Management of non-invasive tumours, benign tumours and breast cancer during the COVID-19 pandemic: recommendations based on a Latin American survey.
Conclusion: The management of patients with BC presents unique challenges during the current world health situation produced by COVID-19 pandemic. Breast care specialists (surgical oncologists, breast care clinicians, clinical oncologists, radiation oncologists and radiologists) from 18 countries in Central and South America submitted through their responses and recommendations for the treatment of BC during the COVID-19 pandemic. PMID: 33209106 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Prostate cancer clinical characteristics and outcomes in Central Sudan.
Conclusion: The findings suggest that Sudanese men who are living in Central Sudan present at diagnosis with large tumours at late stages, and high PSA levels and Gleason scores. Improving awareness and building up the treatment capacity are key to achieving better outcomes. PMID: 33209107 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Axillary surgical approach in metastatic breast cancer patients: a systematic review and meta-analysis.
Authors: Lisboa A FCAP, Silva RB, de Andrade KRC, Veras LPC, Figueiredo ACMG, Pereira MG Abstract A systematic review and meta-analysis were conducted to evaluate the benefit of an axillary surgical approach on overall survival and secondarily of breast surgery amongst patients with metastatic breast cancer which is considered to be an incurable disease. However, an axillary surgical approach showed no association with overall survival in patients with metastatic breast cancer. The true impact of locoregional therapies on long-term outcomes remains unknown, and randomised clinical trials are needed. PMID: 33209...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Can post-treatment oral cancer patients' concerns reflect their cancer characteristics, HRQoL, psychological distress level and satisfaction with consultation?
This study aimed to determine post-treatment oral cancer patients' concerns and its relationship with patients' clinical characteristics, health-related quality of life (HRQoL), psychological distress and patient satisfaction with the follow-up consultation. Methods: A total of 85 oral cancer patients were recruited from a three-armed pragmatic RCT study on the patient concerns inventory for head and neck cancer (PCI-H&N), which was conducted at six hospital-based oral maxillofacial specialist clinics throughout Malaysia. Malaysians aged 18 years and above and on follow-ups from 1 month to 5 years or more were elig...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Subtypes of minimal residual disease and outcome for stage II colon cancer treated by surgery alone.
Conclusions: MRD subtypes define relapse patterns and may be useful to define the risk of relapse in stage II CC patients, in which patients may benefit or not from additional therapy and warrants further studies with a larger number of patients. PMID: 33209110 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Synchronous invasive ductal carcinoma of the breast and clear cell renal carcinoma with rare presentation and behaviour: a case report with a literature review.
Authors: Hassan MA, Fakhrudiin N, Farhat F Abstract The presence of two or more primary tumours is a relatively uncommon phenomenon. Recently with the improvement of diagnostic modalities, such cases are increasingly reported in the literature. This paper presents a rare case of synchronous breast and renal tumour with unusual features including RCC metastasis to the duodenum and stomach, rapid recurrence of the tumour at the nephrectomy site, rapid renal cell carcinoma growth rate and the rare presence of syncytial-type giant cells in the renal cell tumour. PMID: 33209111 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Lack of association between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and pain improvement in patients with oral cancer.
Conclusions: When compared to no treatment, ARBs and ACEis are not associated with significant analgesic effect or decreased inflammatory scores (NLR, PLR and MLR). PMID: 33209112 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Recurrent cervical cancer treated with palliative chemotherapy: real-world outcome.
Authors: Mailankody S, Dhanushkodi M, Ganesan TS, Radhakrishnan V, Christopher V, Ganesharajah S, Sagar TG Abstract Introduction: Cervical cancer is the third most common cancer in India. There is limited data on the treatment of relapsed cervical cancer from India; therefore, we report the outcomes of patients with recurrent cervical cancer who were treated with palliative chemotherapy (CT). Materials and methods: This was a retrospective study of patients with recurrent cervical cancer who received palliative CT from January 2012 to December 2016. The demographic details, clinical profile and survival outcome...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review.
Conclusion: Breast lesions from extramammary primary often pose a diagnostic challenge, since a breast nodule can be the first and often the only presentation of the disease. However, differentiating between primary and secondary NEN breast lesions is essential, owing to different clinical management and prognosis. PMID: 33209114 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Impact of the 8th edition of the AJCC TNM classification on gastric cancer prognosis-study of a western cohort.
