Pazopanib in rare histologies of metastatic soft tissue sarcoma
CONCLUSION: Our study shows that pazopanib is active in rare subtypes of STS.PMID:34824604 | PMC:PMC8580588 | DOI:10.3332/ecancer.2021.1281 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Babita Kataria Aparna Sharma Bivas Biswas Sameer Bakhshi Deepam Pushpam Source Type: research

Clinicopathological characteristics of breast cancer patients from Northern Tanzania: common aspects of late stage presentation and triple negative breast cancer
CONCLUSIONS: Most patients presented in advanced stages and TNBC in their menopause. HR negative tumours were associated with poor histological differentiation and IDC. The high percentage of positive family history of BC and the differences in receptor patterns compared to other parts of the world should urge further genetic research on BC in SSA.PMID:34824605 | PMC:PMC8580599 | DOI:10.3332/ecancer.2021.1282 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Marianne Gnanamuttupulle Oliver Henke Shilanaiman Hilary Ntundu Furaha Serventi Leila E Mwakipunda Patrick Amsi Alex Mremi Kondo Chilonga David Msuya Samuel G Chugulu Source Type: research

Feasibility of genetic testing for cancer risk assessment programme in Nigeria
CONCLUSION: Personalised cancer care utilises GC and testing for cancer risk assessment towards prevention and early detection in high risk women. The study indicates the necessity of expanded cancer genetic services for integration into patient care and cancer prevention.PMID:34824606 | PMC:PMC8580592 | DOI:10.3332/ecancer.2021.1283 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Prisca O Adejumo Toyin I G Aniagwu Olutosin A Awolude Abiodun O Oni Olubunmi O Ajayi Omolara Fagbenle Dasola Ogungbade Makayla Kochheiser Temidayo Ogundiran Olufunmilayo I Olopade Source Type: research

COVID-19 vaccination immune response in patients with solid organ and haematologic malignancies: call for active monitoring
We report preliminary data from the American University of Beirut Medical Center in Lebanon demonstrating relatively low seroconversion rates. Of 36 patients on active anti-cancer therapy who had received two doses of vaccine, 17% were negative for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) anti-spike IgG. These results highlight the importance of maintaining strict precautionary measures against COVID-19 in patients on immunosuppressive treatment. There is an urgent need for active monitoring of immune response post-vaccination in prospective studies involving populations from diverse resource settings.P...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Laudy Chehade Jad Zeitoun Rachelle Bejjany Maya Charafeddine Firas Kreidieh Mona Hassan Ali Taher Nagi El Saghir Ali Shamseddine Ziad Salem Sally Temraz Arafat Tfayli Hazem Assi Ali Bazarbachi Jean El Cheikh Iman Abou Dalle Nesrine Rizk Rami Mahfouz Debor Source Type: research

Barriers and facilitators of colorectal cancer screening in Asia
CONCLUSION: For promoting success in CRC screening programmes, knowing what the barriers and facilitators are is necessary. Awareness and various personal, professional and social factors have been shown to be the major barriers toward CRC screening in most Asian countries.PMID:34824608 | PMC:PMC8580594 | DOI:10.3332/ecancer.2021.1285 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Sare Hatamian Fatemeh Hadavandsiri Zohre Momenimovahed Hamid Salehiniya Source Type: research

Erratum: Near-complete response to low-dose ceritinib in recurrent infantile inflammatory myofibroblastic tumour
Ecancermedicalscience. 2021 Sep 13;15:1286. doi: 10.3332/ecancer.2021.1286. eCollection 2021.ABSTRACT[This corrects the article on p. 1 in vol. 15.].PMID:34824609 | PMC:PMC8580590 | DOI:10.3332/ecancer.2021.1286 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Abhenil Mittal Aarushi Gupta Sameer Rastogi Adarsh Barwad Swati Sharma Source Type: research

Exceptional response to oral metronomic chemotherapy in a rare case of sinonasal mucosal melanoma
Ecancermedicalscience. 2021 Sep 14;15:1287. doi: 10.3332/ecancer.2021.1287. eCollection 2021.ABSTRACTSinonasal mucosal melanoma is a rare malignancy with limited treatment options and a poor prognosis. They are usually diagnosed at an advanced stage owing to their late and nonspecific clinical presentation. Here we present a case of relapsed refractory unresectable malignant melanoma involving the right nasal cavity managed with Oral Metronomic Chemotherapy (OMCT). A 75-year-old male patient was diagnosed with unresectable malignant melanoma involving the right nasal cavity and showed radiological progression after initial...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Anukul Karn Satvik Khaddar Amit Agrawal Akhil Kapoor Source Type: research

