion: Oral metronomic VNR appears to be active and safe in patients with metastatic NSCLC in progression after first-line chemotherapy and second-line immunotherapy. The results reported, although from a limited sample, may suggest its use for long-term stabilisation of the disease with good patient compliance. PMID: 33144881 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Screening of cytochrome 4Z1 expression in human non-neoplastic, pre-neoplastic and neoplastic tissues.
Conclusion: These findings greatly support future plans for the use of CYP4Z1 as a biomarker or target for anti-cancer drugs. However, large-scale validation studies are needed to better delineate the potential use of CYP4Z1 for therapeutic purposes. PMID: 33144882 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

New journal authorship criteria: how ecancermedicalscience is supporting authors and readers from underserved settings.
Authors: Cazap E, Sullivan R, Foxall K Abstract In order to reduce the increasing cancer burden in Lower and Middle Income Countries (LMICs), oncology journals must support authors from underserved settings to become fully involved in the global publication system, without facing barriers to publishing their research such as geographical bias and lack of funding. ecancermedicalscience's goal has always been to publish high-quality research which contributes towards narrowing the gap between those who have access to adequate cancer prevention, treatment and care and those who do not. The time is now right for the jo...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fundamentals to clinical application of nanoparticles in cancer immunotherapy and radiotherapy.
Authors: Selvaraja VK, Gudipudi DK Abstract Cancer immunotherapy has made rapid progress over the past decade leading to high enthusiasm and interest worldwide. Codelivery of immunomodulators with chemotherapeutic agents and radioisotopes has been shown to elicit a strong and sustained immune response in animal models. Despite showing promising results in metastatic and recurrent cancers, the utilisation of immunotherapy in clinical settings has been limited owing to uncertainties in elicited immune response and occurrence of immune-related adverse events. These uncertainties can be overcome with the help of nanopa...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer treatment during the COVID-19 pandemic in the Kurdistan Region of northern Iraq.
Authors: Nidhamalddin SJ, Hasan RO, Abubakr GO Abstract The announcement of the COVID-19 pandemic by the World Health Organisation in March 2020 and the spread of coronavirus in most parts of the world, including Iraq, have posed severe challenges to the management of cancer patients both psychologically and logistically. Special experts at Hiwa Cancer Hospital, Iraq, took serious action aimed to decrease and prevent the spread of the virus among cancer patients while maintaining standard treatment protocols through compiling expert consensus, focusing on the prevention of COVID-19 and cancer patient management. ...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Radiotherapy waiting time in Northern Nigeria: experience from a resource-limited setting.
Conclusion: The study shows that waiting time for radiotherapy in Nigeria was generally longer than what is recommended internationally. This reflects the need to improve access to radiotherapy in order to improve cancer treatment outcomes in resource-limited settings. PMID: 33082847 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer disease progression and death during the COVID-19 pandemic: a multidisciplinary analysis for the Peruvian setting.
Authors: Astigueta-Pérez J, Abad-Licham M, Chávez-Chirinos C, Beraun-Milla L, Lachos-Dávila A, Diaz-Pérez E, Portugal-Valdivia K, Castañeda PP, Alférez IP, Mezones-Holguín E Abstract Since the COVID-19 pandemic began in China in late 2019, infection from the SARS-CoV-2 virus has spread virtually worldwide. This infection has adversely affected several countries; governments have outlined a series of political measures aimed to preserve the health and safety of their populations. In Peru, most actions have prioritised COVID-19 attention, with a subsequent gap in the h...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition.
Authors: Saha A, Anirvan P Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic has affected millions worldwide and has been found to cause severe disease in patients with underlying comorbidities. In patients with known malignancies, in addition to constraints in routine healthcare, the risk of being susceptible to developing severe forms of the disease is of grave concern. While follow-up studies on survivors of the severe acute respiratory syndrome (SARS) 2003 outbreak revealed increased susceptibility to infections, tumours and cardiovascular abnormalities, recent studies implicating angiopoietin 2...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

SARS-CoV-2 testing for asymptomatic adult cancer patients before initiating systemic treatments: a systematic review.
Conclusion: There is a lack of studies which directly address COVID-19 testing of asymptomatic patients before treatment. Our systematic review showed that most of the published data favours routine test for SARS-CoV-2 before initiating systemic treatment but failed to identify a good level of evidence to support these recommendations. Based upon this review, we proposed local recommendations at our centre. Each institution should consider the pros and cons of testing asymptomatic patients, evaluating accessibility to testing resources and local epidemiology. PMID: 33082850 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The care of older cancer patients in the United Kingdom.
Authors: Gomes F, Lewis A, Morris R, Parks R, Kalsi T, Babic-Illamn G, Baxter M, Colquhoun K, Rodgers L, Smith E, Greystoke A, Bayman N, Cree A, Ng C, de Liguori Carino N, Basile S, Moore J, Merchant Z, Swinson D, Parbhoo A, Jones R, Davies E, Danson SJ, Young R, Morgan J, Wyld L, Corrie PG, Doherty GJ, Crawford K, Wright J, Reed M, Ugolini F, Lind M, Cheung KL, Harari D, Simcock R Abstract The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients inc...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research