Conclusion: The 8th edition of the AJCC TNM classification allows for a better prognostic refinement, namely in the new stage III groups after the stratification of lymph node disease in N3a and N3b. Factors that evaluate the biological behaviour of the disease remain excluded from this edition, such as extracapsular extension, which had a prognostic impact in our series. PMID: 33209115 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Tamoxifen exposure in pregnancy after synchronous breast and thyroid cancer.
In conclusion, oncologists should be aware of breast and thyroid cancer co-occurrence and examinations should be conducted together in diagnosis and follow-up. Also, pregnancy is feasible and can be considered after synchronous breast and thyroid cancer diagnosis. Physicians need to emphasise the use of barrier contraceptives to patients undergoing endocrine therapy. However, the optimum timing for pregnancy after breast cancer and the safety of endocrine therapy interruption in hormonal-positive patients should be discussed and managed by a multidisciplinary team. PMID: 33209116 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Brazilian Group of Gastrointestinal Tumours' consensus guidelines for the management of gastric cancer.
Authors: Peixoto RD, Rocha-Filho DR, Weschenfelder RF, Rego JFM, Riechelmann R, Coutinho AK, Fernandes GS, Jacome AA, Andrade AC, Murad AM, Mello CAL, Miguel DSCG, Gomes DBD, Racy DJ, Moraes ED, Akaishi EH, Carvalho ES, Mello ES, Filho FM, Coimbra FJF, Capareli FC, Arruda FF, Vieira FMAC, Takeda FR, Cotti GCC, Pereira GLS, Paulo GA, Ribeiro HSC, Lourenco LG, Crosara M, Toneto MG, Oliveira MB, de Lourdes Oliveira M, Begnami MD, Forones NM, Yagi O, Ashton-Prolla P, Aguillar PB, Amaral PCG, Hoff PM, Araujo RLC, Filho RPDP, Gansl RC, Gil RA, Pfiffer TEF, Souza T, Jr UR, Jesus VHF, Jr WLC, Prolla G Abstract Gastric canc...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Patients' experience with MRI-guided in-bore biopsy versus TRUS-guided biopsy in prostate cancer: a pilot study.
Conclusion: These preliminary results indicate that the MRGB is likely to be more tolerable and acceptable to patients than TRUS-Bx. PMID: 33209118 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Updated general recommendations in cancer management during the COVID-19 pandemic in the Philippines.
The objective of this update is to provide answers to the questions pertaining to the diagnostic testing of SARS-CoV-2 for both cancer patients and healthcare professionals caring for cancer patients, as well as the recommended protective measures and practices that may be instituted in healthcare facilities. PMID: 33209119 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Mapping breast cancer journal publications in conflict settings in the MENA region: a scoping review.
Conclusion: This scoping review has identified key areas in breast cancer research that lack significant research activity in conflict MENA settings. These areas, including but are not limited to palliative care, mental health, and education, can be prioritised and developed through regional collaboration and contextualised capacity strengthening initiatives. PMID: 33209120 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The prognostic influence of tumour budding in Western patients with stage II colorectal cancer.
Conclusion: In this series of Western patients, TB grade was associated with perineural invasion and increased risk of disease relapse. PMID: 33209121 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis.
Authors: Thinggaard AB, Liposits G, Fristrup N Abstract Chronic neutropenia is a rare but important challenge with substantial clinical implications for patients receiving antineoplastic treatment. Treatment-induced neutropenia is a well-known adverse event during chemotherapy and some targeted treatments. Guidelines for administering chemotherapy are rather strict to protect the patient from severe and life-threatening complications. Consequently, patients with chronic neutropenia may receive suboptimal antineoplastic treatment. Autoimmune neutropenia or chronic idiopathic neutropenia (CIN) may affect the antineop...
Source: Ecancermedicalscience - November 20, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Antibiotics, cancer risk and oncologic treatment efficacy: a practical review of the literature.
Authors: Martins Lopes MS, Machado LM, Ismael Amaral Silva PA, Tome Uchiyama AA, Yen CT, Ricardo ED, Mutao TS, Pimenta JR, Shimba DS, Hanriot RM, Peixoto RD Abstract Antibiotics have been extensively used to treat infectious diseases over the past century and have largely contributed to increased life expectancy over time. However, antibiotic use can impose profound and protracted changes to the diversity of the microbial ecosystem, affecting the composition of up to 30% of the bacterial species in the gut microbiome. By modifying human microbiota composition, antibiotics alter the action of several oncologic drugs...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.