The relationship between pre-operative lymphocyte to monocyte ratio and serum cancer antigen-125 among women with epithelial ovarian cancer in Lagos, Nigeria
This study aimed to determine the relationship between pre-operative serum lymphocyte to monocyte ratio (LMR) and CA-125 in EOC. This was a retrospective cross-sectional study among 70 women, diagnosed with EOC in Lagos University Teaching Hospital from January 2013 to December 2019. Data were extracted from the case notes of the patients. LMR was calculated as the absolute lymphocyte count divided by the absolute monocyte count and analysed using Statistical Package for Social Sciences (SPSS) version 25.0. The correlation between LMR and CA-125 was determined using Pearson's correlation coefficient. The mean age of the pa...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Adaiah Priscilla Soibi-Harry Lemchukwu Chukwunonye Amaeshi Sunusi Rimi Garba Rose Ihuoma Anorlu Source Type: research

Frequency of allogenic blood transfusion in patients with gastrointestinal cancer: a cross-sectional study in Peru
CONCLUSION: Our findings suggested that patients with gastrointestinal cancer require large numbers of transfusions of blood cell concentrate and FFP. Also, we showed that cancer of the colon, pancreas and liver demanded more than 75% of blood products.PMID:34824612 | PMC:PMC8580600 | DOI:10.3332/ecancer.2021.1289 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Jeel Moya-Salazar Eulogio C áceres Jorgelina Blejer Carlos Gonzalez Hans Contreras-Pulache Source Type: research

Multidisciplinary management of ovarian germ cell tumours-a single institutional study from India
CONCLUSION: Immature teratoma was the most common histology in our series. The majority presented in the early stage. MOGCT is a highly curable disease with surgery and systemic therapy.PMID:34824613 | PMC:PMC8580601 | DOI:10.3332/ecancer.2021.1290 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Sandip Ganguly Sumedha Gargy Archisman Basu Meheli Chatterjee Anik Ghosh Basumita Chakraborti Bivas Biswas Deepak Dabkara Shweta Rai Arunava Roy Sonia Mathai Jaydip Bhaumik Joydeep Ghosh Source Type: research

Can the CROSS protocol be safely implemented in real world scenario with broader eligibility criteria? Experience from a tertiary care centre in India
CONCLUSION: CROSS protocol can be safely implemented for carefully selected patients of SCC oesophagus outside clinical trial settings with expanded eligibility criteria.PMID:34824614 | PMC:PMC8580591 | DOI:10.3332/ecancer.2021.1291 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Tapesh Bhattacharyya Moses Arunsingh Santam Chakraborty Vishnu Harilal Rohit Sasidharan Saheli Saha Robin Thambudorai Bipradas Roy Sudeep Banerjee Paromita Roy Soumendranath Ray Indranil Mallick Source Type: research

Docetaxel, Oxaliplatin and Capecitabine (TEX) triplet regimen as adjuvant chemotherapy in resected gastric adenocarcinoma
CONCLUSION: Post resection of gastric adenocarcinoma adjuvant triplet TEX chemotherapy is a feasible and effective outpatient regimen. Diarrhoea, neutropenia and neuropathy were the common dose limiting toxicity. Post-surgery only half the numbers of patients are able to complete all planned cycles.PMID:34824615 | PMC:PMC8580596 | DOI:10.3332/ecancer.2021.1292 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Divya Bala Thumaty Raju Titus Chacko Ajoy Oommen John Anjana Joel Josh Thomas Georgy Myla Jacob Inian Samarasam Dipti Masih Rajesh Isaiah Visalakshi Jeyaseelan Ashish Singh Source Type: research

Baseline cardiovascular comorbidities, and the influence on cancer treatment decision-making in women with breast cancer
CONCLUSION: While recent guidelines recommend routine assessment of cardiovascular comorbidities in cancer patients prior to initiation of anticancer therapies, this study highlights the prevailing gap in knowledge on how such data may be used to optimise cancer treatment decision-making.PMID:34824616 | PMC:PMC8580595 | DOI:10.3332/ecancer.2021.1293 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Shridevi Subramaniam Yek-Ching Kong Hafizah Zaharah Cuno S P M Uiterwaal Andrea Richard Nur Aishah Taib Azura Deniel Kok-Han Chee Ros Suzanna Bustamam Mee-Hoong See Alan Fong Cheng-Har Yip Nirmala Bhoo-Pathy Source Type: research

