Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies
Toxicol Pathol. 2024 Jan 28:1926233231224466. doi: 10.1177/01926233231224466. Online ahead of print.ABSTRACTData collected from approximately 1800 male and 1800 female Sprague-Dawley (SD) rats used in 104-week carcinogenicity studies were archived in a historical control database at Labcorp Early Development, Inc, and the neoplastic microscopic observation data from these rats were retrospectively evaluated. Historical control data can provide useful information on the range and incidence of spontaneously occurring background neoplasms in the species and strain of the test animal used in different types of toxicity studies...
Source: Toxicologic Pathology - January 28, 2024 Category: Pathology Authors: Amit Kumar Marie Bockenstedt Victoria Laast Alok Sharma Source Type: research
Soluble CD147 regulates endostatin via its effects on the activities of MMP-9 and secreted proteasome 20S
During progression of rheumatoid arthritis (RA), angiogenesis provides oxygen and nutrients for the cells’ increased metabolic demands and number. To turn on angiogenesis, pro-angiogenic factors must outweigh anti-angiogenic factors. We have previously shown that CD147/extracellular matrix metalloproteinase inducer (EMMPRIN) can induce the expression of the pro-angiogenic factors vascular endothelial growth factor (VEGF) and matrix metallopeptidase 9 (MMP-9) in a co-culture of the human HT1080 fibrosarcoma and U937 monocytic-like cell lines. However, whether CD147 influences anti-angiogenic factors was not known. We now ...
Source: Frontiers in Immunology - January 22, 2024 Category: Allergy & Immunology Source Type: research
Insights into the structure-activity relationship of pyrimidine-sulfonamide analogues for targeting BRAF V600E protein
This study utilized machine learning-based QSAR to elucidate chemical substructures of pyrimidine-sulfonamide analogues that correlated to the BRAF V600E inhibitory activity. The findings indicate that the support vector regression (SVR) combined with 15 fingerprints achieved the highest statistical performances in terms of goodness-of-fit, robustness, and predictability. Nine key fingerprints from pyrimidine-sulfonamide analogues were identified to exert the BRAF V600E inhibitory activity. These key fingerprints were validated using network-based activity cliff landscape and molecular docking. Together, the developed algo...
Source: Biophysical Chemistry - January 19, 2024 Category: Chemistry Authors: Tarapong Srisongkram Dheerapat Tookkane Source Type: research
A case of mucinous fibrosarcoma arising in the suprasternal fossa
Asian J Surg. 2024 Jan 6:S1015-9584(23)02111-5. doi: 10.1016/j.asjsur.2023.12.182. Online ahead of print.NO ABSTRACTPMID:38185555 | DOI:10.1016/j.asjsur.2023.12.182 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - January 7, 2024 Category: Surgery Authors: Zitong Chen Quancang Men Yaning Li Fenghua Zhang Source Type: research
A case of mucinous fibrosarcoma arising in the suprasternal fossa
Asian J Surg. 2024 Jan 6:S1015-9584(23)02111-5. doi: 10.1016/j.asjsur.2023.12.182. Online ahead of print.NO ABSTRACTPMID:38185555 | DOI:10.1016/j.asjsur.2023.12.182 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - January 7, 2024 Category: Surgery Authors: Zitong Chen Quancang Men Yaning Li Fenghua Zhang Source Type: research
The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions
Int J Med Sci. 2024 Jan 1;21(1):123-136. doi: 10.7150/ijms.90189. eCollection 2024.ABSTRACTCREB3 subfamily belongs to the bZIP transcription factor family and comprises five members. Normally they are located on the endoplasmic reticulum (ER) membranes and proteolytically activated through RIP (regulated intramembrane proteolysis) on Golgi apparatus to liberate the N-terminus to serve as transcription factors. CREB3L1 acting as one of them transcriptionally regulates the expressions of target genes and exhibits distinct functions from the other members of CREB3 family in eukaryotes. Physiologically, CREB3L1 involves in the...
Source: International Journal of Medical Sciences - January 2, 2024 Category: Biomedical Science Authors: Ying Zhao Zhou Yu Yajuan Song Liumeizi Fan Ting Lei Yinbin He Sheng Hu Source Type: research
GSE230773 Gene expression profiles associated with myxoid liposarcoma scaffold culture compared to monolayer growth and effect of fusion oncogene FUS-DDIT3
Contributors : Parmida Ranji ; Emma Jonasson ; Lisa Andersson ; Stefan Filges ; Manuel Luna Santamar ía ; Soheila Dolatabadi ; Pierre Åman ; Anders StåhlbergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyxoid liposarcoma (MLS) is the second most common type of liposarcoma and is characterized by the fusion oncogene FUS ‐DDIT3 or the less common EWSR1‐DDIT3. FUS-DDIT3 is causative in tumor development, but the molecular function of FUS-DDIT3 remains largely unknown. In addition, the tumor microenvironment is important in MLS development. However, due to a lack of rele...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE191132 Gene expression profiles associated with myxoid liposarcoma scaffold culture compared to xenograft and effect of fusion oncogene FUS-DDIT3
Contributors : Anders St åhlberg ; Stefan FilgesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyxoid liposarcoma (MLS) is the second most common type of liposarcoma and is characterized by the fusion oncogene FUS ‐DDIT3 or the less common EWSR1‐DDIT3. While the presence of FUS-DDIT3 as a driver oncoprotein in most MLS cases has been confirmed, the exact molecular action behind the capacity of FUS-DDIT3 for transformation is still unclear and therefore creates a challenge in finding new treatments against this type of cancer. The importance of the microenvironment for tumor p...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant mesenchymal liver lesions
Med Ultrason. 2023 Nov 22. doi: 10.11152/mu-4302. Online ahead of print.ABSTRACTThe diagnosis or rare mesenchymal malignant lesions of the liver may be a challenge owing to the rarity of the disease and is usually made by histological confirmation. An ultrasound examination with, if required, color Doppler sonography and contrast-enhanced ultrasound, taking into account the clinical background of the patient, may help to focus the differential diagnosis. In this review, we describe the pathological and ultrasound features of several rare mesenchymal malignant liver lesions which include undifferentiated sarcoma of the live...
Source: Medical Ultrasonography - December 27, 2023 Category: Radiology Authors: Ehsan Safai Zadeh Nicole Schreiber Christian G örg Katharina Paulina Huber Kathleen M öller Analisa Berzigotti Thomas Thomsen Christian Jenssen Ernst-Michael Jung Adrian Lim Masayuki Kitano Ryo Shimizu Yi Dong Xin Wu Cui David Srivastava Christoph F Die Source Type: research