Authors: Usman M, Hameed Y, Ahmad M Abstract The role of human papillomavirus (HPV) in human colorectal cancer (CRC) has already been widely investigated worldwide with conflicting results. Although researchers have tried to establish the link between HPV and CRC through a statistical meta-analysis of the previous studies associating HPV with CRC, they failed to establish a more reliable link due to the shortcomings of the statistical meta-analysis. In the present study, we identified population-wide studies relating HPV with CRC through the PubMed search engine. Then, we examined the available data of HPV prevalen...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Highlights from the 4th PALOP-AORTIC Conference on Cancer, 29-31 July 2020, Luanda, Angola.
Authors: Santos LL, Miguel F, Túlsidas S, Spencer HB, Rodrigues B, Lopes LV, Freitas H Abstract The 4th Países Africanos de Língua Oficial Portuguesa (PALOP)-African Organisation for Research and Training in Cancer (AORTIC) Conference on Cancer was held in July 2020 in Luanda, Angola, under the theme: 'Training to better care'. It was hosted by the Ministry of Health of Angola and AORTIC. It was held virtually using an online platform. The PALOP organisation comprises Lusophone African countries. The conference brought together 360 delegates from 12 countries. Key themes covered during the conf...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Lymphopenia during chemoradiation-foe or friend.
Conclusion: The occurrence of severe lymphopenia was not significantly associated with the outcomes. Gender is the only risk factor significantly linked to severe lymphopenia. PMID: 33144877 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

COVID-19 and haematology services in a cancer centre from a middle-income country: adapting service delivery, balancing the known and unknown during the pandemic.
Authors: Radhakrishnan VS, Nair RKS, Goel G, Ramanan V, Chandy M, Nair R Abstract The COVID-19 pandemic has caused major disruptions in multiple spheres of healthcare delivery in the world. Developing nations have had to tackle this unanticipated crisis in the midst of various other healthcare delivery issues and resource constraints. As a tertiary level cancer care provider located in an eastern Indian city, a COVID-19 hotspot, we share our experience from the perspective of haematology and haematopoietic stem cell transplantation (HSCT) services. The primary challenges related to infection control included infect...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cervical cancer: a meta-analysis, therapy and future of nanomedicine.
Authors: Venkatas J, Singh M Abstract Cervical cancer is one of the leading causes of female death, with an annual mortality rate exceeding 200,000 in developing communities. Despite the past decade bearing witness to a reduction in cervical cancer cases throughout developed countries, the prevalence in developing countries continues to rapidly rise. The increase in cervical cancer cases is attributed to the lack of financial resources and the unavoidable risk factors of the disease. Traditional means of anticancer therapy are compromised by reduced drug potency, non-specificity, negative side effects and the devel...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Dyspnoea at rest predictor of increased in-hospital mortality in metastatic cancer patients undergoing emergent surgery in United States.
In this study, we decided to analyse post-operative outcomes to understand if dyspnoea is a significant prognostic predictor of in-hospital mortality in patients with stage IV cancer who underwent emergent surgery in the United States. Methods: We performed a search of the 2014 National Surgical Quality Improvement Program database (NSQIP) for patients with a diagnosis of malignancy (ICD-9 Codes 145.00-200.00). Cases were divided into two groups: metastatic cancer and non-metastatic cancer. Demographical data including preoperative, intraoperative and postoperative factors, as well as data regarding complications and c...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Metronomic oral vinorelbine in patients with advanced non-small cell lung cancer progressing after nivolumab immunotherapy: a retrospective analysis.
Conclusion: Oral metronomic VNR appears to be active and safe in patients with metastatic NSCLC in progression after first-line chemotherapy and second-line immunotherapy. The results reported, although from a limited sample, may suggest its use for long-term stabilisation of the disease with good patient compliance. PMID: 33144881 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Screening of cytochrome 4Z1 expression in human non-neoplastic, pre-neoplastic and neoplastic tissues.
Conclusion: These findings greatly support future plans for the use of CYP4Z1 as a biomarker or target for anti-cancer drugs. However, large-scale validation studies are needed to better delineate the potential use of CYP4Z1 for therapeutic purposes. PMID: 33144882 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

New journal authorship criteria: how ecancermedicalscience is supporting authors and readers from underserved settings.