Assessment of guideline adherence in breast cancer management among oncologists in Nigeria
CONCLUSION: The study revealed high level of adherence to breast cancer guideline use among oncologists in Nigeria but there is need for more awareness about the locally developed ones like sub-Saharan adapted version and institutional based breast cancer treatment guidelines so as to address the barrier of disparities in target population and resources availability.PMID:34824617 | PMC:PMC8580603 | DOI:10.3332/ecancer.2021.1294 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Bolanle C Adegboyega Adewumi O Alabi Adedayo O Joseph Nwamaka Lasebikan Luther A Agaga Kehinde O Ololade Anthonia C Sowunmi Source Type: research

Metastatic prostate cancer mimicking a rectal cancer: a case report
Ecancermedicalscience. 2021 Sep 23;15:1295. doi: 10.3332/ecancer.2021.1295. eCollection 2021.ABSTRACTThe most common presenting symptoms of prostate cancer, a common cancer in males worldwide, are lower urinary tract symptoms. In rare cases, however, urinary symptoms may not be apparent, and patients can present with gastrointestinal symptoms instead. Even rarer is the involvement of non-regional lymph nodes such as the cervical nodes. Here, we report a case of a 50-year-old male who initially presented with constipation and an enlarging left lateral neck mass. Further work-up revealed metastatic prostatic adenocarcinoma a...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Alfredo V Chua Alvin Christopher S Chu Ashraf A Tawasil Michael D San Juan Source Type: research

Oncology training and education initiatives in low and middle income countries: a scoping review
CONCLUSIONS: There is a paucity of oncology training and education initiatives in LMICs published in English. Initiatives for non-physicians, efforts to foster collaboration within and between LMICs, knowledge sharing initiatives and studies that measure the impact of these initiatives on developing an effective workforce are highly recommended.PMID:34824619 | PMC:PMC8580602 | DOI:10.3332/ecancer.2021.1296 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Safiya Karim Zahra Sunderji Matthew Jalink Sahar Mohamed Indranil Mallick Susan Citonje Msadabwe-Chikuni Nancy J Delgarno Nazik Hammad Scott Berry Source Type: research

High dose interstitial brachytherapy for treatment of carcinoma of the lip as an alternative to surgery: a case report
We present a case of a patient diagnosed with stage II lower LC who refused surgical treatment. Instead, high-dose-rate interstitial BT was performed with 192Ir. A 2-year post-treatment follow-up indicated there were neither serious complications nor recurrence of cancer during that period.PMID:34824620 | PMC:PMC8580587 | DOI:10.3332/ecancer.2021.1297 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Percy Torres-Quispe Lissett Jeanette Fern ández-Rodríguez Yaowen Zhang Angeles Rovirosa-Casino Source Type: research

Exploring primary care level provider interpretation and management of potential breast and cervical cancer signs and symptoms in South Africa
CONCLUSION: Clinical assessment at PHC level is complex and influenced by local health issues. Providing context-relevant training and support for PHC providers, and improving referral and feedback systems, could assist timely diagnosis of women with symptomatic breast and cervical cancer.PMID:34824621 | PMC:PMC8580586 | DOI:10.3332/ecancer.2021.1298 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Jennifer Moodley Jane Harries Suzanne Emilie Scott Amos Deogratius Mwaka Smiji Saji Fiona Mary Walter Source Type: research

Impact of the COVID-19 pandemic on breast and cervical cancer stage at diagnosis in Brazil
Ecancermedicalscience. 2021 Oct 4;15:1299. doi: 10.3332/ecancer.2021.1299. eCollection 2021.ABSTRACTBACKGROUND: The COVID-19 pandemic has led to the need for health services adjustments, which may have compromised management of other diseases. For cancer patients, delays may significantly impair outcomes in some situations. We aimed to assess the impact of the COVID-19 pandemic in breast and cervical cancer diagnosis and treatment compared to the same period prior to the pandemic.METHODS: Data were collected from patients attending their first visit to a Brazilian cancer centre from 1 September 2020 to 31 January 2021 and ...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Renata Colombo Bonadio Ana Paula Messias Otavio Augusto Moreira Let ícia Vecchi Leis Bruna Zanin Orsi Laura Testa Maria Del Pilar Estevez-Diz Source Type: research

