Sclerosing epithelioid fibrosarcoma of bone with hybrid features: clinicopathologic, radiologic, and molecular analysis of three cases
AbstractSclerosing epithelioid fibrosarcoma (SEF) occurring as a primary bone tumor is exceptionally uncommon. Even more rare are cases of SEF that show morphologic overlap with low-grade fibromyxoid sarcoma (LGFMS). Such hybrid lesions arising within the bone have only rarely been reported in the literature. Due to their variegated histomorphology and non-specific radiologic features, these tumors may pose diagnostic difficulties. Herein we describe three molecularly confirmed primary bone cases of sclerosing epithelioid fibrosarcoma that demonstrated prominent areas showing the features of LGFMS and with areas resembli...
Source: Skeletal Radiology - December 20, 2023 Category: Radiology Source Type: research
Cancers, Vol. 16, Pages 43: Congenital Tumors & mdash;Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers, Vol. 16, Pages 43: Congenital Tumors—Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers doi: 10.3390/cancers16010043
Authors:
Kwasniewicz
Wieczorek-Pastusiak
Romaniuk-Doroszewska
Bekiesinska-Figatowska
Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were ...
Source: Cancers - December 20, 2023 Category: Cancer & Oncology Authors: Kwasniewicz Wieczorek-Pastusiak Romaniuk-Doroszewska Bekiesinska-Figatowska Tags: Article Source Type: research
Sclerosing epithelioid fibrosarcoma associated with WRN gene variant presenting as chronic dyspnea and pathologic cervical fracture: a case report and review of the literature
ConclusionSclerosing epithelioid fibrosarcoma is a very rare entity, only cited approximately 100 times in literature to date. Physicians should be aware of this disease entity and consider it in their differential diagnosis. Though pulmonary involvement has been described in the context of sclerosing epithelioid fibrosarcoma, this malignancy may affect many organ systems, warranting extensive investigation. Through our diagnostic workup, we suggest a possible link between sclerosing epithelioid fibrosarcoma and theWRN gene. Further study is needed to advance our understanding of sclerosing epithelioid fibrosarcoma and its...
Source: Journal of Medical Case Reports - December 17, 2023 Category: General Medicine Source Type: research
Cancers, Vol. 15, Pages 5864: Relevance of Molecular Pathology for the Diagnosis of Sex Cord & ndash;Stromal Tumors of the Ovary: A Narrative Review
Cancers, Vol. 15, Pages 5864: Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review
Cancers doi: 10.3390/cancers15245864
Authors:
Alexis Trecourt
Marie Donzel
Nadjla Alsadoun
Fabienne Allias
Mojgan Devouassoux-Shisheboran
Ovarian sex cord–stromal tumors (SCSTs) account for 8% of all primary ovarian neo-plasms. Accurate diagnosis is crucial since each subtype has a specific prognostic and treatment. Apart from fibrosarcomas, stromal tumors are benign while sex cord tumors may recur, sometimes with a significant time to relapse. ...
Source: Cancers - December 15, 2023 Category: Cancer & Oncology Authors: Alexis Trecourt Marie Donzel Nadjla Alsadoun Fabienne Allias Mojgan Devouassoux-Shisheboran Tags: Review Source Type: research
ROS-mediated anticancer effects of EGFR-targeted nanoceria
J Biomed Mater Res A. 2023 Dec 12. doi: 10.1002/jbm.a.37656. Online ahead of print.ABSTRACTThe therapeutic effectiveness of anticancer drugs, including nanomedicines, can be enhanced with active receptor-targeting strategies. Epidermal growth factor receptor (EGFR) is an important cancer biomarker, constitutively expressed in sarcoma patients of different histological types. The present work reports materials and in vitro biomedical analyses of silanized (passive delivery) and/or EGF-functionalized (active delivery) ceria nanorods exhibiting highly defective catalytically active surfaces. The EGFR-targeting efficiency of n...
Source: Cell Research - December 12, 2023 Category: Cytology Authors: Kochurani K Johnson Pramod Koshy Chantal Kopecky Michelle Devadason Joanna Biazik Xiaoran Zheng Yue Jiang Xiaochun Wang Yiling Liu Jeff Holst Jia-Lin Yang Kristopher A Kilian Charles C Sorrell Source Type: research
ROS-mediated anticancer effects of EGFR-targeted nanoceria
J Biomed Mater Res A. 2023 Dec 12. doi: 10.1002/jbm.a.37656. Online ahead of print.ABSTRACTThe therapeutic effectiveness of anticancer drugs, including nanomedicines, can be enhanced with active receptor-targeting strategies. Epidermal growth factor receptor (EGFR) is an important cancer biomarker, constitutively expressed in sarcoma patients of different histological types. The present work reports materials and in vitro biomedical analyses of silanized (passive delivery) and/or EGF-functionalized (active delivery) ceria nanorods exhibiting highly defective catalytically active surfaces. The EGFR-targeting efficiency of n...
Source: Biomed Res - December 12, 2023 Category: Research Authors: Kochurani K Johnson Pramod Koshy Chantal Kopecky Michelle Devadason Joanna Biazik Xiaoran Zheng Yue Jiang Xiaochun Wang Yiling Liu Jeff Holst Jia-Lin Yang Kristopher A Kilian Charles C Sorrell Source Type: research
Identification of common factors among fibrosarcoma, rhabdomyosarcoma, and osteosarcoma by network analysis
In conclusion, the common DEGs identified in this study have been shown to play significant and multiple roles in various other cancers based on the literature review, indicating their significance.PMID:38052344 | DOI:10.1016/j.biosystems.2023.105093 (Source: Biosystems)
Source: Biosystems - December 5, 2023 Category: Biotechnology Authors: Mehran Radak Nakisa Ghamari Hossein Fallahi Source Type: research
GALNT12 promotes fibrosarcoma growth by accelerating YAP1 nuclear localization
Oncol Lett. 2023 Nov 3;26(6):543. doi: 10.3892/ol.2023.14131. eCollection 2023 Dec.ABSTRACTFibrosarcoma is a highly malignant type of soft tissue sarcoma that currently lacks effective treatment options. Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12) belongs to the uridine diphosphate N-acetylgalactosamine gene family, which is involved in numerous biological processes of diseases, such as tumor progression. Its upregulated expression is closely associated with the development of colorectal cancer. However, research on the role of GALNT12 in fibrosarcoma is currently limited. The present study aimed to assess t...
Source: Oncology Letters - November 29, 2023 Category: Cancer & Oncology Authors: Site Yu Wenjie Feng Jizhang Zeng Situo Zhou Yinghua Peng Pihong Zhang Source Type: research
Sclerosing Epithelioid Fibrosarcoma (SEF) versus Low Grade Fibromyxoid Sarcoma (LGFMS): presentation and outcome in the nationwide NETSARC+ series of 330 patients over 13 years
We report on the nationwide exhaustive series of 330 patients with SEF or LGFMS in NETSARC+ since 2010. (Source: European Journal of Cancer)
Source: European Journal of Cancer - November 23, 2023 Category: Cancer & Oncology Authors: JY Blay, C. Tlemsani, M Toulmonde, A. Italiano, M. Rios, E. Bompas, T. Valentin, F. Duffaud, LR Le Nail, S. Watson, N Firmin, P Dubray-Longeras, M Ropars, C. Perrin, A Hervieu, C Lebbe, E Saada-Bouzid, P. Soibinet, F. Fiorenza, F. Bertucci, P. Boudou, G V Tags: Original Research Source Type: research