Authors: Cazap E, Sullivan R, Foxall K Abstract In order to reduce the increasing cancer burden in Lower and Middle Income Countries (LMICs), oncology journals must support authors from underserved settings to become fully involved in the global publication system, without facing barriers to publishing their research such as geographical bias and lack of funding. ecancermedicalscience's goal has always been to publish high-quality research which contributes towards narrowing the gap between those who have access to adequate cancer prevention, treatment and care and those who do not. The time is now right for the jo...
Source: Ecancermedicalscience - November 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Fundamentals to clinical application of nanoparticles in cancer immunotherapy and radiotherapy.
Authors: Selvaraja VK, Gudipudi DK Abstract Cancer immunotherapy has made rapid progress over the past decade leading to high enthusiasm and interest worldwide. Codelivery of immunomodulators with chemotherapeutic agents and radioisotopes has been shown to elicit a strong and sustained immune response in animal models. Despite showing promising results in metastatic and recurrent cancers, the utilisation of immunotherapy in clinical settings has been limited owing to uncertainties in elicited immune response and occurrence of immune-related adverse events. These uncertainties can be overcome with the help of nanopa...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer treatment during the COVID-19 pandemic in the Kurdistan Region of northern Iraq.
Authors: Nidhamalddin SJ, Hasan RO, Abubakr GO Abstract The announcement of the COVID-19 pandemic by the World Health Organisation in March 2020 and the spread of coronavirus in most parts of the world, including Iraq, have posed severe challenges to the management of cancer patients both psychologically and logistically. Special experts at Hiwa Cancer Hospital, Iraq, took serious action aimed to decrease and prevent the spread of the virus among cancer patients while maintaining standard treatment protocols through compiling expert consensus, focusing on the prevention of COVID-19 and cancer patient management. ...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Radiotherapy waiting time in Northern Nigeria: experience from a resource-limited setting.
Conclusion: The study shows that waiting time for radiotherapy in Nigeria was generally longer than what is recommended internationally. This reflects the need to improve access to radiotherapy in order to improve cancer treatment outcomes in resource-limited settings. PMID: 33082847 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer disease progression and death during the COVID-19 pandemic: a multidisciplinary analysis for the Peruvian setting.
Authors: Astigueta-Pérez J, Abad-Licham M, Chávez-Chirinos C, Beraun-Milla L, Lachos-Dávila A, Diaz-Pérez E, Portugal-Valdivia K, Castañeda PP, Alférez IP, Mezones-Holguín E Abstract Since the COVID-19 pandemic began in China in late 2019, infection from the SARS-CoV-2 virus has spread virtually worldwide. This infection has adversely affected several countries; governments have outlined a series of political measures aimed to preserve the health and safety of their populations. In Peru, most actions have prioritised COVID-19 attention, with a subsequent gap in the h...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition.
Authors: Saha A, Anirvan P Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic has affected millions worldwide and has been found to cause severe disease in patients with underlying comorbidities. In patients with known malignancies, in addition to constraints in routine healthcare, the risk of being susceptible to developing severe forms of the disease is of grave concern. While follow-up studies on survivors of the severe acute respiratory syndrome (SARS) 2003 outbreak revealed increased susceptibility to infections, tumours and cardiovascular abnormalities, recent studies implicating angiopoietin 2...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

SARS-CoV-2 testing for asymptomatic adult cancer patients before initiating systemic treatments: a systematic review.
Conclusion: There is a lack of studies which directly address COVID-19 testing of asymptomatic patients before treatment. Our systematic review showed that most of the published data favours routine test for SARS-CoV-2 before initiating systemic treatment but failed to identify a good level of evidence to support these recommendations. Based upon this review, we proposed local recommendations at our centre. Each institution should consider the pros and cons of testing asymptomatic patients, evaluating accessibility to testing resources and local epidemiology. PMID: 33082850 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The care of older cancer patients in the United Kingdom.