Factors associated with unmet supportive care needs of oncology patients at Dessie Referral Hospital, 2020
CONCLUSION AND RECOMMENDATION: This study shows that the prevalence of unmet supportive care needs in cancer patients is high in each domain. Age, income, cancer stage, cancer site, treatment option, time since diagnosis and sources of information were associated across one or more unmet supportive care needs domains. Therefore, the government and health professionals should work together to improve the unmet needs of cancer patients.PMID:34824623 | PMC:PMC8580717 | DOI:10.3332/ecancer.2021.1300 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Husniya Yasin Amane Asressie Molla Tessema Kemal Ahmed Seid Anissa Mohammed Hassen Hussien Endris Assen Zinet Abegaz Asfaw Salih Mohamed Endrie Foziya Mohammed Hussien Source Type: research

Healthcare delivery for non-communicable diseases among breast cancer survivors in Sri Lanka: Is there a missed opportunity?
The objective of this study was to describe healthcare delivery for NCDs among female breast cancer survivors treated at the National Cancer Institute of Sri Lanka (NCISL) and identify opportunities to optimise non-cancer medical care in this cohort.METHODS: A total of 420 women were identified from the breast cancer database at the NCISL, who were 50-80 years at the time of their breast cancer diagnosis, were within 12-24 months from the date of diagnosis, had completed their active cancer treatment and were in complete remission. Of this population, 228 (54%) women who had documented NCDs at the time of diagnosis were id...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Don Thiwanka Wijeratne Christopher M Booth Sanjeewa Seneviratne Bishal Gyawali Matt Jalink Malinthi Soysa Sachith Abhayaratna Hasitha Promod Punika Wijesinghe Sanjeeva Gunasekera Source Type: research

Pilot Nanostring PanCancer pathway analysis of colon adenocarcinoma in a tertiary healthcare centre in Kerala, India
Ecancermedicalscience. 2021 Oct 12;15:1302. doi: 10.3332/ecancer.2021.1302. eCollection 2021.ABSTRACTThe prevalence of microsatellite instability and deoxyribonucleic acid mismatch repair deficiency in colorectal adenocarcinoma (CRC) cases is higher in India compared to western populations. No major study on the molecular pathogenesis is currently available in the Indian population. We conducted a pilot study to explore the differences in molecular pathogenesis of microsatellite stable (MSS) and microsatellite unstable CRC from a tertiary care centre in Kerala, South India. Using Nanostring PanCancer panel assay in Stage I...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Prasanth S Ariyannur Reenu Anne Joy Veena Menon Roopa Rachel Paulose Keechilat Pavithran Damodaran M Vasudevan Source Type: research

Perceptions regarding tobacco control strategies amongst female youth in Delhi, India - a qualitative study
Ecancermedicalscience. 2021 Oct 12;15:1303. doi: 10.3332/ecancer.2021.1303. eCollection 2021.ABSTRACTTobacco-related cancer is one of the commonest causes of cancer-related mortality in low- and middle-income countries. As per Global Youth Tobacco Survey-4, India; nearly one-fifth of students aged 13-15 used any form of the tobacco product. Tobacco related challenges have been countered through various tobacco control strategies; however, ignorance and non-compliance to tobacco control strategies to combat the tobacco epidemic shield the tobacco industry in India as well. There is limited literature on perception of tobacc...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Swati Jain Vikrant Mohanty Shipra Arora Shekhar Grover Mohit Bidhuri Neha Singh Source Type: research

Cutaneous metastases of embryonal rhabdomyosarcoma in a black African child: the role of dermoscopy in reducing time to and cost of diagnosis
We report dermoscopic features of cutaneous metastasis of embryonal rhabdomyosarcoma seen in a black African child.PMID:34824627 | PMC:PMC8580718 | DOI:10.3332/ecancer.2021.1304 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Nkechi Enechukwu Ezejiofor Ogochukwu Ifeanyi Gabriel Olabiyi Ogun Adebola Olufunmilayo Ogunbiyi Source Type: research

Erratum: Comparative efficacy of modified FOLFIRINOX, gemcitabine plus capecitabine and gemcitabine plus nab-paclitaxel as adjuvant treatment for resected pancreatic cancer: a Bayeasian network meta-analysis
Ecancermedicalscience. 2021 Oct 12;15:1305. doi: 10.3332/ecancer.2021.1305. eCollection 2021.ABSTRACT[This corrects the article on p. 1 in vol. 15.].PMID:34824628 | PMC:PMC8580714 | DOI:10.3332/ecancer.2021.1305 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Victor Hugo Fonseca de Jesus Rachel P Riechelmann Source Type: research