Authors: Gomes F, Lewis A, Morris R, Parks R, Kalsi T, Babic-Illamn G, Baxter M, Colquhoun K, Rodgers L, Smith E, Greystoke A, Bayman N, Cree A, Ng C, de Liguori Carino N, Basile S, Moore J, Merchant Z, Swinson D, Parbhoo A, Jones R, Davies E, Danson SJ, Young R, Morgan J, Wyld L, Corrie PG, Doherty GJ, Crawford K, Wright J, Reed M, Ugolini F, Lind M, Cheung KL, Harari D, Simcock R Abstract The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients inc...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Geriatric oncology in Mexico.
Authors: Gomez-Moreno C, Verduzco-Aguirre H, Soto-Perez-de-Celis E Abstract Mexico is an upper-middle income country located in North America, with an increasing life expectancy and a growing population of older adults. Due to population ageing and lifestyle changes, the number of cancer cases amongst older individuals is expected to increase in the upcoming decades, representing a challenge to the healthcare system. The challenges for implementing geriatric oncology care in Mexico include a fragmented healthcare system, as well as the lack of geriatric training amongst healthcare professionals. In this mini-review...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Perspectives on cancer care in older patients in France.
Authors: Hauchecorne M, Pierro M, Brain E, Bringuier M, Soubeyran P, Chakiba C, Mathoulin-Pelissier S, Paillaud E, Geiss R, Besse B, Mourey L, Vincent H, Baldini C Abstract In France, cancer is the leading cause of death. Its incidence is increasing due to the growing population and longer life expectancy. Although older adults represent most new cases, they remain underrepresented in clinical trials. Their prognosis is often worse due to delayed diagnosis and multimorbidities. Geriatric oncology has made great strides worldwide, highlighted by important studies implementing geriatric assessment in clinical researc...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Olaparib treatment in older patients with ovarian cancer: need for 'real-world' data beyond clinical trials.
Discussion: Our 'real-world' experience shows that unselected older patients represent a significant larger proportion in real life than in RCTs; furthermore, older patients in a real-world setting may experience more side effects possibly affecting the quality of life. The median PFS data suggest that older patients may not derive the same clinical benefit than their fit and younger counterparts.There is a need to enrol vulnerable/frail older patients into RCTs, ensuring that data will also be applicable in standard clinical settings. Incorporating geriatric assessment into these trials should be encouraged. PMID: 330...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Definition and assessment of frailty in older patients: the surgical, anaesthesiological and oncological perspective.
Authors: Dottorini L, Turati L, Mattei L, Formenti P Abstract The number of oncology, surgery and anaesthesia procedures in older patients has greatly increased in recent years due to ageing populations. Older patients are typically characterised by physical changes such as comorbidities, decline in physiological activities and cognitive impairment. All these factors, together with polypharmacological therapies, may substantially impact perioperative outcome, quality of recovery and, more in general, quality of life. A comprehensive multidisciplinary approach to perioperative care is thus needed. The assessment of ...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Rapidly established telehealth care for blood cancer patients in Nepal during the COVID-19 pandemic using the free app Viber.
Authors: Poudyal BS, Gyawali B, Rondelli D Abstract National lockdown to control the spread of COVID-19 in Nepal started in March 2020. This lockdown mandated closure of private and public transportation. The patients with hematological malignancies were at risk of delayed consultation, admission and missing scheduled chemotherapy. Since there is no official tele-health or e-health system established in hospitals, we decided to use Viber, a free text and call app to trace and provide information about patient admission and treatment schedule. This use of Viber during the pandemic was found to be very helpful, none ...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The ongoing COVID-19 pandemic will create a disease surge among cancer patients.
Authors: Meyer M, Bindelglas E, Kupferman ME, Eggermont AM Abstract With major parts of the United States in lockdown, parts of Europe and the UK possibly going back on lockdown or expecting a second COVID-19 wave and rapidly rising rates elsewhere other than Asia, many people are forgoing regular cancer screenings and prevention services. More worrisome, some may be experiencing early signs or symptoms, yet they are not seeking evaluation, treatment or surveillance examinations. The long-term impact of this on patients, families and health care providers will be substantial. Not only will this strain sophisticated...
Source: Ecancermedicalscience - October 22, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Dermatofibrosarcoma protuberance in a black African cohort-a clinicopathologic study.
Conclusion: Dermatofibrosarcoma protuberance is rare in our population and occurs more commonly in males and on the trunk. Recurrence can occur beyond the recommended follow-up period of 10 years. PMID: 33014128 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Erratum: RENATA study-Latin American prospective experience: clinical outcome of patients treated with palbociclib in hormone receptor-positive metastatic breast cancer-real-world use.