Emerging biomarkers in metastatic urothelial carcinoma: tumour mutational burden, PD-L1 expression and APOBEC polypeptide-like signature in a patient with complete response to anti-programmed cell death protein-1 inhibitor
Ecancermedicalscience. 2021 Oct 22;15:1306. doi: 10.3332/ecancer.2021.1306. eCollection 2021.ABSTRACTImmunotherapy has recently been incorporated into the treatment guidelines for metastatic urothelial carcinoma. Nevertheless, the role of prognostic and predictive biomarkers in this setting is not completely defined. To date, PD-L1 expression and a high tumour mutational burden (TMB) seem to predict better responses to immune checkpoint inhibitors, but patients without these biomarkers may still respond to immunotherapy. There are some caveats regarding these biomarkers, such as lack of standardisation of techniques, tumou...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Marcello Moro Queiroz Zenaide Silva de Souza Aline Bobato Lara Gongora Felipe de Galiza Barbosa Carlos Alberto Buchpiguel Marilia Germanos de Castro Mariana Petaccia de Macedo Rafael Ferreira Coelho Ethan Samuel Sokol Anamaria Aranha Camargo Diogo Assed B Source Type: research

African American participation in cancer clinical trials
CONCLUSION: Educating AA patients about the biomedical research process, addressing concerns about CCTs, building trust with community members and improving communication with healthcare providers could improve AA participation in CCTs. Future interventions should consider the effect of diversified healthcare teams in addressing trust deficit in CCTs among AAs. Healthcare practitioners seeking to consent AA into CCTs and biomedical research could consider incorporating cultural competence into their practice for effective interaction with this population and to address their questions about biomedical research.PMID:3482463...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Jordan Swaby Ernie Kaninjing Motolani Ogunsanya Source Type: research

Impact of stigma and stigma-focused interventions on screening and treatment outcomes in cancer patients
CONCLUSION: Cancer related stigma remains high in both clinical settings and amongst the general public. There is need for more interventions to combat cancer stigma and its effect in both patient and non-patient population. Anti-cancer public enlightenment campaigns should be sensitively designed to not further fuel stigma against patients with certain types of cancers.PMID:34824631 | PMC:PMC8580722 | DOI:10.3332/ecancer.2021.1308 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Elizabeth O Akin-Odanye Anisah J Husman Source Type: research

Comparison of health access, lifestyle, prostate cancer knowledge and screening among black men residing in West Africa and the USA
This study evaluated health access and lifestyle association with prostate cancer (PCa) knowledge and screening among black men.METHODOLOGY: This study used data from the Prostate Cancer Transatlantic Consortium familial cohort study. Data were gathered from a cross-sectional survey of 500 community-dwelling black men in Nigeria, Cameroon, and the USA. Information on socio-demographics, health care access, PCa knowledge score and screening behaviour was obtained, and the association between these variables was evaluated.RESULTS: The majority (81.6%) were Nigerian. The age ranges were 35-49 (55.2%) and ≥65 (8.4%). The in...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Orlando Rivera Col ón Opeyemi Bolajoko Folakemi Odedina Folakemi Odedina Source Type: research

Knowledge, preferences and willingness to use at-home prostate and colorectal cancer screening tests in African American and Haitian men
Ecancermedicalscience. 2021 Oct 25;15:1310. doi: 10.3332/ecancer.2021.1310. eCollection 2021.ABSTRACTHaitian (HA) and African American (AA) men have the highest prostate cancer (PCa) and colorectal cancer (CRC) age-adjusted mortality rates compared with other racial/ethnic groups worldwide. One contributing factor to mortality differences is that a low percentage of age-eligible HA and AA men screen for PCa and CRC, even when healthcare access and insurance are available. Reasons for cancer screening disparities may be differences in knowledge, preferences and willingness in HA and AA men. However, limited information exis...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Alexandra Jean-Louis Fern J Webb Source Type: research

Pazopanib in rare histologies of metastatic soft tissue sarcoma
CONCLUSION: Our study shows that pazopanib is active in rare subtypes of STS.PMID:34824604 | PMC:PMC8580588 | DOI:10.3332/ecancer.2021.1281 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Babita Kataria Aparna Sharma Bivas Biswas Sameer Bakhshi Deepam Pushpam Source Type: research

Clinicopathological characteristics of breast cancer patients from Northern Tanzania: common aspects of late stage presentation and triple negative breast cancer
CONCLUSIONS: Most patients presented in advanced stages and TNBC in their menopause. HR negative tumours were associated with poor histological differentiation and IDC. The high percentage of positive family history of BC and the differences in receptor patterns compared to other parts of the world should urge further genetic research on BC in SSA.PMID:34824605 | PMC:PMC8580599 | DOI:10.3332/ecancer.2021.1282 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Marianne Gnanamuttupulle Oliver Henke Shilanaiman Hilary Ntundu Furaha Serventi Leila E Mwakipunda Patrick Amsi Alex Mremi Kondo Chilonga David Msuya Samuel G Chugulu Source Type: research

Feasibility of genetic testing for cancer risk assessment programme in Nigeria
CONCLUSION: Personalised cancer care utilises GC and testing for cancer risk assessment towards prevention and early detection in high risk women. The study indicates the necessity of expanded cancer genetic services for integration into patient care and cancer prevention.PMID:34824606 | PMC:PMC8580592 | DOI:10.3332/ecancer.2021.1283 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Prisca O Adejumo Toyin I G Aniagwu Olutosin A Awolude Abiodun O Oni Olubunmi O Ajayi Omolara Fagbenle Dasola Ogungbade Makayla Kochheiser Temidayo Ogundiran Olufunmilayo I Olopade Source Type: research

COVID-19 vaccination immune response in patients with solid organ and haematologic malignancies: call for active monitoring
We report preliminary data from the American University of Beirut Medical Center in Lebanon demonstrating relatively low seroconversion rates. Of 36 patients on active anti-cancer therapy who had received two doses of vaccine, 17% were negative for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) anti-spike IgG. These results highlight the importance of maintaining strict precautionary measures against COVID-19 in patients on immunosuppressive treatment. There is an urgent need for active monitoring of immune response post-vaccination in prospective studies involving populations from diverse resource settings.P...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Laudy Chehade Jad Zeitoun Rachelle Bejjany Maya Charafeddine Firas Kreidieh Mona Hassan Ali Taher Nagi El Saghir Ali Shamseddine Ziad Salem Sally Temraz Arafat Tfayli Hazem Assi Ali Bazarbachi Jean El Cheikh Iman Abou Dalle Nesrine Rizk Rami Mahfouz Debor Source Type: research

Barriers and facilitators of colorectal cancer screening in Asia
CONCLUSION: For promoting success in CRC screening programmes, knowing what the barriers and facilitators are is necessary. Awareness and various personal, professional and social factors have been shown to be the major barriers toward CRC screening in most Asian countries.PMID:34824608 | PMC:PMC8580594 | DOI:10.3332/ecancer.2021.1285 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Sare Hatamian Fatemeh Hadavandsiri Zohre Momenimovahed Hamid Salehiniya Source Type: research

Erratum: Near-complete response to low-dose ceritinib in recurrent infantile inflammatory myofibroblastic tumour
Ecancermedicalscience. 2021 Sep 13;15:1286. doi: 10.3332/ecancer.2021.1286. eCollection 2021.ABSTRACT[This corrects the article on p. 1 in vol. 15.].PMID:34824609 | PMC:PMC8580590 | DOI:10.3332/ecancer.2021.1286 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Abhenil Mittal Aarushi Gupta Sameer Rastogi Adarsh Barwad Swati Sharma Source Type: research

Exceptional response to oral metronomic chemotherapy in a rare case of sinonasal mucosal melanoma
Ecancermedicalscience. 2021 Sep 14;15:1287. doi: 10.3332/ecancer.2021.1287. eCollection 2021.ABSTRACTSinonasal mucosal melanoma is a rare malignancy with limited treatment options and a poor prognosis. They are usually diagnosed at an advanced stage owing to their late and nonspecific clinical presentation. Here we present a case of relapsed refractory unresectable malignant melanoma involving the right nasal cavity managed with Oral Metronomic Chemotherapy (OMCT). A 75-year-old male patient was diagnosed with unresectable malignant melanoma involving the right nasal cavity and showed radiological progression after initial...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Anukul Karn Satvik Khaddar Amit Agrawal Akhil Kapoor Source Type: research

The relationship between pre-operative lymphocyte to monocyte ratio and serum cancer antigen-125 among women with epithelial ovarian cancer in Lagos, Nigeria
This study aimed to determine the relationship between pre-operative serum lymphocyte to monocyte ratio (LMR) and CA-125 in EOC. This was a retrospective cross-sectional study among 70 women, diagnosed with EOC in Lagos University Teaching Hospital from January 2013 to December 2019. Data were extracted from the case notes of the patients. LMR was calculated as the absolute lymphocyte count divided by the absolute monocyte count and analysed using Statistical Package for Social Sciences (SPSS) version 25.0. The correlation between LMR and CA-125 was determined using Pearson's correlation coefficient. The mean age of the pa...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Adaiah Priscilla Soibi-Harry Lemchukwu Chukwunonye Amaeshi Sunusi Rimi Garba Rose Ihuoma Anorlu Source Type: research