Authors: Petracci F, Abuin GG, Pini A, Chacón M Abstract [This corrects the article on p. 1 in vol. 14.]. PMID: 33014129 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Possible mechanisms of action of clarithromycin and its clinical application as a repurposing drug for treating multiple myeloma.
Authors: Takemori N, Ooi HK, Imai G, Hoshino K, Saio M Abstract Clarithromycin (CAM), a semisynthetic macrolide antibiotic, is a widely used antibacterial drug. Recently, the efficacy of CAM as an add-on drug for treating multiple myeloma (MM) has been noted. Its effect on treating MM has been confirmed in combination chemotherapies that include CAM. However, a single treatment of CAM has no efficacy for treating MM. Many myeloma growth factors (MGFs) including interleukin (IL)-6 are known to be closely involved in the development of MM. CAM has been shown to suppress many MGFs, particularly IL-6. The possible mech...
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Early molecular response in East African Philadelphia chromosome-positive chronic myeloid leukaemia patients treated with Imatinib and barriers to access treatment.
Conclusion: Patients are younger, and early MR rates are lower compared to other studies. The finding of hepatomegaly as a risk factor for unfavourable early MR was described previously in West Africa. Adherence to therapy is high in the first months of treatment. Furthermore, research is needed to understand the poor MR and the common presentation of hepatomegaly. Outreach clinics might be a solution to reduce impediments to treatment. PMID: 33014131 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Conserving the axilla in breast cancer.
Authors: Jozsa F, Ahmed M Abstract It is recognised that surgical conservatism is the most effective way of managing the axilla in breast cancer patients undergoing primary breast conserving surgery. The extended clinical scenarios in which a less aggressive approach can be safely adopted warrant consideration-including a group of patients who potentially could bypass surgical staging of the axilla altogether. The application of omission of further surgical management and axillary radiotherapy in the primary surgical and neoadjuvant chemotherapy settings are considered. PMID: 33014132 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Assessing the benefits and harms of direct oral anticoagulants in patients with cancer for the prophylaxis and treatment of venous thromboembolism: a systematic review and meta-analysis.
Conclusion: In this meta-analysis, we found that DOACs not only significantly decreased the risk of VTE or recurrent VTE in patients with cancer but also significantly increased the risk of bleeding and CRNMB, with neither beneficial nor detrimental effects on survival. The quantification of these benefits and risks will assist in individualised shared decision-making. PMID: 33014133 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Excellent response to erlotinib in breast carcinoma with rare EGFR mutation-a case report.
We describe a diagnostically challenging case of metastatic breast carcinoma, with extensive lung disease and poor Eastern Cooperative Oncology Group (ECOG) performance status, which expressed an uncommon EGFR mutation (Exon 21L861Q) and which benefitted from erlotinib following failure of all primary treatment modalities. The case uncovers the presence of these unusual mutations in breast carcinoma and highlights the importance of performing molecular analysis and the appropriate targeted therapy. This approach can be an important problem-solving tool, especially in cases where the patient is not fit for the other standar...
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research.
Conclusions: NM in Nigeria appears underutilised. Furthermore, the studies to characterise the access gaps and implementation needs will contribute to the design of practical strategies to strengthen NM services in Nigeria. PMID: 33014135 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Cancer research in the 57 Organisation of Islamic Cooperation (OIC) countries, 2008-17.
Conclusion: Cancer is seriously under-researched in most of the OIC countries. This will undermine the ability of these countries and OIC as a whole to deliver on better cancer control for their populations. New policies, OIC leadership and funding are urgently needed to address this situation. PMID: 33014136 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - October 6, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasound guided biopsy.
We present the case of a patient with obstructive jaundice and a mixed cystic and solid pancreatic mass, accompanied by multiple hepatic lesions. The histological study of the material obtained by endoscopic ultrasound guided biopsy demonstrated a proliferation of atypical epithelioid cells, accompanied by a spindle cell component with marked pleomorphism and numerous osteoclast-like giant cells. The epithelioid component showed positive immunostaining with cytokeratin cocktail and cytokeratin 7. The spindle cell component showed coexpression of cytokeratins and vimentin. The osteoclast-like giant cells were positive for C...
Source: Ecancermedicalscience - September 1, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research