Frequency of allogenic blood transfusion in patients with gastrointestinal cancer: a cross-sectional study in Peru
CONCLUSION: Our findings suggested that patients with gastrointestinal cancer require large numbers of transfusions of blood cell concentrate and FFP. Also, we showed that cancer of the colon, pancreas and liver demanded more than 75% of blood products.PMID:34824612 | PMC:PMC8580600 | DOI:10.3332/ecancer.2021.1289 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Jeel Moya-Salazar Eulogio C áceres Jorgelina Blejer Carlos Gonzalez Hans Contreras-Pulache Source Type: research

Multidisciplinary management of ovarian germ cell tumours-a single institutional study from India
CONCLUSION: Immature teratoma was the most common histology in our series. The majority presented in the early stage. MOGCT is a highly curable disease with surgery and systemic therapy.PMID:34824613 | PMC:PMC8580601 | DOI:10.3332/ecancer.2021.1290 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Sandip Ganguly Sumedha Gargy Archisman Basu Meheli Chatterjee Anik Ghosh Basumita Chakraborti Bivas Biswas Deepak Dabkara Shweta Rai Arunava Roy Sonia Mathai Jaydip Bhaumik Joydeep Ghosh Source Type: research

Can the CROSS protocol be safely implemented in real world scenario with broader eligibility criteria? Experience from a tertiary care centre in India
CONCLUSION: CROSS protocol can be safely implemented for carefully selected patients of SCC oesophagus outside clinical trial settings with expanded eligibility criteria.PMID:34824614 | PMC:PMC8580591 | DOI:10.3332/ecancer.2021.1291 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Tapesh Bhattacharyya Moses Arunsingh Santam Chakraborty Vishnu Harilal Rohit Sasidharan Saheli Saha Robin Thambudorai Bipradas Roy Sudeep Banerjee Paromita Roy Soumendranath Ray Indranil Mallick Source Type: research

Docetaxel, Oxaliplatin and Capecitabine (TEX) triplet regimen as adjuvant chemotherapy in resected gastric adenocarcinoma
CONCLUSION: Post resection of gastric adenocarcinoma adjuvant triplet TEX chemotherapy is a feasible and effective outpatient regimen. Diarrhoea, neutropenia and neuropathy were the common dose limiting toxicity. Post-surgery only half the numbers of patients are able to complete all planned cycles.PMID:34824615 | PMC:PMC8580596 | DOI:10.3332/ecancer.2021.1292 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Divya Bala Thumaty Raju Titus Chacko Ajoy Oommen John Anjana Joel Josh Thomas Georgy Myla Jacob Inian Samarasam Dipti Masih Rajesh Isaiah Visalakshi Jeyaseelan Ashish Singh Source Type: research

Baseline cardiovascular comorbidities, and the influence on cancer treatment decision-making in women with breast cancer
CONCLUSION: While recent guidelines recommend routine assessment of cardiovascular comorbidities in cancer patients prior to initiation of anticancer therapies, this study highlights the prevailing gap in knowledge on how such data may be used to optimise cancer treatment decision-making.PMID:34824616 | PMC:PMC8580595 | DOI:10.3332/ecancer.2021.1293 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Shridevi Subramaniam Yek-Ching Kong Hafizah Zaharah Cuno S P M Uiterwaal Andrea Richard Nur Aishah Taib Azura Deniel Kok-Han Chee Ros Suzanna Bustamam Mee-Hoong See Alan Fong Cheng-Har Yip Nirmala Bhoo-Pathy Source Type: research

Assessment of guideline adherence in breast cancer management among oncologists in Nigeria
CONCLUSION: The study revealed high level of adherence to breast cancer guideline use among oncologists in Nigeria but there is need for more awareness about the locally developed ones like sub-Saharan adapted version and institutional based breast cancer treatment guidelines so as to address the barrier of disparities in target population and resources availability.PMID:34824617 | PMC:PMC8580603 | DOI:10.3332/ecancer.2021.1294 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Bolanle C Adegboyega Adewumi O Alabi Adedayo O Joseph Nwamaka Lasebikan Luther A Agaga Kehinde O Ololade Anthonia C Sowunmi Source Type: research

Metastatic prostate cancer mimicking a rectal cancer: a case report
Ecancermedicalscience. 2021 Sep 23;15:1295. doi: 10.3332/ecancer.2021.1295. eCollection 2021.ABSTRACTThe most common presenting symptoms of prostate cancer, a common cancer in males worldwide, are lower urinary tract symptoms. In rare cases, however, urinary symptoms may not be apparent, and patients can present with gastrointestinal symptoms instead. Even rarer is the involvement of non-regional lymph nodes such as the cervical nodes. Here, we report a case of a 50-year-old male who initially presented with constipation and an enlarging left lateral neck mass. Further work-up revealed metastatic prostatic adenocarcinoma a...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Alfredo V Chua Alvin Christopher S Chu Ashraf A Tawasil Michael D San Juan Source Type: research

Oncology training and education initiatives in low and middle income countries: a scoping review
CONCLUSIONS: There is a paucity of oncology training and education initiatives in LMICs published in English. Initiatives for non-physicians, efforts to foster collaboration within and between LMICs, knowledge sharing initiatives and studies that measure the impact of these initiatives on developing an effective workforce are highly recommended.PMID:34824619 | PMC:PMC8580602 | DOI:10.3332/ecancer.2021.1296 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Safiya Karim Zahra Sunderji Matthew Jalink Sahar Mohamed Indranil Mallick Susan Citonje Msadabwe-Chikuni Nancy J Delgarno Nazik Hammad Scott Berry Source Type: research

High dose interstitial brachytherapy for treatment of carcinoma of the lip as an alternative to surgery: a case report
We present a case of a patient diagnosed with stage II lower LC who refused surgical treatment. Instead, high-dose-rate interstitial BT was performed with 192Ir. A 2-year post-treatment follow-up indicated there were neither serious complications nor recurrence of cancer during that period.PMID:34824620 | PMC:PMC8580587 | DOI:10.3332/ecancer.2021.1297 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Percy Torres-Quispe Lissett Jeanette Fern ández-Rodríguez Yaowen Zhang Angeles Rovirosa-Casino Source Type: research

Exploring primary care level provider interpretation and management of potential breast and cervical cancer signs and symptoms in South Africa
CONCLUSION: Clinical assessment at PHC level is complex and influenced by local health issues. Providing context-relevant training and support for PHC providers, and improving referral and feedback systems, could assist timely diagnosis of women with symptomatic breast and cervical cancer.PMID:34824621 | PMC:PMC8580586 | DOI:10.3332/ecancer.2021.1298 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Jennifer Moodley Jane Harries Suzanne Emilie Scott Amos Deogratius Mwaka Smiji Saji Fiona Mary Walter Source Type: research

Impact of the COVID-19 pandemic on breast and cervical cancer stage at diagnosis in Brazil
Ecancermedicalscience. 2021 Oct 4;15:1299. doi: 10.3332/ecancer.2021.1299. eCollection 2021.ABSTRACTBACKGROUND: The COVID-19 pandemic has led to the need for health services adjustments, which may have compromised management of other diseases. For cancer patients, delays may significantly impair outcomes in some situations. We aimed to assess the impact of the COVID-19 pandemic in breast and cervical cancer diagnosis and treatment compared to the same period prior to the pandemic.METHODS: Data were collected from patients attending their first visit to a Brazilian cancer centre from 1 September 2020 to 31 January 2021 and ...
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Renata Colombo Bonadio Ana Paula Messias Otavio Augusto Moreira Let ícia Vecchi Leis Bruna Zanin Orsi Laura Testa Maria Del Pilar Estevez-Diz Source Type: research

Factors associated with unmet supportive care needs of oncology patients at Dessie Referral Hospital, 2020
CONCLUSION AND RECOMMENDATION: This study shows that the prevalence of unmet supportive care needs in cancer patients is high in each domain. Age, income, cancer stage, cancer site, treatment option, time since diagnosis and sources of information were associated across one or more unmet supportive care needs domains. Therefore, the government and health professionals should work together to improve the unmet needs of cancer patients.PMID:34824623 | PMC:PMC8580717 | DOI:10.3332/ecancer.2021.1300 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - November 26, 2021 Category: Cancer & Oncology Authors: Husniya Yasin Amane Asressie Molla Tessema Kemal Ahmed Seid Anissa Mohammed Hassen Hussien Endris Assen Zinet Abegaz Asfaw Salih Mohamed Endrie Foziya Mohammed Hussien Source Type: research